Hengyang, China

University of South China

usc.edu.cn
Hengyang, China

This page describes a mainland Chinese university. For the identically-named Taiwan institution, see Nanhua University.The University of South China is a university in Hengyang, China, merged in 2000 by its two predecessors: the ] and ]. The University of South China, with a nation-wide enrollment, is administered by Hunan Provincial Government, and co-funded by Commission of Science, Technology and Industry for National Defence and a few other ministries of the central government.In October 2002, University of South China incorporated the Sixth Institute of National Nuclear Industry as its subordinating part and took over No. 415 Hospital as one of its affiliated hospitals. In July 2004, the Chinese People's Liberation Army Navy set up a training base for its reservist officers in University of South China. The University of South China was initially authorized to award bachelor degrees, and in 1986 began awarding master degrees. In 1991, it began to collaborate with other universities and research institutes in doctoral programs, and was authorized to award doctoral degrees in 2003.The university has 72 undergraduate majors, covering as many as 8 disciplinary areas . There are 6 provincial key disciplines, 5 disciplines administrated by the Chinese government, and 1 key discipline of national defence. 18 Programs are entitled to award Ph. D. degree, 124 MA or M.S. degrees, and 35 professional degrees. The mining engineering, nuclear technology and its application, pathology and pathological physiology, and pharmacology are Hunan provincial key construction disciplines. There are 2 ministerial key laboratories, i.e. the dissolution and mineral laboratory, the coordinating laboratory of the International Radon Calculation Program of IAEA in Asia, 1 provincial key laboratory, i.e. the radon laboratory.Nuclear science, medical science and environment-related science are the three pillarstones of the university.The university began its international student education in 2011, and there are now more than 50 students from 8 countries, most of them majoring in clinical medicine. Wikipedia.

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— He is Dr. Xinping Song from the 3D Urology and Prpstate Clinic. After decades of concentrating on the traditional Chinese medicine, not only has he brought health to thousands of patients at home and abroad, but also he has succeeded in promoting traditional Chinese medicine culture to overseas. Dr. Xinping Song has personally proved that Chinese private doctors can create a medical miracle which can be said to be "a model of Chinese private doctors." Always hardest in the first step Concentrate on solving patients’ trouble "The thing I think most for these years is how to relieve the pain for the patient. Perhaps now I have made a little bit achievement, but it is still far from enough. I hope that my efforts for decades would not be in vain and I can bring health to more patients......" These kind of heartfelt words have been expressed by Dr. Xinping Song for many times, from which it is not difficult to imagine his decades of hardships. In 1986, Xinping Song graduated from School of Medicine at the University of South China, and he became the chief doctor at the public hospital. At that time, Dr. Song saw more and more patients suffering from pain because of urinary problems, which made him benevolent as a medical practitioner. To this end, he began the in-depth study on the diagnosis and treatment of urinary diseases in 1988, and he finally invented an effective treatment method against relevant symptoms and diseases with independent intellectual property rights which is based on the principles of Chinese acupuncture combined with Western medicine theory and has been accepted and approved by the Chinese medical community after 6 years of rigorous clinical trials. So far, Dr. Xinping Song has had his medical ethics and career for more than 28 years. In order to facilitate patients to see the doctor but not affect their work, Xinping Song has insisted on working from the early dawn to late dusk for a long time by using the rest and meal time of morning, noon, and night to help patients. He often forgot to eat, thus he made himself suffer from stomach and heart diseases. And he was even found to fall in a faint at the clinic by patients because of tiredness for several times. But the first sentence he said when he woke up was that a patient still did not receive treatment. Because of placing patient's health in the first place at all times, he was down with the cumulative illness because of its outbreak, which took about six months to slowly recover. Brave to face the difficulties and hardships Make traditional Chinese medicine world-famous In 1990, some prostate-related diseases have not been well overcome by the medical circle, but under enormous pressure, Xinping Song has successfully overcome these difficult problems step by step through his own painstaking researches and continuous clinical validation. Based on this, numerous patients who have gone to see him for a long time are generally abandoned by a large hospital with incurable diseases. During that time, Xinping Song often said that if he did not help them, then they may be tortured by the disease for a long time, perhaps he would try harder to get more people back to health. It is precisely because of this determination and perseverance that Xinping Song has never retreated from helping patients solve the problems, and thus he has succeeded in curing diseases for numerous people. To this end, many patients even knelt down to praise him to renew their lives. As the saying goes, false friends are worse than bitter enemies. Years of hardships have not defeated Xinping Song, but he fell into an accidental "trap" in 2001. Because of the medical skills, medical ethics, and word of mouth from patients, Xinping Song’s success has caused peer jealousies. Among them, the most serious attack towards him was the "hepatitis C incident" created out of nothing by the peer who bought over the clinic’s doctor and did malicious slander in 2001. During that period, Xinping Song was very low-spirited and depressed, but he still was strict with self-discipline, adhered to medical ethics, and offered service for the patient, because he knew that after all, rumors are just rumors; and one day they would be always vanished. Finally, there came a reward for good deeds. During that period of time, Xinping Song’s domestic and foreign patients submitted a jointly-signed written statement to a higher authority, and the national health department has investigated and made a fair and just judge. The past malicious slander and rumors on the Xinping Song have collapsed themselves without being attacked under the effects of time, conscience, and morality. As the saying goes, the gold will always shine. With superb medical skills and medical ethics, Xinping Song has proved his own value and won the respect of patients around the world through decades of concentrated efforts. Countless patients have come to him because of admiring his fame and eagered to get their good health back from this good doctor and found the true meaning of health. John Kennedy, Ph.D., from the United States, admitted Dr. Song saved his life, and China is a very safe country with very friendly Chinese people here. Today, Dr. Xinping Song is still in the front line to relieve pain for more patients through hard-working. Brave to march forward in front of difficulties and hardships; Devote everything to place patients in the first place; Virtuous medical ethics and technique and superb skills;...... Recalling Dr. Xinping Song's career on the medical road, it can be described as excellent and great, which is a major reason for winning today's reputation of the "private doctor model". In the present medical circle, they should be proud of having such a surgeon-Dr. Xinping Song; at the same time, people should also be glad to have more such doctors appear only for guarding people’s healthy life. For more information, please visit https://www.prostatecancer.vip/


