Sao Paulo, Brazil
Sao Paulo, Brazil

The University of São Paulo is a public university in the Brazilian state of São Paulo. It is the largest Brazilian university and the country's most prestigious educational institution, the best university in Ibero-America, and one of the most prestigious universities in the world. According to reports by the Ministry of Science and Technology, more than 25% of scientific papers published by Brazilian researchers in high quality conferences and journals are produced at the University of São Paulo.USP is one of the largest institutions of higher education in Latin America, with approximately 90,000 enrolled students. It has eleven campuses, four of them in São Paulo . The other campuses are in the cities of Bauru, Lorena, Piracicaba, Pirassununga, Ribeirão Preto and two in São Carlos. USP is involved in teaching, research and university extension in all areas of knowledge. Wikipedia.

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CBJ Hong Kong Ocean Engineering Ltd and University of Sao Paulo | Date: 2017-01-18

Provided is a method of installing and constructing a hollow cylindrical pier for fixing an offshore platform structure to the bed, wherein a steel cylinder (101) with an inner diameter slightly greater than the hollow cylindrical pier is driven into the bed (2) until at least the bearing stratum is reached to ensure fixing, and part of the steel cylinder (101) is exposed above the water surface (1); draining ponding inside the steel cylinder (101), and excavating bed sediment inside the steel cylinder (101); cutting off the steel cylinder (101); hoisting a first hollow cylindrical pier section (1A) with a sealed bottom end vertically downwards from the water surface (1) towards the steel cylinder (101), pre-tensioning an overlapping hollow cylindrical pier section on the hollow cylindrical pier section via a shear key structure and then fixedly connecting same with the previous hollow cylindrical pier section, and hoisting same in turn such that after the sealed bottom end of the first hollow cylindrical pier section (1A) reaches near the bottom end of steel cylinder (101), at least part of the lastly hoisted overlapping hollow cylindrical pier section is exposed above the water surface (1); and pouring concrete (107) into a gap between the steel cylinder (101) and the hollow cylindrical piers. Further provided are a method of installing and constructing an offshore platform structure and a hollow cylindrical pier for fixing to the bed and an offshore platform structure.

News Article | April 13, 2017

Washington, DC, April 13, 2017 (GLOBE NEWSWIRE) -- WASHINGTON, April 13 – The Association of Academic Health Centers (AAHC), in conjunction with its international subsidiary AAHCI, is pleased to announce the next phase of its groundbreaking Aligned Institutional Mission (AIM) Program, a means for academic health centers around the world to optimize and measure the alignment of their education, research, and patient care missions. “AAHC/AAHCI successfully completed the Development Phase of this innovative program and is ready to move forward with the pivotal Pilot Phase that will test and refine program elements to prepare AIM for a full global launch,” said Steven A. Wartman, MD, PhD, AAHC president and CEO. “The feedback we have received from the Development Phase institutions has been outstanding. This pioneering program assists academic health centers on an individualized basis to optimally align their mission components to help create learning health systems for the 21st century.” The Pilot Phase of the program includes seven sites: East Tennessee State (USA), Florida International University (USA), Semmelweis University (Hungary), University of Kansas (USA), University of Malaya (Malaysia), University of Sao Paulo (Brazil), and University of Queensland-Brisbane Diamantina Health Partners (Australia). Following the completion of the Pilot Phase, the association plans a full-scale roll-out to all members in 2018. The AIM program works closely with a distinguished group of consultants, all of whom have had extensive experience in leadership positions with academic health centers: “The AIM Program offers participating institutions a program tool for internal assessment and goal setting; a peer consultant review period; and peer consultant recommendations and strategic improvement planning,” said Wartman. “Participating in the AIM program offered UAMS a valuable opportunity to assess its programs specifically within the framework of how they align our institution with our stated health improvement mission,” said Dan Rahn, MD, chancellor of the University of Arkansas Medical School (an institution that participated in the Development Phase of the program), adding “[u]sing the AIM assessment tool and then hosting a constructive site visit connected all of those changes into a coherent story that illustrates how we moved from our strategic vision to reengineering how we deliver care, manage data, ensure sustainability, align education, research and patient care, and ultimately impact population health.” AAHC is a non-profit association dedicated to advancing health and well-being through the vigorous leadership of academic health centers. A photo accompanying this announcement is available at

