Henaut L.,University of Picardie Jules Verne |
Mentaverri R.,University of Picardie Jules Verne |
Mentaverri R.,Laboratoire Of Biochimie |
Liabeuf S.,University of Picardie Jules Verne |
And 8 more authors.
Annales de Biologie Clinique | Year: 2015
Vascular calcification (VC) is a degenerative pathology of the vessel wall. In the general population, VC appearance is associated with aging, but this pathology can also develop as a consequence of atherosclerosis, diabetes, inflammatory and chronic kidney disease. VC is strongly associated with increased risk of mortality and cardiovascular disease. Although VC has long been considered as the result of a passive precipitation of mineral, it is now well established that this pathology results from an active and highly regulated cellular process, which shares similarities with bone formation. This review summarizes our current knowledge on VC formation, and details the modalities of action of the main actors known to modulate this process. © 2015, John Libbey Eurotext. All rights reserved.
Cornu J.-N.,Foch Hospital |
Neuzillet Y.,Foch Hospital |
Neuzillet Y.,University of Paris Saint Quentin en Yvelines |
Herve J.-M.,Foch Hospital |
And 7 more authors.
World Journal of Urology | Year: 2012
Purpose: To describe the epidemiology, clinical features, and prognostic factors of local recurrence (LR) in a large case series of patients treated by radical cystectomy (RC) for bladder cancer. Methods: A retrospective study was conducted on 903 patients treated in a single tertiary reference center. All cases of LR were identified. Descriptive analysis was performed on the clinical features, evolution, and overall mortality of these patients. Prognostic factors of LR were assessed using the Mann-Whitney test for continuous variables and the χ2 test for categorical variables. Results: Fifty-three patients were diagnosed with LR during follow-up (5.9 %). One patient had concomitant distant metastasis. Pain was the most frequent symptom leading to diagnosis. Mean time interval from RC to LR was 14.4 ± 13 months (1-64) with 50 % of cases diagnosed in the first postoperative year. Overall median survival of patients diagnosed with LR was 9 months [95 % confidence interval (6-11)]. Advanced pathological stage (T3 or T4) and lymph-node invasion were associated with increased LR rate in univariate and multivariate analysis. Presence of squamous cell carcinoma (SCC) was associated with a poorer prognosis after LR compared to pure urothelial carcinoma (p = 0.04). None of the parameters tested was associated with time interval between RC and LR diagnosis. Conclusions: LR is not uncommon, favored by high pathological stage (T3/T4), and has a very bad prognosis, particularly when SCC is present. LR must be carefully tracked during follow-up after RC, and optimal management of these cases remains to be determined. © 2012 Springer-Verlag.