Rome, Italy

The Sapienza University of Rome, officially Sapienza – Università di Roma, also called simply Sapienza formerly known as Università degli studi di Roma "La Sapienza", is a coeducational, autonomous state university in Rome, Italy. It is the largest European university by enrollments and the oldest of Rome's four state universities, founded in 1303. In Italian, sapienza means "wisdom" or "knowledge".Being the biggest Italian University, Sapienza is member of several national and international groups, as: European Spatial Development Planning, Partnership of a European Group of Aeronautics and Space Universities, CINECA, Santander Network, Institutional Network of the Universities from the Capitals of Europe, Mediterranean Universities Union.Sapienza is present in all major international university rankings. It is among the best Italian universities.According to the Academic Ranking of World Universities compiled by the Jiao Tong University of Shanghai, Sapienza is regularly ranked first among Italian universities. Sapienza is positioned within the 101-150 group of universities and among the top 3% of universities in the world.According to La Sapienza is #8th in Europe and #1 in Italy.In 2013, the Center for World University Rankings ranked the Sapienza University of Rome 62nd in the world and the top in Italy in its World University Rankings.According to the American society "U.S News & World Report", La Sapienza is the most prestigious Italian University Wikipedia.

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National Institute of Nuclear Physics, Italy and University of Rome La Sapienza | Date: 2015-05-14

An echo-scintigraphic probe for medical applications and the method of merging images. It is constituted by the union of an ultrasound probe suitably integrated, both in geometric terms, and in terms of image processing, with a scintigraphic probe or gamma camera (3). With a single application of said probe, one is able to provide a double image of the object under examination. The ultrasound probe is housed in the head, above the plane of the collimator and kept projecting to favor the direct contact with the body part of the patient to be examined. The collimator is able to obtain images of the biodistribution of a radiolabelled drug by radiation with frontal incidence, maintaining the characteristics of the ultrasound probe. The probe is applicable to both clinical diagnosis and intraoperative diagnosis of cancer with the use of radio tracers. A guided diagnostic method is disclosed that realizes a functional integration of a pair of ultrasound and scintigraphic images concurrently obtained by the echo-scintigraphic probe.

Giona M.,University of Rome La Sapienza
Journal of Statistical Mechanics: Theory and Experiment | Year: 2017

The theory of space-time and non-Markovian spin-driven Diffusion processes introduced in Giona (2016 J. Stat. Mech. submitted) is extended to random space-time displacements and to a continuum of spins. The comparison of space-time diffusion models with the continuous time random walk of Montroll and Weiss is developed in order to highlight the analogies and the differences between these two processes. A similar comparison is performed for other classes of processes such as the multistate random walk and the correlated continuous time random walk. Moreover, the article develops the correspondence between space-time and non-Markovian spin-driven diffusion models, analyzes their relativistic properties, and introduces the concept of hyperbolic homogenization. Some preliminary observations on the use of these models in order to frame relativistic quantum mechanics within a stochastic transport paradigm without enforcing the analytic continuation of the time variable to the imaginary axis are outlined. © 2017 IOP Publishing Ltd and SISSA Medialab srl.

Accettura A.,University of Rome La Sapienza
International Journal of Safety and Security Engineering | Year: 2014

A great variety of hazardous materials (HazMat) are transported by road and, with a few exceptions, no particular restrictions are posed to their routes and no surveillance is exerted during their trip. On the other hand, it is recognized that the potential consequences of an accident involving these materials may be severe or even catastrophic. Such road tankers may therefore represent an attractive target for terrorists, as also recognized by the A.D.R. regulation, which identifies some high consequences dangerous goods (HCDG) classes, requires the adoption of security measures and lists the essential elements to be included in the security plan, which should be prepared when transporting such materials. However, as a matter of fact, the HCDG list includes practically all fuel tankers (gasoline, LPG, kerosene, etc.) so that providing all these vehicles with proper security devices may be impracticable and rather expensive; moreover, workers' privacy should be safeguarded. The present work focuses on critical security issues to be addressed when transporting HCDGs and considers some devices and procedures aimed at reducing the risk. The complexity of the system can be modulated based on the available resources and specific circumstances (type of dangerous good, route features, and others). An attempt is also made to further subdivide HCDG classes into three large groups, based on the type of consequence (fire, overpressure and missiles, toxic cloud) and on the expected impact areas associated with a deliberate release of the product into the environment. This will allow to properly scale the complexity of the proposed security apparatuses and procedures.

Califano C.,University of Rome La Sapienza | Moog C.H.,CNRS Research Institute of Communication and Cybernetics of Nantes
IEEE Transactions on Automatic Control | Year: 2017

A full characterization of accessibility is provided for nonlinear time-delay systems. It generalizes the rank condition which is known for weak controllability of linear time-delay systems, as well as the celebrated geometric approach for delay-free nonlinear systems and the characterization of their accessibility. Besides, fundamental results are derived on integrability and basis completion which are of major importance for a number of general control problems for nonlinear time-delay systems. They are shown to impact preconceived ideas about canonical forms for nonlinear time-delay systems. © 2016 IEEE.

This study is focused on showing technical and economic issues related to the use of low temperature PCM (Phase Change Material) storage system coupled to a condensing micro CHP. That one is a single cylinder engine of rated power and thermal outputs equal to 5 kW and 13.1 kW respectively, equipped with a three-way catalyst to meet the regulations on pollutants emission. Two different system layouts were built and economical-environmental performance was evaluated. Specifically, a traditional water tank and a PCMs array were analysed. A two-family house characterized by a normalized primary energy need equal to 50.523 kWh/m2 y was assumed as the end user. That energy need is referred to the climatic conditions typical of Middle region in Italy. Finally, the LCOE (Levelised Cost of Electricity), calculated over a system lifespan of 15 years, has been chosen as the main indicator to compare the different options optimizing the CHP switching-on strategies. © 2016 The Authors.

Energy retrofitting of existing building stock and new expansion of urban settlements entail a new relationship between consumption and production sites. Especially, new production facilities linked to the renewables boom are not taken into account by the urban governance. Energy planning instruments could be the viable tool to manage the new energy transition focusing on territorial resources. The Sustainable Energy Action Plan is the most common and widespread due to its voluntary nature. The study analysed the SEAPs of three big Italian Cities to assess an integrated framework for planning renewablesat the metropolitan scale. © 2016 The Authors.

Bosi F.,University of Rome La Sapienza | Andreozzi G.B.,University of Rome La Sapienza
American Mineralogist | Year: 2017

Flux-grown spinel crystals belonging to the MgAl2O4-MgCr2O4 spinel series were investigated to reveal the effects of Cr substituting for Al on cation distribution and their influence on Mg-Al intra-crystalline exchange. Samples were structurally and chemically characterized by single-crystal X-ray diffraction and electron microprobe, and cation distribution was obtained with a tested optimization model for site populations. The results evidenced that the contribution of the tetrahedral bond distance to the unit-cell parameter is smaller than that of the octahedral bond distance, which is driven by the substitution of Cr for Al. Moreover, the influence that Cr exerts on Mg-Al order-disorder intersite exchange is non-linear along the whole series. The comparison between the cation distributions derived from crystal-chemical data and the O'Neill-Navrotsky thermodynamic model (with αMg-Al = 23 kJ/mol and βMg-Al = 13 kJ/mol) shows large discrepancies, which can be reconciled assuming αMg-Al values variable from 23 to 100 kJ/mol as a function of Cr. This suggests that, irrespective of temperature, the Al ordering at the octahedrally coordinated site increases with increasing Cr substitution for Al. The geothermometric implications of the present study point out that closure temperatures, calculated from a well-tested intersite geothermometer, are reliable for spinels with magnesiochromite component smaller than 85%, i.e., Cr/(Cr+Al) < 0.85, whereas spinels with larger magnesiochromite component yield unreliable closure temperature. © 2017 by Walter de Gruyter Berlin/Boston 2017.

Raymond J.,University of Rome La Sapienza | Ricci-Tersenghi F.,CNR Institute of Neuroscience
Journal of Machine Learning Research | Year: 2017

Inference methods are often formulated as variational approximations: these approximations allow easy evaluation of statistics by marginalization or linear response, but these estimates can be inconsistent. We show that by introducing constraints on covariance, one can ensure consistency of linear response with the variational parameters, and in so doing inference of marginal probability distributions is improved. For the Bethe approximation and its generalizations, improvements are achieved with simple choices of the constraints. The approximations are presented as variational frameworks; iterative procedures related to message passing are provided for finding the minima. ©2017 Jack Raymond and Federico Ricci-Tersenghi.

Niaki M.K.,University of Rome La Sapienza | Nonino F.,University of Rome La Sapienza
Journal of Manufacturing Technology Management | Year: 2017

Purpose - The purpose of this paper is to identify the impacts of additive manufacturing (AM) in manufacturing, business strategies and business performance and to determine the contingent factors driving performance. Accordingly, this study also clarifies the relationship between these impacts and company and product characteristics. Design/methodology/approach - The authors conducted an exploratory study using multiple case research methodology, sampling 16 heterogeneous companies based on the theoretical replication approach. The potential impacts of AM were identified by reviewing the previous literature. For the driving factors, the paper follows the literature on AM, as well as the theories arisen from technology management literature. The qualitative information was collected by means of semi-structured interviews and documentary analysis to measure the effectiveness of AM in these aspects. Findings - The paper derives and provides empirical insights regarding how this technology affects the industry. This study reveals how the implementation of AM in the Rapid Manufacturing (RM) of products made of metal has boosted productivity. These findings also demonstrate an increasing competitiveness of the early adopter SMEs using RM. Research limitations/implications - This empirical research has been conducted by means of qualitative data. Therefore, researchers are encouraged to test the propositions by quantitative measures. Practical implications - The paper provides insights for the adaption of AM and its impacts on business strategies and performance. Originality/value - This paper contributes to expanding the literature by depicting explicit links between the implementation of this revolutionary technology and business strategies and performance. © 2017 Emerald Publishing Limited.

Loprencipe G.,University of Rome La Sapienza | Zoccali P.,University of Rome La Sapienza
Journal of Modern Transportation | Year: 2017

In the evaluation of road roughness and its effects on vehicles response in terms of ride quality, loads induced on pavement, drivers’ comfort, etc., it is very common to generate road profiles based on the equation provided by ISO 8608 standard, according to which it is possible to group road surface profiles into eight different classes. However, real profiles are significantly different from the artificial ones because of the non-stationary feature of the first ones and the not full capability of the ISO 8608 equation to correctly describe the frequency content of real road profiles. In this paper, the international roughness index, the frequency-weighted vertical acceleration awz according to ISO 2631, and the dynamic load index are applied both on artificial and real profiles, highlighting the different results obtained. The analysis carried out in this work has highlighted some limitation of the ISO 8608 approach in the description of performance and conditions of real pavement profiles. Furthermore, the different sensitivity of the various indices to the fitted power spectral density parameters is shown, which should be taken into account when performing analysis using artificial profiles. © 2017, The Author(s).

D'Urso P.,University of Rome La Sapienza
Information Sciences | Year: 2017

Fifty years have gone by since the publication of the first paper on clustering based on fuzzy sets theory. In 1965, L.A. Zadeh had published “Fuzzy Sets” [335]. After only one year, the first effects of this seminal paper began to emerge, with the pioneering paper on clustering by Bellman, Kalaba, Zadeh [33], in which they proposed a prototypal of clustering algorithm based on the fuzzy sets theory. Starting from this paper, several uncertain clustering methods based on different theoretical approaches for modeling the uncertainty have been proposed. The present paper presents a systematic literature review of these clustering approaches. In particular, with respect to the Statistical Reasoning System, we first illustrate the connection between Information and Uncertainty from the perspective of the so-called Informational Paradigm, according to which Information is constituted by “Informational ingredients”, specifically the “Empirical Information,” represented by statistical data, and “Theoretical information” consisting of background knowledge and basic modeling assumptions. We then describe different kinds of uncertainty affecting the Information. Focusing on the uncertainty associated with a particular statistical methodology, i.e. Cluster Analysis, and adopting as theoretical platform the Informational Paradigm, we present a systematic literature review of different uncertainty-based clustering approaches -i.e. Fuzzy clustering, Possibilistic clustering, Shadowed clustering, Rough sets-based clustering, Intuitionistic fuzzy clustering, Evidential clustering, Credibilistic clustering, Type-2 fuzzy clustering, Neutrosophic clustering, Hesitant fuzzy clustering, Interval-based fuzzy clustering, and Picture fuzzy clustering. We thus show how all these clustering approaches are able of managing in different ways the uncertainty associated with the two components of the Informational Paradigm, i.e. the Empirical and Theoretical Information. © 2017 Elsevier Inc.

Iamonico D.,University of Rome La Sapienza
Phytotaxa | Year: 2017

As part of the studies on Amaranthaceae Juss. (e.g. Iamonico 2014, 2015, Sánchez Del Pino & Iamonico 2016), and the preparation of the new Checklist of the Italian vascular alien Flora (Galasso et al. 2016), I present here a note on an Amaranthus hybrid which was reported for Italy by Cacciato (1966) as “Amaranthus ×galii Sennen & Gonzalo” (Sennen 1929: 34). This name was proposed by Sennen & Gonzalo (l.c.) without a diagnosis, and it is a nomen nudum and invalid under Art. 38.1 of the ICN (McNeill et al. 2012). Furthermore, Sennen & Gonzalo in Sennen (1929: 34) cited Amaranthus patulus Bertoloni (1837: 19) and A. retroflexus Linnaeus (1753: 991) as parental taxa of the new hybrid. According to the current knowledge (see Iamonico 2016), A. patulus is a heterotypic synonym of A. hybridus Linnaeus (1753: 990). Consequently, the hybrid concept of Sennen & Gonzalo refers to A. × ozanonii (Thellung 1914: 263) Schuster & Goldschmidt in Ascherson & Graebner 1920 : 20) (= A. hybridus × A. retroflexus). © 2017 Magnolia Press.

Laurenza E.,University of Rome La Sapienza
Advances in Intelligent Systems and Computing | Year: 2017

Data fusion is a major task in data management. Frequently, different sources store data about the same real-world entities, however with conflicts in the values of their features. Data fusion aims at solving those conflicts in order to obtain a unique global view over those sources. Some solutions to the problem have been proposed in the database literature, yet they have a number of limitations for real cases: for example they leave toomany alternatives to users or produce biased results. This paper proposes a novel algorithm for data fusion actually addressing conflict resolution in databases and overcoming some existing limitations. © Springer International Publishing Switzerland 2017.

Lupo C.,University of Rome La Sapienza | Ricci-Tersenghi F.,University of Rome La Sapienza
Physical Review B - Condensed Matter and Materials Physics | Year: 2017

Numerical simulations of spin glass models with continuous variables set the problem of a reliable but efficient discretization of such variables. In particular, the main question is how fast physical observables computed in the discretized model converge toward the ones of the continuous model when the number of states of the discretized model increases. We answer this question for the XY model and its discretization, the q-state clock model, in the mean-field setting provided by random graphs. It is found that the convergence of physical observables is exponentially fast in the number q of states of the clock model, so allowing a very reliable approximation of the XY model by using a rather small number of states. Furthermore, such an exponential convergence is found to be independent from the disorder distribution used. Only at T=0, the convergence is slightly slower (stretched exponential). Thanks to the analytical solution to the q-state clock model, we compute accurate phase diagrams in the temperature versus disorder strength plane. We find that, at zero temperature, spontaneous replica symmetry breaking takes place for any amount of disorder, even an infinitesimal one. We also study the one step of replica symmetry breaking (1RSB) solution in the low-temperature spin glass phase. © 2017 American Physical Society.

Scutari G.,Purdue University | Facchinei F.,University of Rome La Sapienza | Lampariello L.,University for Business Studies
IEEE Transactions on Signal Processing | Year: 2017

In this two-part paper, we propose a general algorithmic framework for the minimization of a nonconvex smooth function subject to nonconvex smooth constraints, and also consider extensions to some structured, nonsmooth problems. The algorithm solves a sequence of (separable) strongly convex problems and maintains feasibility at each iteration. Convergence to a stationary solution of the original nonconvex optimization is established. Our framework is very general and flexible and unifies several existing successive convex approximation (SCA)-based algorithms. More importantly, and differently from current SCA approaches, it naturally leads to distributed and parallelizable implementations for a large class of nonconvex problems. This Part I is devoted to the description of the framework in its generality. In Part II, we customize our general methods to several (multiagent) optimization problems in communications, networking, and machine learning; the result is a new class of centralized and distributed algorithms that compare favorably to existing ad-hoc (centralized) schemes. © 2016 IEEE.

Astiaso Garcia D.,University of Rome La Sapienza
Sustainable Cities and Society | Year: 2017

Urban areas management includes the planning of efficient strategies and measures for ensuring good standards of environmental quality in urban areas. The main aim of this paper is to disclose some useful techniques and strategies for improving urban ecological sustainability, satisfying the main principles of conservation tacking into account social and economic feasibilities. Urban ecological sustainability has been considered using an interdisciplinary approach which aims to integrate social aspects, green architecture designs and traditional ecological issues. Before analysing green areas management and bioengineering for improving ecological sustainability of urban areas, the first part of the paper includes an overview of related themes, such as an analysis of the main interactions between ecological sustainability and energy supply in urban areas, social and economic aspects, interactions between urbanisation and biodiversity conservation. The results pinpoint strategies and techniques for improving urban ecological sustainability mainly considering environmental public awareness and green areas management and focusing on Southern Europe contexts but replicable and adaptable in different circumstances. © 2017 Elsevier Ltd

Garra R.,University of Rome La Sapienza
Mathematical Methods in the Applied Sciences | Year: 2017

In this paper, we study a mathematical model of nonlinear thermoelastic wave propagation in fluid-saturated porous media, considering memory effect in the heat propagation. In particular, we derive the governing equations in one dimension by using the Gurtin–Pipkin theory of heat flux history model and specializing the relaxation function in such a way to obtain a fractional Erdélyi–Kober integral. In this way, we obtain a nonlinear model in the framework of time-fractional thermoelasticity, and we find an explicit analytical solution by means of the invariant subspace method. A second memory effect that can play a significant role in this class of models is parametrized by a generalized time-fractional Darcy law. We study the equations obtained also in this case and find an explicit traveling wave type solution. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Venditti I.,University of Rome La Sapienza
Materials | Year: 2017

This review concerns the recently emerged class of composite colloidal photonic crystals (PCs), in which gold nanoparticles (AuNPs) are included in the photonic structure. The use of composites allows achieving a strong modification of the optical properties of photonic crystals by involving the light scattering with electronic excitations of the gold component (surface plasmon resonance, SPR) realizing a combination of absorption bands with the diffraction resonances occurring in the body of the photonic crystals. Considering different preparations of composite plasmonic-photonic crystals, based on 3D-PCs in presence of AuNPs, different resonance phenomena determine the optical response of hybrid crystals leading to a broadly tunable functionality of these crystals. Several chemical methods for fabrication of opals and inverse opals are presented together with preparations of composites plasmonic-photonic crystals: the influence of SPR on the optical properties of PCs is also discussed. Main applications of this new class of composite materials are illustrated with the aim to offer the reader an overview of the recent advances in this field. © 2017 by the authors.