Liu J.,University of South China | Liu J.,University of New Mexico | Jin X.,University of New Mexico | Liu K.J.,University of New Mexico | Liu W.,University of New Mexico
Journal of Neuroscience | Year: 2012

Blood-brain barrier (BBB) disruption occurs early enough to be within the thrombolytic time window, and this early ischemic BBB damage is closely associated with hemorrhagic transformation and thus emerging as a promising target for reducing the hemorrhagic complications of thrombolytic stroke therapy. However, the mechanisms underlying early ischemic BBB damage remain poorly understood. Here, we investigated the early molecular events of ischemic BBB damage using in vitro oxygen-glucose deprivation (OGD) and in vivo rat middle cerebral artery occlusion (MCAO) models. Exposure of bEND3 monolayer to OGD for 2 h significantly increased its permeability to FITC-labeled dextran and promoted the secretion of metalloproteinase-2 and-9 (MMP-2/9) and cytosolic translocation of caveolin-1 (Cav-1). This same OGD treatment also led to rapid degradation of tight junction protein occludin and dissociation of claudin-5 from the cytoskeleton, which contributed to OGD-induced endothelial barrier disruption. Using selective MMP-2/9 inhibitor SB-3CT (2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane) or their neutralizing antibodies or Cav-1 siRNA,wefound thatMMP-2was the major enzyme mediating OGD-induced occludin degradation, while Cav-1 was responsible for claudin-5 redistribution. The interaction between Cav-1 and claudin-5 was further confirmed by coimmunoprecipitation. Consistent with these in vitro findings, we observed fluorescence tracer extravasation, increased gelatinolytic activity, and elevated interstitial MMP-2 levels in ischemic subcortical tissue after 2 h MCAO. Moreover, occludin protein loss and claudin-5 redistribution were detected in ischemic cerebromicrovessels. These data indicate that cerebral ischemia initiates two rapid parallel processes, MMP-2-mediated occludin degradation and Cav-1-mediated claudin-5 redistribution, to cause BBB disruption at early stroke stages relevant to acute thrombolysis. © 2012 the authors.


Wang Y.,University of South China
Medicinal Chemistry | Year: 2011

Lung cancer is a leading cause of death in human. Cancer stem cells have been regarded as basis for failure of current therapeutic options. Salinomycin was shown to kill these cancer stem cells in some types of cancer such as breast cancer and leukemia. The in vitro anticancer activities of salinomycin have been validated against the lung cancer cell line A549 via sulforhodamine B and colony formation assay. Salinomycin has been demonstrated to significantly rupture the in vitro lung cancer tumorospheres from ALDH positive A549 lung cells using flow cytometry. Expression of stem cell markers OCT-4, NANOG and SOX2 in ALDH positive A549 lung cells was decreased significantly by real-time RT-PCR analysis after 24 hour salinomycin treatment. Taken together, salinomycin may provide a promising approach for lung cancer chemotherapy. © 2011 Bentham Science Publishers Ltd.


