Rome, Italy

The Sapienza University of Rome, officially Sapienza – Università di Roma, also called simply Sapienza formerly known as Università degli studi di Roma "La Sapienza", is a coeducational, autonomous state university in Rome, Italy. It is the largest European university by enrollments and the oldest of Rome's four state universities, founded in 1303. In Italian, sapienza means "wisdom" or "knowledge".Being the biggest Italian University, Sapienza is member of several national and international groups, as: European Spatial Development Planning, Partnership of a European Group of Aeronautics and Space Universities, CINECA, Santander Network, Institutional Network of the Universities from the Capitals of Europe, Mediterranean Universities Union.Sapienza is present in all major international university rankings. It is among the best Italian universities.According to the Academic Ranking of World Universities compiled by the Jiao Tong University of Shanghai, Sapienza is regularly ranked first among Italian universities. Sapienza is positioned within the 101-150 group of universities and among the top 3% of universities in the world.According to La Sapienza is #8th in Europe and #1 in Italy.In 2013, the Center for World University Rankings ranked the Sapienza University of Rome 62nd in the world and the top in Italy in its World University Rankings.According to the American society "U.S News & World Report", La Sapienza is the most prestigious Italian University Wikipedia.

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National Institute of Nuclear Physics, Italy and University of Rome La Sapienza | Date: 2015-05-14

An echo-scintigraphic probe for medical applications and the method of merging images. It is constituted by the union of an ultrasound probe suitably integrated, both in geometric terms, and in terms of image processing, with a scintigraphic probe or gamma camera (3). With a single application of said probe, one is able to provide a double image of the object under examination. The ultrasound probe is housed in the head, above the plane of the collimator and kept projecting to favor the direct contact with the body part of the patient to be examined. The collimator is able to obtain images of the biodistribution of a radiolabelled drug by radiation with frontal incidence, maintaining the characteristics of the ultrasound probe. The probe is applicable to both clinical diagnosis and intraoperative diagnosis of cancer with the use of radio tracers. A guided diagnostic method is disclosed that realizes a functional integration of a pair of ultrasound and scintigraphic images concurrently obtained by the echo-scintigraphic probe.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.87M | Year: 2017

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates. The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines. Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.

HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along with methods to make results of analyses and outcomes comparable across centers and sustainable through Rheumatology associations. The overall idea of the HarmonicSS project is to bring together the largest well characterized regional, national and international longitudinal cohorts of patients with Primary Sjgrens Syndrome (pSS) including those participating in clinical trials, and after taking into consideration the ethical, legal, privacy and IPR issues for sharing data from different countries, to semantically interlink and harmonize them into an integrative pSS cohort structure on the cloud. Upon this harmonized cohort, services for big data mining, governance and visual analytics will be integrated, to address the identified clinical and health policy pSS unmet needs. In addition, tools for specific diagnostic procedures (e.g. ultrasonography image segmentation), patient selection for clinical trials and training will be also provided. The users of the HarmonicSS platform are researchers (basic/translational), clinicians, health policy makers and pharma companies. pSS is relevant not only due to its clinical impact but also as one of the few model diseases to link autoimmunity, cancer development (lymphoproliferation) and the pathogenetic role of infection. Thus, the study of pSS can facilitate research in many areas of medicine; for this reason, the possibility for sustainability and expandability of the platform is enhanced. Moreover, pSS has a significant impact on the healthcare systems, similar to that of rheumatoid arthritis.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-22-2016 | Award Amount: 5.15M | Year: 2017

The key objective of our project is to bridge the gap between secondary schools and higher education and research by better integrating formal and informal learning scenarios and adapting both the technology and the methodology that students will most likely be facing in universities. We are focusing on the context of secondary schools, often referred to as high schools, which provide secondary education between the ages of 11 and 19 depending on the country, after primary school and before higher education. The learning context from the perspective of the students is the intersection of formal and informal spaces, a dynamic hybrid learning environment where synchronous activities meet in both virtual and real dimensions. For this, we propose to develop an innovative Up to University (Up2U) ecosystem based on proven experiences in higher education and big research that facilitates open, more effective and efficient co-design, co-creation, and use of digital content, tools and services adapted for personalised learning and teaching of high school students preparing for university. We will address project based learning and peer-to-peer learning scenarios. We strongly believe that all the tools and services the project is going to use and/or make available (i.e. incorporate, design, develop and test) must be sustainable after the lifetime of the project. Therefore, the project is going to develop business plans and investigate appropriate business models using the expertise of the Small Medium Enterprise and National Research and Education Network partners and their contacts with third-party business actors. Our plan is to make it easy for new schools to join the Up2U infrastructure and ecosystem that will form a federated market-place for the learning community.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: LCE-02-2016 | Award Amount: 15.84M | Year: 2017

