The University of South Florida, also known as USF, is a member institution of the State University System of Florida, one of the state's three flagship universities for public research, and is located in Tampa, Florida, USA. Founded in 1956, USF is the eighth largest university in the nation and the third largest in the state of Florida, with a total enrollment of 47,122 as of 2009. USF has an autonomous campus in St. Petersburg, and branch centers in Sarasota and Lakeland. Wikipedia.
H. Lee Moffitt Cancer Center, Research Institute and University of South Florida | Date: 2017-05-03
The current invention pertains to a molecular conjugate comprising an antagonist of a cell surface receptor specific to a target cell and an immune effector, such as a T cell modulator, conjugated to the antagonist. The target cell can be a cell responsible for development of a disease in a subject, for example, a cancer cell. In certain embodiments, the immune effector is an immune effector protein or an immune effector fragment thereof. The current invention also pertains to a method of treating a disease in a subject, the method comprising administering to the subject a pharmaceutically effective amount of the molecular conjugates of the current invention to the subject. The methods of the current invention can be used to treat cancer, such as breast cancer, ovarian cancer, prostate cancer, lung cancer, pancreatic cancer, or melanoma.
University of South Florida and Transgenex Therapeutics LLC | Date: 2017-03-29
Described herein are compositions and methods of forming multi-cellular tumoroids. Also described herein are methods of using the multi-cellular tumoroids.
University of South Florida | Date: 2016-11-14
A radial arm model in combination with a two-way mesh to permit puncturing, dissection/transection, and suturing of the underlying simulation vessels. The current invention also includes a method of training for such a procedure using said model, along with a method of fabricating or manufacturing such a model.
University of South Florida | Date: 2016-11-14
Provided are methods of treating an inflammatory disease in a subject in need thereof by administering an amount of microRNA 142, an amount of microRNA 223 or an amount of microRNA 142 and an amount of micro RNA 223 to the subject in need thereof.
University of South Florida | Date: 2016-06-29
Unit cell bistable elements, and particular arrangements thereof, that can transform or morph a structure from one shape to another. In certain embodiments, the current invention includes unit cell bistable elements, and particular arrangements and uses thereof, that can transform or morph a structure from one shape to another. In an embodiment, the current invention provides a method/ability to transform any four-bar compliant mechanism into a bistable compliant mechanism. It is an object of the current invention to facilitate structures morphing from one specific shape to another specific shape using unit cell bistable elements.
University of South Florida, King Abdullah University of Science and Technology | Date: 2017-02-08
Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of separating CO_(2 )from a gas, and the like.
University of South Florida | Date: 2016-11-23
Human umbilical cord blood-derived monocytes that markedly promote A clearance through heterodimerization of sAPP with A and resultant sAPP production for prevention or treatment of Alzheimers disease and other neurodegenerative disorders (including stroke and TBI). It was discovered that multiple low-dose infusions of human umbilical cord blood cells (HUCBCs) ameliorate cognitive impairments and reduce A-associated neuropathology in PSAPP transgenic mice, which markedly promotes amyloid precursor protein (APP) -cleavage and resultant sAPP production for pharmaceutical purposes, in particular for treating or slowing the progression of Alzheimers disease.
University of South Florida | Date: 2017-01-25
In one embodiment, a portable wastewater treatment system includes an anaerobic reactor in which organic material within the wastewater can be broken down, a membrane filter that receives wastewater from the anaerobic reactor and filters the water to produce permeate, and a small shipping container in which the reactor and the membrane filter are contained.
University of South Florida | Date: 2017-05-24
In one embodiment, a reversible anchoring device includes a base having a threaded shaft and an internal passage that extends through the base along a longitudinal direction of the base and a cap having a top surface, a bottom surface, a threaded circular opening formed in the bottom surface adapted to thread onto the threaded shaft of the base, and a suture opening that extends from the top surface of the cap to the threaded circular opening through which a suture can pass.
Batzill M.,University of South Florida
Surface Science Reports | Year: 2012
Graphene, a single atomic layer of sp 2 hybridized carbon, exhibits a zero-band gap with linear band dispersion at the Fermi-level, forming a Dirac-cone at the K-points of its Brillouin zone. In this review, we focus on basic materials science issues of this intriguing material. The scope of this work is further narrowed by concentrating on graphene grown at transition metal surfaces, mostly under vacuum conditions, and neglecting other graphene synthesis approaches, namely growth on SiC or by graphene oxide reduction. Thus one large section of this review focuses on metal/graphene interfaces. We summarize recent surface science studies on the structure, interaction, and the growth of graphene on various metals. Metal supported graphene is a recurring theme throughout this review as it provides model-systems for studying adsorption and graphene modifications on well-defined, large area samples, and thus is ideal for employing surface science techniques. Other aspects of graphene are also reviewed. Approaches for creating and characterizing graphene nanostructures, in particular graphene nanoribbons, are discussed. Graphene nanoribbons play an important role for potential electronic applications because the lateral electron confinement in the ribbons opens a band-gap in graphene. Materials issues of nanoribbons, like formation of well-defined edges are introduced. Atomic-scale defect-structures in graphene are another topic. The known defect structures in graphene are categorized and atomic scale characterization of these defects by scanning tunneling microscopy (stocktickerSTM) and high resolution transmission electron microscopy (TEM) is illustrated. Important for applications of graphene is our ability of modifying its properties. Therefore, studies of substitutional doping of graphene with nitrogen or boron, hydrogenation or fluorination of graphene, and the adsorption of molecules with strong electron affinity are included in this review. This review is restricted to a summary of surface science studies on well-ordered systems. Other important graphene research areas such as transport measurements on pure and modified graphene are not included. The goal of this review is to give a concise overview of the materials science of graphene from the surface science perspective. © 2011 Elsevier B.V. All rights reserved.