We previously reported that hydrogen sulfide (H(2)S) produces protection in PC12 cells during 1-methy-4-phenylpyridinium ion (MPP(+)) challenge. The present study aims to clarify the mechanisms underlying the neuroprotective effects of H(2)S. We showed that both glybenclamide, an ATP-sensitive potassium (K(ATP)) channel blocker, and LY294002, a specific PI(3)K-AKT pathway inhibitor, reversed the neuroprotective effect of NaHS (a H(2)S donor) against MPP(+)-induced cytotoxicity to PC12 cells and that NaHS up-regulated the activity of AKT in PC12 cells, which was abolished by blockade of K(ATP) channels with glybenclamide. In addition, NaHS up-regulated the expression of Bcl-2 and blocked MPP(+)-induced down-regulation of Bcl-2, and this augmentation of Bcl-2 expression was prevented by both glybenclamide and LY294002. These data provided the evidence that the neuroprotective action of H(2)S against MPP(+) toxicity to PC12 cells is via the K(ATP)/PI(3)K/AKT/Bcl-2 pathway. We also demonstrated that NaHS attenuated the inhibitory effect of MPP(+) ERK1/2 activation in PC12 cells, whereas U0126, a specific MEK inhibitor, did not reverse the neuroprotective effect of NaHS, which indicated that attenuating MPP(+)-triggered down-regulation of ERK1/2 activation is involved in the protection of H(2)S against MPP(+) neurotoxicity, but ERK1/2 is not an essential effector mediating the neuroprotective effect of H(2)S. In conclusion, the present observations identify a crucial role of the K(ATP)/PI(3)K/AKT/Bcl-2 pathway in H(2)S-exerted neuroprotection against the toxicity of MPP(+). Findings from the present study will help shed light on the mechanisms of H(2)S-elicited neuroprotective effects on MPP(+) toxicity.


Feng S.,University of South China | Cao Z.,University of South China | Wang X.,CAS Guangzhou Institute of Geochemistry
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2013

Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely expressed in a variety of animal species and humans. Recent animal and human data suggested that AHR is involved in various signaling pathways critical to cell normal homeostasis, which covers multiple aspects of physiology, such as cell proliferation and differentiation, gene regulation, cell motility and migration, inflammation and others. Dysregulation of these physiological processes is known to contribute to events such as tumor initiation, promotion, and progression. Increasing epidemiological and experimental animal data provided substantial support for an association between abnormal AHR function and cancer, implicating AHR may be a novel drug-interfering target for cancers. The proposed underlying mechanisms of its actions in cancer involved multiple aspects, (a) inhibiting the functional expression of the key anti-oncogenes (such as p53 and BRCA1), (b) promoting stem cells transforming and angiogenesis, (c) altering cell survival, proliferation and differentiation by influencing the physiologic processes of cell-cycle, apoptosis, cell contact-inhibition, metabolism and remodel of extracellular matrix, and cell-matrix interaction, (d) cross-talking with the signaling pathways of estrogen receptor and inflammation. This review aims to provide a brief overview of recent investigations into the role of AHR and the underlying mechanisms of its actions in cancer, which were explored by the new technologies emerging in recent years. © 2013 Elsevier B.V.


The APJ is a class A, rhodopsin-like G protein-coupled receptor (GPCR) with high sequence similarity to the angiotensin receptor AT1. APJ has been shown to be widely expressed in humans tissues, including the central nervous system, cardiovascular system, adipocytes and others. APJ plays an important role in the occurrence and development of cardiovascular and metabolic diseases including atherosclerosis (AS), coronary heart disease (CAD), heart failure(HF), pulmonary arterial hypertension (PAH), myocardial hypertrophy and atrial fibrillation, especially hypertension. Previous researchers found that apelin/APJ could induce vasodilation and then reduce blood pressure. Despite APJ is closely associated with many diseases, there are no drugs that can activate or inhibit APJ directly. In the current review, we have summarized recently reported peptides, small molecule agonists and antagonists targeting APJ. Given the role of apelin/APJ in hypertension and other cardiovascular diseases, we believe that the peptides and compounds based on APJ will be developed for treatment of these diseases.


Wang G.,University of South China | Wang G.,NRC Institute for Fuel Cell Innovation | Zhang L.,NRC Institute for Fuel Cell Innovation | Zhang J.,NRC Institute for Fuel Cell Innovation
Chemical Society Reviews | Year: 2012

In this critical review, metal oxides-based materials for electrochemical supercapacitor (ES) electrodes are reviewed in detail together with a brief review of carbon materials and conducting polymers. Their advantages, disadvantages, and performance in ES electrodes are discussed through extensive analysis of the literature, and new trends in material development are also reviewed. Two important future research directions are indicated and summarized, based on results published in the literature: the development of composite and nanostructured ES materials to overcome the major challenge posed by the low energy density of ES (476 references). © 2012 The Royal Society of Chemistry.