Fiorenza D.,University of Rome La Sapienza | Monaco D.,International School for Advanced Studies | Panati G.,University of Rome La Sapienza
Annales Henri Poincare | Year: 2016

We consider a real periodic Schrödinger operator and a physically relevant family of m≥1 Bloch bands, separated by a gap from the rest of the spectrum, and we investigate the localization properties of the corresponding composite Wannier functions. To this aim, we show that in dimension d≤3, there exists a global frame consisting of smooth quasi-Bloch functions which are both periodic and time-reversal symmetric. Aiming to applications in computational physics, we provide a constructive algorithm to obtain such a Bloch frame. The construction yields the existence of a basis of composite Wannier functions which are real-valued and almost-exponentially localized. The proof of the main result exploits only the fundamental symmetries of the projector on the relevant bands, allowing applications, beyond the model specified above, to a broad range of gapped periodic quantum systems with a time-reversal symmetry of bosonic type. © 2015, Springer Basel.

Casali N.,University of Rome La Sapienza | Casali N.,National Institute of Nuclear Physics, Italy
Astroparticle Physics | Year: 2017

The most sensitive process able to probe the Majorana nature of neutrinos and discover Lepton Number Violation is the neutrino-less double beta decay. Thanks to the excellent energy resolution, efficiency and intrinsic radio-purity, cryogenic calorimeters are primed for the search for this process. A novel approach able to improve the sensitivity of the current experiments is the rejection of α interactions, that represents the dominant background source. In TeO2 calorimeters, α particles can be tagged as, in contrast to electrons, they do not emit Cherenkov light. Nevertheless, the very low amount of detected Cherenkov light undermines the complete rejection of α background. In this paper we compare the results obtained in previous measurements of the TeO2 light yield with a detailed Monte Carlo simulation able to reproduce the number of Cherenkov photons produced in β/γ interactions within the calorimeter and their propagation in the experimental set-up. We demonstrate that the light yield detectable from a 5 × 5 × 5 cm3 TeO2 bolometer can be increased by up to 60% by increasing the surface roughness of the crystal and improving the light detector design. Moreover, we study the possibility to disentangle α, β and γ interactions, which represent the ultimate background source. Unfortunately γ rejection is not feasible but α rejection can be achieved exploiting high sensitivity light detectors. © 2017 Elsevier B.V.

Di Stefano S.,University of Rome La Sapienza | Ercolani G.,University of Rome Tor Vergata
Journal of Physical Chemistry B | Year: 2017

An extension of the Jacobson-Stockmayer theory is presented to include the reversible formation of [2]catenanes in a ring-chain system under thermodynamic control. The extended theory is based on the molar catenation constant, measuring the ease of catenation of two ring oligomers, whose expression was obtained in a previous work. Two scenarios have been considered: that of "thick" (hydrocarbon-like) chains and that of "thin" (DNA-like) chains. In the case of "thick" chains, the formation of catenanes can be neglected, unless in the unlikely case of a very large value of the equilibrium constant for linear propagation (K ≈ 108 mol-1 L, or larger). For K tending to infinity, the system becomes a chain-free system where only ring-catenane equilibria occur. Under this condition, there is a critical concentration below which only rings are present at equilibrium and above which the ring fraction remains constant, and the excess monomer is converted only into catenanes. In the case of "thin" chains, the formation of catenanes cannot be neglected even for values of K as low as 102 mol-1 L, thus justifying the use of the extended theory. (Figure Presented). © 2017 American Chemical Society.

Parisi G.,University of Rome La Sapienza
Journal of Statistical Physics | Year: 2017

Bethe lattice spins glasses are supposed to be marginally stable, i.e. their equilibrium probability distribution changes discontinuously when we add an external perturbation. So far the problem of a spin glass on a Bethe lattice has been studied only using an approximation where marginal stability is not present, which is wrong in the spin glass phase. Because of some technical difficulties, attempts at deriving a marginally stable solution have been confined to some perturbative regimes, high connectivity lattices or temperature close to the critical temperature. Using the cavity method, we propose a general non-perturbative approach to the Bethe lattice spin glass problem using approximations that should be hopefully consistent with marginal stability. © 2017 Springer Science+Business Media New York

Battaglia L.,University of Rome La Sapienza
Journal of Mathematical Physics | Year: 2017

We consider the B2 and G2 Toda systems on a compact surface (Σ,g), namely, systems of two Liouville-type PDEs coupled with a matrix of coefficients A = or . We attack the problem using variational techniques, following the previous work [Battaglia, L. et al., Adv. Math. 285, 937-979 (2015)] concerning the A2 Toda system, namely, the case A = . We get the existence and multiplicity of solutions as long as χ(Σ) ≤ 0 and a generic choice of the parameters. We also extend some of the results to the case of general systems.

A sequence of eighteen Nephrolepidina populations, coming from the Oligo-Miocene outcrop of Mt. Torretta (L'Aquila-central Apennines), are investigated applying the biometric analysis on the embryo-nepionic chambers and on the fifth stage of the neanic equatorial chamberlets, supplying additional data about parameters and factors that had already demonstrated to have taxonomic-biostratigraphic significance. The occurrence of the whole sequence of different evolutionary stages, Nephrolepidina praemarginata-N. morgani-N. tournoueri, is confirmed. These chronospecies, characterizing the Mediterranean lineage, follow an evolutionary development according to the principles of "embryonic and nepionic acceleration". The data evidence that the "Degree of stolonic distalization" (Factor FD5) and the "Shape Index" (Factor SI5), measured at the 5th neanic stage, have a very good fitting with the previously evidenced overall trend to elongate the shape of the equatorial chamberlets, connected with their packing (golden selection) and a gradually more distal position of the radial stolons (Neanic acceleration). However, according to the biometrical investigation of embryo-nepionic apparatuses, there are significant taxonomic issues, hampering an effective application of the genus to high-resolution biostratigraphy. Both the typological and the quantitative specific, phylogenetic and biostratigraphic definitions, could be improved by means of an integration of the embryonic-nepionic-neanic data. In that way, a significant preliminary goal is reached, suggesting two new, tentative, preliminary biometric boundaries between the chronospecies.

Iamonico D.,University of Rome La Sapienza
Phytotaxa | Year: 2017

The name Agrimonia eupatoria subsp. major stat. nov. (Rosaceae) is proposed. A lectoptype and isolectotype are proposed for the Boissier’s basionym on the basis of the examination of type materials and other specimens. For the nomenclatural purposes the names A. graeca (nom. inval. according to the Art. 36.1c of the ICN), A. eupatoria sensu stricto (lectotype at LINN), A. eupatoria subsp. grandis (neotype at FI, designated in this paper), “A. eupatoria var. grandis” by Vollmann (iso-nym, Art. 6.3 Notes2 of the ICN) and “A. grandis” by Dobroczajeva (isonym, Art. 6.3 Notes2 of the ICN) are also discussed. A morphological comparison among the taxa included in the Agrimonia eupatoria aggregate, as well as a diagnostic key, are also given. © 2017 Magnolia Press.

Luco J.E.,University of California at San Diego | Lanzi A.,University of Rome La Sapienza
Earthquake Engineering and Structural Dynamics | Year: 2017

The paper presents a new damping model in which the inherent damping forces during inelastic vibrations are taken to be proportional to the first derivative of the restoring forces with respect to time. The model can also be interpreted as the damping forces being proportional to an estimate of the elastic component of velocity rather than to the total velocity, which includes plastic and elastic components. The model reduces to the conventional viscous damping model for elastic response but differs from it during inelastic deformations. Although the model is based on the initial properties of the structure, the resulting response is similar to that obtained by the conventional viscous approach using current properties (tangent stiffness). The new damping model is evaluated by comparisons with the response for different viscous damping models obtained by numerical inelastic time-history analyses of a multi-story structure subjected to different earthquake excitations. © 2017 John Wiley & Sons, Ltd.

Benedetti A.,University of Rome La Sapienza | Benedetti A.,GIRMM Informal Group of Micropaleontological and Malacological Researches
Micropaleontology | Year: 2015

A well-preserved new specimen of Granorotalia sublobata from the type population shows the presence of spines in the microspheric generation, the same as for Ornatorotalia spinosa. The spines are irregularly distributed along the periphery of the test. The discovery of this taxonomic character points to a systematic redefinition, in which the two genera are assigned to a new family Ornatorotaliidae, in the superfamily Rotaliacea. Aside from the microspheric spinosity, Ornatorotaliids are characterized among rotaliaceans by a complex enveloping canal system, vertical funnels in both ventral and dorsal sides of the tests, umbilical flap or toothplate, and the absence of folia. © 2015, Micropaleontology Press. All rights reserved.

Pasca M.,University of Rome La Sapienza
Structures and Architecture - Proceedings of the 3rd International Conference on Structures and Architecture, ICSA 2016 | Year: 2016

Infrastructure projects are characterized by large territorial extension and can be really intrusive elements in both natural and man-made existing environment with a significant impact on several factors, including landscape. With particular reference to linear infrastructures (roads and railways), physical and safety restraints lead to the presence of several overpassing structures, bridges and viaducts, for which the structural design is fundamental in the definition of the element aesthetics and cannot be studied separately. The interaction with the existing environment is analyzed according to Visual Impact approach not only for out-standing elements but also, and in particular, for the so-called “everyday” viaducts for which the visual quality if often neglected and substituted by mere building cost analysis. An attempt is made to identify some basic principles that could be taken into account in design in order to achieve a better integration between different disciplines and approaches for good quality projects. © 2016 Taylor & Francis Group, London.

The clinical indications and guidelines for low-density lipoprotein (LDL)-apheresis set by the 1st Italian Consensus Conference held in Ostuni in 1990 and completed in 1992, but never published, are reported schematically. In 1994, within the Project "Prevention and control of the factors of the disease (FATMA)" by the Italian National Research Council, subproject 8 "Control of cardiovascular disease", a "Hearing on therapeutic apheresis: need for a target-oriented project" was organised. The meeting was the last scientific initiative on LDL-apheresis supported by public funds in Italy. After roughly two decades of use of LDL-apheresis, new guidelines were required based on the latest scientific evidence. In 2006, the Italian multicentre study on LDL-apheresis Working Group (IMSLDLa-WP), a scientific initiative at national level, was developed. It initially gathered together 19 Italian centres qualified for the application of lipid apheresis and LDL-apheresis (2007-2008), then 23 in 2010, located in the north, south, centre of Italy and in Sicily and Sardinia. The multicentre study aimed to validate the protocol for selecting patients and to create a network between the Italian centres. A secondary objective was the creation of a database of patients with familial hypercholesterolaemia and other severe forms of dyslipidaemia undergoing treatment with LDL-apheresis using the available techniques. Since LDL-apheresis has multidisciplinary treatment indications, the agreement on the new guidelines was reached through a panel of experts, of different medical and surgical specialties, with scientific and medical interest in the treatment indications, application and development of LDL-apheresis. The initiatives of the IMSLDLa-WP led to the 2nd Italian Consensus Conference on LDL-apheresis held in Rome in 2009. The previous and most recent guidelines are reported here synoptically. © SIMTI Servizi Srl.

Moretti L.,University of Rome La Sapienza | Cantisani G.,University of Rome La Sapienza | Di Mascio P.,University of Rome La Sapienza | Caro S.,University of Los Andes, Colombia
Tunnelling and Underground Space Technology | Year: 2017

This work computes and compares the life cycle costs of two different road tunnel pavements and their corresponding lighting systems. The study evaluated rigid and flexible pavements during life periods of 20 and 30 years for different traffic conditions and for tunnel lengths between 750 m to 2000 m. The design of the pavements and lightening systems, and their corresponding maintenance strategies, followed the requirements stated in current Italian standards. This information was used to estimate the net present values of the construction and maintenance costs for both the pavements and the tunnel lighting systems, using official unit prices valid in Italy. The results showed that for tunnels equal or shorter than 1000 m, the option of using a concrete pavement offered a better economic and technical solution from the initial year of service in comparison to the flexible structure. For tunnels equal or longer than 1200 m, the discounted costs related to concrete pavements were slightly higher than those obtained for the asphalt pavement. However, due to the low pavement maintenance and lightening system costs, the concrete pavement reaches a break-even point in these cases after a few years of service. The results also suggest that the expected traffic level in the tunnel has a neglectable impact in the economic analyses, independently of the type of pavement or tunnel length. This study demonstrates that the quantification of the life cycle costs related with the selection of the road type is an efficient practice to support decision-making processes during the design stage of a tunnel structure. © 2017 Elsevier Ltd

Fedele L.,University of Rome La Sapienza
Risk, Reliability and Safety: Innovating Theory and Practice - Proceedings of the 26th European Safety and Reliability Conference, ESREL 2016 | Year: 2017

The asbestos is a mineral with a fibrous structure in the group of natural hydrous silicates, present in the rocky form in many parts of the world with particular focus on countries such as Canada, Russia and South Africa. The only asbestos mines on the European continent are located in Italy and Greece. The term “asbestos” embraces a family of silicates which occur as flexible bundles of thin fibre units with nanometric diameter and micrometric to millimetric length. © 2017 Taylor & Francis Group, London.

The Brukenthal collection preserves an accurate depiction of the medieval harbour of Messina, which is found in the background of the Crucifixion attributed to Antonello, a native of the city. This paper aims to explore this testimony by framing it in a critical perspective, with concern to the harbour peninsula called, among other names. Lingua Phari. Topographic data shall be distinguished by means of written sources, in order to recall the architectural setting of the area, especially the early style of the Church of the Holy Savior (dating from the twelfth century). The analysis shall focus on the middle level between the "Mernar perspective provided by liturgical rubrics and religious memoirs, and the landscape experienced as a stage for recognition and a tool of memory.

Martin A.-S.,University of Rome La Sapienza
Proceedings of the International Astronautical Congress, IAC | Year: 2016

Space activities are risked and the increase level of commercial and private interests in outer space lead States on developing national legal frameworks for space activities, particularly with regard of their responsibilities. Moreover, there is a general duty to bring domestic law into conformity with obligations under international treaties. Nowadays, States face up to new challenges, in particular concerning the proliferation of space debris, destructive collisions, the crowding of satellites, the growing saturation of the radio-frequency spectrum, end-of-life satellites and space tourism. Hence, several activities of States consist in strengthening or developing their national space laws and policies, as well as in reforming or establishing the governance of national space activities. In France, space policy rests essentially on National Space Agency (CNES) and space activities are led by the domestic space law of the 3rd June 2008, entered into force the 10th December 2010. This law sets rules in a context of privatization of space activities and the opening of the Guiana Space Centre to other launchers than Ariane, such as Soyouz (Russia) and Vega (Italy).

Breccia P.,University of Rome La Sapienza
Proceedings of the International Astronautical Congress, IAC | Year: 2016

The core of space law, by nature and by necessity, forms part of international law. Article III of Outer Space Treaty specifically obliges States to act in accordance with international law including the UN Charter. During the travaux préparatoires Article III was debated that, regarding certain matters, space law may diverge from accepted international law. Indeed, it is generally accepted by scholars that Article III does not imply an automatic extension of international law to outer space and celestial bodies, including the UN Charter in toto. However, even though space law claims to some extent priority over general international law, it does not mean that it is a self-contained regime. International space law neither possesses an independent identity on general international law, nor does it come into being outside the law-making process established by the latter. Since the beginning of the space age, international law has been shaping space law. Despite the peculiarity of space environment Article III provides that space law is intrinsically and extensively linked with international law and its other branches, defining their interactions and synergies. This paper examines that international law clarifies and develops basic principles applicable to outer space in order to guarantee space security and sustainability. Throughout the ICJ decisions and international practice, the notion of sustainable development has softly grown as a concept firstly, and then qualified as an objective. Accordingly, the need for adopting measures most likely to achieve the objective with which specific states conduct must be consistent also in carrying on space activities. Numerous are the efforts on space security to define standards and principles that ought to guide the behaviour for ensuring that conduct of states is consistent with international law. Nowadays, due to the rapid expansion of space activities and the lack of international binding instruments this process is coming into being throughout UN resolutions, guidelines, TCBMs and codes of conduct. These non legally binding instruments are important tools in the evolving process of international law for providing to the states a conduct in order to cover fundamental areas of concerns. In consideration of the difficulties and complexity of the traditional law-making process in adapting the existent corpus iuris spatialis to the new needs, the flexibility of the wording of Article III ascertains that international law, throughout its sources, will be extended to the use of outer space in the broadest sense. Copyright © 2016 by the International Astronautical Federation (IAF). All rights reserved.

Medaglia E.,University of Rome La Sapienza
Proceedings of the International Astronautical Congress, IAC | Year: 2016

Advanced performance allowed by satellite on-board subsystems and payloads are, and even more will be in future, granted by accurate calibration. Ground-based calibration processes are long and expensive, as they require specialized equipment and highly skilled personnel, and cannot obviously manage the small variations induced by the stress at launch, and later by the space environment, as well as follow the changes in the behaviour during the operational lifetime. To cope with these issues, in-flight calibration can be a challenging but effective solution, and this is an approach which attract increasing interest. Notice that in order to avoid workload increases at the ground station, this in-flight calibration needs to be autonomous, too. Star trackers are a good example for these calibration needs. They are extremely accurate devices, and actually require a careful calibration. In many cases, this calibration (for high class instruments) is fully accomplished in state of-the-art facilities far before final integration of the satellite. Only relatively less accurate instruments follow a more economically viable process, with really coarse calibration (maybe better "validation") at the factory, and then an in-flight calibration process within the limits of the mission requirements as the mission itself goes on. The aim of the proposed paper is to discuss the possible extension of this second method to a general rule, valid also for precise star trackers. In fact, extension to precise equipment of the low-cost approach would allow a reduction in cost, and above all a larger, quicker availability of accurate sensors. The main issue is the identification of the components of a minimum set of parameters actually requiring measurements at the ground facility to provide a good enough guess solution leading later to a successful in flight calibration. This identification moves through a correct modelling of the sensor behaviour, an estimate of the relevant contributions to the global error of the different sensor's characteristics, and the assessment of the easiness of their measurement (i.e. the so-called "observability" in terms of control literature). The results obtained for a standard sensor with a process involving a least squares method analysis in the ground-facility, and then combining the least squares analysis and an extended Kalman filter on-board will be presented. Notice that the coupling between coarse test on Earth and accurate process in the real space environment can be an approach useful not only to star trackers but to additional categories of spacecraft sensors and equipment. Copyright © 2016 by the International Astronautical Federation (IAF). All rights reserved.

Capobianco R.,University of Rome La Sapienza
CEUR Workshop Proceedings | Year: 2014

In the last years, Learning by Imitation (LbI) has been increasingly explored in order to easily instruct robots to execute complex motion tasks. However, most of the approaches do not consider the case in which multiple and sometimes conflicting demonstrations are given by different teachers. Nevertheless, it seems advisable that the robot does not start as a tabula-rasa, but re-using previous knowledge in imitation learning is still a difficult research problem. In order to be used in real applications, LbI techniques should be robust and incremental. For this reason, the challenge of our research is to find alternative methods for incremental, multi-teacher LbI.

