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Hengyang, China

This page describes a mainland Chinese university. For the identically-named Taiwan institution, see Nanhua University.The University of South China is a university in Hengyang, China, merged in 2000 by its two predecessors: the ] and ]. The University of South China, with a nation-wide enrollment, is administered by Hunan Provincial Government, and co-funded by Commission of Science, Technology and Industry for National Defence and a few other ministries of the central government.In October 2002, University of South China incorporated the Sixth Institute of National Nuclear Industry as its subordinating part and took over No. 415 Hospital as one of its affiliated hospitals. In July 2004, the Chinese People's Liberation Army Navy set up a training base for its reservist officers in University of South China. The University of South China was initially authorized to award bachelor degrees, and in 1986 began awarding master degrees. In 1991, it began to collaborate with other universities and research institutes in doctoral programs, and was authorized to award doctoral degrees in 2003.The university has 72 undergraduate majors, covering as many as 8 disciplinary areas . There are 6 provincial key disciplines, 5 disciplines administrated by the Chinese government, and 1 key discipline of national defence. 18 Programs are entitled to award Ph. D. degree, 124 MA or M.S. degrees, and 35 professional degrees. The mining engineering, nuclear technology and its application, pathology and pathological physiology, and pharmacology are Hunan provincial key construction disciplines. There are 2 ministerial key laboratories, i.e. the dissolution and mineral laboratory, the coordinating laboratory of the International Radon Calculation Program of IAEA in Asia, 1 provincial key laboratory, i.e. the radon laboratory.Nuclear science, medical science and environment-related science are the three pillarstones of the university.The university began its international student education in 2011, and there are now more than 50 students from 8 countries, most of them majoring in clinical medicine. Wikipedia.

We previously reported that hydrogen sulfide (H(2)S) produces protection in PC12 cells during 1-methy-4-phenylpyridinium ion (MPP(+)) challenge. The present study aims to clarify the mechanisms underlying the neuroprotective effects of H(2)S. We showed that both glybenclamide, an ATP-sensitive potassium (K(ATP)) channel blocker, and LY294002, a specific PI(3)K-AKT pathway inhibitor, reversed the neuroprotective effect of NaHS (a H(2)S donor) against MPP(+)-induced cytotoxicity to PC12 cells and that NaHS up-regulated the activity of AKT in PC12 cells, which was abolished by blockade of K(ATP) channels with glybenclamide. In addition, NaHS up-regulated the expression of Bcl-2 and blocked MPP(+)-induced down-regulation of Bcl-2, and this augmentation of Bcl-2 expression was prevented by both glybenclamide and LY294002. These data provided the evidence that the neuroprotective action of H(2)S against MPP(+) toxicity to PC12 cells is via the K(ATP)/PI(3)K/AKT/Bcl-2 pathway. We also demonstrated that NaHS attenuated the inhibitory effect of MPP(+) ERK1/2 activation in PC12 cells, whereas U0126, a specific MEK inhibitor, did not reverse the neuroprotective effect of NaHS, which indicated that attenuating MPP(+)-triggered down-regulation of ERK1/2 activation is involved in the protection of H(2)S against MPP(+) neurotoxicity, but ERK1/2 is not an essential effector mediating the neuroprotective effect of H(2)S. In conclusion, the present observations identify a crucial role of the K(ATP)/PI(3)K/AKT/Bcl-2 pathway in H(2)S-exerted neuroprotection against the toxicity of MPP(+). Findings from the present study will help shed light on the mechanisms of H(2)S-elicited neuroprotective effects on MPP(+) toxicity. Source