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-13-2016 | Award Amount: 5.38M | Year: 2017

Key industrial sectors e.g. automotive, are rapidly transformed by digital and communication technologies leading to the fourth industrial revolution. New ones are in the making, e.g. Smart Cities, which inspire a new breed of applications and services. The salient characteristic of these sectors, known as verticals, is that they are rapidly becoming open ecosystems built on top of common physical infrastructures and resources. This requires a high degree of technological convergence among vertical industries empowering them with enhanced technical capacity to trigger the development of new, innovative products, applications and services. 5G network infrastructures and embodied technologies are destined to become a stakeholder driven, holistic environment for technical and business innovation integrating networking, computing and storage resources into one programmable and unified infrastructure. It is this 5G vision that when it is further projected to accommodate verticals raises a number of technical issues Motivated by them, 5GinFIRE project aspires to address two interlinked questions: - Q1: How such a holistic and unified environment should look like? - Q2: How can 5GinFIRE host and integrate verticals and concurrently deal with reconciling their competing and opposing requirements? Addressing these key questions, 5GinFIRE main technical objective is to build and operate an Open, and Extensible 5G NFV-based Reference (Open5G-NFV) ecosystem of Experimental Facilities that integrates existing FIRE facilities with new vertical-specific ones and enables experimentation of vertical industries. In order to guarantee architectural and technological convergence the proposed environment will be built in alignment with on-going standardization and open source activities. Accordingly, the Open5G-NFV FIRE ecosystem may serve as the forerunner experimental playground wherein innovations may be proposed before they are ported to emerging mainstream 5G networks.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INT-12-2015 | Award Amount: 2.60M | Year: 2016

EULAC Focus addresses the whole set of topics included in the Call. It delivers a significant contribution to the improvement of EUCELAC relations through a better understanding of the three dimensions selected by the call: cultural, scientific and social. The main objective is that of giving focus to these three dimensions of EUCELAC relations, with a view to determining synergies and cross-fertilization, as well as identifying asymmetries in bi-lateral and bi-regional relations. Research is focused on areas crucial to explain the current state of relations between EU and LAC, and will be pursued at two levels: a) research activities; b) strategic set of recommendations. In order to guarantee high impact, the research is pursued in six interdisciplinary WPs, organized matricially. Three are horizontal : Cross-cutting pathways, Towards a common vision for EUCELAC and Dissemination and outreach. The other three are thematic/vertical: Cultural, Scientific and Social Dimension, and not only intersect the horizontal WPs but also interact between them. To achieve the objectives, the project is organized by the multidisciplinary and well balanced consortium of19 members from 15 counties. The consortium represents a unique group of highly competent and experienced institutions, composed specifically for the purpose of this project,comprising, in both regions, Gov Research Agencies, Research institutes, Universities, University Association, and two International European LA Organizations active in analytical and policy oriented research and dissemination. EULAC Focus builds upon the outcomes of prior mapping conducted at the bi-regional level and will facilitate access to end-users, as well as feeding into the work of the EU-LAC Foundation and informing bi-regional networking activities of the JIRI and T-APs work. The number of partners has been carefully defined to ensure project goals and proper diversity, while allowing for efficient project management.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-22-2016 | Award Amount: 12.56M | Year: 2016