Toni D.,University of Rome La Sapienza
Journal of cardiovascular medicine (Hagerstown, Md.) | Year: 2017

Neuroimaging has a key role in the assessment and treatment of acute stroke. Cerebral computer tomography is the first step to differentiate hemorragic from ischemic stroke and to detect, in the latter, early signs representative of the lesion severity and predicting a possible hemorrhagic infarction after thrombolytic treatment.Advanced neuroimaging techniques are relevant in the assessment of the ischemic and/or hypo-perfused area, being an essential tool in uncertain situations or when the time of symptoms onset is unavailable, increasing the efficacy and safety of endovenous thrombolysis by enlarging its therapeutic window and leading to more accurate selection of patients to be treated.Moreover, advanced neuroimaging may be of help in choosing the patients to be submitted to endovascular treatment when occlusion of an intracranial artery is documented, either after intravenous thrombolysis or as a primary approach.Here we describe the impact of neuroimaging in the decisional process in acute ischemic stroke, presenting the literature evidence on the topic, especially regarding the recent trials on endovascular treatment.

Cafagna F.,University of Rome La Sapienza
Nuncius | Year: 2017

The essay aims to discuss the fortune of the well-known iconography of the "transparent body" by Leonardo da Vinci, clearly and first of all in the field of artistic anatomy. Some of the most illuminating evidence of this legacy can be found in the plates realized in Paris at the end of the 17th century by the mysterious Valencian engraver Crisóstomo Martínez. These incredible documents are strictly connected to the odd vogue of transparency that, in the same years, seems to affect also European literature, e.g. the pastoral novel Le Berger extravagant by Charles Sorel, the science fiction stories by Cyrano de Bergerac and the famous and "exemplar" tale El licenciadoVidriera by Miguel de Cervantes. © 2017 Copyright 2017 by Koninklijke Brill NV, Leiden, The Netherlands.

Pizza S.,University of Rome La Sapienza | Brown B.,University of Stockholm | McMillan D.,University of Stockholm | Lampinen A.,University of Stockholm
Conference on Human Factors in Computing Systems - Proceedings | Year: 2016

In recent years, the smartwatch has returned as a form factor for mobile computing with some success. Yet it is not clear how smartwatches are used and integrated into everyday life differently from mobile phones. For this paper, we used wearable cameras to record twelve participants' daily use of smartwatches, collecting and analysing incidents where watches were used from over 34 days of user recording. This allows us to analyse in detail 1009 watch uses. Using the watch as a timepiece was the most common use, making up 50% of interactions, but only 14% of total watch usage time. The videos also let us examine why and how smartwatches are used for activity tracking, notifications, and in combination with smartphones. In discussion, we return to a key question in the study of mobile devices: how are smartwatches integrated into everyday life, in both the actions that we take and the social interactions we are part of. © 2016 ACM.

Francisci S.,University of Rome La Sapienza | Montanari A.,University of Rome La Sapienza
Biochimica et Biophysica Acta - Molecular Cell Research | Year: 2017

Mitochondrial (mt) tRNA gene mutations are an important cause of human morbidity and are associated with different syndromes. We have previously shown that the mitochondrial protein synthesis elongation factor EF-Tu and isolated sequences from the carboxy-terminal domain of yeast and human mt leucyl-tRNA synthetases (LeuRS), have a wide range of suppression capability among different yeast mt tRNA mutants having defective respiratory phenotype. Here we show that the rescuing capability can be restricted to a specific sequence of six amino acids from the carboxy-terminal domain of mt LeuRS. On the other hand by overexpressing a mutated version of mt EF-Tu in a yeast strain deleted for the endogenous nuclear gene we identified the specific region involved in suppression. Results support the possibility that a small peptide could correct defects associated with many mt tRNA mutations, suggesting a novel therapy for mitochondrial diseases treatment. The involvement of the mt EF-Tu in cellular heat stress response has also been suggested. © 2017 Elsevier B.V.

Trombetta B.,University of Rome La Sapienza | Cruciani F.,University of Rome La Sapienza
Human Genetics | Year: 2017

The presence of large and near-identical inverted repeat sequences (called palindromes) is a common feature of the constitutively haploid sex chromosomes of different species. Despite the fact palindromes originated in a non-recombining context, they have evolved a strong recombinational activity in the form of abundant arm-to-arm gene conversion. Their independent appearance in different species suggests they can have a profound biological significance that has yet to be fully clarified. It has been theorized that natural selection may have favored palindromic organization of male-specific genes and that the establishment of intra-palindrome gene conversion has strong adaptive significance. Arm-to-arm gene conversion allows the efficient removal of deleterious mutations, increases the fixation rate of beneficial mutations and has played an important role in modulating the equilibrium between gene loss and acquisition during Y chromosome evolution. Additionally, a palindromic organization of duplicates could favor the formation of unusual chromatin structures and could optimize the use of gene conversion as a mechanism to maintain the structural integrity of male-specific genes. In this review, we describe the structural features of palindromes on mammalian sex chromosomes and summarize different hypotheses regarding palindrome evolution and the functional benefits of arm-to-arm gene conversion on the unique haploid portion of the nuclear genome. © 2017 Springer-Verlag Berlin Heidelberg

RATIONALE: The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC).PATIENT CONCERNS: A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule. Histological examination revealed an ATC with a little area of papillary thyroid cancer (PTC). The patient was resistant to selective single-target treatment.DIAGNOSES: Immunophenotyping and gene analyses found a significant increase in FGF2 and FGFR1 expression in the primary ATC area (FGF2 = 38.2 ± 6.2% in ATC vs 34.6 ± 6.0% in the differentiated area of PTC, P < 0.05; FGFR1: 41.7 ± 6.0% in ATC vs 34.4 ± 4.2% in PTC, P < 0.001) and in metastatic neck lymph nodes (P < 0.001 vs normal control tissues). Unlike conventional imaging, F-FDG PET/CT with PERCIST 1.0 criteria promptly and quantitatively detected disease recurrence and remission before and after multitarget therapy, combining anatomic, metabolic, and functional data.INTERVENTIONS: Foscarnet was administered given the positivity for FGF2, FGFR1 and FGFR4 in ATC. Low molecular wight heparin and Sunitinib were coadministere to limiti metastatic progression and on neck tumor masse, respectively.OUTCOMES: The rationale for the clinical response to this innovative multitarget association with foscarnet is based on the histological and genetic finding that fibroblast growth factors and their receptor super-family are up-regulated in the primary anaplastic thyroid tumor and in the metastatic lymph node of our patient.LESSONS: We propose that fibroblast growth factors and their receptor super-family play a key role as potential therapeutic targets in anaplastic thyroid cancer and the positive relevance of this suggestion for patient care, especially for an individualized management.

Dominici G.,University of Palermo | Palumbo F.,University of Rome La Sapienza
Systemic Practice and Action Research | Year: 2013

The increase in the complexity and variability of the business environment, due to constant and rapid changes in markets, calls for more flexible and effective production systems. Of the most valuable production systems, the Japanese lean production system (LPS) is the best known and studied, but is still not the most widely applied with success outside Japan. The reason for the low level of success of lean production outside its native country is the lack of understanding of the strong interactions which hold between enterprises and business systems. In order to fill this gap in our knowledge, we investigate the systemic interactions according to the viable system view. To develop our analysis, we combine the elements of two of the major viable systems theories: the Viable System Model (VSM) of Stafford Beer, and the Viable System Approach (VSA) of Gaetano Golinelli. We combine these two perspectives to create a cohesive framework that combines the internal structural analysis of VSM with the analysis of links to the environmental suprasystems of VSA. In line with this framework, we examine the peculiar aspects of the Japanese LPS in order to find the relevant correspondences between the Japanese LPS and the Viable Systems perspective. We portray the peculiarities of the lean production system, shedding light on its roots in the Japanese business environment (Dominici 2008, 2010), and we show how it has worked as an incubator to create those managerial practices that represent the LPS. We also show how the Japanese kaisha can be effectively represented as a viable system in homeostatic interaction with the Japanese business environment. We conclude with an analysis of the results and summary of the possibilities for further research. © 2012 Springer Science+Business Media, LLC.

Bergshoeff E.A.,University of Groningen | Riccioni F.,University of Rome La Sapienza
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2011

We show that the branes of ten-dimensional IIA/IIB string theory must satisfy, upon toroidal compactification, specific wrapping rules in order to reproduce the number of supersymmetric branes that follows from a supergravity analysis. The realization of these wrapping rules suggests that IIA/IIB string theory contains a whole class of generalized Kaluza-Klein monopoles. © 2011 Elsevier B.V.

Bergshoeff E.A.,University of Groningen | Riccioni F.,University of Rome La Sapienza
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2011

We probe doubled geometry with dual fundamental branes, i.e. solitons. Restricting ourselves first to solitonic branes with more than two transverse directions we find that the doubled geometry requires an effective wrapping rule for the solitonic branes which is dual to the wrapping rule for fundamental branes. This dual wrapping rule can be understood by the presence of Kaluza-Klein monopoles. Extending our analysis to supersymmetric solitonic branes with less than or equal to two transverse directions we show that such solitons are precisely obtained by applying the same dual wrapping rule to these cases as well. This extended wrapping rule cannot be explained by the standard Kaluza-Klein monopole alone. Instead, it suggests the existence of a class of generalized Kaluza-Klein monopoles in ten-dimensional string theory. © 2011 Elsevier B.V.

Charbonneau P.,Duke University | Corwin E.I.,University of Oregon | Parisi G.,University of Rome La Sapienza | Zamponi F.,French National Center for Scientific Research
Physical Review Letters | Year: 2015

Recent theoretical advances offer an exact, first-principles theory of jamming criticality in infinite dimension as well as universal scaling relations between critical exponents in all dimensions. For packings of frictionless spheres near the jamming transition, these advances predict that nontrivial power-law exponents characterize the critical distribution of (i) small interparticle gaps and (ii) weak contact forces, both of which are crucial for mechanical stability. The scaling of the interparticle gaps is known to be constant in all spatial dimensions d - including the physically relevant d=2 and 3, but the value of the weak force exponent remains the object of debate and confusion. Here, we resolve this ambiguity by numerical simulations. We construct isostatic jammed packings with extremely high accuracy, and introduce a simple criterion to separate the contribution of particles that give rise to localized buckling excitations, i.e., bucklers, from the others. This analysis reveals the remarkable dimensional robustness of mean-field marginality and its associated criticality. © 2015 American Physical Society.

Pelissetto A.,University of Rome La Sapienza
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

We consider the O(N)-symmetric ϕ4 theory in two and three dimensions and determine the nonperturbative mass renormalization needed to obtain the ϕ4 continuum theory. The required nonperturbative information is obtained by resumming high-order perturbative series in the massive renormalization scheme, taking into account their Borel summability and the known large-order behavior of the coefficients. The results are in good agreement with those obtained in lattice calculations. © 2015 The Authors.

Azatov A.,University of Rome La Sapienza | Galloway J.,University of Rome La Sapienza | Luty M.A.,University of California at Davis
Physical Review Letters | Year: 2012

In supersymmetric theories with a strong conformal sector, soft supersymmetry breaking at the TeV scale naturally gives rise to confinement and chiral symmetry breaking at the same scale. We consider two such scenarios, one where the strong dynamics induces vacuum expectation values for elementary Higgs fields, and another where the strong dynamics is solely responsible for electroweak symmetry breaking. In both cases, the mass of the Higgs boson can exceed the LEP bound without tuning, solving the supersymmetry naturalness problem. A good precision electroweak fit can be obtained, and quark and lepton masses are generated without flavor-changing neutral currents. In addition to standard supersymmetry signals, these models predict production of multiple heavy standard model particles (t, W, Z, and b) from decays of resonances in the strong sector. © 2012 American Physical Society.

Azatov A.,University of Rome La Sapienza | Galloway J.,University of Rome La Sapienza | Luty M.A.,University of California at Davis
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

In supersymmetric theories with a strong conformal sector, soft supersymmetry breaking naturally gives rise to confinement and chiral symmetry breaking in the strong sector at the TeV scale. We construct and analyze models where such a sector dynamically breaks electroweak symmetry, and take the first steps in studying their phenomenology. We consider two scenarios, one where the strong dynamics induces vacuum expectation values for elementary Higgs fields, and another where the strong dynamics is solely responsible for electroweak symmetry breaking. In both cases there is no fine-tuning required to explain the absence of a Higgs boson below the LEP bound, solving the supersymmetry naturalness problem. Quark and lepton masses arise from conventional Yukawa couplings to elementary Higgs bosons, so there are no additional flavor-changing effects associated with the strong dynamics. A good precision electroweak fit can be obtained because the strong sector is an SU(2) gauge theory with one weak doublet, and has adjustable parameters that control the violation of custodial symmetry. In addition to the standard supersymmetry signals, these models predict production of multiple heavy standard model particles (t, W, Z, and b) from decays of resonances in the strong sector. The strong sector has no approximate parity symmetry, so WW scattering is unitarized by states that can decay to WWW as well as WW. © 2012 American Physical Society.

Cabello A.,University of Seville | Cabello A.,University of Stockholm | Sciarrino F.,University of Rome La Sapienza
Physical Review X | Year: 2012

A loophole-free violation of Bell inequalities is of fundamental importance for demonstrating quantum nonlocality and long-distance device-independent secure communication. However, transmission losses represent a fundamental limitation for photonic loophole-free Bell tests. A local precertification of the presence of the photons immediately before the local measurements may solve this problem.We show that local precertification is feasible by integrating three current technologies: (i) enhanced single-photon down-conversion to locally create a flag photon, (ii) nanowire-based superconducting single-photon detectors for a fast flag detection, and (iii) superconducting transition-edge sensors to close the detection loophole. We carry out a precise space-time analysis of the proposed scheme, showing its viability and feasibility.

Bergshoeff E.A.,University of Groningen | Marrani A.,CERN | Riccioni F.,University of Rome La Sapienza
Nuclear Physics B | Year: 2012

We complete the classification of half-supersymmetric branes in toroidally compactified IIA/IIB string theory in terms of representations of the T-duality group. As a by-product we derive a last wrapping rule for the space-filling branes. We find examples of T-duality representations of branes in lower dimensions, suggested by supergravity, of which . none of the component branes follow from the reduction of any brane in ten-dimensional IIA/IIB string theory. We discuss the constraints on the charges of half-supersymmetric branes, determining the corresponding T-duality and U-duality orbits. © 2012 Elsevier B.V.

Bergshoeff E.A.,University of Groningen | Ortin T.,Institute Fisica Teorica UAM CSIC | Riccioni F.,University of Rome La Sapienza
Nuclear Physics B | Year: 2012

We discuss some general properties of "defect branes", i.e. branes of co-dimension two, in (toroidally compactified) IIA/IIB string theory. In particular, we give a full classification of the supersymmetric defect branes in dimensions 3 ≤ D≤ 10 as well as their higher-dimensional string and M-theory origin as branes and a set of "generalized" Kaluza-Klein monopoles. We point out a relation between the generalized Kaluza-Klein monopole solutions and a particular type of mixed-symmetry tensors. These mixed-symmetry tensors can be defined at the linearized level as duals of the supergravity potentials that describe propagating degrees of freedom. It is noted that the number of supersymmetric defect branes is always twice the number of corresponding central charges in the supersymmetry algebra. © 2011 Elsevier B.V.

Charbonneau P.,Duke University | Corwin E.I.,University of Oregon | Parisi G.,University of Rome La Sapienza | Zamponi F.,French National Center for Scientific Research
Physical Review Letters | Year: 2012

The mechanical properties of jammed packings depend sensitively on their detailed local structure. Here we provide a complete characterization of the pair correlation close to contact and of the force distribution of jammed frictionless spheres. In particular we discover a set of new scaling relations that connect the behavior of particles bearing small forces and those bearing no force but that are almost in contact. By performing systematic investigations for spatial dimensions d=3-10, in a wide density range and using different preparation protocols, we show that these scalings are indeed universal. We therefore establish clear milestones for the emergence of a complete microscopic theory of jamming. This description is also crucial for high-precision force experiments in granular systems. © 2012 American Physical Society.

De Domenico A.,CEA Grenoble | De Domenico A.,Grenoble Informatics Laboratory | Calvanese Strinati E.,CEA Grenoble | Di Benedetto M.-G.,University of Rome La Sapienza
IEEE Communications Surveys and Tutorials | Year: 2012

Dynamic spectrum policies combined with software defined radio are powerful means to improve the overall spectral efficiency allowing the development of new wireless services and technologies. Medium Access Control (MAC) protocols exploit sensing stimuli to build up a spectrum opportunity map (cognitive sensing). Available resources are scheduled (dynamic spectrum allocation), improving coexistence between users that belong to heterogeneous systems (dynamic spectrum sharing). Furthermore, MAC protocols may allow cognitive users to vacate selected channels when their quality becomes unacceptable (dynamic spectrum mobility). The contribution of this survey is threefold. First, we show the fundamental role of the MAC layer and identify its functionalities in a cognitive radio (CR) network. Second, a classification of cognitive MAC protocols is proposed. Third, advantages, drawbacks, and further design challenges of cognitive MAC protocols are discussed. © 2005 IEEE.

Bergshoeff E.A.,University of Groningen | Riccioni F.,University of Rome La Sapienza
Journal of High Energy Physics | Year: 2013

We show that the same wrapping rules that have been derived for the branes of IIA and IIB string theory also apply to the branes of the toroidally compactified heterotic string theory. Moreover, we show that applying these wrapping rules to the IIA theory compactified over K3 is consistent with the well-known duality between the heterotic string theory compactified over T 4 and the IIA string theory compactified over K3. We derive a simple rule that relates, in any dimension, the T-duality representation of the branes of the toroidally compactified heterotic theory to the relevant R-symmetry representation of the central charges in the supersymmetry algebra. We show that, in the general case, the degeneracy of the BPS conditions of the heterotic branes is twice as large as that of the branes of IIA and IIB string theory. © 2013 SISSA, Trieste, Italy.

University of Rome La Sapienza, University of Naples Federico II, ICFO - Institute of Photonic Sciences, Federal University of Rio de Janeiro and National University of Singapore | Date: 2014-12-10

The present invention concerns an ultra-sensitive photonic tiltmeter or goniometer utilizing a novel optical effect named photonic polarization gear effect, based on the orbital angular momentum of the light, to measure with high resolution and sensitivity the roll angle of a rotating object relative to a fixed measurement stage, or to perform related angular measurements. More in detail, the present invention concerns an optical system that uses a pair of photonic devices named q-plates in combination with suitable polarization optics to greatly enhance the measurement sensitivity and resolution of angular measurements based on the polarization of light. Our invention can be combined with all existing methods for the measurement of roll angles based on the polarization of light and results in an enhancement of the corresponding angular resolution and sensitivity.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.3.7 | Award Amount: 4.29M | Year: 2008

Embedded systems are specialised computers used in larger systems or machines to control equipments such as automobiles, home appliances, communication, control and office machines. Such pervasivity is particularly evident in immersive realities, i.e., scenarios in which invisible embedded systems need to continuosly interact with human users, in order to provide continuous sensed information and to react to service requests from the users themselves. The SM4ALL project will investigate an innovative middleware platform for inter-working of smart embedded services in immersive and person-centric environments, through the use of composability and semantic techniques for dynamic service reconfiguration. By leveraging on P2P technologies, the platform is inherently scalable and able to resist to devices churn and failures, while preserving the privacy of its human users as well as the security of the whole environment. This is applied to the challenging scenario of private houses and home-care assistance in presence of users with different abilities and needs (e.g., young able bodied, aged and disabled).\nThe specific composition of the Consortium, consisting of top-class universities and research centers (UOR, TUW, RUG, KTH and FOI), of user partners specialized in domotics and home-care assistance (FSL and THFL) and a SME specialized in specific brain-computer interfaces (GTEC), and of leader companies in the embedded sector (TID and ED) guarantees a widespread dissemination and exploitation of the project results, coupled with a privileged position inside ARTEMIS and ARTEMISIA (due to the presence of UOR, TUW and ED in such bodies).