The APJ is a class A, rhodopsin-like G protein-coupled receptor (GPCR) with high sequence similarity to the angiotensin receptor AT1. APJ has been shown to be widely expressed in humans tissues, including the central nervous system, cardiovascular system, adipocytes and others. APJ plays an important role in the occurrence and development of cardiovascular and metabolic diseases including atherosclerosis (AS), coronary heart disease (CAD), heart failure(HF), pulmonary arterial hypertension (PAH), myocardial hypertrophy and atrial fibrillation, especially hypertension. Previous researchers found that apelin/APJ could induce vasodilation and then reduce blood pressure. Despite APJ is closely associated with many diseases, there are no drugs that can activate or inhibit APJ directly. In the current review, we have summarized recently reported peptides, small molecule agonists and antagonists targeting APJ. Given the role of apelin/APJ in hypertension and other cardiovascular diseases, we believe that the peptides and compounds based on APJ will be developed for treatment of these diseases. Source

Lin Y.-W.,University of South China
Proteins: Structure, Function and Bioinformatics

Rational design of functional enzymes is a powerful strategy to gain deep insights into more complex native enzymes, such as nitric oxide reductase (NOR). Recently, we engineered a functional model of NOR by creating a two His and one Glu (2-His-1-Glu) non-heme iron center in sperm whale myoglobin (swMb L29E, F43H, H64, called Fe BMb(-His)). It was found that Fe BMb(-His) adopts a low-spin state with bis-His coordination in the absence of metal ions binding to the designed metal center. However, no structural information was available for the variant in this special spin state. We herein performed molecular modeling of Fe BMb(-His) and compared with the X-ray structure of its copper bound derivative, Cu(II)-CN --Fe BMb(-His), resolved recently at a high resolution (1.65 Å) (PDB entry 3MN0). The simulated structure shows that mutation of Leu to Glu at position 29 in the hydrophobic heme pocket alters the folding behavior of Mb. The hydrogen bond between Glu29 and His64 further plays a role in stabilizing the bis-His (His64/His93) coordination structure. This study offers an excellent example of using molecular modeling to gain insights in rational design of both structural and functional proteins. © 2010 Wiley-Liss, Inc. Source

A field investigation was conducted for the vegetation composition and (226)Ra uptake by native plant species at a uranium mill tailings impoundment in South China. 80 species belonging to 67 genera in 32 families were recorded in the sampling sites. The Poaceae and Asteraceae were the dominant families colonizing the impoundment. The number of the plant species and vegetation community composition in the sampling sites seemed most closely related to the activities of (226)Ra and the pH value of the uranium tailings. The plant species in the sampling sites with relatively low activities of (226)Ra and relatively high pH value formed a relatively stable vegetation community. The plant species in the sampling sites with medium activities of (226)Ra and medium pH value formed the transitional vegetation community. The plant species in the sampling sites with relatively high activities of (226)Ra and relatively low pH value formed a simple unstable vegetation community that was similar to that on the unused grassland. The activities of (226)Ra and transfer factors (TFs) varied greatly with the plant species. The high activities of (226)Ra and TFs were found in the leaves of Pteris multifida (150.6 Bq/g of AW; 9.131), Pteridium aquilinum (122.2 Bq/g of AW; 7.409), and Dryopteris scottii (105.7 Bq/g of AW; 6.408). They satisfied the criteria for a hyperaccumulator for (226)Ra. They may be the candidates for phytoremediation of (226)Ra in the uranium mill tailings impoundment areas and the contaminated soils around. Copyright © 2013 Elsevier Ltd. All rights reserved. Source

Wang G.,University of South China | Wang G.,NRC Institute for Fuel Cell Innovation | Zhang L.,NRC Institute for Fuel Cell Innovation | Zhang J.,NRC Institute for Fuel Cell Innovation
Chemical Society Reviews

In this critical review, metal oxides-based materials for electrochemical supercapacitor (ES) electrodes are reviewed in detail together with a brief review of carbon materials and conducting polymers. Their advantages, disadvantages, and performance in ES electrodes are discussed through extensive analysis of the literature, and new trends in material development are also reviewed. Two important future research directions are indicated and summarized, based on results published in the literature: the development of composite and nanostructured ES materials to overcome the major challenge posed by the low energy density of ES (476 references). © 2012 The Royal Society of Chemistry. Source

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