The ZikaPLAN initiative combines the strengths of 25 partners in Latin America, North America, Africa, Asia, and various centres in Europe to address the urgent research gaps (WP 1-8) in Zika, identifying short-and long term solutions (WP 9-10) and building a sustainable Latin-American EID Preparedness and Response capacity (WP 11-12). We will conduct clinical studies to further refine the full spectrum and risk factors of congenital Zika syndrome (including neurodevelopmental milestones in the first 3 years of life), and delineate neurological complications associated with Zika due to direct neuroinvasion and immune-mediated responses. Laboratory based research to unravel neurotropism, investigate the role of sexual transmission, determinants of severe disease, and viral fitness will envelop the clinical studies. Burden of disease and modelling studies will assemble a wealth of data including a longitudinal cohort study of 17,000 subjects aged 2-59 in 14 different geographic locations in Brazil over 3 years. Data driven vector control and vaccine modelling as well as risk assessments on geographic spread of Zika will form the foundation for evidence-informed policies. The Platform for Diagnostics Innovation and Evaluation will develop novel ZIKV diagnostic tests in accordance with WHO Target Product Profiles. Our global network of laboratory and clinical sites with well-characterized specimens is set out to accelerate the evaluation of the performance of such tests. Based on qualitative research, we will develop supportive, actionable messages to affected communities, and develop novel personal protective measures. Our final objective is for the Zika outbreak response effort to grow into a sustainable Latin-American network for emerging infectious diseases research preparedness. To this end we will engage in capacity building in laboratory and clinical research, collaborate with existing networks to share knowledge and tackle regulatory and other bottlenecks.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-04-2014 | Award Amount: 5.31M | Year: 2015

LANDMARK is a pan-European multi-actor consortium of leading academic and applied research institutes, chambers of agriculture and policy makers that will develop a coherent framework for soil management aimed at sustainable food production across Europe. The LANDMARK proposal builds on the concept that soils are a finite resource that provides a range of ecosystem services known as soil functions. Functions relating to agriculture include: primary productivity, water regulation & purification, carbon-sequestration & regulation, habitat for biodiversity and nutrient provision & cycling. Trade-offs between these functions may occur: for example, management aimed at maximising primary production may inadvertently affect the water purification or habitat functions. This has led to conflicting management recommendations and policy initiatives. There is now an urgent need to develop a coherent scientific and practical framework for the sustainable management of soils. LANDMARK will uniquely respond to the breadth of this challenge by delivering (through multi-actor development): 1. LOCAL SCALE: A toolkit for farmers with cost-effective, practical measures for sustainable (and context specific) soil management. 2. REGIONAL SCALE - A blueprint for a soil monitoring scheme, using harmonised indicators: this will facilitate the assessment of soil functions for different soil types and land-uses for all major EU climatic zones. 3. EU SCALE An assessment of EU policy instruments for incentivising sustainable land management. There have been many individual research initiatives that either address the management & assessment of individual soil functions, or address multiple soil functions, but only at local scales. LANDMARK will build on these existing R&D initiatives: the consortium partners bring together a wide range of significant national and EU datasets, with the ambition of developing an interdisciplinary scientific framework for sustainable soil management.

Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: ENERGY.2013.10.1.10 | Award Amount: 21.20M | Year: 2014

Concentrating Solar Thermal Energy encompasses Solar Thermal Electricity (STE), Solar Fuels, Solar Process Heat and Solar Desalination that are called to play a major role in attaining energy sustainability in our modern societies due to their unique features: 1) Solar energy offers the highest renewable energy potential to our planet; 2) STE can provide dispatchable power in a technically and economically viable way, by means of thermal energy storage and/or hybridization, e.g. with biomass. However, significant research efforts are needed to achieve this goal. This Integrated Research Programme (IRP) engages all major European research institutes, with relevant and recognized activities on STE and related technologies, in an integrated research structure to successfully accomplish the following general objectives: a) Convert the consortium into a reference institution for concentrating solar energy research in Europe, creating a new entity with effective governance structure; b) Enhance the cooperation between EU research institutions participating in the IRP to create EU added value; c) Synchronize the different national research programs to avoid duplication and to achieve better and faster results; d) Accelerate the transfer of knowledge to industry in order to maintain and strengthen the existing European industrial leadership in STE; e) Expand joint activities among research centres by offering researchers and industry a comprehensive portfolio of research capabilities, bringing added value to innovation and industry-driven technology; f) Establish the European reference association for promoting and coordinating international cooperation in concentrating solar energy research. To that end, this IRP promotes Coordination and Support Actions (CSA) and, in parallel, performs Coordinated Projects (CP) covering the full spectrum of current concentrating solar energy research topics, selected to provide the highest EU added value and filling the gaps among national programs.