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.1.5 | Award Amount: 19.59M | Year: 2008

P2P-Next develops an open source, efficient, trusted, personalized, user-centric, and participatory television and media delivery system with social and collaborative connotation using the emerging Peer-to-Peer (P2P) paradigm, which takes into account the existing EU legal framework.\nThe P2P-Next integrated project will build a next generation Peer-to-Peer (P2P) content delivery platform, to be designed, developed, and applied jointly by a consortium consisting of high-profile academic and industrial players.\nThe current infrastructure of the Internet is not suited to simultaneous transmission of live events to millions of people (i.e. broadcasting). With millions of potential users, this will easily congest the Internet. Also, the use of Audiovisual Media is moving from a collective and passive approach to personal active behavior. At the same time use patterns are moving away from the classic model of linear broadcast TV. The TV set no longer has the monopoly of delivery of audiovisual content; the PC and mobile devices are also becoming increasingly important.\nIn such heterogeneous and demanding environments, P2P-based technology is considered an essential ingredient for future efficient and low-cost delivery of professional and user created content. This development will have important consequences for the existing business models and institutions, as well as for content production, content distribution, and end user experience.\nIn response to these challenges, the objective of P2P-Next is to move forward the technical enablers to facilitate new business scenarios for the complete value chain in the content domain, i.e. from a linear unidirectional push mode to a user centric, time and place independent platform paradigm.\nP2P-Next will develop a platform that takes open source development, open standards, and future proof iterative integration as key design principles.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-2 | Award Amount: 6.99M | Year: 2013

The key concept behind this proposal is the development of a very high resolution and high efficiency brain dedicated Positron Emission Tomograph (PET) imager that can visualize neurotransmitter pathways and their disruptions in the quest to better diagnose and consequently to better treat schizophrenia. In addition, the plan is for this compact PET imager to be integrated with a Magnetic Resonance Imager Radio Frequency (MRI RF) system to be able to operate as a brain insert in a hybrid imaging setup with practically any MRI scanner. From the technical point of view, we propose to optimize the PET technology for imaging of the human brain with the accuracy typically achieved for small animal brain imaging. To achieve this, we will incorporate the solid state based MRI-compatible PET modules that will be designed to achieve below systemic 1mm spatial resolution in a tomographic reconstruction of the human brain. We aim to achieve the level of PET-MRI compatibility allowing for simultaneous PET and MRI imaging. By combining PET measurements of neurotransmission with fMRI (functional MRI) measurements of Blood Oxygen Level Detection (BOLD) signal changes we will advance to a position where it is possible to learn more about the neurochemical determination of neural activity reflected in BOLD signal changes. The novelty is that both the PET and RF coil systems are integrated into a portable and compact design dedicated to brain examination. This will allow current MR equipment to be easily upgraded into PET/MR systems. To achieve its diagnostic goal, MINDView will be paired with the set of dedicated specific PET imaging agents and endogenous compounds that will be labeled with short-lived positron isotopes. The goal is that dopaminergic, glutamatergic and other pathways will be able to be studied with the new high performance imaging tool. Innovative paradigms such as activation and perturbation and their impact on brain function will be in focus.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: SST-2007-3.1-01;SST-2007-3.1-02 | Award Amount: 996.66K | Year: 2008

CityNetMobil focus is on automated transport systems and its approach, is to organise dissemination actions to raise the awareness around these systems. Awareness to increase acceptance, by politicians, local mobility planners and general public, of automated transport systems as a more inclusive urban transport solution, providing better access to all, environmentally friendly, capable of reducing urban transport share of energy consumption and CO2 emission, and safer than conventional transport modes. Seventh in a stream of projects, CityNetMobil, will diffuse the results obtained by all its predecessors, coordinate the activities of a group of cities interested in these kind of systems and willing to host events to make people acquainted with such technology, and network toward other cities to introduce automated transport systems to them. The latest of the six predecessor projects, CityMobil, had first the idea of creating a reference group of cities with the aim of receiving suggestions on mobility problems which could be addressed with advanced transport systems. Such reference group however proved to be more than just a prompter of mobility problems; soon cities asked for some kind of action by the project side to promote advanced transport systems there. CityNetMobil will start from such reference group, re-invite the member cities and any other who would join, to a selection process and then organise events in five selected cities. CityNetMobil will prepare common dissemination material to inform and invite people to the events and to greet people there (e.g. audiovisual material, posters and gadgets). Each CityNetMobil event will feature the installation of a small showcase of moving automated vehicles, a conference and an exhibition with audiovisuals and poster display. To maximise the visibility of the events the possibility of concomitance with other scientific or cultural events will be sought.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.1.1-07 | Award Amount: 2.84M | Year: 2013

The E-GEM project proposes to evolve the current status of GNSS Reflectometry (GNSS-R) methods for the purpose of Earth monitoring, paving the way for operational applications in the domains of ocean altimetry and scaterometry (mainly wave height and surface winds, but also soil moisture, and biomass, monitoring of ice layers). The approach of the E-GEM project is to bring together lead experts in GNSS-R technologies and experienced teams in Earth Observation domains, in order to address the data needs and requirements of GMES services and other Earth monitoring initiatives, and how can GNSS-R methods best respond to the identified challenges in these domains. A strong connection with the users basis as well as with institutional, public and private stakeholders interested in the development and usage of the technology, will also steer the projects efforts, and increase the awareness of this promising technology. Within the E-GEM project, three experimental platforms will be developed for GNSS-R data acquisition: a space-borne, an airborne and a ground instrument will acquire large amounts of data to support the development of algorithms. This data, together with the large effort put on the development and validation of algorithms and processing chains, will aim at obtaining high-resolution products for altimetry, wave height and surface winds. The expected improvements should largely result from the usage of the GPS P code (with the space- and airborne acquired signal), and Galileos AltBOC signals. For these purposes, the E-GEM project will rely strongly on the achievements of the GNSS-R community so far - in which European teams have historically had a leading role so far - and will bring together the individual efforts and other on-going projects into a joint working platform dedicated to the development and integration of GNSS-R technologies into GMES operational services.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.1.1-07 | Award Amount: 2.48M | Year: 2013

APHORISM project proposes the development and testing of two new methods to combine Earth Observation satellite data from different sensors, and ground data. The aim is to demonstrate that this two types of data, appropriately managed and integrated, can provide new improved Copernicus products useful for seismic and volcanic crisis management. The first method, APE A Priori information for Earthquake damage mapping, concerns the generation of maps to address the detection and estimate of damage caused by a seism. The use of satellite data to investigate earthquake damages is not an innovative issue. We can find a wide literature and projects concerning such issue, but usually the approach are only based on change detection techniques and classifications algorithms. The novelty of APE relies on the exploitation of a priori information derived by InSAR time series to measure surface movements, shakemaps obtained from seismological data, and vulnerability information. This a priori information is then integrated with change detection map to improve accuracy and to limit false alarms. The second method deals with volcanic crisis management. The method, MACE - Multi-platform volcanic Ash Cloud Estimation, concerns the exploitation of GEO (Geosynchronous Earth Orbit) sensor platform, LEO (Low Earth Orbit) satellite sensors and ground measures to improve the ash detection and retrieval and to characterise the volcanic ash clouds. The basic idea of MACE consists of an improvement of volcanic ash retrievals at the spacetime scale by using both the LEO and GEO estimations and in-situ data. Indeed the standard ash thermal infrared retrieval is integrated with data coming from a wider spectral range from visible to microwave. The ash detection is also extended in case of cloudy atmosphere or steam plumes. APE and MACE methods have been defined in order to provide products oriented toward the next ESA Sentinels satellite missions.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: HCO-06-2015 | Award Amount: 2.98M | Year: 2015

Smoking is the largest avoidable cause of preventable morbidity worldwide. It causes most of the cases of lung cancer and chronic obstructive pulmonary disease (COPD) and contributes to the development of other lung diseases. The control of smoking is considered as a highly important intervention for the prevention of lung diseases. Tobacco consumption is highly influenced by socioeconomic factors. SmokeFreeBrain aims to address the effectiveness of a multi-level variety of interventions aiming at smoking cessation in high risk target groups within High Middle Income Countries (HMIC) such as unemployed young adults, COPD and asthma patients, as well as within the general population in Low Middle Income Countries (LMIC). The project addresses existing approaches aiming to prevent lung diseases caused by tobacco while at the same time it develops new treatments and analyzes their contextual adaptability to the local and global health care system. SmokeFreeBrain follows an interdisciplinary approach exploiting consortiums expertise in various relevant fields in order to generate new knowledge. State of the art techniques in toxicology, pulmonary medicine, neuroscience and behavior will be utilized to evaluate the effectiveness of: (i) Public Service Announcement (PSA) against smoking, (ii) the use of electronic cigarettes with and without nicotine as a harm reduction approach and/or cessation aid, (iii) a specifically developed neurofeedback intervention protocol against smoking addiction, (iv) a specifically developed intervention protocol based on behavioral therapy, social media/mobile apps and short text messages (sms) and (v) pharmacologic interventions. The main objective of the project is to evaluate the interventions in terms of health economics, by studying their cost-effectiveness, and proposing a scalable plan and a clear pathway to embedding the proposed interventions into policy and practice both in LMIC as well as in HMIC.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.3.2-3 | Award Amount: 17.07M | Year: 2010

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of resistance. The proposal includes development of both slow release and gel formulations, pharmacokinetic and challenge experiments in macaques as well as human studies including a collaborative study with an EDCTP-funded project to use multiplex and proteomic technologies as well as culture-independent DNA-based analysis of mucosal microbiota to investigate biomarkers and establish a baseline signature from which perturbations can be recognised. This is a large consortium comprising 30 partners from 8 EU countries and from Switzerland, Ukraine, South Africa and the United States.Partners include microbicide developers, IPM and Particle Sciences, and producers, Gilead, Tibotec and Virco. Two SMEs will also participate in RTD aspects. The consortium is multidisciplinary with scientists engaged in basic discovery working with new targets and developing novel chemistry to produce compounds with improved safety and efficacy profiles as well as altered patterns of resistance.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.7 | Award Amount: 7.86M | Year: 2012

Future advancements in ICT domain are closely linked to the understanding about how multi-level complex systems function. Indeed, multi-level dependencies may amplify cascade failures or make more sudden the collapse of the entire system. Recent large-scale blackouts resulting from cascades in the power-grid coupled to the control communication system witness this point very clearly. A better understanding of multi-level systems is essential for future ICTs and for improving life quality and security in an increasingly interconnected and interdependent world. In this respect, complex networks science is particularly suitable for the many challenges that we face today, from critical infrastructures and communication systems, to techno-social and socio-economic networks.MULTIPLEX proposes a substantial paradigm shift for the development of a mathematical, computational and algorithmic framework for multi-level complex networks. Firstly, this will lead to a significant progress in the understanding and the prediction of complex multi-level systems. Secondly, it will enable a better control, and optimization of their dynamics. By combining mathematical analyses, modelling approaches and the use of massive heterogeneous data sets, we shall address several prominent aspects of multi-level complex networks, i.e. their topology, dynamical organization and evolution.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA-2007-2.2-02 | Award Amount: 4.87M | Year: 2008

The objective of the research program is to design, optimize and develop a space plasma thruster based on helicon-radio-frequency technology and its application to a nano-satellite for attitude and position control. Moreover a detailed feasibility study will be also conducted to evaluate the possibility of using the plasma thruster to heat and decompose a secondary propellant. The feasibility study will asses the possibility of building up a combined-two-mode-thruster able to operate in the low-thrust high-efficiency plasma-mode and high-thrust low-efficiency secondary-propellant-plasma-enhanced mode. Only the plasma thruster will be developed and fully tested during this study. The main characteristics of the thruster are: Power 50 W Weight within 1.5 kg Thrust >1.5 mN Specific Impulse (Isp) >1200 s The program will develop thought the following steps: a) Deep numerical-theoretical investigation through dedicated plasma-simulation tools. b) Extensive experimental campaign to validate codes, to investigate the physics phenomena involved and to proof thruster performance. c) The development of a thruster-prototype to be mounted on board of a mini-satellite to demonstrate technology feasibility, d)The study of all the critical issues related to the application to a mini-satellite e) the design and manufacturing of the mini-satellite mock up including all critical components f) analysis of scaling law to lower and higher power. As a final results of the project, a detailed analysis will be conducted in order to evaluate the possible application of the thruster in space missions requiring low thrust accurate attitude and position control.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.4.4 | Award Amount: 13.86M | Year: 2012

Scalable end-user access to Big Data is critical for effective data analysis and value creation. Optique will bring about a paradigm shift for data access by\n\n* providing a semantic end-to-end connection between users and data sources\n* enabling users to rapidly formulate intuitive queries using familiar vocabularies and conceptualisations\n* seamlessly integrating data spread across multiple distributed data sources, including streaming sources\n* exploiting massive parallelism for scalability far beyond traditional RDBMSs\n\nand thus reducing the turnaround time for information requests to minutes rather than days.\n\nThese objectives will be achieved by bringing together leading experts and cutting edge technology from diverse communities to develop an extensible platform that will provide a complete and generic solution to the data access challenges posed by Big Data.\n\nThe platform will: (i) Use an ontology and declarative mappings to capture user conceptualisations and to transform user queries into complete, correct and highly optimised queries over the data sources; (ii) Integrate distributed heterogeneous sources, including streams; (iii) Exploit massively parallel technologies and holistic optimisations to maximise performance; (iv) Include tools to support query formulation and ontology and mapping management; (v) Use semi-automatic bootstrapping of ontologies and mappings and query driven ontology construction to minimise installation overhead.\n\nDevelopment of the platform will be informed by and continuously evaluated against the requirements of complex real-world challenges, with two large European companies providing the project with comprehensive use cases, and access to user groups and TB scale data sets.\n\nExperience from the use case deployments will be used to develop high quality tutoring and training resources, and to engage in an aggressive dissemination and exploitation program aimed at achieving the widest possible uptake of Optique technology.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.3 | Award Amount: 18.32M | Year: 2010

There has been much hype about the so-called Internet of Things. The idea of such a globally interconnected continuum emerged with the RFID technology, and this concept has considerably been extended to the current vision that envisages a plethora of heterogeneous objects interacting with the physical environment.Today, a large number of different means are used to enable communication between heterogeneous devices. We see these as Intranet of things, representing vertical silos that do not support interoperability. However, this balkanisation of efforts will lead to a predictable slowdown in devising a viable global solution. Furthermore, existing solutions do not address the scalability requirements for a future Internet of Things, they provide inappropriate models of governance and fundamentally neglect privacy and security in their design.IoT-A, the Internet-of-Things Architecture, proposes the creation of an architectural reference model together with the definition of an initial set of key building blocks. Together they are envisioned as crucial foundations for fostering a future Internet of Things. Using an experimental paradigm, IoT-A will combine top-down reasoning about architectural principles and design guidelines with simulation and prototyping to explore the technical consequences of architectural design choices.IoT-A will lead to the following tangible outcomes: 1) architectural reference model for the interoperability of Internet-of-Things systems, outlining principles and guidelines for the technical design of its protocols, interfaces, and algorithms; 2) corresponding mechanism for its efficient integration into the service layer of the Future Internet; 3) novel resolution infrastructure, allowing scalable look up and discovery of Internet-of-Things resources, entities of the real world, and their associations; 4) novel platform components; 5) implementation of real-life use cases demonstrating the benefits of the developed architecture.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: YOUNG-2-2014 | Award Amount: 2.45M | Year: 2015

Research on international youth mobility has been fragmented, mostly based on relatively small samples and case studies. YMOBILITY develops a comprehensive research programme which addresses the following: Identifying, and quantifying, the main types of international youth mobility in the EU, and their key characteristics. Particular attention will be given to differences between and within three main types: highly skilled, less skilled and students Understanding what determines which individuals do and which do not participate in international mobility as personal and professional development strategies: their motives, migration channels and information sources Analysing the individual outcomes in terms of both employability and careers (skills and competences) and non-economic terms (welfare and identities). Analysing the territorial outcomes for the regions of both origin and destination, in economic, demographic and cultural terms Differentiating between short-term and long-term outcomes, taking into account return migration and future intentions to migrate. Identifying implications for policies in migration but also of education, the economy and housing The research will utilise existing secondary data for the whole of the EU, but will mainly rely on primary quantitative data (large-scale surveys to be undertaken by polling agency) and qualitative data (interviews with migrants and returned migrants). The study will focus on 9 countries representing different contexts for youth mobility: Romania, Slovakia and Latvia as sources of emigration and return; the UK and Sweden as destinations for migrants; Germany, Italy, Ireland and Spain as both major destinations and countries of origin. The policy analysis will be informed by interviews undertaken with key informants, such as migrant associations and policy-makers. Experimental methods will be used to assess how individuals will respond to different scenarios of future economic and social change.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: REFLECTIVE-11-2015 | Award Amount: 1.90M | Year: 2016

Traditional valorisation approaches focus on linear processes: from academia to society. In order to bring valorisation to a higher level, all relevant actors need to cooperate in an equal setting: co-creation. Co-creation transcends boundaries, but it does not happen naturally. Therefore, the ACCOMPLISSH consortium, consisting of 14 universities from 12 countries (representing all the sub disciplines in SSH), will actively involve the other partners from the so called Quadruple Helix (industry, governments and societal partners) within the project. The project has chosen an Open Innovation approach. The ACCOMPLISSH project (Accelerate co-creation by setting up a multi-actor platform for impact from Social Sciences and Humanities) will create a platform for dialogue where not only universities are involved. The dialogue platform is organised in such a way that academia, industry, governments and societal partners equally contribute in identifying barriers and enablers of co-creation. The results from both practice and the theory of co-creation form the basis of the valorisation concept and will be tested in the project in a quadruple helix setting. This concept will be tested and developed in such a way that it is transferable, scalable and customized for academia, industry, governments and societal partners in the whole of Europe. The impact profile of SSH research could be far stronger and more visible than it currently is. There are significant barriers to the valorisation of SSH research which still need to be understood in detail. In order to push the envelope within universities, we acknowledge that next to SSH researchers, the research support officers are key players in valorisation of SSH research. The project will identify all barriers and enablers of co-creation in order to develop an innovative valorisation concept, which will foster knowledge exchange within the quadruple helix and strengthens the position of SSH research.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-07-2014 | Award Amount: 4.52M | Year: 2015

Today the European Public Sector Players lack the necessary infrastructure and technology to allow them to integrate their computing clouds. Furthermore, legislative barriers often make it difficult to use available commercial technological solutions. The SUNFISH project aims to provide a specific and new solution to face these issues. SUNFISH will enable the secure federation of private clouds based on the Public Sector needs: federated private clouds belonging to different Public Sector Entities will be able to share data and services transparently, while maintaining required security levels. The SUNFISH project will develop and integrate software enabling secure cloud federation as required by European Public Sector bodies. The project will achieve this by meeting firstly the specific challenges faced by the Maltese and Italian Ministries of Finance, as well as by the UK Regional Cyber Crime Units, the three SUNFISH selected use cases. Solutions will be developed to be usable by other European Public Organisations, and potentially also by private sector players. SUNFISH will improve security in federated cross-border clouds, boosting the development of a cloud computing market in sectors where privacy and control of information propagation are essential (e.g., e-government, e-health etc.) while encouraging a better resource utilisation of Public Administration cloud infrastructure. The secure system for federated private clouds developed through the project will guarantee a high level of safety, a continuous monitoring of inter-cloud communications, and the ability to roll out services cheaply, in a fast, flexible and secure way even between different private clouds. The SUNFISH project aims to reduce the management cost of private clouds owned by Public Administrations, and - beyond pure costs savings to accelerate the transition to 21st century interoperable and scalable public services, boosting enforcement of the European Digital Single Market.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.3.5 | Award Amount: 4.73M | Year: 2012

BILOBA aims to develop and pre-clinically validate a multifunctional point-of-care platform capable of performing real-time cancer biomarker detection in a tandem configuration. The configuration exploits a label-free detection based on the resonance shifts, and the spectral analysis of enhanced fluorescence emitted by biomolecules immobilized on the surface. Utilizing both labeled and label-free analysis on one sensor increases the sensitivity and the reliability of optically read-out surface bound assays.\nThe standard optical label-free detection is the surface plasmon resonance (SPR) method. Its sensitivity suffers from the strong absorption of waves bound to the metal surface. Here, a similar concept, already at the proof of principle stage, will be advantageously implemented by applying the unique properties of Bloch Surface Waves (BSW) sustained on 1D Photonic Crystals (1DPC). Therein, a surface wave without absorption is excited, giving rise to an enormous narrowing of resonances and an associated increase in sensitivity. Furthermore, fluorescence enhancement due to near field effects will be exploited. By engineering the BSW dispersion both detection schemes will be combined.\nThe goal of the project is to explore, design, and set-up BSW systems optimized for analytical sensing, and develop a corresponding analytical instrument. Immobilization protocols and biochemical assays have to be established for optimizing the binding site surface density and for detecting the target biomarkers. The development of a sophisticated, robust fluidic system to ensure a high signal-to-noise ratio even in the case of lowest analyte concentrations accompanies this work.\nThe results will be applied to early cancer biomarker analysis by validating the projects results in pre-clinical tests. The target application is the detection of Angiopoetin1 and Vascular Endothelial Growth Factor with these proteins being indicative of angiogenesis associated to human cancer progression.