Hu N.,University of South China
Journal of environmental radioactivity | Year: 2014

A field investigation was conducted for the vegetation composition and (226)Ra uptake by native plant species at a uranium mill tailings impoundment in South China. 80 species belonging to 67 genera in 32 families were recorded in the sampling sites. The Poaceae and Asteraceae were the dominant families colonizing the impoundment. The number of the plant species and vegetation community composition in the sampling sites seemed most closely related to the activities of (226)Ra and the pH value of the uranium tailings. The plant species in the sampling sites with relatively low activities of (226)Ra and relatively high pH value formed a relatively stable vegetation community. The plant species in the sampling sites with medium activities of (226)Ra and medium pH value formed the transitional vegetation community. The plant species in the sampling sites with relatively high activities of (226)Ra and relatively low pH value formed a simple unstable vegetation community that was similar to that on the unused grassland. The activities of (226)Ra and transfer factors (TFs) varied greatly with the plant species. The high activities of (226)Ra and TFs were found in the leaves of Pteris multifida (150.6 Bq/g of AW; 9.131), Pteridium aquilinum (122.2 Bq/g of AW; 7.409), and Dryopteris scottii (105.7 Bq/g of AW; 6.408). They satisfied the criteria for a hyperaccumulator for (226)Ra. They may be the candidates for phytoremediation of (226)Ra in the uranium mill tailings impoundment areas and the contaminated soils around. Copyright © 2013 Elsevier Ltd. All rights reserved.


Lin Y.-W.,University of South China
Proteins: Structure, Function and Bioinformatics | Year: 2011

Rational design of functional enzymes is a powerful strategy to gain deep insights into more complex native enzymes, such as nitric oxide reductase (NOR). Recently, we engineered a functional model of NOR by creating a two His and one Glu (2-His-1-Glu) non-heme iron center in sperm whale myoglobin (swMb L29E, F43H, H64, called Fe BMb(-His)). It was found that Fe BMb(-His) adopts a low-spin state with bis-His coordination in the absence of metal ions binding to the designed metal center. However, no structural information was available for the variant in this special spin state. We herein performed molecular modeling of Fe BMb(-His) and compared with the X-ray structure of its copper bound derivative, Cu(II)-CN --Fe BMb(-His), resolved recently at a high resolution (1.65 Å) (PDB entry 3MN0). The simulated structure shows that mutation of Leu to Glu at position 29 in the hydrophobic heme pocket alters the folding behavior of Mb. The hydrogen bond between Glu29 and His64 further plays a role in stabilizing the bis-His (His64/His93) coordination structure. This study offers an excellent example of using molecular modeling to gain insights in rational design of both structural and functional proteins. © 2010 Wiley-Liss, Inc.


Huang L.,University of South China
European review for medical and pharmacological sciences | Year: 2013

Recently, widespread interest has grown regarding melatonin treatment of hypertension including its cardioprotective effects. Studies in rodents indicate that melatonin plays a role in the pathogenesis of hypertension in rats with metabolic syndrome. Piromelatine, a melatonin agonist, serotonin 5-HT-1A and 5-HT-1D agonist and serotonin 5-HT2B antagonist is a multimodal agent with sleep promoting, anti-diabetic, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potential, currently in development for the treatment of insomnia. In this report we assessed the effects of piromelatine and melatonin treatment on blood pressure in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Five groups of 12-wk-old rats (10/group) were treated for 5 weeks with a vehicle, piromelatine (5, 15 and 50 mg/kg BW) and melatonin (10 mg/kg BW) and an age-matched WKY control group. Systolic blood pressure (tail-cuff method) was measured weekly at 9:00 a.m. and at 9:00 p.m. The rats body weight, plasma glucose, insulin, triglyceride, adiponectin, total cholesterol, HDL and LDL/VLDL cholesterol were also measured. Our results showed that both piromelatine and melatonin reduced SHR blood pressure significantly both during the morning and the evening. Piromelatine, but not melatonin, also reduced SHR body weight gain and both significantly decreased plasma glucose and insulin levels and increased adiponectin levels. Piromelatine, similar to melatonin, has an antihypertensive effect and also attenuates body weight, improves metabolic profiles and might be useful in the treatment of hypertension and the metabolic syndrome.

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