To evaluate the influence of abatacept (ABA) and associated contributing factors on pandemic 2009 influenza A/H1N1 vaccine immunogenicity in rheumatoid arthritis (RA) patients. The response to a nonadjuvanted monovalent pandemic 2009 influenza A/H1N1 killed virus vaccine was analyzed in 11 RA patients using ABA (RA-ABA), most with concomitant nonbiologic disease-modifying antirheumatic drugs (DMARDS), and compared to 33 age-matched RA patients on methotrexate (MTX) and 55 healthy controls, all without previous seroprotection. Clinical and laboratory evaluations were performed before and 21 days after vaccination. Anti-influenza antibody titers were measured by hemagglutination inhibition assay. Seroprotection (antibody titers ≥1:40) and the factor increase (FI) in the geometric mean titers (GMTs) were calculated. Prevaccination lymphocyte counts and gammaglobulin levels were determined. Sex distribution, disease duration, and the Disease Activity Score in 28 joints were similar in the RA groups (P > 0.05). After vaccination, seroprotection was significantly reduced in RA-ABA patients compared to RA-MTX patients (9% versus 58%; P = 0.006) and controls (69%; P ≤ 0.001). FI-GMT was severely reduced in RA-ABA patients compared to RA-MTX patients (1.8 [1.4-2.3] versus 8.7 [5.2-17.4]; P < 0.001) and controls (11.5 [8.0-16.7]; P ≤ 0.001). Lymphocyte counts were comparable in RA groups (P > 0.05), but RA-ABA patients had slightly lower gammaglobulin levels than RA-MTX patients (0.9 gm/dl [0.6-1.8] versus 1.2 gm/dl [0.8-1.7]; P = 0.03), although almost all were within the normal range values. The current study established that ABA, in association with traditional DMARDs, significantly reduces the humoral response to pandemic 2009 influenza A/H1N1 vaccine in RA patients. The results suggest an influence of costimulatory modulation in humoral response to this vaccine. Copyright © 2013 by the American College of Rheumatology.

Thanks to modern treatment with all-trans retinoic acid and chemotherapy, acute promyelocytic leukemia (APL) is now the most curable type of leukemia. However, this progress has not yielded equivalent benefit in developing countries. The International Consortium on Acute Promyelocytic Leukemia (IC-APL) was established to create a network of institutions in developing countries that would exchange experience and data and receive support from well-established US and European cooperative groups. The IC-APL formulated expeditious diagnostic, treatment, and supportive guidelines that were adapted to local circumstances. APL was chosen as a model disease because of the potential impact on improved diagnosis and treatment. The project included 4 national coordinators and reference laboratories, common clinical record forms, 5 subcommittees, and laboratory and data management training programs. In addition, participating institutions held regular virtual and face-to-face meetings. Complete hematological remission was achieved in 153/180 (85%) patients and 27 (15%) died during induction. After a median follow-up of 28 months, the 2-year cumulative incidence of relapse, overall survival (OS), and disease-free survival (DFS) were 4.5%, 80%, and 91%, respectively. The establishment of the IC-APL network resulted in a decrease of almost 50% in early mortality and an improvement in OS of almost 30% compared with historical controls, resulting in OS and DFS similar to those reported in developed countries.

Berlinck R.G.,University of Sao Paulo
Natural product reports | Year: 2012

The chemistry and biology of organic natural guanidines are reviewed, including the isolation, structure determination, synthesis, biosynthesis and biological activities of alkaloids, non-ribosomal peptides, guanidine-bearing terpenes, polyketides and shikimic acid derivatives from natural sources.

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