Agency: European Commission | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2 | Award Amount: 3.67M | Year: 2010

The pace of technological change is accelerating. Radical discontinuities seem to happen more frequently. This means that the useful lifespan of knowledge and capability is becoming shorter and that the obsolescence of knowledge/capability is increasingly the norm in innovation. For incremental innovation, specialisation is a winning strategy, but radical innovation requires an interdisciplinary approach and a diversity of knowledge base that in general SMEs struggle to access. COLLECTIVE aims at solving the major constraints of SMEs innovation (to achieve successful, repeated organizational innovation; access to learning and knowledge processing; access to cognitive diversity; have the possibility to be connected to foster collaborative projects) by feeding the innovation ecosystem, basing on 3 key-concepts: (a)communities become the new organisational unit of the innovation process and define the ecosystem of innovation; (b) generation of innovative ideas, new product development and diffusion of innovations are carried out in parallel by self-organising communities of different actors (i.e.: customers, suppliers, users, experts, social stakeholders); (c) the key aspect that will define success or failure in discontinuous innovation projects will be the amount of cognitive diversity that firms (or groups of) will be able to gather and manage. iCOMMUNITY ICT operational platform will be the backbone of this innovation ecosystem and will let SMEs and SMEAGs: (1) identify future emergent technological and economic trends/discontinuities by developing network-based approaches to early detect weak signals; (2) manage distributed intelligence and creativity in the process of new product development in order to individuate new product ideas and related business models; (3) design new modular products in a collaborative way reducing the market risk since relevant inputs and feedback from customers and end users will be constantly embedded in the design process.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2009.4.3 | Award Amount: 4.39M | Year: 2010

Measuring is a key to scientific progress. This is particularly true for research concerning complex systems, whether natural or human-built. Multilingual and multimedia information systems are increasingly complex: they need to satisfy diverse user needs and support challenging tasks. Their development calls for proper evaluation methodologies to ensure that they meet the expected user requirements and provide the desired effectiveness.\nLarge-scale worldwide experimental evaluations provide fundamental contributions to the advancement of state-of-the-art techniques through common evaluation procedures, regular and systematic evaluation cycles, comparison and benchmarking of the adopted approaches, and spreading of knowledge. In the process, vast amounts of experimental data are generated that beg for analysis tools to enable interpretation and thereby facilitate scientific and technological progress.\nPROMISE will provide a virtual laboratory for conducting participative research and experimentation to carry out, advance and bring automation into the evaluation and benchmarking of such complex information systems, by facilitating management and offering access, curation, preservation, re-use, analysis, visualization, and mining of the collected experimental data. PROMISE will: foster the adoption of regular experimental evaluation activities; bring automation into the experimental evaluation process; promote collaboration and re-use over the acquired knowledge-base; stimulate knowledge transfer and uptake.\nEurope is unique: a powerful economic community that politically and culturally strives for equality in its languages and an appreciation of diversity in its citizens. New Internet paradigms are continually extending the media and the task where multiple language based interaction must be supported. PROMISE will direct a world-wide research community to track these changes and deliver solutions so that Europe can achieve one of its most cherished goals.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.4.3 | Award Amount: 10.33M | Year: 2010

The goal of SMART VORTEX is to provide a technological infrastructure consisting of a comprehensive suite of interoperable tools, services, and methods for intelligent management and analysis of massive data streams to achieve better collaboration and decision making in large-scale collaborative projects concerning industrial innovation engineering.\n\nSMART VORTEX captures the tractable product data streams in the product lifecycle of design and engineering. In each phase of this lifecycle, different streams of product data are generated. Amongst other, these product data streams contain streams from sensors (data rates of Gigabytes per second), simulation, experimental, and testing data (millions of complex data sets), design data (complex and exchanged between different domains), multi-media collaboration data (heterogeneous, and high information density), and higher level inferred events generated by analyses. These data streams are produced and consumed in all phases of the product lifecycle. The large volume of data in these streams makes the detection of pertinent information a hard problem for both technological infrastructures and humans. SMART VORTEX uses a Data Stream Management for managing, searching, annotating, analysing and performing feature extraction on these data streams.\n\nWithin the lifecycle of design and engineering projects a large number of people need to collaborate in order to achieve the individual project goals, such as bringing the next generation flat panel TV to the market before the competition does, identifying opportunities for improvements of existing products, or the maintenance of products in use. These projects are basically large distributed collaborative processes, where people from different domains of expertise and different organizations have to work together. SMART VORTEX supports these people, systems, and products with collaborative tools and decision support systems managing the constantly produced massive product data streams. SMART VORTEX ensures the efficiency and success of the collaboration by delivering the pertinent information at the right moment.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2011.2.1.4-3 | Award Amount: 4.05M | Year: 2011

People in Europe acknowledge that nature is important to them and to society at large. Economists have shown that indeed, biodiversity has total economic values running into the trillions of euros worldwide and hundreds of millions even for minor ecosystem services on local scales. In spite of these immense values, politicians and the general public in Europe do not appear to really act for nature. In the ballot box, people think about their job security, their mortgage or foreign immigrants not about the loss of nature. Politicians feel tempted to focus on these same narrow issues. As a result, European biodiversity continues to decline. Can economic methods to assess the value of biodiversity be improved such that they reach out to what really motivates action? Can alternative approaches be developed that lie closer to what connects people to nature and can appeal to their actions in stead of only to their feelings? The BIOMOT project, funded by the FP 7 programme of the European Union, will address these challenges. Involving eight research institutes in seven European countries and uniting a unique group of economists, governance experts, psychologists and philosophers, BIOMOT will undertake empirical research in the seven European countries, focusing on (a) the motivational capacity of economic valuation methods, (b) the types of motivation for nature that underlie successful policy actions for biodiversity at various scales and (c) the motivations that drive citizens, business and public leaders to take action for nature. On that basis, BIOMOT will develop a general theory of motivation for biodiversity and think through its implications for biodiversity policies, for business and civil society actors and for public communication.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-07-2014 | Award Amount: 2.02M | Year: 2015

Many low-power devices such as smartphones, tablets, notebooks as well as several other embedded systems cant always cope with the increased demand for processing power, memory and storage required by modern applications in gaming, vision, security, robotics, aerospace, etc. As a result, most such applications are only executed on high-end servers. RAPID tackles this challenge by taking advantage of high-performance accelerators and high-bandwidth networks. Following our approach, compute or storage intensive tasks are seamlessly offloaded from the low-power devices to more powerful heterogeneous accelerators, supporting multiple virtual CPUs and GPUs. We propose, for the first time, a secure unified model where almost any device or infrastructure, ranging from smartphone, notebook, laptop and desktop to private and public cloud can operate as an accelerated entity and/or as an accelerator serving other less powerful devices in a secure way. RAPID offers a registration mechanism, which permits the accelerated entities to automatically find and connect to nearby accelerators with the required resources. Next, a runtime system, running on each such accelerated entity, takes into account several parameters such as the local status, the environmental conditions, the task requirements, and the status of the accelerators it is connected to in order to decide whether local tasks (or incoming tasks if the entity also acts as an accelerator) should be executed locally or remotely. Novel scheduling algorithms, admission control policies, Service Level Agreements and license policies are employed to serve multiple accelerated applications efficiently on heterogeneous cloud infrastructures. An easy-to-use task-based programming model will be defined, while a novel runtime will automatically offload and execute the tasks transparently to the programmer. Within the RAPID project the first public acceleration cloud service will become available and commercially exploitable.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-5-2015 | Award Amount: 4.84M | Year: 2015

E-CAM will create, develop and sustain a European infrastructure for computational science applied to simulation and modelling of materials and of biological processes of industrial and societal importance. Building on the already significant network of 15 CECAM centres across Europe and the PRACE initiative, it will create a distributed, sustainable centre for simulation and modelling at and across the atomic, molecular and continuum scales. The ambitious goals of E-CAM will be achieved through three complementary instruments: 1. development, testing, maintenance, and dissemination of robust software modules targeted at end-user needs; 2. advanced training of current and future academic and industrial researchers able to exploit these capabilities; 3. multidisciplinary, coordinated, top-level applied consultancy to industrial end-users (both large multinationals and SMEs). The creation and development of this infrastructure will also impact academic research by creating a training opportunity for over 300 researchers in computational science as applied to their domain expertise. It will also provide a structure for the optimisation and long-term maintenance of important codes and provide a route for their exploitation. Based on the requests from its industrial end-users, E-CAM will deliver new software in a broad field by creating over 200 new, robust software modules. The modules will be written to run with maximum efficiency on hardware with different architectures, available at four PRACE centres and at the Hartree Centre for HPC in Industry. The modules will form the core of a software library (the E-CAM library) that will continue to grow and provide benefit well beyond the funding period of the project. E-CAM has a 60 month duration, involves 48 staff years of effort, has a total budget of 5,836,897 and is requesting funding from the EC of 4,836,897, commensurate with achieving its ambitious goals.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.90M | Year: 2015

The etymology of the word colloid stems from the Greek word for glue. The systematic study of colloids (as we perceive them nowadays) is considered to have begun in the middle of the 19th century. However, the word colloid itself had been mentioned before in very different senses. The development of the physics and chemistry of colloids really took off in the 20th century. Colloids found different applications in almost every part of our lives, and it might even seem that these systems are fully understood and tamed. In reality, this is far from the case! Both fundamental understanding and a clear application strategy are required. This is most evident when it comes to the relationship between the nature and arrangement of the colloidal particles and their macroscopic response to an external field (be that shear, electric, magnetic or gravitational fields). To elucidate this relationship we unite 7 academic and 2 industrial partners and 5 associate partners to train 15 ESRs. We aim to develop the concept of COLLoids with DEsigned respoNSE, leading to our acronym: COLLDENSE. Scientific projects are divided into three main workpackeges according to the complexity of the building blocks: deformable colloids, hybrid colloids and colloidal mixtures. The subjects vary from soft repulsive colloids, magnetic colloids, soft microgel particles, telechelic star polymers to droplets with interfaces stabilised by solid particles and DNA nano-constructs. The detailed analysis of mixtures of these components, as well as of their equilibrium and nonequilibrium thermodynamics and rheology, is the other important facet of the project. In order to obtain a complete understanding of the colloidal behaviour under an external drive we employ the three main tools of the modern natural science: experiment, computer simulations and analytical theory. This complete approach will also yield a broad training experience for the young members of the network.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: WASTE-7-2015 | Award Amount: 7.82M | Year: 2016

NoAW : No Agro-Waste. Innovative approaches to turn agricultural waste into ecological and economic assets. Driven by a near zero-waste society requirement, the goal of NoAW project is to generate innovative efficient approaches to convert growing agricultural waste issues into eco-efficient bio-based products opportunities with direct benefits for both environment, economy and EU consumer. To achieve this goal, the NoAW concept relies on developing holistic life cycle thinking able to support environmentally responsible R&D innovations on agro-waste conversion at different TRLs, in the light of regional and seasonal specificities, not forgetting risks emerging from circular management of agro-wastes (e.g. contaminants accumulation). By involving all agriculture chain stakeholders in a territorial perspective, the project will: (1) develop innovative eco-design and hybrid assessment tools of circular agro-waste management strategies and address related gap of knowledge and data via extensive exchange through the Knowledge exchange Stakeholders Platform, (2) develop breakthrough knowledge on agro-waste molecular complexity and heterogeneity in order to upgrade the most widespread mature conversion technology (anaerobic digestion) and to synergistically eco-design robust cascading processes to fully convert agro-waste into a set of high added value bio-energy, bio-fertilizers and bio-chemicals and building blocks, able to substitute a significant range of non-renewable equivalents, with favourable air, water and soil impacts and (3) get insights of the complexity of potentially new, cross-sectors, business clusters in order to fast track NoAW strategies toward the field and develop new business concepts and stakeholders platform for cross-chain valorisation of agro-waste on a territorial and seasonal basis.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 9.02M | Year: 2009

WISER will support the implementation of the Water Framework Directive (WFD) by developing tools for the integrated assessment of the ecological status of European surface waters (with a focus on lakes and coastal/transitional waters), and by evaluating recovery processes in rivers, lakes and coastal/transitional waters under global change constraints. The project will (1) analyse existing data from more than 90 databases compiled in previous and ongoing projects, covering all water categories, Biological Quality Elements (BQEs) and stressor types and (2) perform targeted field-sampling exercises including all relevant BQEs in lakes and in coastal/transitional waters. New assessment systems will be developed and existing systems will be evaluated for lakes and coastal/transitional waters, with special focus on how uncertainty affects classification strength, to complete a set of assessment methodologies for these water categories. Biological recovery processes, in all water categories and in different climatic conditions, will be analysed, with focus on mitigation of hydromorphological and eutrophication pressures. Large-scale data will be used to identify linkages between pressure variables and BQE responses. Specific case studies, using a variety of modelling techniques, will address selected pressure-response relationships and the efficacy of mitigation measures. The responses of different BQEs and different water categories to human-induced degradation and mitigation will be compared, with special focus on response signatures of BQEs within and among water categories. Guidance for the next steps of the intercalibration exercise will be given by comparing different intercalibration approaches. Stakeholders will be included from the outset, by building small teams of stakeholders and project partners responsible for a group of deliverables, to ensure the applicability and swift implementation of results.

Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: SST.2008.4.1.4. | Award Amount: 2.47M | Year: 2009

The strong effort that the European Commission and all the Member States are paying to the reduction of road fatalities in Europe is giving significant results. Despite these significant improvement in the European countries, the situation in Emerging Economies is dramatically getting worse. The implementation of effective countermeasures and the achievement of a higher safety level for the vulnerable users in Emerging Economies requests a significant improvement of the local analysis, planning and design capabilities. The main aim of the project is to increase the level of safety of the whole road transport system and its components, focussing the attention on vulnerable road users, thus contributing to the overall scope of reducing the number of fatalities and the severity of injuries caused by road accidents. The proposal is structured according to the following method: Analysis of local requirements: this action focuses on the local accident databases regarding vulnerable road users, the actual situation of road infrastructure, land-use planning and local current road safety management procedures. Analysis of the transferability conditions of the European methodologies, tools and measures to the Emerging Economies. Definition of suitable measures, methodologies and tools to improve vulnerable road users safety planning and managing in Emerging Economies. Development of recommendations and guidelines for the road system infrastructure design to safely carry vulnerable road users and motorised vehicles in Emerging Economies. Pilot projects, dissemination and training to decision makers, stakeholders, etc. The main output of the project will be recommendations and guidelines for improvement of accident data collection procedures and road safety oriented land-use planning as well as education material.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.5 | Award Amount: 2.98M | Year: 2010

Making efficient use of energy in buildings is a paramount challenge to conserve energy and reduce greenhouse effects. GreenerBuildings will investigate how buildings can dynamically adapt their operations according to actual use, aiming at substantial energy savings.\nPeople spend a great deal of time in buildings, may these be offices, hospitals or commercial buildings. While active indoor, people desire to have comforting lighting and microclimate conditions that adapt to their activity and wishes. With GreenerBuildings we propose to realise an integrated solution that addresses the challenge of energy-aware adaptation from basic(energy harvesting) sensors and actuators, up to the embedded software for coordinating thousands of smart objects with the goals of energy saving and user support. Our vision is that buildings can respond to their actual use and changes in their environment; interact with their occupants through novel ubiquitous sensing and occupant behaviour inference techniques and that can transparently adapt a buildings function and operation. The project embraces the following key principles in order to achieve its goals: living lab experimentation/validation, agile consortium, a spiral development model, and a user centric approach. In particular, the validation will consider test cases with at least 1.000 devices deployed in different living lab buildings.\nThe specific composition of the Consortium, consisting of top-class universities and research centres (TUE, RUG, CINI, UOR, ITRI), of leader industrial partners specialized in building automation and lighting (PRE) and of SMEs specialised in energy harvesting sensors and actuators (ENO), and of thermodynamics applications (FSA), guarantees a widespread dissemination and exploitation of the project results, based on well funded scientific and technological innovation.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.47M | Year: 2017

