The University of Seville is a university in Seville, Spain. Founded under the name of Colegio Santa María de Jesús in 1505, it has a present student body of over 65,000, and is one of the top-ranked universities in the country. Seville is the 2000-year-old artistic, cultural, and financial capital of Andalusia in southern Spain; it is situated on the plain of the River Guadalquivir. Wikipedia.
Cabello A.,University of Seville
Physical Review Letters | Year: 2013
We show that the maximum quantum violation of the Klyachko-Can- Binicioǧlu-Shumovsky (KCBS) inequality is exactly the maximum value satisfying the following principle: The sum of probabilities of pairwise exclusive events cannot exceed 1. We call this principle "global exclusivity," since its power shows up when it is applied to global events resulting from enlarged scenarios in which the events in the inequality are considered jointly with other events. We identify scenarios in which this principle singles out quantum contextuality, and show that a recent proof excluding nonlocal boxes follows from the maximum violation imposed by this principle to the KCBS inequality. © 2013 American Physical Society.
Aguilera A.,University of Seville |
Garcia-Muse T.,University of Seville
Annual Review of Genetics | Year: 2013
Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur during DNA repair, chromosome duplication, and transmission or via recombination provide a natural source of genetic variation. They occur at low frequency because of the intrinsic variable nature of genomes, which we refer to as genome instability. However, genome instability can be enhanced by exposure to external genotoxic agents or as the result of cellular pathologies. We review the causes of genome instability as well as how it results in hyper-recombination, genome rearrangements, and chromosome fragmentation and loss, which are mainly mediated by double-strand breaks or single-strand gaps. Such events are primarily associated with defects in DNA replication and the DNA damage response, and show high incidence at repetitive DNA, non-B DNA structures, DNA-protein barriers, and highly transcribed regions. Identifying the causes of genome instability is crucial to understanding genome dynamics during cell proliferation and its role in cancer, aging, and a number of rare genetic diseases. © 2013 by Annual Reviews. All rights reserved.
Campos-Rodriguez F.,University of Seville
Annals of internal medicine | Year: 2012
Obstructive sleep apnea (OSA) is a risk factor for cardiovascular death in men, but whether it is also a risk factor in women is unknown. To investigate whether OSA is a risk factor for cardiovascular death in women and assess whether continuous positive airway pressure (CPAP) treatment is associated with a change in risk. Prospective, observational cohort study. 2 sleep clinics in Spain. All women consecutively referred for suspected OSA between 1998 and 2007. Every woman had a diagnostic sleep study. Women with an apnea-hypopnea index (AHI) less than 10 were the control group. Obstructive sleep apnea was diagnosed when the AHI was 10 or higher (classified as mild to moderate [AHI of 10 to 29] or severe [AHI ≥30]). Patients with OSA were classified as CPAP-treated (adherence ≥4 hours per day) or untreated (adherence <4 hours per day or not prescribed). Participants were followed until December 2009. The end point was cardiovascular death. 1116 women were studied (median follow-up, 72 months [interquartile range, 52 to 88 months]). The control group had a lower cardiovascular mortality rate (0.28 per 100 person-years [95% CI, 0.10 to 0.91]) than the untreated groups with mild to moderate OSA (0.94 per 100 person-years [CI, 0.10 to 2.40]; P = 0.034) or severe OSA (3.71 per 100 person-years [CI, 0.09 to 7.50]; P < 0.001). Compared with the control group, the fully adjusted hazard ratios for cardiovascular mortality were 3.50 (CI, 1.23 to 9.98) for the untreated, severe OSA group; 0.55 (CI, 0.17 to 1.74) for the CPAP-treated, severe OSA group; 1.60 (CI, 0.52 to 4.90) for the untreated, mild to moderate OSA group; and 0.19 (CI, 0.02 to 1.67) for the CPAP-treated, mild to moderate OSA group. The study was observational and not randomized, and OSA was diagnosed by 2 different methods. Severe OSA is associated with cardiovascular death in women, and adequate CPAP treatment may reduce this risk. None.
