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Pietrzak A.,Medical University of Lublin | Bartosinska J.,Medical University of Lublin | Hercogova J.,Charles University | Lotti T.M.,University Of Rome rconi | Chodorowska G.,Medical University of Lublin
Dermatologic Therapy | Year: 2012

Vitiligo is an acquired, depigmenting skin disease with still unclear, multifactorial etiopathogenesis. However, there is growing evidence that vitiligo affects not only the skin but it may also be connected with metabolic abnormalities, including glucose intolerance and lipid abnormalities, all of which confirms the systemic nature of the disease. Recently, it has been shown that melanocytes, especially those found in the adipose tissue, due to their ability to decrease inflammation and oxidative damage, are capable of preventing the metabolic syndrome. The article presents updated knowledge on potential metabolic disturbances in vitiligo. © 2012 Wiley Periodicals, Inc.. Source

Scuderi C.,University of Rome La Sapienza | Stecca C.,University of Rome La Sapienza | Iacomino A.,University Of Rome rconi | Steardo L.,University of Rome La Sapienza
IUBMB Life | Year: 2013

Given the huge amount and great complexity of astrocyte functions in the maintenance of brain homeostasis, it is easily understood how alterations in their physiology may be involved in the pathogenesis of many, if not all, neurological disorders. This assumption is strongly supported by accumulated evidence produced in humans and in experimental models of pathology. Based on these considerations, it is reasonable to encourage studies aimed at improving the knowledge about the implicated mechanisms, and astroglial cells can be considered as the innovative target for new, and possibly more effective, drug therapies. © 2013 IUBMB Life, 65(12):957-961, 2013. Copyright © 2013 International Union of Biochemistry and Molecular Biology. Source

Hercogova J.,Charles University | Schwartz R.A.,The New School | Lotti T.M.,University Of Rome rconi | Lotti T.M.,Vitiligo Research Foundation
Dermatologic Therapy | Year: 2012

The classification of vitiligo is mandatory for clinical and research purposes. Although the etiology and pathobiology of vitiligo remain unknown, a working classification of vitiligo is imperative for the scientific community to communicate. The authors delineate herein their efforts for vitiligo classification utilizing clinical, genetic, pathobiological, epidemiological, and molecular characteristics of vitiligo. These different classification approaches may aid clinicians to identify the most suitable treatment for each individual vitiligo subject. © 2012 Wiley Periodicals, Inc.. Source

Lotti T.,University Of Rome rconi | Zanardelli M.,University of Florence | D'Erme A.M.,University of Florence
Wiener Medizinische Wochenschrift | Year: 2014

Vitiligo is an acquired depigmentary skin disorder of unknown origin characterized by well-demarcated, white macules of varying size and distribution. Despite relevant new research and progresses, why melanocytes disappear to induce the characteristic achromic lesions of vitiligo is not fully understood. In spite of recent findings implicating genetic, immune and oxidative stress factors, the exact pathogenesis of vitiligo remains obscure. An innovative concept based on a functional cross-talk between the nervous and immune system is emerging. Neuropeptides released from peripheral nerve endings could synergize with new cytokines to adversely affect melanocyte function and viability. Evidence is increasing regarding the role of neuropeptides in the pathogenesis of vitiligo and a new winning approach to vitiligo therapy based on neuropeptides regulation is at the horizon. © 2014 Springer-Verlag. Source

Bottai G.,University of Florence | Mancina R.,University of Florence | Muratori M.,University of Florence | Di Gennaro P.,University of Florence | Lotti T.,University Of Rome rconi
Journal of the European Academy of Dermatology and Venereology | Year: 2013

Background Reactive oxygen species (ROS) cause severe damage to extracellular matrix and to molecular structure of DNA, proteins and lipids. Accumulation of these molecular changes apparently constitutes the basis of cell ageing. 17b-estradiol (E2) has a key role in skin ageing homeostasis as evidenced by the accelerated decline in skin appearance seen in the perimenopausal years. Oestrogens improve many aspects of the skin such as skin thickness, vascularization, collagen content and quality. Despite these clinical evidences, the effects of oestrogens on skin at the cellular level need further clarification. Materials and Methods HaCaT and human fibroblasts were cultured under various conditions with E2 and H2O2; then were subjected to immunofluorescence and western blot analysis. Lipoperoxidation was investigated using BODIPY. Results In human fibroblasts oxidative stress decreases procollagen-I synthesis, while E2 significantly increases it. Fibroblasts and HaCaT cells viability in the presence of E2 demonstrates a notably increased resistance to H 2O2 effects. Furthermore E2 is able to counteract H2O2-mediated lipoperoxidation and DNA oxidative damage in skin cells. Discussion In this study we highlight that the menopause-associated oestrogens decline is involved in reduced collagen production and that E2 could counteract the detrimental effects of oxidative stress on the dermal compartment during skin aging. Furthermore, our data show that physiological concentrations of oestrogens are able to interfere with ROS-mediated cell viability reduction and to protect human skin cells against oxidative damage to cellular membranes and nucleic acids structure. Conclusion Our experimental data show that the presence of 17β-estradiol may protect skin cells against oxidative damage and that the dramatic lowering of oestrogen levels during menopause, could render skin more susceptible to oxidative damage. © 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology. Source

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