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Sarajevo, Bosnia and Herzegovina

The University of Sarajevo is the largest and oldest university in Bosnia and Herzegovina, and is the oldest institution of tertiary education in the ex-Yugoslav states. It was originally established in 1531 as an Ottoman Islamic law college; the university in its modern, secular incarnation being established and effectively added to that in 1949. Today, with 23 faculties and around 50,000 enrolled students, it ranks among the largest universities in the Balkans in terms of enrollment. Since opening its doors in 1949, 122,000 students received bachelor's degrees, 3,891 received master's degrees and 2,284 received doctorate degrees in 45 different fields.It is now widely regarded as the most prestigious university in Bosnia and Herzegovina, and employs more than one thousand faculty members. Wikipedia.

Zukanovic A.,University of Sarajevo
Acta medica academica | Year: 2013

The aim of this research was to assess the efficiency of different multifactor models in caries prediction. Data from the questionnaire and objective examination of 109 examinees was entered into the Cariogram, Previser and Caries-Risk Assessment Tool (CAT) multifactor risk assessment models. Caries risk was assessed with the help of all three models for each patient, classifying them as low, medium or high-risk patients. The development of new caries lesions over a period of three years [Decay Missing Filled Tooth (DMFT) increment = difference between Decay Missing Filled Tooth Surface (DMFTS) index at baseline and follow up], provided for examination of the predictive capacity concerning different multifactor models. The data gathered showed that different multifactor risk assessment models give significantly different results (Friedman test: Chi square = 100.073, p=0.000). Cariogram is the model which identified the majority of examinees as medium risk patients (70%). The other two models were more radical in risk assessment, giving more unfavorable risk -profiles for patients. In only 12% of the patients did the three multifactor models assess the risk in the same way. Previser and CAT gave the same results in 63% of cases - the Wilcoxon test showed that there is no statistically significant difference in caries risk assessment between these two models (Z = -1.805, p=0.071). Evaluation of three different multifactor caries risk assessment models (Cariogram, PreViser and CAT) showed that only the Cariogram can successfully predict new caries development in 12-year-old Bosnian children. Copyright © 2013 by Academy of Sciences and Arts of Bosnia and Herzegovina. Source

To determine the correlation of intravesical prostatic protrusion (IPP) and bladder wall thickness (BWT) with clinical and urodynamic parameters, as well as their sensitivity and specificity with regard to bladder outlet obstruction in patients with a benign prostatic enlargement (BPE). MATERIALS AND methods: 111 patients with lower urinary tract symptoms and confirmed BPE completed the International Prostatic Symptom Score (I-PSS), as well as a transabdominal ultrasound to determine their prostate volume, a grade of IPP and BWT. All the patients were then subjected to the complete urodynamic studies (UDS). The IPP showed a good correlation with the prostate volume (r = 0.61) and serum PSA (r = 0.48); p = 0.0000, free uroflowmetry (r = -0.27; p = 0.004), as well as the determinants of urodynamic obstruction: bladder outlet obstruction index-BOOI (r = 0.36; p < 0.0001), and ICS and Schaefer obstruction class nomograms (rho = 0.33 and rho = 0.39, respectively; p < 0.001), while the BWT showed only a statistical correlation with age (r = 0.23; p = 0.02) and serum PSA (r = 0.4; p = 0.0000), regardless of an significant correlation with the IPP (r = 0.45; p = 0.0000). The ANOVA test showed a significant difference between the IPP grades for the observed clinical and urodynamic variables with an increase in significance for IPP>10 mm. The area under the ROC curve in the prediction of obstruction for the IPP is 0.71 (sensitivity 59.6, specificity 81.4), while the AUC for the BWT is 0.61 (sensitivity 64.5, specificity 59.2). The stepwise logistic regression model shows that most significant independent variables for the obstruction are the IPP, Q(max) free and age, with the area under the ROC curve of 0.78 (95% CI 0.695 to 0.856). The IPP higher than 10 mm as a non-invasive predictor of infravesical obstruction shows good correlations with clinical and urodynamic parameters, while the specificity and PPV against obstruction are significant. Despite a good correlation with IPP, the BWT is only a modest indicator of obstruction. Source

