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San Diego, CA, United States

The University of San Diego is a private Roman Catholic university in San Diego, California. The university offers 40 baccalaureate degrees, and several degrees in law, nursing, ,and other doctorate programs. The university comprises seven different academic colleges. Wikipedia.

Schmitz H.P.,University of San Diego
Health Policy and Planning | Year: 2016

Global efforts to address alcohol harm have significantly increased since the mid-1990s. By 2010, the World Health Organization (WHO) had adopted the non-binding Global Strategy to Reduce the Harmful Use of Alcohol. This study investigates the role of a global health network, anchored by the Global Alcohol Policy Alliance (GAPA), which has used scientific evidence on harm and effective interventions to advocate for greater global public health efforts to reduce alcohol harm. The study uses process-tracing methodology and expert interviews to evaluate the accomplishments and limitations of this network. The study documents how network members have not only contributed to greater global awareness about alcohol harm, but also advanced a public health approach to addressing this issue at the global level. Although the current network represents an expanding global coalition of like-minded individuals, it faces considerable challenges in advancing its cause towards successful implementation of effective alcohol control policies across many low- and middle-income countries (LMICs). The analysis reveals a need to transform the network into a formal coalition of regional and national organizations that represent a broader variety of constituents, including the medical community, consumer groups and development-focused non-governmental organizations. Considering the growing harm of alcohol abuse in LMICs and the availability of proven and cost-effective public health interventions, alcohol control represents an excellent 'buy' for donors interested in addressing non-communicable diseases. Alcohol control has broad beneficial effects for human development, including promoting road safety and reducing domestic violence and health care costs across a wide variety of illnesses caused by alcohol consumption. © 2015 The Author; all rights reserved.

Kim S.Y.,University of San Diego
Continental Shelf Research | Year: 2010

The spatio-temporal variability of submesoscale eddies off southern San Diego is investigated with two-year observations of subinertial surface currents [O(1)m depth] derived from shore-based high-frequency radars. The kinematic and dynamic quantities - velocity potential, stream function, divergence, vorticity, and deformation rates - are directly estimated from radial velocity maps using optimal interpolation. For eddy detection, the winding-angle approach based on flow geometry is applied to the calculated stream function. A cluster of nearly enclosed streamlines with persistent vorticity in time is identified as an eddy. About 700 eddies were detected for each rotation (clockwise and counter-clockwise). The two rotations show similar statistics with diameters in the range of 5-25km and Rossby number of 0.2-2. They persist for 1-7 days with weak seasonality and migrate with a translation speed of 4-15cms-1 advected by background currents. The horizontal structure of eddies exhibits nearly symmetric tangential velocity with a maximum at the defined radius of the eddy, non-zero radial velocity due to background flows, and Gaussian vorticity with the highest value at the center. In contrast divergence has no consistent spatial shape. Two episodic events are presented with other in situ data (subsurface current and temperature profiles, and local winds) as an example of frontal-scale secondary circulation associated with drifting submesoscale eddies. © 2010 Elsevier Ltd.

Terkeltaub R.,University of San Diego
Nature Reviews Rheumatology | Year: 2010

Gout, a disease recognized since antiquity, has increased in prevalence in recent years and the clinical profile of this disease has become increasingly complex, owing to large numbers of cases with iatrogenic factors, multiple comorbidities, advanced age, and hyperuricemia and arthritis refractory to treatment. In this Review, key advances in gout research made during the past decade are summarized. Revised strategies for safe and effective employment of dietary measures and pharmacologic treatments for active gouty arthritis, prevention of gout flares and urate lowering are also reviewed, with an emphasis on dosing of colchicine and allopurinol, and the evidence-based approach to systemic glucocorticosteroid treatment of acute gout. Also discussed are new and emerging treatments for gout and hyperuricemia, and the potential influence of dual energy CT imaging on treatment. In this context, the therapeutic role of febuxostat, and clinical development of pegylated uricase urate-lowering therapy and interleukin 1 antagonism for gouty inflammation are reviewed. Collectively, novel approaches will hopefully lead to improved management of hyperuricemia and gout, and also to improvements in patient-centered outcomes, even for those who have previously failed to respond to treatment. © 2010 Macmillan Publsihers Limited. All rights reserved.

Herbst K.L.,University of San Diego
Acta Pharmacologica Sinica | Year: 2012

Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue (SAT) of RADs. RAD SAT likely results from the growth of a brown stem cell population with secondary lymphatic dysfunction in MSL, or by primary vascular and lymphatic dysfunction in lipedema and DD. People with RADs do not lose SAT from caloric limitation and increased energy expenditure alone. In order to improve recognition of RADs apart from obesity, the diagnostic criteria, histology and pathophysiology of RADs are presented and contrasted to familial partial lipodystrophies, acquired partial lipodystrophies and obesity with which they may be confused. Treatment recommendations focus on evidence-based data and include lymphatic decongestive therapy, medications and supplements that support loss of RAD SAT. Associated RAD conditions including depression, anxiety and pain will improve as healthcare providers learn to identify and adopt alternative treatment regimens for the abnormal SAT component of RADs. Effective dietary and exercise regimens are needed in RAD populations to improve quality of life and construct advanced treatment regimens for future generations. © 2012 CPS and SIMM All rights reserved.

Satler J.D.,Ohio State University | Carstens B.C.,Ohio State University | Hedin M.,University of San Diego
Systematic Biology | Year: 2013

Species are a fundamental unit for biological studies, yet no uniform guidelines exist for determining species limits in an objective manner. Given the large number of species concepts available, defining species can be both highly subjective and biased. Although morphology has been commonly used to determine species boundaries, the availability and prevalence of genetic data has allowed researchers to use such data to make inferences regarding species limits. Genetic data also have been used in the detection of cryptic species, where other lines of evidence (morphology in particular) may underestimate species diversity. In this study, we investigate species limits in a complex of morphologically conserved trapdoor spiders (Mygalomorphae, Antrodiaetidae, Aliatypus) from California. Multiple approaches were used to determine species boundaries in this highly genetically fragmented group, including both multilocus discovery and validation approaches (plus a chimeric approach). Additionally, we introduce a novel tree-based discovery approach using species trees. Results suggest that this complex includes multiple cryptic species, with two groupings consistently recovered across analyses. Due to incongruence across analyses for the remaining samples, we take a conservative approach and recognize a three species complex, and formally describe two new species (Aliatypus roxxiae, sp. nov. and Aliatypus starretti, sp. nov.). This study helps to clarify species limits in a genetically fragmented group and provides a framework for identifying and defining the cryptic lineage diversity that prevails in many organismal groups. © The Author(s) 2013.

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