Alzheimers disease (AD) affects more than 7 million people in Europe and this figure is expected to double every 20 years. Despite intensive efforts, no disease-modifying treatments or preventive strategies are available. The lack of specific, sensitive and minimally invasive diagnostics to identify people with early-stage AD to be included in clinical drug intervention trials is among the main reasons for many notable trial failures. The main challenges in developing the required diagnostics are identification of AD biomarkers and development of their detection techniques. The complex and interdisciplinary nature of the research underlines the need for innovative training of a new generation of researchers in the field. BBDiag responds to such a need and establishes a much-needed ETN for blood based early-AD diagnostics to address these challenges. It brings together leading academic and industrial experts from five major consortia in Europe and uses their synergies to build a triple-i research & training platform with the required multidisciplinary expertise and cutting-edge technologies. BBDiag Fellows will be trained under the Vitae Researcher Development Framework innovatively combined with the BBDiag platform for gaining interdisciplinary scientific and transferable skills as well as personal quality, creative thinking and business mind-set. The ETN has a highly innovative research programme for the discovery of AD biomarkers, development of novel biosensing techniques and point of care tools, and for technological exploitation of the diagnostics. These advances will strongly support improved care provision and development of disease-modifying treatments and preventive strategies for AD patients. More importantly, BBDiag will deliver its first generation of 13 highly-skilled, creative and entrepreneurial Fellows, setting them on a path to successful careers in academia or industry to ensure that the medical and societal challenges imposed by AD are met.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.87M | Year: 2017

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates. The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines. Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 4.71M | Year: 2009

With progress in nanotechnology, biophysics, and polymer synthesis, colloidal science has reached a new level of importance. A large variety of complex colloids of different shapes, with binding specificity, and variable softness has been synthesized, opening quite exciting ways for engineering materials at the nanoscale. The purpose of COMPLOIDS is to obtain a fundamental understanding of the Physics governing the self-organization and the dynamical behavior of complex colloidal particles in the bulk, under confinement and out of equilibrium. For this purpose, the partners will consider a variety of novel, experimentally accessible colloidal systems that share the common properties of anisotropy, associativity and softness of their constituent particles. A well-coordinated combination of experiment, theory and simulation will explore the fundamental Physics, define similarities and differences between the systems considered and search for common underlying mechanisms of self-organization that are distinct to these complex and highly versatile colloidal systems. The technical objective of COMPLOIDS is to apply the gained knowledge with the goal of engineering novel materials in close collaboration with participating high-technology EU-companies. Young researchers will also profit from COMPLOIDS in a variety of ways. They will be exposed in high-level research working, within a highly connected and interdisciplinary team of researchers and developing state-of-the art tools in the Statistical Physics of Soft Matter. Further, they will attend world-rate graduate programs and courses in the participating academic partners and they will obtain hands-on experience of the industry sector through the participation of industrial partners.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-2.2.2-3 | Award Amount: 15.91M | Year: 2008

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of biological age and predict the onset of age-related diseases and/or residual lifetime are termed biomarkers of ageing. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (GEHA offspring) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) classical ones for which data from several smaller studies have been published; (b) new ones, based on recent preliminary data, as well as (c) novel ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: GC-ENERGY 2010.10.2-2 | Award Amount: 4.60M | Year: 2011

This project aims to the development at an initial industrial level of an advanced, lithium ion battery for efficient application in the sustainable vehicle market. The basic structure of this battery involves a lithium-metal (tin)-carbon, Sn-C, alloy anode, a lithium nickel manganese oxide, LiNi0.5Mn1.5O4, cathode and a ceramic-added, gel-type membrane electrolyte. This battery is expected to meet the target of the topic that calls for innovative developments of lithium-based, automotive energy storage technologies improving energy density, cycle life, cost, sustainability and safety. To confirm this expectation, a strong European consortium exploiting the complementary experience of various interconnected unities, involving academic laboratories and industrial companies, has been established. The academic partners will address the work on the optimization of the basic, electrochemical properties of the electrode and electrolyte materials, while the industrial partners will focus on the determination of battery key aspects, such as: i) the value of energy density under a large size capacity configuration, ii) the definition of the safety by abuse test procedure protocols, iii) the overall cost, iv) the environmental sustainability and v) the recycling process. It is expected that these combined efforts will lead to the industrial production of a battery having an energy density of the order of 300 Wh/kg, a cost considerably lower than batteries already on the market, environmental compatibility and highly reduced safety hazard. In synthesis, this project compares well with others in progress worldwide for the development of lithium batteries directed to an efficient application in the sustainable vehicle market.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-3.6a-2015 | Award Amount: 9.61M | Year: 2016

ADAS&ME (Adaptive ADAS to support incapacitated drivers &Mitigate Effectively risks through tailor made HMI under automation) will develop adapted Advanced Driver Assistance Systems, that incorporate driver/rider state, situational/environmental context, and adaptive interaction to automatically transfer control between vehicle and driver/rider and thus ensure safer and more efficient road usage. To achieve this, a holistic approach will be taken which considers automated driving along with information on driver/rider state. The work is based around 7 provisionally identified Use Cases for cars, trucks, buses and motorcycles, aiming to cover a large proportion of driving on European roads. Experimental research will be carried out on algorithms for driver state monitoring as well as on HMI and automation transitions. It will develop robust detection/prediction algorithms for driver/rider state monitoring towards different driver states, such as fatigue, sleepiness, stress, inattention and impairing emotions, employing existing and novel sensing technologies, taking into account traffic and weather conditions via V2X and personalizing them to individual drivers physiology and driving behaviour. In addition, the core development includes multimodal and adaptive warning and intervention strategies based on current driver state and severity of scenarios. The final outcome is the successful fusion of the developed elements into an integrated driver/rider state monitoring system, able to both be utilized in and be supported by vehicle automation of Levels 1 to 4. The system will be validated with a wide pool of drivers/riders under simulated and real road conditions and under different driver/rider states; with the use of 2 cars (1 conventional, 1 electric), 1 truck, 2 PTWs and 1 bus demonstrators. This challenging task has been undertaken by a multidisciplinary Consortium of 30 Partners, including an OEM per vehicle type and 7 Tier 1 suppliers.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SST-2007-3.2-01 | Award Amount: 25.69M | Year: 2008

The European Bus System of the Future (EBSF) project is conceived as a driver to increase the attractiveness and raise the image of the bus systems in urban areas, by means of new technologies on vehicles and infrastructure in combination with operational best practices, in a system approach. For the first time in European research, these concepts are fully endorsed by all stakeholders, with all major bus manufacturers joining their industrial capabilities along with operators and authorities pooling together in this pre-competitive research project. This project is funded on the consideration that the bus still remains the most universal solution for balanced and sustainable urban development from an economic, environmental and social standpoint, serving 80% of the total European Public Transport. The research will conceive and develop an innovative high quality bus system which will demonstrate the full potential of a new generation of urban bus networks, using state of the art clean vehicular technologies. It will integrate all necessary elements and include a breakthrough design of vehicles, infrastructures and operations placing emphasis on system approach, and identifying the potential for technical harmonisation and standardisation. The project focuses on the bus system in urban and suburban areas. For this reason all the features of the traditional bus services will be examined and developed in conjunction with the relationships between itself and the other modes of transport, in order to concentrate the objectives of the project on the development and improvement of all the characteristics of the EU Bus System of the Future. During its 48 months lifetime, the project will produce several outputs of two main families: Practical and Theoretical deliverables. The former include the results of activities aiming at technology development, and their integration, whereas the latter include concepts, tools, simulations, specifications, and recommendations

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 2.70M | Year: 2011

There is now overwhelming evidence that the current organisation ofour economies and societies is seriously damaging biologicalecosystems and human living conditions in the very short term, withpotentially catastrophic effects in the long term. The enforcement ofnovel policies may be triggered by a grassroot approach, with a keycontribution from information and communication technologies (ICT).Nowadays low-cost sensing technologies allow the citizens to directlyassess the state of the environment; social networking tools alloweffective data and opinion collection and real-time informationspreading processes. In addition, theoretical and modeling toolsdeveloped by physicists, computer scientists and sociologists havereached the maturity to analyse, interpret and visualize complex datasets. The proposed project intends to integrate all crucial phases(environmental monitoring, awareness enhancement, behavioural change)in the management of the environment in a unified framework, bycreating a new technological platform combining sensing technologies,networking applications and data-processing tools; the Internet andthe existing mobile communication networks will provide theinfrastructure hosting such a platform, allowing its replication indifferent times and places. Case studies concerning different numbersof participants will test the scalability of the platform, aiming atinvolving as many citizens as possible leveraging on the low cost andhigh usability of the sensing devices. The integration ofparticipatory sensing with the monitoring of subjective opinions isnovel and crucial, as it exposes the mechanisms by which the localperception of an environmental issue, corroborated by quantitativedata, evolves into socially-shared opinions, eventually drivingbehavioural changes. Enabling this level of transparency criticallyallows an effective communication of desirable environmentalstrategies to the general public and to institutional agencies.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: FI.ICT-2011.1.7 | Award Amount: 68.51M | Year: 2011

The goal of the FI-WARE project is to advance the global competitiveness of the EU economy by introducing an innovative infrastructure for cost-effective creation and delivery of services, providing high QoS and security guarantees. FI-WARE is designed to meet the demands of key market stakeholders across many different sectors, e.g., healthcare, telecommunications, and environmental services. FI-WARE unites major European industrial actors. The key deliverables of FI-WARE will be an open architecture and a reference implementation of a novel service infrastructure, building upon generic and reusable building blocks developed in earlier research projects. We will demonstrate how this infrastructure supports emerging Future Internet (FI) services in multiple Usage Areas, and will exhibit significant and quantifiable improvements in the productivity, reliability and cost of service development and delivery building a true foundation for the Future Internet. From an architectural perspective, FI-WARE is based on the following main foundations: Service Delivery Framework the infrastructure to create, publish, manage and consume FI services across their life cycle, addressing all technical and business aspects. Cloud Hosting the fundamental layer which provides the computation, storage and network resources, upon which services are provisioned and managed. Support Services the facilities for effective accessing, processing, and analyzing massive streams of data, and semantically classifying them into valuable knowledge. IoT Enablement the bridge whereby FI services interface and leverage the ubiquity of heterogeneous, resource-constrained devices in the Internet of Things. Interface to Networks open interfaces to networks and devices, providing the connectivity needs of services delivered across the platform. Security the mechanisms which ensure that the delivery and usage of services is trustworthy and meets security and privacy requirements.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2009.1.1 | Award Amount: 4.15M | Year: 2010

Wireless communications, perpetually a source of innovation, is entering new and uncharted territory. In order to enhance system performance and cater for the services and applications of the future, there is the need for cooperative and cognitive communications paradigms that support advanced coexistence technologies for radio optimization. In short, wireless communications is moving towards a disruptive phase, where the speed and capability of interdisciplinary knowledge integration, for systems cooperation and coexistence, becomes a requirement for survival. This needs new thinking, and the development of architectures and facilitators for novel flexible radio technologies. To account for this paradigm shift and position Europe to benefit most from it, experts in areas of cooperation and coexistence, comprising but not limited to realms such as cognitive radio, cognitive networking and flexible networking, must integrate and harmonize their agendas. Through this approach, to paraphrase a common adage, the whole will become stronger than the sum of the parts. Moreover, there is the need to produce a next generation of European researchers, with the right skills-sets to solve the challenges of optimisation for cooperative and coexisting wireless systems. The ACROPOLIS NoE is specifically designed to meet these challenges; it has a strong, interdisciplinary, joint-research agenda, fostering rapid innovation that is of the highest quality and is able to bridge the gaps in European research. Its structure allows it to react rapidly to changes in the research landscape, where integration of research activities to achieve critical mass, and spreading of excellence throughout industry, other research organisations and elsewhere, are at the very heart of its formulation and ideals. To summarise, ACROPOLIS fosters relevant European excellence in research and education, and through the amalgamation of this strives to achieve new heights that would otherwise be impossible.

Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: KBBE-2007-2-5-05 | Award Amount: 7.37M | Year: 2009

MYCORED aims at developing strategic solutions to reduce contamination by mycotoxins of major concern in economically important food and feed chains. The following toxins and commodities are especially considered in the project: aflatoxins, trichothecenes, zearalenone, fumonisins in wheat/maize food and feed chains; ochratoxin A in the grape-wine and wheat chains; and aflatoxins in the dried fruit chain. Novel methodologies, efficient handling procedures and information, dissemination and educational strategies are considered in a context of multidisciplinary integration of know-how and technology to reduce mycotoxins exposure worldwide. Five work-packages (WPs) will develop novel solution driven strategies to reduce both pre-and post-harvest contamination in feed and food chains. They involve: i) optimization of plant resistance and fungicide use; ii) biocontrol to reduce toxigenic fungi in cropping systems, iii) predictive modelling and optimise logistics; iv) novel post-harvest and storage practices and v) application of new food processing technologies. Two horizontal WPs will develop enabling methodologies for i) advanced diagnostics and quantitative detection of toxigenic fungi and ii) rapid and multi-toxin detection of mycotoxins and relevant biomarkers. The project will significantly build on the outcome of several European projects (through most coordinators/partners of FP5 and FP6) on mycotoxins by supporting, stimulating and facilitating education and cooperation with countries having major mycotoxin concerns related to (international) trade and human health. The direct involvement of ICPC countries (Argentina, Egypt, Russia, South Africa, Turkey) and international organizations (CIMMYT,IITA) together with strong alliances with major research institutions in the USA (3 USDA Centers/5 Universities), Australia, Malaysia will strengthen the project through sharing experiences and resources from several past/ongoing mycotoxin projects in a global context.

HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along with methods to make results of analyses and outcomes comparable across centers and sustainable through Rheumatology associations. The overall idea of the HarmonicSS project is to bring together the largest well characterized regional, national and international longitudinal cohorts of patients with Primary Sjgrens Syndrome (pSS) including those participating in clinical trials, and after taking into consideration the ethical, legal, privacy and IPR issues for sharing data from different countries, to semantically interlink and harmonize them into an integrative pSS cohort structure on the cloud. Upon this harmonized cohort, services for big data mining, governance and visual analytics will be integrated, to address the identified clinical and health policy pSS unmet needs. In addition, tools for specific diagnostic procedures (e.g. ultrasonography image segmentation), patient selection for clinical trials and training will be also provided. The users of the HarmonicSS platform are researchers (basic/translational), clinicians, health policy makers and pharma companies. pSS is relevant not only due to its clinical impact but also as one of the few model diseases to link autoimmunity, cancer development (lymphoproliferation) and the pathogenetic role of infection. Thus, the study of pSS can facilitate research in many areas of medicine; for this reason, the possibility for sustainability and expandability of the platform is enhanced. Moreover, pSS has a significant impact on the healthcare systems, similar to that of rheumatoid arthritis.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.12M | Year: 2017

The manufacturing industry is entering a new era in which new ICT technologies and collaboration applications are integrated with traditional manufacturing practices and processes, which brings virtual organisations to factories, i.e. Manufacturing 2.0. Virtual factory to future manufacturing slows the flexible amalgamation of manufacturing resources in multiple organisations to create timely, demand driven product lines. The project vF Interoperation suppoRting buSiness innovaTion (FIRST) provides the new technology and methodology to describe manufacturing assets; to compose and integrate the existing services into collaborative virtual manufacturing processes; and to deal with evolution of changes. From the overarching objective to enhance manufacturing integration through the application of advanced IT solutions, the innovative project brings together an experienced researcher with expertise in the designing an interoperability framework for facilitating interoperability on data/information, services and process levels respectively. These outcomes lead to significant business innovations for virtual factories, made possible by an internationally recognised group expertise in (manufacturing) services/assets description languages, semantic services discover methods, and automated interoperability. The experienced researcher has an existing background in service oriented business process management; ontology based process model registration and management; and web service discovery and selection. She combines this with a perspective on application of those technologies. The FIRST project will take advantage of this complementary experience as well as the academic and industrial relationships in Europe and China respectively, taking advantage of the unique opportunity to address the concept from both perspectives.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-22-2016 | Award Amount: 5.15M | Year: 2017

The key objective of our project is to bridge the gap between secondary schools and higher education and research by better integrating formal and informal learning scenarios and adapting both the technology and the methodology that students will most likely be facing in universities. We are focusing on the context of secondary schools, often referred to as high schools, which provide secondary education between the ages of 11 and 19 depending on the country, after primary school and before higher education. The learning context from the perspective of the students is the intersection of formal and informal spaces, a dynamic hybrid learning environment where synchronous activities meet in both virtual and real dimensions. For this, we propose to develop an innovative Up to University (Up2U) ecosystem based on proven experiences in higher education and big research that facilitates open, more effective and efficient co-design, co-creation, and use of digital content, tools and services adapted for personalised learning and teaching of high school students preparing for university. We will address project based learning and peer-to-peer learning scenarios. We strongly believe that all the tools and services the project is going to use and/or make available (i.e. incorporate, design, develop and test) must be sustainable after the lifetime of the project. Therefore, the project is going to develop business plans and investigate appropriate business models using the expertise of the Small Medium Enterprise and National Research and Education Network partners and their contacts with third-party business actors. Our plan is to make it easy for new schools to join the Up2U infrastructure and ecosystem that will form a federated market-place for the learning community.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.2.2-2 | Award Amount: 3.88M | Year: 2012

The increasing number of elderly people will have a major impact on the prevalence of age-related diseases, which will pose major challenges to keep health systems in Europe sustainable. Current knowledge is insufficient to identify the transition of normal brain ageing into Alzheimer`s Disease (AD)-like brain damage. Elucidation of the genes and pathways contributing to the earliest stages of AD pathology and associated neurodegeneration should be instrumental to allow intervention when the condition is still reversible. The aim of the DEVELAGE project is to characterise shared molecular pathways between early developmental processes in the brain and brain ageing. Our concept is based on the hypothesis that disorders of neural development contribute to age-related neurodegeneration, that developmentally essential proteins might have a role in neurodegeneration, and that neurodegeneration-related proteins and genes are important during the development of the brain. The DEVELAGE approach is unique in that it is brain tissue-based, derived from neuropathological diagnosis with detailed molecular analysis of the spectrum of developmental and ageing changes in the very same brain samples used for a comprehensive array of investigations in humans as well as in experimental models at genetic, epigenetic, transcription and protein levels. DEVELAGE contributes to the understanding of biological variation by examining relevant number of cases with different phases of ageing and neurodegeneration as well as developing brains with or without developmental disorders. Pathways examined in humans will be validated in animal models, including a non-human primate, and vice versa. The combination of human samples and animal models susceptible to experimental manipulation will promote the translation of clinically relevant data into experimentally testable predictions and promotes the exploitation of therapeutically relevant targets to reverse or halt disease progresssion.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST.2008.3.1.1. | Award Amount: 3.97M | Year: 2010

The CATS project objective is the final development and experimentation of a new urban transport service based on a new generation vehicle. Its major innovation is the utilisation of a single type of vehicle for two different usages: individual use or collective transport. This new transport service is aimed at filling the gap between public mass transport and private individual vehicles. It is based on two operating principles: the self service concept where small and clean urban vehicles are offered on a short term rental basis, and the flexible shuttle service where a variable length of vehicles convoy, driven by a professional driver, operates at fixed hours along a line on a permanent basis or on a case by case basis. Both these principles are integrated in a single service (composed of vehicles and stations) called Cristal. The final aim of this new service is a more efficient mobility in cities through a more balanced use of small clean vehicles and mass transport. This inclusive new transport system is well adapted to the needs of people with reduced mobility, young passengers and tourists. Four Cristal vehicles and two stations will be made available by Lohr Industrie to the project for experiments. The CATS project will investigate through an in depth mobility needs analysis, on-site demonstration and showcases, the impact of the introduction of such a new system in three different European cities (Strasbourg FR, Ploeisti, RO, Formello, IT).The impact on environment and especially on CO2 emissions, as well as the acceptance and the evaluation of market take-up of the system will be studied. CATS will complement the design and manufacture of the Cristal vehicle via a detailed definition of its operating principles and by a design of its urban settings (stations, infrastructures,) in accordance with cities and citizens needs. A full evaluation plan is then foreseen as well as transferability assessment.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.38M | Year: 2009