inteGRIDy aims to integrate cutting-edge technologies, solutions and mechanisms in a scalable Cross-Functional Platform connecting energy networks with diverse stakeholders, facilitating optimal and dynamic operation of the Distribution Grid (DG), fostering the stability and coordination of distributed energy resources and enabling collaborative storage schemes within an increasing share of renewables. inteGRIDy will: a) Integrate innovative smart grid technologies, enabling optimal and dynamic operation of the distribution systems assets within high grid reliability and stability standards b) Validate innovative Demand Response technologies and relevant business models c) Utilize storage technologies and their capabilities to relieve the DG and enable significant avoidance of RES curtailment, enhancing self-consumption and net metering d) Enable interconnection with transport and heat networks, forming Virtual Energy Network synergies ensuring energy security e) Provide modelling & profiling extraction for network topology representation, innovative DR mechanisms and Storage characterization, facilitating decision making in DGs operations f) Provide predictive, forecasting tools & scenario-based simulation, facilitating an innovative Operation Analysis Framework g) Develop new business and services to create value for distribution domain stakeholders and end users/prosumers in an emerging electricity market. inteGRIDy will impact on: a) operations by reconfigurable topology control & supervision b) market by providing new services c) customer by enhanced engagement through DR mechanisms d) transmission by novel forecasting scenarios for the MV/LV areas e) part of the production incorporating innovative storage targeting the optimum use of RES f) environment by CO2 reduction inteGRIDy approach will be deployed and validated in 6 large-scale and 4 small-scale real-life demonstration covering different climatic zones and markets with different maturity.

Parisi G.,University of Rome La Sapienza | Zamponi F.,Laboratoire Of Physique Theorique
Reviews of Modern Physics | Year: 2010

Hard spheres are ubiquitous in condensed matter: they have been used as models for liquids, crystals, colloidal systems, granular systems, and powders. Packings of hard spheres are of even wider interest as they are related to important problems in information theory, such as digitalization of signals, error correcting codes, and optimization problems. In three dimensions the densest packing of identical hard spheres has been proven to be the fcc lattice, and it is conjectured that the closest packing is ordered (a regular lattice, e.g., a crystal) in low enough dimension. Still, amorphous packings have attracted much interest because for polydisperse colloids and granular materials the crystalline state is not obtained in experiments for kinetic reasons. A theory of amorphous packings, and more generally glassy states, of hard spheres is reviewed here, that is based on the replica method: this theory gives predictions on the structure and thermodynamics of these states. In dimensions between two and six these predictions can be successfully compared with numerical simulations. The limit of large dimension is also discussed where an exact solution is possible. Some of the results presented here were published, but others are original: in particular, an improved discussion of the large dimension limit and new results on the correlation function and the contact force distribution in three dimensions. The main assumptions that are beyond the theory presented are clarified and, in particular, the relation between static computation and the dynamical procedures used to construct amorphous packings. There remain many weak points in the theory that should be better investigated. © 2010 The American Physical Society.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: NMBP-17-2016 | Award Amount: 6.31M | Year: 2017

NEXTOWER shall introduce a set of innovative materials to boost the performance of atmospheric air-based concentrated solar power (CSP) systems to make them commercially viable. In particular, tower systems are appealing for the great environmental compatibility and offer tremendous potential for efficient (electrical and thermal) power generation. Yet, their industrial exploitation has been so far hindered by limitations in the materials used both for the central receiver - the core component - and for thermal storage. Such limitations dictate maximum working temperature and in-service overall durability (mainly driven by failure from thermal cycling and thermal shocks). Improving the efficiency of a tower system entails necessarily improving the central receiver upstream and possibly re-engineering the whole systems downstream to work longer and at much higher temperature, especially in the thermal storage compartment. NEXTOWER will address this need by taking a comprehensive conceptual and manufacturing approach that will optimize bulk and joining materials for durability at the component level to achieve 25 years of maintenance-free continued service of the receiver and maximum thermodynamic efficiency at the system level. This is made possible through a unique combination of excellence in materials design and manufacturing, CSP full-scale testing facilities brought together in the Consortium, supporting the making of a new full scale demo SOLEAD (in Turkey) within the project. The successful achievement of a new generation of materials allowing for virtually maintenance free operations and increased working temperature shall result in the next-generation of air-coolant CSP highly competitive over other CSP alternatives and sustainable power supply options.

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