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Rome, Italy

The University of Rome II also known as University of Rome Tor Vergata is a public research university located in Rome, Italy. Its current president is Giuseppe Novelli, a professor in the Faculty of Medicine and Surgery.It was established in 1981 with the goal of providing high quality education for students preparing to meet the ever-evolving needs and opportunities of the 21st century workforce. Despite its young age, Tor Vergata has already reached high quality standards in Italy and Europe. Located in the South-Eastern suburb of Rome, the university combines a liberal arts tradition with emphasis on career orientation in the field of Economics, Engineering, science and Medicine.Many Professors of the University are important members of the italian cultural and political environment. Wikipedia.

This document explains some of the relevant methodological issues involved in planning a clinical study using survival and time-to-event outcome data, particularly in the field of haematopoietic stem cell transplantation, and indicates the appropriate statistical methods to use for the analysis. As the majority of these methods are commonly used in survival and event-history analysis, this document discusses their potential and limitations with reference to common SCT research situations. Some reference is given to methods, recently appearing in the literature that may be capable of handling complex investigations. These guidelines also address various practical issues, such as recoding or transforming variables in regression models or reporting results. © 2013 Macmillan Publishers Limited All rights reserved. Source

During physiological aerobic metabolism, the epidermis undergoes significant oxidative stress as a result of the production of reactive oxygen species (ROS). To maintain a balanced oxidative state, cells have developed protective antioxidant systems, and preliminary studies suggest that the transcriptional factor p63 is involved in cellular oxidative defence. Supporting this hypothesis, the ΔNp63α isoform of p63 is expressed at high levels in the proliferative basal layer of the epidermis. Here we identify the CYGB gene as a novel transcriptional target of ΔNp63 that is involved in maintaining epidermal oxidative defence. The CYGB gene encodes cytoglobin, a member of the globin protein family, which facilitates the diffusion of oxygen through tissues and acts as a scavenger for nitric oxide or other ROS. By performing promoter activity assays and chromatin immunoprecipitation, reverse transcriptase quantitative PCR and western blotting analyses, we confirm the direct regulation of CYGB by ΔNp63α. We also demonstrate that CYGB has a protective role in proliferating keratinocytes grown under normal conditions, as well as in cells treated with exogenous hydrogen peroxide. These results indicate that ΔNp63, through its target CYGB has an important role in the cellular antioxidant system and protects keratinocytes from oxidative stress-induced apoptosis. The ΔNp63–CYGB axis is also present in lung and breast cancer cell lines, indicating that CYGB-mediated ROS-scavenging activity may also have a role in epithelial tumours. In human lung cancer data sets, the p63–CYGB interaction significantly predicts reduction of patient survival.Oncogene advance online publication, 22 June 2015; doi:10.1038/onc.2015.222. © 2015 Macmillan Publishers Limited Source

Stanev Y.S.,University of Rome Tor Vergata
Nuclear Physics B

We derive a generating function for all the 3-point functions of higher spin conserved currents in four dimensional conformal field theory. The resulting expressions have a rather surprising factorized form which suggests that they can all be realized by currents built from free massless fields of arbitrary (half-)integer spin . s. This property is however not necessarily true also for the higher-point functions. As an illustration we analyze the general 4-point function of conserved abelian . U(1) currents of scale dimension equal to three and find that apart from the two free field realizations there is a unique possible function which may correspond to an interacting theory. Although this function passes several non-trivial consistency tests, it remains an open challenging problem whether it can be actually realized in an interacting CFT. © 2012 Elsevier B.V. Source

Cecconi F.,University of Rome Tor Vergata
Nature Cell Biology

Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src. Source

Pietroiusti A.,University of Rome Tor Vergata

With the development of nanotechnology, a growing number of people are expected to be exposed to its products, the engineered nanomaterials (ENMs). Some physico-chemical properties of ENMs, linked to their size in the nanoscale (1-100 nm), make them potentially more reactive, and therefore raise concern about possible adverse effects in humans. In this article, I discuss human diseases which may be predicted after exposure to ENMs, and how their pathogenetic mechanisms may be linked to exposure; in this regard, special emphasis has been given to the triad of oxidative stress/inflammation/ genotoxicity and to the interaction of ENMs/proteins in different biological compartments. The analysis of possible adverse effects has been made on an organ-by-organ basis, starting from the skin, respiratory system and gastrointestinal tract. These sites are in fact not only those exposed to the highest amounts of ENMs, but are also the portals of entry to internal organs for possible systemic effects. Although the list and the relevance of possible human disorders linked to ENM exposure are at least as impressive as that of their direct or indirect beneficial effects for human health, we must be clear that ENM-linked diseases belong to the realm of possible risk (i.e. cannot be excluded, but are unlikely), whereas ENMs with proven beneficial effects are on the market. Therefore, the mandatory awareness about possible adverse effects of ENMs should in no way be interpreted as a motivation to disregard the great opportunity represented by nanotechnology. © 2012 The Royal Society of Chemistry. Source

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