University of Rome La Sapienza

en.uniroma1.it/
Rome, Italy

The Sapienza University of Rome, officially Sapienza – Università di Roma, also called simply Sapienza formerly known as Università degli studi di Roma "La Sapienza", is a coeducational, autonomous state university in Rome, Italy. It is the largest European university by enrollments and the oldest of Rome's four state universities, founded in 1303. In Italian, sapienza means "wisdom" or "knowledge".Being the biggest Italian University, Sapienza is member of several national and international groups, as: European Spatial Development Planning, Partnership of a European Group of Aeronautics and Space Universities, CINECA, Santander Network, Institutional Network of the Universities from the Capitals of Europe, Mediterranean Universities Union.Sapienza is present in all major international university rankings. It is among the best Italian universities.According to the Academic Ranking of World Universities compiled by the Jiao Tong University of Shanghai, Sapienza is regularly ranked first among Italian universities. Sapienza is positioned within the 101-150 group of universities and among the top 3% of universities in the world.According to webometrics.info La Sapienza is #8th in Europe and #1 in Italy.In 2013, the Center for World University Rankings ranked the Sapienza University of Rome 62nd in the world and the top in Italy in its World University Rankings.According to the American society "U.S News & World Report", La Sapienza is the most prestigious Italian University Wikipedia.


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Patent
National Institute of Nuclear Physics, Italy and University of Rome La Sapienza | Date: 2015-05-14

An echo-scintigraphic probe for medical applications and the method of merging images. It is constituted by the union of an ultrasound probe suitably integrated, both in geometric terms, and in terms of image processing, with a scintigraphic probe or gamma camera (3). With a single application of said probe, one is able to provide a double image of the object under examination. The ultrasound probe is housed in the head, above the plane of the collimator and kept projecting to favor the direct contact with the body part of the patient to be examined. The collimator is able to obtain images of the biodistribution of a radiolabelled drug by radiation with frontal incidence, maintaining the characteristics of the ultrasound probe. The probe is applicable to both clinical diagnosis and intraoperative diagnosis of cancer with the use of radio tracers. A guided diagnostic method is disclosed that realizes a functional integration of a pair of ultrasound and scintigraphic images concurrently obtained by the echo-scintigraphic probe.


Patent
National Institute of Nuclear Physics, Italy and University of Rome La Sapienza | Date: 2017-03-22

The present invention relates to an echo-scintigraphic probe (1) for medical applications and the method of merging images. It is constituted by the union of an ultrasound probe (11) suitably integrated, both in geometric terms, and in terms of image processing, with a scintigraphic probe or gamma camera (3). With a single application of said probe (1), one is able to provide a double image of the object under examination. The ultrasound probe (11) is housed in the head (8), above the plane of the collimator (14) and kept projecting to favor the direct contact with the body part (20) of the patient (13) to be examined. The collimator (14) is able to obtain images of the biodistribution of a radiolabeled drug by radiation with frontal incidence, maintaining the characteristics of the ultrasound probe (11). The probe (1) is applicable to both clinical diagnosis and intraoperative diagnosis of cancer with the use of radio tracers. The invention also concerns a guided diagnostic method that realizes a functional integration of a pair of ultrasound and scintigraphic images concurrently obtained by the echo-scintigraphic probe (1) according to the invention.