Aguilera A.,University of Seville |
Garcia-Muse T.,University of Seville
Molecular Cell | Year: 2012
RNA:DNA hybrid structures known as R loops were thought to be rare byproducts of transcription. In the last decade, however, accumulating evidence has pointed to a new view in which R loops form more frequently, impacting transcription and threatening genome integrity as a source of chromosome fragility and a potential cause of disease. Not surprisingly, cells have evolved mechanisms to prevent cotranscriptional R loop formation. Here we discuss the factors and cellular processes that control R loop formation and the mechanisms by which R loops may influence gene expression and the integrity of the genome. © 2012 Elsevier Inc.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.87M | Year: 2016
Cancer is a major social problem, and it is the main cause of death between the ages 45-65 years. In the treatment of cancer, radio therapy (RT) plays an essential role. RT with hadrons (protons and light ions), due to their unique physical and radiobiological properties, offers several advantages over photons for specific cancer types. In particular, they penetrate the patient with minimal diffusion, they deposit maximum energy at the end of their range, and they can be shaped as narrow focused and scanned pencil beams of variable penetration depth. Although significant progress has been made in the use of particle beams for cancer treatment, an extensive research and development program is still needed to maximize the healthcare benefits from these therapies. The Optimization of Medical Accelerators (OMA) is the aim of the here-proposed European Training Network, in line with the requirements of the ECs Medical Exposure Directive. OMA joins universities, research centers and clinical facilities with industry partners to address the challenges in treatment facility design and optimization, numerical simulations for the development of advanced treatment schemes, and in beam imaging and treatment monitoring. The proposed R&D program ranges from life sciences (oncology, cell and micro biology and medical imaging.), physics and accelerator sciences, mathematics and IT, to engineering. It is hence ideally suited for an innovative training of early stage researchers. By closely linking all above research areas, OMA will provide an interdisciplinary education to its Fellows. This will equip them with solid knowledge also in research areas adjacent to their core research field, as well as with business competences and hence give them a perfect basis for a career in research.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2016
ENSAR2 is the integrating activity for European nuclear scientists who are performing research in three of the major subfields defined by NuPECC: Nuclear Structure and Dynamics, Nuclear Astrophysics and Nuclear Physics Tools and Applications. It proposes an optimised ensemble of Networking (NAs), Joint Research (JRAs) and Transnational Access Activities (TAs), which will ensure qualitative and quantitative improvement of the access provided by the current ten infrastructures, which are at the core of this proposal. The novel and innovative developments that will be achieved by the RTD activities will also assure state-of-the-art technology needed for the new large-scale projects. Our community of nuclear scientists profits from the diverse range of world-class research infrastructures all over Europe that can supply different ion beams and energies and, with ELI-NP, high-intensity gamma-ray beams up to 20 MeV. We have made great effort to make the most efficient use of these facilities by developing the most advanced and novel equipment needed to pursue their excellent scientific programmes and applying state-of-the-art developments to other fields and to benefit humanity (e.g. archaeology, medical imaging). Together with multidisciplinary and application-oriented research at the facilities, these activities ensure a high-level socio-economic impact. To enhance the access to these facilities, the community has defined a number of JRAs, using as main criterion scientific and technical promise. These activities deal with novel and innovative technologies to improve the operation of the facilities. The NAs of ENSAR2 have been set-up with specific actions to strengthen the communities coherence around certain resarch topics and to ensure a broad dissemination of results and stimulate multidisciplinary, application-oriented research and innovation at the Research Infrastructures.
