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Columbia, SC, United States

The University of South Carolina is a public, co-educational research university located in Columbia, South Carolina, United States, with seven satellite campuses. Its campus covers over 359 acres in downtown Columbia not far from the South Carolina State House. The University is categorized by the Carnegie Foundation for the Advancement of Teaching as having "very high research activity" and curricular community engagement. It has been ranked as an "up-and-coming" university by U.S. News & World Report, and its undergraduate and graduate International Business programs have ranked among the top three programs in the nation for over a decade. It also houses the largest collection of Robert Burns and Scottish literature materials outside of Scotland, and the largest Ernest Hemingway collection in the world.Founded in 1801 as South Carolina College, South Carolina is the flagship institution of the University of South Carolina System and offers more than 350 programs of study leading to bachelor's, master's, and doctoral degrees from fourteen degree-granting colleges and schools. The University of South Carolina System has an enrollment of approximately 47,724 students, with 32,848 on the main Columbia campus as of fall 2013. USC also has several thousand future students in feeder programs at surrounding technical colleges. Professional schools on the Columbia campus include social work, business, engineering, law, medicine, and pharmacy. Wikipedia.


Spinale F.G.,University of South Carolina
Circulation research | Year: 2013

The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural proteins, signaling molecules, and proteases. Changes in the overall integrity and activational state of these ECM constituents can contribute to tissue structure and function, which is certainly true of the myocardium. Changes in the expression patterns and activational states of a family of ECM proteolytic enzymes, the matrix metalloproteinases (MMPs), have been identified in all forms of left ventricle remodeling and can be a contributory factor in the progression to heart failure. However, new clinical and basic research has identified some surprising and unpredicted changes in MMP profiles in left ventricle remodeling processes, such as with pressure or volume overload, as well as with myocardial infarction. From these studies, it has become recognized that proteolytic processing of signaling molecules by certain MMP types, particularly the transmembrane MMPs, actually may facilitate ECM accumulation and modulate fibroblast transdifferentiation; both are critical events in adverse left ventricle remodeling. Based on the ever-increasing substrates and diversity of biological actions of MMPs, it is likely that continued research about the relationship of left ventricle remodeling in this family of proteases will yield new insights into the ECM remodeling process and new therapeutic targets. Source


Patent
University of South Carolina | Date: 2015-08-24

Described is a method to fabricate a gold/mesoporous silica hybrid nanoparticle. According to the process, a gold nanoparticle can be conjugated onto the surface of a mesoporous silica nanoparticle to yield a photothermal stable theranostic platform, gold/mesoporous silica hybrid nanoparticle. The nanoparticles can be useful for disease detection, treatment, and monitoring.


Patent
University of South Carolina | Date: 2015-06-12

In general, the present disclosure is directed toward a novel hybrid spintronic device for converting chemical absorption into a change in magnetoresistance. This device uses a novel magnetic material which depends on the attachment of an organic structure to a metallic film for its magnetism. Changes in the chemical environment lead to absorption on the surface of this organometallic bilayer and thus modify its magnetic properties. The change in magnetic properties, in turn, leads to a change in the resistance of a magnetoresistive structure or a spin transistor structure, allowing a standard electrical detection of the chemical change in the sensor surface.


Patent
University of South Carolina | Date: 2015-08-12

A microcantilever based photoacoustic sensor is generally provided. In one embodiment, the microcantilever includes: a substrate; a GaN layer on the substrate, wherein the GaN layer defines a cantilever extending beyond an edge of the substrate, with a base area of the cantilever defined by the area spanning the edge of the substrate; a HFET deflection transducer positioned on the cantilever; a pair of electrical contacts, each electrically connected to the HFET deflection transducer; and a microfluidic channel in fluid communication with an analyte reservoir, wherein the analyte reservoir is positioned at the base of the cantilever. A sensing system is also generally provided.


Patent
University of South Carolina | Date: 2015-05-29

Methods for restoring tidal areas adjacent to a tidal water area are provided. The method can comprise: pumping water from the tidal water area; and directing a high-pressure water stream, using the water pumped from the tidal water area, to the bottom surface of the tidal water area during an incoming tide period. The high-pressure water stream impacts the bottom surface of the tidal water area with sufficient force to dislodge sediment from the bottom surface into the tidal water area.

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