The present invention relates to a rectifier for a sensor of electromagnetic signal, said electromagnetic signal having a frequency between 300Ghz and 10THz. Said rectifier comprising: - a semiconductor substrate (1 ) doped p comprising a electrons/holes gathering well (2) for gathering electrons/holes; said electrons/holes gathering well (2) being arranged inside said semiconductor substrate (1 ) and comprising at least a first zone doped n/p (21 ); said first zone doped n/p (21 ) having an end surface (21 A); - a metal end surface (41 ) of an antenna (4), said antenna being capable of receiving and concentrating said electromagnetic signal; - a layer doped p (3) having a first surface (31) and a second surface (32), opposite to said first surface (31 ). In particular, a first portion of said first surface (31) of said layer doped p (3) is in contact with said end surface (21 A) of said first zone doped n/p (21 ) of the electrons/holes gathering well (2), so as to form a first metallurgical junction (G1 ), and a first portion of said second surface (32) of said layer doped p (3) is in contact with said metal end surface (41 ), so as to form a second metallurgical junction (G2). The concentration of the doping of said layer doped p (3) and the concentration of the doping of said first zone doped n/p (21) of said electrons/holes gathering well (2) are such that said first metallurgical junction (G1) has a first potential barrier (VZ1) inside and the work function of the metal of said metal end surface (41 ) is selected such that it is equal to that of a semiconductor doped n/p and such that said second metallurgical junction (G2) has a second potential barrier (Vzz) inside. Said first metallurgical junction (G1 ) and said second metallurgical junction (G2) form a double metallurgical junction n-p-n/p-n-p with a double potential barrier composed of said first potential barrier (Vz1) and said second potential barrier (Vz2), where said double metallurgical junction n-p-n/p-n-p comprises a first depletion zone (Z1 ), and a second depletion zone (Z2), in contact with said first depletion zone (Z1 ) along a line of contact (A), disposed within said layer doped p (3), said first depletion zone (Z1 ) having a thickness greater than the thickness of the second depletion zone (Z2); said first potential barrier (Vzi) being associated with said first depletion zone (Z 1 ), and said second potential barrier (Vz2) being associated with said second depletion zone (Z2). Said layer doped p (3) is dimensioned in such a way that said double potential barrier has a value such as to allow said layer doped p (3) being completely deprived of holes/electrons, so that, when a variable electric field is induced by said electromagnetic signal received by said antenna (4), said double metallurgical junction n-p-n/p-n-p is subjected to said variable electric field, and a first potential difference (AV^) and a second potential difference (AVZ2) are generated, through the first depletion zone (Z1 ) and through the second depletion zone (Z2) respectively, where each potential difference (Vzi, Vz2) is proportional to the thickness of the respective depletion zone (Z1, Z2) and is added algebraically to the respective potential barrier (Vz1, Vz2). The present invention relates also to a charge gathering system comprising said rectifier.


Patent
Sb Solar and University of Rome La Sapienza | Date: 2015-03-31

A rechargeable electrochemical metal ion cell includes negative and positive electrodes, and an electrolyte system between them. The negative electrode includes a metal capable of releasing and accepting metal ions. The positive electrode includes at least one compound capable of releasing and accepting metal ions different from those of the negative electrode. The electrolyte system includes: a glycol-based electrolyte solution containing a salt of a metal included in the negative electrode and a salt of a metal included in the positive electrode; a matrix adapted to retain the electrolyte solution, where two reversible reactions take place simultaneously in the cell: a reversible deposition and dissolution process of ions of a metal included in the negative electrode takes place in the negative electrode and a reversible ion exchange process of a metal included in the positive electrode takes place in the positive electrode. The metals are different from one another.


Patent
University Degli Studi and University of Rome La Sapienza | Date: 2017-08-09

The present invention relates to salts of anthelmintic compounds with a benzimidazolic structure, such as albendazole (ABZ), fenbendazole (FBZ), triclabendazole (TRBZ), or sulphoxides thereof, flubendazole (FLZ), mebendazole (MBZ), oxibendazole (OBZ), thiabendazole (TBZ), cambendazole (CBZ), parbendazole (PBZ), nocodazole (NCZ), the use thereof and a process for preparation thereof.


HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along with methods to make results of analyses and outcomes comparable across centers and sustainable through Rheumatology associations. The overall idea of the HarmonicSS project is to bring together the largest well characterized regional, national and international longitudinal cohorts of patients with Primary Sjgrens Syndrome (pSS) including those participating in clinical trials, and after taking into consideration the ethical, legal, privacy and IPR issues for sharing data from different countries, to semantically interlink and harmonize them into an integrative pSS cohort structure on the cloud. Upon this harmonized cohort, services for big data mining, governance and visual analytics will be integrated, to address the identified clinical and health policy pSS unmet needs. In addition, tools for specific diagnostic procedures (e.g. ultrasonography image segmentation), patient selection for clinical trials and training will be also provided. The users of the HarmonicSS platform are researchers (basic/translational), clinicians, health policy makers and pharma companies. pSS is relevant not only due to its clinical impact but also as one of the few model diseases to link autoimmunity, cancer development (lymphoproliferation) and the pathogenetic role of infection. Thus, the study of pSS can facilitate research in many areas of medicine; for this reason, the possibility for sustainability and expandability of the platform is enhanced. Moreover, pSS has a significant impact on the healthcare systems, similar to that of rheumatoid arthritis.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: LCE-02-2016 | Award Amount: 15.84M | Year: 2017