The deterioration of food commodities by biotic factors is a serious and widespread problem. In particular, the contamination of different food and feed commodities by ochratoxin A (OTA) produced by several widespread fungi represents a serious health risk due to the high toxicity of OTA. This toxin causes nephrotoxic, genotoxic, immunosuppressive and carcinogenic effects on humans and animals. It is therefore necessary to have a close surveillance of the presence of this mycotoxin in food, beverages and feed through efficient, reliable and rapid analytical methods. The availability of low cost analytical methods which join reliability and rapidity is highly desired by the small medium enterprises (SMEs). In this project we will develop a novel system able to perform detection and quantification of OTA in wine, beer and feed, through a linear array of a-Si:H photosensors deposited on a glass substrate. The photosensors will be coupled with surfaces treated in different ways in order to establish the best functionalization of the considered food matrix and will be integrated in a compact, portable equipment. Several food and feed matrices (wine, beer, cereals), both naturally contaminated or fortified with OTA, will be extracted with different extraction methods and analysed by the novel system. The liquid samples (wine, beer) will be also analysed by direct deposition without any extraction procedure. The results obtained with this system will be compared with those obtained by using traditional analytical methods. Therefore the proposed system will allow to perform low cost, rapid and reliable analyses, not only in a well equipped laboratory but also in a canteen, or in a brewery as well as in a farm, satisfying the requirements of SMEs for an effective food quality control.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: Ocean.2010-3 | Award Amount: 13.98M | Year: 2011

The ECO2 project sets out to assess the risks associated with the storage of CO2 below the seabed. Carbon Capture and Storage (CCS) is regarded as a key technology for the reduction of CO2 emissions from power plants and other sources at the European and international level. The EU will hence support a selected portfolio of demonstration projects to promote, at industrial scale, the implementation of CCS in Europe. Several of these projects aim to store CO2 below the seabed. However, little is known about the short-term and long-term impacts of CO2 storage on marine ecosystems even though CO2 has been stored sub-seabed in the North Sea (Sleipner) for over 13 years and for one year in the Barents Sea (Snhvit). Against this background, the proposed ECO2 project will assess the likelihood of leakage and impact of leakage on marine ecosystems. In order to do so ECO2 will study a sub-seabed storage site in operation since 1996 (Sleipner, 90 m water depth), a recently opened site (Snhvit, 2008, 330 m water depth), and a potential storage site located in the Polish sector of the Baltic Sea (B3 field site, 80 m water depth) covering the major geological settings to be used for the storage of CO2. Novel monitoring techniques will be applied to detect and quantify the fluxes of formation fluids, natural gas, and CO2 from storage sites and to develop appropriate and effective monitoring strategies. Field work at storage sites will be supported by modelling and laboratory experiments and complemented by process and monitoring studies at natural CO2 seeps that serve as analogues for potential CO2 leaks at storage sites. ECO2 will also investigate the perception of marine CCS in the public and develop effective means to disseminate the project results to stakeholders and policymakers. Finally, a best practice guide for the management of sub-seabed CO2 storage sites will be developed applying the precautionary principle and valuing the costs for monitoring and remediation.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2011.2.2.1-3 | Award Amount: 8.07M | Year: 2011

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorders and associated obsessive-compulsive symptoms, through disentangling the interplay between environmental factors and genetic background; translate research findings into clinical applications by developing disease prediction models and investigation of a treatment strategy; and will establish a Pan-European infrastructure for the study of tic disorders. We hypothesise that the onset and/or exacerbation of tic and comorbid obsessive-compulsive disorders is associated with increased preceding occurrence of Group A beta-haemolytic Streptococcus (GAS) infections of specific molecular subtypes, and that this association is based on genetic susceptibility factors and mediated through immunological mechanisms related to psychosocial stress and immunological factors in host and GAS strains. Large-scale cohort studies will involve affected patients and at-risk first-degree relatives within an integrated, multidisciplinary research strategy. Treatment effects of active surveillance and standardized antibiotic treatment of GAS colonisation, thus addressing one of the main environmental factors involved (GAS infections) will be evaluated. Our approach will result in the identification of genetic and environmental susceptibility factors and will greatly contribute to a better understanding of the underlying mechanisms of tic disorders, with a focus on elucidating the role of autoimmunity. Our consortium brings together the highest expertise in the field of tic disorders across Europe in academia and industry, including a number of SMEs and a professional management company.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.2.3.3-1 | Award Amount: 16.37M | Year: 2011

To address the call for proposals Biology and control of vector-borne infections in Europe launched by the European Commission, we want to investigate the biological, ecological and epidemiological components of vector-borne diseases (VBD) introduction, emergence and spread, and to propose innovative tools for controlling them, building on the basis of acquired knowledge. We have selected the main groups of arthropod vectors involved in the transmission of vector-borne diseases in Europe: ticks, mosquitoes, sandflies, and biting midges (Culicoides). We have also selected the main diseases of actual or possible importance in human and veterinary public health. Rodents, insectivores and rodent-borne diseases have also been considered, both for their direct importance in public health, and for the major role of rodents and insectivores as reservoir hosts of many pathogens. We have put a strong focus on vector- and disease-quantitative modelling. The resulting predictive models will be used to assess climate or environmental change scenarios, as well as vector or disease control strategies. Human behaviour and risk perception are an important component of VBD introduction, emergence and spread. The consequences triggered by VBD for human and veterinary public health in Europe are just starting to emerge in public awareness. We will also account for this aspect of human and veterinary public health in our proposal. Finally, the set of innovative research methods, tools and results obtained during the project will be a step forward a generic approach of VBD in terms of disease monitoring and early warning systems, and will reinforce the general framework for an integrated pest and disease management system. For all these aspects, we will benefit from, and amplify the strong scientific results, capacity building, and research networks established by EDEN project on emerging, vector-borne diseases in a changing European environment.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2011.2.1.1-1 | Award Amount: 39.64M | Year: 2011

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and on their malignant leukaemic counterparts. Reference epigenomes will be generated by state-of-the-art technologies from highly purified cells for a comprehensive set of epigenetic marks in accordance with quality standards set by IHEC. This resource-generating activity will be conducted at dedicated centres to be complemented by confederated hypothesis-driven research into blood-based diseases, including common leukaemias and autoimmune disease (T1D), by epigenetic targets and compound identification, and by discovery and validation of epigenetic markers for diagnostic use. By focussing on 100 samples of known genetic variation BLUEPRINT will complete an epigenome-wide association study, maximizing the biomedical relevance of the reference epigenomes. Key to the success of BLUEPRINT will be the integration with other data sources (i.e. ICGC, 1000 genomes and ENCODE), comprehensive bioinformatic analysis, and user-friendly dissemination to the wider scientific community. The involvement of innovative companies will energize epigenomic research in the private sector by creating new targets for compounds and the development of smart technologies for better diagnostic tests. BLUEPRINT will outreach through a network of associated members and form critical alliances with leading networks in genomics and epigenomics within Europe and worldwide. Through its interdisciplinarity and scientific excellence combined with its strong commitment to networking, training and communication BLUEPRINT strives to become the cornerstone of the EU contribution to IHEC.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: GC.NMP.2012-1 | Award Amount: 3.74M | Year: 2012

This project is aimed to the identification and development of nanostructured electrode and electrolyte materials to promote the practical implementation of the very high energy lithium-sulfur battery. In particular, the project will be directed to the definition and test of a new, lithium metal-free battery configuration based on the use of lithiated silicon as the anode and a nanostructured sulfur-carbon composite as the cathode. It is expected that this battery will offer an energy density at least three times higher than that available from the present lithium battery technology, a comparatively long cycle life, a much lower cost (replacement of cobalt-based with a sulfur-based cathode) and a high safety degree (no use of lithium metal). All the necessary steps for reaching this goal are considered, starting from material synthesis and characterization, exploiting nanotechnology for improving rate capability and fast charging, the fabrication and test of large scale prototypes and to the completion of the cycle by setting the conditions for the recycling process. A team of experts have been selected as partners of the project, including a number of academic laboratories, all with worldwide recognized experience in the lithium battery field, whose task will be that of defining the most appropriate electrode and electrolyte nanostructures. The project will benefit by the support of a laboratory expert in battery modeling to provide the theoretical guidelines for materials optimization. Large research laboratories, having advanced and modern battery producing machineries will be involved in the preparation and test of middle size battery prototypes. Finally, chemical and battery manufacturing industries will assure the necessary materials scaling-up and the fabrication and test of large batteries and particular attention will be devoted to the control of the safety and to definition and practical demonstration of its most appropriate recycling process.

Agency: European Commission | Branch: FP7 | Program: NOE | Phase: ICT-2007.1.1 | Award Amount: 4.75M | Year: 2008

The BONE-proposal builds on the foundations laid out by the ePhoton/ONe projects in the previous Framework Programme. This Network of Excellence has brought together over several years the research activities within Europe in the field of Optical Networks and the BONE-project intends to validate this effort by stimulating a more intensified collaboration, exchange of researchers and building on Virtual Centres of Excellence that can serve to European industry with education and training, research tools and testlabs and pave the way to new technologies and architectures.\nThe Network of the Future, which is the central theme of this Call, will have to cope with a wide variety of applications running on a wide variety of terminals and with an increasing number of connected devices and increasing speed and data-loads. The BONE-proposal does not look into issues as convergence between mobile and fixed networks, nor does it consider issues regarding the optimised broadband access in the last mile using a wide variety of technologies such as DSL, cable, WiMAX, WiFi, PLC,... The BONE-proposal looks further into the future and takes as the final Network of the Future:\n- a high capacity, flexible, reconfigurable and self-healing optical Core and Metro network which supports the transport of massive amounts of data\n- a FTTx solution in which the x is as close as possible to the home, at the home, or even in the home. From this point the user is connected using terminal-specific technologies (wireless to handheld devices, fiber to home cinema, wireless to laptop, fixed connection to desktop,...)\nBONE clearly identifies the existence of the current technologies and also recognizes the fact that users also require the mobility of wireless access, but this mobile connection ends at a gateway or access points and from there a fixed connection is required and this fixed connection will finally be an optical link.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: KBBE.2013.2.4-01 | Award Amount: 11.53M | Year: 2014

Food Integrity the state of being whole, entire, or undiminished or in perfect condition. Providing assurance to consumers and other stakeholders about the safety, authenticity and quality of European food (integrity) is of prime importance in adding value to the European Agri-food economy. The integrity of European foods is under constant threat from fraudulently labelled imitations that try to exploit that added value. The FOODINTEGRITY project will directly address this issue and will be an international focal point for harmonisation and exploitation of research and technology for insuring the integrity of European food. Comprising an inner core of project participants from industry, academia, research institutes, technology providers and a global network of stakeholders, FOODINTEGRITY will rationalise and harmonise capability to provide a coherent structure and process for assuring the food supply. FOODINTEGRITY will: facilitate the sharing of information between stakeholder groups regarding European food integrity; establish processes for harmonising & exploiting existing databases; establish fit for purpose methodology to address stakeholder needs; identify and address research gaps by procuring and delivering 3M of commissioned projects; establish a self-sustaining Food-fraud early warning system for identifying emerging fraud risks; establish a self-sustaining worldwide network of stakeholders to ensure maximum uptake of the project legacy. Improved verification procedures will be developed for food control and industry stakeholders using 3 key commodities as exemplars: olive oil, spirit drinks & seafood. In addition a consumer study in China will assess their consumer attitudes in the face of substantial counterfeiting of European food. Finally it will establish expert food authenticity platforms that will supply independent expert opinion on food authenticity/food fraud to the European Commission, Codex and other national/international bodies

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.16M | Year: 2008

Bioethanol has been increasingly becoming the renewable energy source that could reduce the oil dependence of the developed countries. Biorefineries can use the locally grown agriculture to produce ethanol. However, food chain supply is beginning to suffer the effects of the ethanol massive production raising major ethical concerns. Cellulosic ethanol can overcome the environmental risks that accompany the surge of harvest biomass feedstocks and thus can represent a real and pursuable technology for the future. According to the US DOE life-cycle analysis, ethanol from cellulose reduces greenhouse gas emissions by 90% compared to gasoline. Cellulosic biomass is the most abundant biomaterial on earth it is available almost in any country. Vegetal residues (wheat and rice straw, olive oils residues, etc.) can constitute a renewable source of raw materials for cellulosic ethanol production plants. Currently only a few pilot plants are producing bioethanol from lignocellulosic feedstock using an enzymatic hydrolysis process. Olive oil residues can constitute a valuable resource as a low cost feedstock for cellulosic ethanol production. At least 2 million tonnes of cellulose are discarded on the Mediterranean area every year, representing both an environmental problem and a waste of a valuable resource. The ETOILE project intends to develop a new integrated process where olive mill waste water from traditional three-phase centrifugation process is purified and at the same time cellulase enzymes are obtained. These enzymes are then used onto the solid olive oil residues, such as olive pulp and husks, to obtain ethanol. The research envisaged will thus provide a viable alternative to the growing bioethanol industry seeking for new cost-effective production processes competitive with oil industry.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.3.2-9 | Award Amount: 3.01M | Year: 2009

Malaria, one of the worlds most devastating diseases, is caused by protozoan parasites of the genus Plasmodium and is obligatory transmitted to humans by anopheline mosquitoes. The African mosquito species Anopheles gambiae s.s., is the major vector of this disease. Research groups from 3 European countries and 3 African teams will integrate their resources and scientific expertise in malaria research to expand knowledge of mosquito biology and of vector-parasite interactions, exploiting the opportunities provided by the recently available genome information and technological developments for mosquito vectors. The joint scientific program of the MALVECBLOK Consortium integrates for the first time three crucial aspects of biology of An. gambiae: reproduction, immunity and population biology, with the aim to ultimately provide novel concepts and targets for malaria control. The main objectives will address: (i) The molecular bases of reproductive biology of the mosquito vector, and its effects on immunity and Plasmodium transmission; (ii) The molecular mechanisms which determine the mosquito immune status and regulate Plasmodium sporogony and transmission, in both laboratory settings and natural populations; (iii) The role of genetic polymorphism in genes controlling reproduction and immunity on structure of mosquito populations and malaria transmission in Africa. In order to reach these objectives, MALVECBLOK will employ a number of concerted strategies in support of its 3-year agenda. Special attention will be given to cutting-edge training opportunities and sharing of resources, by implementing interactive programmes for the training and exchange of personnel at all levels, and by rationalising and coordinating investment. The innovative knowledge generated under this trans-disciplinary project will promote European scientific competitiveness and will impact global health issues.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-2.3.4. | Award Amount: 15.84M | Year: 2011

The objective of the eleven participating Research Infrastructures (RIs) is to build up collaborations and to create long-term synergies to facilitate their implementation and enhance their efficiency and attractiveness. The CRISP proposal focuses on four R&D tasks that are of utmost importance for these RIs: (i) Accelerators, (ii) Instruments & Experiments, (iii) Detectors & Data Acquisition, and (iv) Information Technology (IT) & Data Management. Progress in accelerator technology is essential to provide the RIs with the best possible sources of X-rays, ions and neutrons and to tackle the next challenges in nuclear and high-energy physics. Joint developments for novel experimental schemes and their related instrumentation will create new scientific opportunities at the RIs and offer tremendous potential across all fields of natural sciences. New initiatives and approaches are required to cope with the ever-increasing flow of scientific data, and a joint effort to establish the base elements of adequate platforms for the processing, storage and access to data shall be undertaken. The RIs will exchange know-how and combine complementary expertise, ensuring cost-efficient and coherent development plans. The generated synergies will be crucial to respond to the rapidly evolving and mobile scientific user community. It will allow the RIs to strengthen their role in the advancement of knowledge and to stimulate scientific and technological progress, indispensable to address the grand challenges of our society in health, environment, sustainable energy, transport and communication. The proposed activities will be of enormous benefit as well to other large scale facilities in the European Research Area, such as regional or national light and x-ray sources, high-energy and nuclear facilities.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.5 | Award Amount: 3.00M | Year: 2010

The aftermath of too many dramatic events involving public structures and private buildings collapse makes imperative to ask ourselves whether anything can be done to mitigate their effects or avoid them and save the lives taken as a result of their occurrence. Wireless sensor network (WSN)-based systems for structural health monitoring could be the answer to this crucial question were they able to provide long lasting monitoring and robust and reliable data delivery as requested by increasing safety demands.This is unfortunately unavailable today.The GENESI project proposes research addressing all the critical barriers and challenges that prevent the application of WSNs for monitoring structures, buildings and spaces. In particular, by combining new hardware and software design, the GENESI will produce systems for structural health monitoring that are long lasting, pervasive and totally distributed and autonomous.New wireless sensor nodes will be build that are capable of achieving virtual infinite lifetime through a well-balanced combination of cutting edge technologies, such as energy harvesting from multiple sources, the first small factor fuel cells, low-cost radio triggering for minimizing idle energy consumption and algorithms for smart interference management.New software will complement the GENESI hardware in the quest of long lasting system lifetime by taking into account the when and how much of energy availability. At the same time, end user requirements will be met according to a newly defined application driven Quality of Service concept.Novel task allocation algorithms, cross-layer protocol stacks, situation awareness and context discovery mechanisms complete the definition of a system that addresses the major challenges of the ICT theme of FP7. Finally, involving end users directly into the research cycle as key players,GENESI is poised to address realistic\nsocietal needs while fostering technology transfer and market exploitation.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NFRP-01-2014 | Award Amount: 6.64M | Year: 2015

The thermal-hydraulics Simulations and Experiments for the Safety Assessment of Metal cooled reactor (SESAME) project supports the development of European liquid metal cooled reactors (ASTRID, ALFRED, MYRRHA, SEALER). The project focusses on pre-normative, fundamental, safety-related, challenges for these reactors with the following objectives: Development and validation of advanced numerical approaches for the design and safety evaluation of advanced reactors; Achievement of a new or extended validation base by creation of new reference data; Establishment of best practice guidelines, Verification & Validation methodologies, and uncertainty quantification methods for liquid metal fast reactor thermal hydraulics. The SESAME project will improve the safety of liquid metal fast reactors by making available new safety related experimental results and improved numerical approaches. These will allow system designers to improve the safety relevant equipment leading to enhanced safety standards and culture. Due to the fundamental and generic nature of SESAME, developments will be of relevance also for the safety assessment of contemporary light water reactors. By extending the knowledge basis, SESAME will allow the EU member states to develop robust safety policies. At the same time, SESAME will maintain and further develop the European experimental facilities and numerical tools. The consortium of 25 partners provides American-European-wide scientific and technological excellence in liquid metal thermal hydraulics, as well as full alignment with ESNII and with NUGENIA where of interest. A close interaction with the European liquid metal cooled reactor design teams is foreseen involving them in the Senior Advisory Committee. They will actively advise on the content of the project and will be the prime end-users, ensuring their innovative reactor designs will reach highest safety standards using frontier scientific developments.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: CIRC-05-2016 | Award Amount: 3.38M | Year: 2017