Velija-Asimi Z.,University of Sarajevo
Bosnian Journal of Basic Medical Sciences | Year: 2013

The aim of study was to evaluate endocrine changes in PCOS women during metformin treatment. One hundred women with PCOS, aged 20-40 years were included. A complete hormonal and metabolic pattern was recorded for each subject every 6 months. Metformin treatment after 6 and 12 months significantly reduced weight, BMI, waist circumference, insulin and HOMA-IR (p=0.000) with high differences of variances within repeated measurements. There was significant reduction of PRL, testosterone and estradiol (p=0.000) with small differences within repeated measurements. Metformin did not have effect on TSH. However, results showed important reduction of CRP, LH, LH/FSH, androstendione, DHEA-S and progesterone (p=0.000) with moderate differences within measures. Metformin restored menstrual cyclicity in most participants. At baseline in study group was 69% women with oligomenorrhoea, amenorrhoea or polymenorrhoea. After 12 months of treatment, only 20% PCOS women had irregular menstrual cycle (p=0.000). Hirsutism was also reduced. Intriguingly during first 6 months of treatment in PCOS women 9 pregnancies occurred (p=0.000), while during last 6 months treatment were 2 pregnancies (p=0.317), in total 11(13%). Multiple regression model revealed that the presence of anovulation in PCOS women was strongly associated with BMI, waist, FSH and age. Insulin resistance was significantly predicted by BMI, cholesterol, progesterone and presence of hirsutism. The metformin therapy significantly improved insulin resistance, imbalance of endocrine hormones, hirsutism and menstrual cyclicity in women with PCOS. The most important predictors for duration of metformin treatment in PCOS women were testosterone, progesterone, FSH, CRP and presence of anovulation. © 2013 Association of Basic Medical Sciences of FBIH. All rights reserved. Source

Redzic S.,University of Sarajevo
Journal of Medicinal Plants Research | Year: 2010

Both Mediterranean and sub-Mediterranean regions of Bosnia and Herzegovina are known for very prominent traditional usage of wild medicinal and aromatic plants for the treatment of various diseases. Ethno botanical interview method was used to collect information from the sample population comprised of 55 adults, of different religious background (Catholics, Muslims, and Orthodox), with an average age of 63. This resulted in the collection of 96 wild plants from 46 different plant families. These plants are used in preparation of up to 200 different ethno pharmaceuticals and used for 430 different treatments, mainly of chronic diseases: respiratory system (63 species), stomach and intestinal system (55 species), liver and gall bladder (60 species), urinary system (33 species), genital system (42 species), nervous system (30 species), cardiovascular system (27 species), skin conditions (56 species). 60 species are being used for the treatment of some other health disorders. In ecological sense, 40% of these species are constituents of meadow and rock debris communities, 34% of termophilous forest and shrub communities, while 20% of species are constituents of abandoned places. © 2010 Academic Journals. Source

Dorner I.,University of Sarajevo
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We address the issue of model dependence of partial proton decays due to exchange of a single scalar leptoquark within a minimal viable SU(5) framework. The minimal setup predicts a flavor part of decay widths for p→π +ν̄ and p→K +ν̄ processes to depend solely on the known masses and mixing parameters of the quark sector and one extra phase. We accordingly establish an accurate lower limit on the mass of the scalar leptoquark in connection with the relevant experimental constraints on the matter stability. The ratio of decay widths for p→π +ν̄ and p→K +ν̄ channels turns out to be phase independent and predicts strong suppression of the former width with respect to the latter one. Our results offer a possibility to test the minimal scenario if and when proton decay is observed. © 2012 American Physical Society. Source

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