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Saskatoon, Canada

The University of Saskatchewan is a Canadian public research university, founded in 1907, and located on the east side of the South Saskatchewan River in Saskatoon, Saskatchewan, Canada. An "Act to establish and incorporate a University for the Province of Saskatchewan" was passed by the provincial legislature in 1907. It established the provincial university on April 3, 1907 "for the purpose of providing facilities for higher education in all its branches and enabling all persons without regard to race, creed or religion to take the fullest advantage". The University of Saskatchewan is now the largest education institution in the Canadian province of Saskatchewan.The university began as an agricultural college in 1907 and established the first Canadian university-based department of extension in 1910. 300 acres were set aside for university buildings and 1,000 acres for the U of S farm, and agricultural fields. In total 10.32 km2 was annexed for the university. The main University campus is situated upon 2,425 acres , with another 500 acres allocated for Innovation Place Research Park. The University of Saskatchewan agriculture college still has access to neighbouring urban research lands. The University of Saskatchewan's Vaccine and Infectious Disease Organization facility, develops DNA-enhanced immunization vaccines for both humans and animals.Since its origins as an agricultural college, research has played an important role at the university. Discoveries made at the U of S include sulphate-resistant cement and the cobalt-60 cancer therapy unit. The university offers over 200 academic programs. Duncan P. McColl was appointed as the first registrar, establishing the first convocation from which Chief Justice Edward L. Wetmore was elected as the first chancellor. Walter Charles Murray became the first president of the university's board of governors. Wikipedia.

Leary S.C.,University of Saskatchewan
Antioxidants and Redox Signaling | Year: 2010

Reversible changes in the redox state of cysteine residues represent an important mechanism with which to regulate protein function. In mitochondria, such redox reactions modulate the localization or activity of a group of proteins, most of which function in poorly defined pathways with essential roles in copper delivery to cytochrome c oxidase (COX) during holoenzyme biogenesis. To date, a total of 8 soluble (COX17, COX19, COX23, PET191, CMC1-4) and 3 integral membrane (COX11, SCO1, SCO2) accessory proteins with cysteine-containing domains that reside within the mitochondrial intermembrane space (IMS) have been identified in yeast, all of which have human orthologues. Compelling evidence from studies of COX17, SCO1, and SCO2 argues that regulation of the redox state of their cysteines is integral to their metallochaperone function. Redox also appears to be crucial to the regulation of a SCO-dependent, mitochondrial signaling pathway that modulates the rate of copper efflux from the cell. Here, I review our understanding of redox-dependent modulation of copper delivery to COX and IMS-localized copper-zinc superoxide dismutase (SOD1) during the maturation of each enzyme, and discuss how this in turn may serve to functionally couple mitochondrial copper handling pathways with those localized elsewhere in the cell to regulate cellular copper homeostasis. © 2010, Mary Ann Liebert, Inc.

Agnihotri N.,University of Saskatchewan
Journal of Photochemistry and Photobiology C: Photochemistry Reviews | Year: 2013

Photoinduced charge transfer (CT) is a fundamental process that determines the overall energy conversion efficiency of organic solar photovoltaic cells (OPVs). This review focuses on the advantages and pitfalls of theoretical/computational methods available to describe CT excitations in donor-acceptor (D-A) complexes. Studies of porphyrin-fullerene constructs as model D-A systems will be used to illustrate progress in this area. © 2013 Elsevier B.V.

Fang J.,University of Saskatchewan
Drug Metabolism Reviews | Year: 2014

Anthocyanins are a subgroup of flavonoids responsible for the blue, purple, and red color of many fruits, flowers, and leaves. Consumption of foods rich in anthocyanins has been associated with a reduced risk of cardiovascular disease and cancer. The fate of anthocyanins after oral administration follows a unique pattern rather different from those of other flavonoids. Anthocyanins could be absorbed from the stomach as well as intestines. Active transporters may play a role in the absorption of anthocyanins from the stomach as well as in their transfer within the kidney or liver. Anthocyanins such as cyanidin-3-glucoside and pelargonidin-3-glucoside could be absorbed in their intact form into the gastrointestinal wall; undergo extensive first-pass metabolism; and enter the systemic circulation as metabolites. Phenolic acid metabolites were found in the blood stream in much higher concentrations than their parent compounds. These metabolites could be responsible for the health benefits associated with anthocyanins. Some anthocyanins can reach the large intestine in significant amounts and undergo decomposition catalyzed by microbiota. In turn, these decomposition products may contribute to the health effects associated with anthocyanins in the large intestine. This review comprehensively summarizes the existing knowledge about absorption, distribution, metabolism, and elimination of anthocyanins as well as their decomposition within the gastrointestinal lumen. © 2014 Informa Healthcare USA, Inc.

Sumner D.,University of Saskatchewan
Journal of Fluids and Structures | Year: 2010

Pairs of circular cylinders immersed in a steady cross-flow are encountered in many engineering applications. The cylinders may be arranged in tandem, side-by-side, or staggered configurations. Wake and proximity interference effects, which are determined primarily by the longitudinal and transverse spacing between the cylinders, and also by the Reynolds number, have a strong influence on the flow patterns, aerodynamic forces, vortex shedding, and other parameters. This paper reviews the current understanding of the flow around two "infinite" circular cylinders of equal diameter immersed in a steady cross-flow, with a focus on the near-wake flow patterns, Reynolds number effects, intermediate wake structure and behaviour, and the general trends in the measurements of the aerodynamic force coefficients and Strouhal numbers. A primary focus is on the key experimental and numerical studies that have appeared since the last major review of this subject more than 20 years ago. © 2010 Elsevier Ltd.

Direct bronchoprovocation challenges (eg, methacholine), which act directly on a specific airway smooth muscle receptor, are the most commonly performed challenge tests. Cut points have been arbitrarily selected to give high sensitivity and negative predictive values. In subjects with clinically current symptoms (within a few days) who inhale methacholine without deep inhalations, a normal methacholine test (provocative concentration causing a 20% fall in FEV1 [PC20] > 16 mg/mL) rules out (current) asthma with reasonable certainty. A positive test in the moderate or greater range (PC 20 < 1 mg/mL) has high specificity and positive predictive value, comparable to the indirect challenges. Values between these levels are consistent with, but not diagnostic of, asthma. The positive predictive value (for clinical asthma) will increase the closer the PC20 is to 1 mg/mL, the higher the pretest probability is for asthma and the more the methacholine-induced symptoms resemble the naturally occurring symptoms. Direct challenges are more sensitive and less specifi c than indirect challenges (exercise, adenosine monophosphate, mannitol, etc). © 2010 American College of Chest Physicians.

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