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 382.50K | Year: 2017
Networks are present in our lives in numerous different environments: to name just a few, networks can model social relationships, they can model the Internet and links between web pages, they might model the spread of a virus infection between people, and they might represent computer processors/sensors that have to exchange information. This project aims to obtain new insights into the behaviour of networks, which are studied from a geometric and computational perspective. Thereto, the project brings together researchers from different areas such as computational geometry, discrete mathematics, graph drawing, and probability. Among of the topics of research are enumerative problems on geometric networks, crossing numbers, random networks, imprecise models of data, restricted orientation geometry. Combinatorial approaches are combined with algorithms. Algorithmic applications of networks are also studied in the context of unmanned aerial vehicles (UAVs) and in the context of musical information retrieval (MIR). The project contains the work packages: Geometric networks, Stochastic Geometry and Networks, Restricted orientation geometry, Graph-based algorithms for UAVs and for MIR, and Dissemination and gender equality promotion. The project connects researchers from 14 universities located in Austria, Belgium, Canada, Chile, Czech Republic, Italy, Mexico, and Spain, who will collaborate and share their different expertise in order to obtain new knowledge on the combinatorics of networks and applications.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-33-2016 | Award Amount: 2.86M | Year: 2017
Despite process heat is recognized as the application with highest potential among solar heating and cooling applications, Solar Heat for Industrial Processes (SHIP) still presents a modest share of about 0.3% of total installed solar thermal capacity. As of todays technology development stage economic competitiveness restricted to low temperature applications; technology implementation requiring interference with existing heat production systems, heat distribution networks or even heat consuming processes - Solar thermal potential is mainly identified for new industrial capacity in outside Americas and Europe. In this context, INSHIP aims at the definition of a ECRIA engaging major European research institutes with recognized activities on SHIP, into an integrated structure that could successfully achieve the coordination objectives of: more effective and intense cooperation between EU research institutions; alignment of different SHIP related national research and funding programs, avoiding overlaps and duplications and identifying gaps; acceleration of knowledge transfer to the European industry, to be the reference organization to promote and coordinate the international cooperation in SHIP research from and to Europe, while developing coordinated R&D TRLs 2-5 activities with the ambition of progressing SHIP beyond the state-of-the-art through: an easier integration of low and medium temperature technologies suiting the operation, durability and reliability requirements of industrial end users; expanding the range of SHIP applications to the EI sector through the development of suitable process embedded solar concentrating technologies, overcoming the present barrier of applications only in the low and medium temperature ranges; increasing the synergies within industrial parks, through centralized heat distribution networks and exploiting the potential synergies of these networks with district heating and with the electricity grid.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-26-2016 | Award Amount: 5.31M | Year: 2017
MULTIDRONE aims to develop an innovative, intelligent, multi-drone platform for media production to cover outdoor events, which are typically held over wide areas (at stadium/city level). The 4-10 drone team, to be managed by the production director and crew, will have: a) increased decisional autonomy, by minimizing production crew load and interventions and b) improved robustness, security and safety mechanisms (e.g., embedded flight regulation compliance, enhanced crowd avoidance, autonomous emergency landing, communications security), enabling it to carry out its mission even against adverse conditions or crew inaction and to handle emergencies. Such robustness is particularly important, as the drone team has to operate close to crowds and may face an unexpected course of events and/or environmental hazards. Therefore, it must be contextually aware and adaptive with improved perception of crowds, individual people and other hazards. As this multi-actor system will be heterogeneous, consisting of multiple drones and the production crew, serious human-in-the-loop issues will be addressed to avoid operator overload, with the goal of maximizing shooting creativity and productivity, whilst minimizing production costs. Overall, MULTIDRONE will boost research on multiple-actor systems by proposing novel multiple-actor functionalities and performance metrics. Furthermore, the overall multidrone system will be built to serve identified end user needs. Specifically, innovative, safe and fast multidrone audiovisual shooting will provide a novel multidrone cinematographic shooting genre and new media production techniques that will have a large impact on the financially important EU broadcasting/media industry. It will boost production creativity by allowing the creation of rich/novel media output formats, improving event coverage, adapting to event dynamics and offering rapid reaction speed to unexpected events.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: COMPET-01-2015 | Award Amount: 3.98M | Year: 2016
VEGAS proposes to address the key challenge of European non-dependence and competitivness regarding rad-hard FPGA for space applications. VEGAS will evaluate (following ESCC rules) and validate the first rad-hard FPGA in 65nm to directly compete with the US offering and reach TRL 7. The VEGAS project sets clear and measurable main objectives to reach a TRL 7 from TRL 5 (end of BRAVE project) as follows: 1. Validation by end users of rad-hard FPGA developped under the BRAVE project TRL 6 achieved 2. Space evaluation of the first rad-hard FPGA developped under the BRAVE project TRL 7 achieved 3. Software CAD tools improvement by including timing and SEE mitigation tools VEGAS will complement the ongoing ESA funded BRAVE project. BRAVE covers all hardware and software development to reach a first prototype of NG-FPGA-MEDIUM (30k LUTs) and NG-FPGA-LARGE (130k LUTs) . VEGAS will cover all required steps to ESCC evaluate / validate the BRAVE NG-FPGA-MEDIUM and NG-FPGA-LARGE prototype and add additional software tools to reach a competitive software offering.