inteGRIDy aims to integrate cutting-edge technologies, solutions and mechanisms in a scalable Cross-Functional Platform connecting energy networks with diverse stakeholders, facilitating optimal and dynamic operation of the Distribution Grid (DG), fostering the stability and coordination of distributed energy resources and enabling collaborative storage schemes within an increasing share of renewables. inteGRIDy will: a) Integrate innovative smart grid technologies, enabling optimal and dynamic operation of the distribution systems assets within high grid reliability and stability standards b) Validate innovative Demand Response technologies and relevant business models c) Utilize storage technologies and their capabilities to relieve the DG and enable significant avoidance of RES curtailment, enhancing self-consumption and net metering d) Enable interconnection with transport and heat networks, forming Virtual Energy Network synergies ensuring energy security e) Provide modelling & profiling extraction for network topology representation, innovative DR mechanisms and Storage characterization, facilitating decision making in DGs operations f) Provide predictive, forecasting tools & scenario-based simulation, facilitating an innovative Operation Analysis Framework g) Develop new business and services to create value for distribution domain stakeholders and end users/prosumers in an emerging electricity market. inteGRIDy will impact on: a) operations by reconfigurable topology control & supervision b) market by providing new services c) customer by enhanced engagement through DR mechanisms d) transmission by novel forecasting scenarios for the MV/LV areas e) part of the production incorporating innovative storage targeting the optimum use of RES f) environment by CO2 reduction inteGRIDy approach will be deployed and validated in 6 large-scale and 4 small-scale real-life demonstration covering different climatic zones and markets with different maturity.


Bianco P.,University of Rome La Sapienza
Annual review of cell and developmental biology | Year: 2014

Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton. This cell coincides with a specific type of bone marrow perivascular cell. In skeletal physiology, this skeletal stem cell is pivotal to the growth and lifelong turnover of bone and to its native regeneration capacity. In hematopoietic physiology, its role as a key player in maintaining hematopoietic stem cells in their niche and in regulating the hematopoietic microenvironment is emerging. In the alternative description, MSCs are ubiquitous in connective tissues and are defined by in vitro characteristics and by their use in therapy, which rests on their ability to modulate the function of host tissues rather than on stem cell properties. Here, I discuss how the two views developed, conceptually and experimentally, and attempt to clarify the confusion arising from their collision.


Bianco P.,University of Rome La Sapienza
Blood | Year: 2011

The revived interest in (hematopoietic) stem cell (HSC) niches has highlighted the role of multiple cellular players found in the bone environment. Initially focused on the role of osteoblasts and sinusoid endothelial cells, the quest for HSC niche cells has recently focused on a unique role for osteoprogenitor cells (skeletal stem cells, mesenchymal stem cells). Strongly validated by observations of HSC dysregulation dictated by the dysregulation of osteoprogenitors, the role of osteoprogenitors in the HSC niche integrates data from different studies into a unified view. As preosteoblastic, periendothelial cells residing at the sinusoid wall, skeletal progenitors reconcile the notions of "osteoblastic" and "sinusoidal" niches with one another. In addition, they bring into focus the cross-regulation of skeletal and hematopoietic physiology as rooted into the interplay of two stem cells (hematopoietic and skeletal) sharing a single niche. As direct regulators of hematopoietic space formation, sinusoid development, and hematopoietic function(s), as well as direct progenitors of positive and negative regulators of HSCs such as osteoblasts and adipocytes, skeletal progenitors have emerged as pivotal organizers of a complex, highly plastic niche. This development seems to represents an evolutionary advance over the deterministic stem cell niches found in archetypal invertebrate systems. © 2011 by The American Society of Hematology.


Pirozzoli S.,University of Rome La Sapienza
Annual Review of Fluid Mechanics | Year: 2011

We review numerical methods for direct numerical simulation (DNS) and large-eddy simulation (LES) of turbulent compressible flow in the presence of shock waves. Ideal numerical methods should be accurate and free from numerical dissipation in smooth parts of the flow, and at the same time they must robustly capture shock waves without significant Gibbs ringing, which may lead to nonlinear instability. Adapting to these conflicting goals leads to the design of strongly nonlinear numerical schemes that depend on the geometrical properties of the solution. For low-dissipation methods for smooth flows, numerical stability can be based on physical conservation principles for kinetic energy and/or entropy. Shock-capturing requires the addition of artificial dissipation, in more or less explicit form, as a surrogate for physical viscosity, to obtain nonoscillatory transitions. Methods suitable for both smooth and shocked flows are discussed, and the potential for hybridization is highlighted. Examples of the application of advanced algorithms to DNS/LES of turbulent, compressible flows are presented. © 2011 by Annual Reviews. All rights reserved.

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