RES URBIS aims at making it possible to convert several types of urban bio-waste into valuable bio-based products, in an integrated single biowaste biorefinery and by using one main technology chain. This goal will be pursued through: - collection and analysis of data on urban bio-waste production and present management systems in four territorial clusters that have been selected in different countries and have different characteristics. - well-targeted experimental activity to solve a number of open technical issues (both process- and product-related), by using the appropriate combination of innovative and catalogue-proven technologies. - market analysis whitin several economic scenarios and business models for full exploitation of bio-based products (including a path forward to fill regulatory gaps). Urban bio-waste include the organic fraction of municipal solid waste (from households, restaurants, caterers and retail premises), excess sludge from urban wastewater treatment, garden and parks waste, selected waste from food-processing (if better recycling options in the food chain are not available), other selected waste streams, i.e. baby nappies. Bio-based products include polyhydroxyalkanoate (PHA) and related PHA-based bioplastics as well as ancillary productions: biosolvents (to be used in PHA extraction) and fibers (to be used for PHA biocomposites). Territorial and economic analyses will be done either considering the ex-novo implementation of the biowaste biorefinery or its integration into existing wastewater treatment or anaerobic digestion plants, with reference to clusters and for different production size. The economic analysis will be based on a portfolio of PHA-based bioplastics, which will be produced at pilot scale and tested for applications: - Biodegradable commodity film - Packaging interlayer film - Speciality durables (such as electronics) - Premium slow C-release material for ground water remediation

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-02-2015 | Award Amount: 5.86M | Year: 2016

MinWaterCSP addresses the challenge of significantly reducing the water consumption of CSP plants while maintaining their overall efficiency. Its objective is to reduce evaporation losses and mirror cleaning water usage for small- and large-scale CSP plants through a holistic combination of next generation technologies in the fields of i) hybrid dry/wet cooling systems ii) wire structure heat transfer surfaces iii) axial flow fans iv) mirror cleaning techniques and v) optimized water management. MinWaterCSP will reduce water evaporation losses by 75 to 95% compared to wet cooling systems. It aims to increase the net efficiency of the steam Rankine cycle by 2%, or alternatively reduce the capital cost of a dry-cooling system by 25%, while maintaining cycle efficiency. To complement this, mirror cleaning water consumption will be reduced by 25% through an improved mirror cleaning process for parabolic trough collectors, the development of a cleaning robot for linear Fresnel collectors and a reduced number of cleaning cycles enabled by an enhanced monitoring of the reflectance of the mirrors. Also, comprehensive water management plans for CSP plants in various locations will be developed and combined with plant performance simulations to maximize the impact of the achieved design improvements in a complete system context. Zero liquid discharge and the option of making use of solar energy or low grade waste heat for water treatment will be considered. MinWaterCSP will improve the cost-competitiveness of CSP. This will make CSP more attractive for investment purposes and drives growth in the CSP plant business as well as job creation at European companies which provide technologically advanced CSP plant components. In addition, by making CSP technology more attractive MinWaterCSP contributes to solve the global climate challenge by reducing carbon-dioxide emissions and increasing energy generation from renewable resources.

Agency: European Commission | Branch: H2020 | Program: Shift2Rail-RIA | Phase: S2R-OC-IP2-02-2015 | Award Amount: 1.01M | Year: 2016

The VITE proposal is addressed to the call S2R-OC-IP2-02-2015-IT virtualization of testing environment. The main objective of VITE proposal is to reduce on-site tests for signalling systems leading to reducing overall testing costs. To achieve this main objective the work is organized in two main streams: First, to propose a testing framework by carefully analysing users needs and current situation and from there building a process that can be accepted by all railway stakeholders and whose main strength will be to perform as many tests as possible in the lab. An analysis of uncertainties and a simulation of GSMR QoS as well as a proposed methodology for test protocols optimisation will also be addressed. Secondly, to propose a standard architecture for the lab testing including the interface specifications for both the connection between real equipment and the lab tools as for the connection between different labs for remote testing. This architecture will be developed together with some SW tools that will help to automatise lab testing. To validate the test process framework and the lab architecture demonstrations by the participating labs using real track and train data from three of the most significant European countries deploying ETCS (Spain, Italy and Belgium), as well as an assessment by NoBos, DeBos and users from these three countries are also foreseen. Finally VITE has some dissemination and coordination actions to ensure the success and usefulness of the project in particular regarding the coordination with S2R-CFM-IP2-01-2015 and other S2R initiatives. The expected impact of the project is to significantly contribute to the development of a Zero Onsite testing environment. The VITE consortium involves users (RU and IM), independent labs, NoBos/DeBos and engineering and technological companies, all of them leading companies in the railway sector and in particular in signalling and ERTMS. This consortium thus complements the know-how and expertise of the S2R JU members.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-28-2015 | Award Amount: 4.60M | Year: 2016

Multispectral Optoacoustic Tomography (MSOT) brings a revolution to bio-optical imaging. Being insensitive to photon scattering, MSOT dramatically improves upon conventional bio-optic barriers by enabling (1) three-dimensional high-resolution optical imaging deep inside tissues (several millimetres to centimetres), by (2) high-scalability, ranging from optical-resolution microscopy to acoustic-resolution optical mesoscopy and macroscopy and by (3) novel label-free anatomical, physiological and molecular contrast at the tissue and single-cell-level, based on spectrally-resolved optical absorption. MSOT, originally supported by an ERC Advanced Award (2008) (TUM: Prof. Ntziachristos), is already commercialized by iThera Medical for macroscopy with systems sold around the world for small animal imaging. In parallel, ERC MSOT funding developed a mesoscopic implementation, termed raster-scan optoacoustic mesoscopy (RSOM), which has demonstrated innovative imaging capacity at 1-5mm depths. Driven by leading dermatologists (TUM: Prof. Biedermann; SUR: Prof. Costanzo) and market leader SMEs in optoacoustic and ultrasound technology (iThera, Rayfos, Sonaxis), INNODERM will design and prototype a handheld, portable, scalable, label-free RSOM device for point-of care dermatology applications, based on recommendations developed under an ERC proof of concept grant (2013) on MSOT. INNODERM brings together key photonic & ultrasound technologies and will validate the technical and economic viability of RSOM in dermatology suites for fast diagnosis and skin disease monitoring. RSOM can go beyond the abilities of current optical or optoacoustic devices and offer a paradigm shift in dermatology imaging, substantiating successful business cases.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ICT-24-2015 | Award Amount: 2.50M | Year: 2016

The FP7 coordination action RockEU has been extremely successful in building a strong European robotics community, leading to the creation of euRobotics aisbl - the private partner of the SPARC PPP and development of the Strategic Research Agenda and the Multi-Annual Roadmap, which are the main guidelines for shaping European robotics R&D&I. RockEU2 builds on and extends this successful community integration by providing analysis of innovation and skills and by developing major outreach activities. This extension is achieved by intensifying and strengthening collaboration within the community and by taking a leading role in the development of strategy. This includes activities in market observation, technology watch, innovation support, analysis of funded proposals, regulations assessment, and standardisation support. RockEU2 aims to Intensifying cooperation with international funding agencies (e.g. for joint calls), policy makers, and end-users as key enablers in the R&D&I process that contribute to the outreach and innovation themes. Outreach to the cognitive science community is another key part of this proposal. Improving the uptake of cognitive sciences results by the robotics community is an important target, leading to more innovative robotics products and applications, boosting innovation. Integration of activities started by the FP7-funded CAs euRathlon and RoCKIn on using robot competitions to foster research and innovation has great potential for improved public awareness of European robotics. Participation in robot competitions is attractive for young researchers and develops excellent engineering skills. The impact of robot competitions both for public awareness as well as for industry will be analysed and its results will influence the roadmap for future European robot competitions and outreach campaigns. The consortium consists of partners playing key roles in their respective communities and contributing unique competences to the consortium

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2009.3.2.2 | Award Amount: 4.08M | Year: 2010

The Biowalk4Biofuels Project aims to develop an alternative and innovative system for biowaste energy recovery and use of GHG emissions to produce biofuels, using macroalgae as a catalyser, in a multidisciplinary approach. The objectives of the project are: production of a cost-efficient biogas without using cereal crops; optimise the production of biogas per amount of biowaste and CO2 used, with low land use for plant facilities; and increase and optimize the types of biowastes that can be utilised for biogas production. To achieve the underlined objectives, research activities are to be carried out on the selection of adequate macroalgae species that can reach high output biomass yields and high carbohydrate content. Pre-cultivation of protoplasts will allow to obtain easily available biomass for feeding the cultivation open floating ponds within shorter periods, thanks to the rapid proliferation of germplasm, diminishing the life-cycle of macroalgae. In addition, the relationship between growth and energy potential of selected species with the amounts/characteristic of GHG emissions and biowaste introduced in the cultivation medium is to be studied. . After fermenting the algal biomass and other biowastes, the cycle is closed by producing biogas to be used for electricity and heat generation and as a transport fuel. A high quality biogas is expected, hence a purification step will proceed the final product. Furthermore, organic residues output from the methanation biodigestor are to be used as fertilizer after solid/liquid separation. The liquid fraction of the digestate will be treated in a biological oxidation system .A portion of the unseparated outlet effluent from the oxidation system (solids \ liquid) will be fed to the macroalgae cultivation (instead of the enrichment with chemical N-P-K fertilizers). Meanwhile, the other portion will be reused as feeding for the AD plant section. This process solution will permit to feed with several critical biowastes the biodigester, transforming them into a resource. The expected impact is to produce a cost-efficient, low energy-intensive, purified biogas, to reduce negative environmental impacts from industry (GHG emissions) and biowaste. The multidisciplinary approach solution to reduce GHG emission and process biowaste, while producing energy, seeking for the future replications in other locations.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2010.3.1.1-2 | Award Amount: 4.85M | Year: 2011

The Routes project is addressed to discover new routes in wastewater and sludge treatment which allow: a) to prepare sludge for agricultural utilization by transforming it in a very clean and stabilized product regarding the presence of organic micropollutants (conventional and emerging ones) and of heavy metals, and with respect to hygienic aspects and to phytotoxicity; b) to minimize sludge production by innovative solutions which can be based on different approaches, i.e.: i) metabolic uncoupling where the free energy released by electrons transport is dissipated in heat, in the activation of alternative metabolic routes or in the accumulation of polymeric products, ii) the use of microbial fuel cells, iii) the use of sequencing batch biofilter granular reactor (SBBGR), iiii) the integration of a side-stream process in membrane bioreactors; c) to promote recovery of valuable materials from anaerobic digestion, i.e. biopolymers as polyhydroxyalkanoates and fertilizers; e) to set up and prove at practical scale a novel technique for sludge disposal (wet oxidation) as sustainable alternative to nowadays the most used incineration; f) to minimize energy pumping by adjusting solid concentration, on a practical installation where sludge is pumped from the production site to a centralized plant. The general objective of the Routes proposal is therefore to set up a panel of different solutions to be applied in different conditions and circumstances, strictly following the waste hierarchy of the Directive 08/98 on waste. The above solutions will be studied either in laboratory or at practical scale, depending on the maturity of the technology, in order to provide to the Commission and the technical and scientific community applicable solutions and new routes for sludge management, also based on the best integration between the water and sludge treatment lines.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-5.1-2014 | Award Amount: 5.99M | Year: 2015

The overall aim of ELIPTIC is to develop new use concepts and business cases to optimise existing electric infrastructure and rolling stock, saving both money and energy. ELIPTIC will advocate electric public transport sector at the political level and help develop political support for the electrification of public transport across Europe. ELIPTIC looks at three thematic pillars: Safe integration of ebuses into existing electric PT infrastructure through (re)charging ebuses en route, upgrading trolleybus networks with battery buses or trolleyhybrids and automatic wiring/de-wiring technology upgrading and/or regenerating electric public transport systems (flywheel, reversible substations) Multi-purpose use of electric public transport infrastructure: safe (re)charging of non-public transport vehicles (pedelecs, electric cars/ taxis, utility trucks) With a strong focus on end users, ELIPTIC will analyse 23 use cases within the three thematic pillars. The project will support uptake and exploitation of results by developing guidelines and tools for implementation schemes for upgrading and/or regenerating electric public transport systems. Option generator and decision-making support tools, strategies and policy recommendations will be created to foster Europe-wide take up and rollout of various development schemes. Partners and other cities will benefit from ELIPTICs stakeholder and user forum approach. ELIPTIC addresses the challenge of transforming the use of conventionally fuelled vehicles in urban areas by focusing on increasing the capacity of electric public transport, reducing the need for individual travel in urban areas and by expanding electric intermodal options (e.g. linking e-cars charging to tram infrastructure) for long-distance commuters. The project will strengthen the role of electric public transport, leading to both a significant reduction in fossil fuel consumption and to an improvement in air quality through reduced local emissions.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: GC.SST.2013-4. | Award Amount: 22.22M | Year: 2013

Electrification of the public transport is a raising trend in Europe, and electric buses are soon expected to enter markets as one of the most interesting options for matching urban environmental targets. Electrification is driven by both economics and politics. However, although technology is not yet fully matured and ready for wide commercialisation, a large demonstration project will facilitate the market up-take of electric buses in Europe. Furthermore, as unambiguous and extensive information about overall effects of electrified bus systems and related needs for changes on infrastructure do not exist today, UITP sees its objectives and those matching perfectly, and this led UITP to build a consortium of 40 partners, who were already considering their actions along this theme, and to collectively design the 42-months demonstration project ZeEUS Zero-Emission Urban Bus Systems. ZeEUS project focus on the todays challenge in the electrification of bus system, the extension of the fully-electric solution to a wider part of the urban network. This goes through the development of electric vehicles of large capacity, and the creation of an infrastructure capable of providing the required charging energy, operated according to non-disruptive and grid-balancing principles. The ZeEUS project will cover innovative electric bus solutions with different types of electrical power-train systems. Full-electric battery-based busses will be demonstrated in five locations (Barcelona, Bonn, Muenster, Plzen and Rome), whereas plug-in hybrid or range-extender type of power-trains will be demonstrated in three sites (London, Glasgow and Stockholm). The lifetime of project ZeEUS is long enough to collect sufficient amount of statistically valid data and make comprehensive analysis to deliver meaningful lessons learned, guidelines and provide feedback to the R&D activity of manufacturers and suppliers to make technology mature for wide commercialisation.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.2.3-01 | Award Amount: 4.24M | Year: 2011

EcoBioCAP will provide the EU food industry with customizable, ecoefficient, biodegradable packaging solutions with direct benefits both for the environment and EU consumers in terms of food quality and safety. This next-generation packaging will be developed using advanced composite structures based on constituents (biopolyesters, fibres, proteins, polyphenolic compounds, bioadhesives and high performance bio-additives) derived from food (oil, dairy, cereal and beer) industry by-products only and by applying innovative processing strategies to enable customisation of the packagings properties to fit the functional, cost, safety and environmental impact requirements of the targeted fresh perishable foods (fruit and vegetable, cheese and ready to eat meal). Demonstration activities with SMEs and industrial partners will enable the EcoBioCAP technology to be optimised in terms stability, safety, environmental impact and cost-effectiveness before full exploitation. The development of a decision support system for use by the whole packaging chain will make the EcoBioCAP technology is accessible to all stakeholders. Extensive outreach activities will not only disseminate the project results to the scientific community but also ensure that consumers and end-users are informed of the usage conditions and benefits of such bio-degradable packaging and how it should be disposed of.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.1.1-1.;AAT.2010.1.1-3. | Award Amount: 5.10M | Year: 2012

Vision-2020, whose objectives include the reduction of emissions and a more effective transport systems, puts severe demands on aircraft velocity and weight. These require an increased load on wings and aero-engine components. The greening of air transport systems means a reduction of drag and losses, which can be obtained by keeping laminar boundary layers on external and internal airplane parts. Increased loads make supersonic flow velocities more prevalent and are inherently connected to the appearance of shock waves, which in turn may interact with a laminar boundary layer. Such an interaction can quickly cause flow separation, which is highly detrimental to aircraft performance, and poses a threat to safety. In order to diminish the shock induced separation, the boundary layer at the point of interaction should be turbulent. The main objective of the TFAST project is to study the effect of transition location on the structure of interaction. The main question is how close the induced transition may be to the shock wave while still maintaining a typical turbulent character of interaction. The main study cases - shock waves on wings/profiles, turbine and compressor blades and supersonic intake flows - will help to answer open questions posed by the aeronautics industry and to tackle more complex applications. In addition to basic flow configurations, transition control methods (stream-wise vortex generators and electro-hydrodynamic actuators) will be investigated for controlling transition location, interaction induced separation and inherent flow unsteadiness. TFAST for the first time will provide a characterization and selection of appropriate flow control methods for transition induction as well as physical models of these devices. Emphasis will be placed on closely coupled experiments and numerical investigations to overcome weaknesses in both approaches.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2010.4.2.3-1 | Award Amount: 1.95M | Year: 2011

The project will provide a theoretically and empirically grounded analysis of everyday practices in the workplace, of the macro and micro-level processes which act as drivers for and constraints upon sustainable practices in different types of workplaces across different European countries, and the relationship between work and outside work practices. These analyses will constitute the empirical basis for developing: agent-based models, which will provide a detailed account of barriers to and drivers for cooperation in transitioning to a low-carbon Europe; and back-casting scenarios, which will allow the mapping out of different pathways to a desirable, future low-carbon Europe. These results will be translated into detailed, articulated descriptions of how to encourage cooperative interaction to reach a sustainable Europe. The project will focus on 6 European case studies of large-scale organizations operating under different national and international contexts and occupying different relevant positions in the sustainability debate (state and private). It will focus on three main categories of practices at work, responsible for the GHG emissions of each organization: consumption of materials and energy, generation of waste and waste management, and organization-related mobility. The project will follow a multi-method approach that will include both qualitative and quantitative methodologies (interviews, questionnaires, agent-based modelling etc.) The findings will provide European policy makers with a more integrated understanding of how the workplace can become a crucial centre for engaging individuals, collectives (e.g., trade unions) and management in new sustainability practices, and with recommendations for context-sensitive policies that would enhance successful cooperation among agents in the transition to a low-carbon Europe.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2010.1.4-08 | Award Amount: 1.24M | Year: 2011

The Coordinating Action (hereafter the project) will establish an effective collaboration network among key role players in Mediterranean and Black Sea fisheries research and management. The participants in the project include national research institutes from Mediterranean and Black Sea countries with a long history and active participation in fisheries research and assessment, who provide advice to national, regional and international fisheries management organisms. The project will seek the active collaboration of regional and international fisheries management organisms as external participants in the project, in order to identify the gaps (in terms of data, knowledge, training, coordination) which hamper at present the full application of the Ecosystem Approach in the management of Mediterranean and Black Sea fisheries. The project will have a strong training and capacity building component in order to help harmonize data collection and methodologies used in fisheries assessment and management in the Mediterranean and Black Sea. The project will serve to establish the guidelines for the application of the Ecosystem Approach to Fisheries in the Mediterranean and Black Sea, both in EU member states and third countries. The project is organized in 6 workpackages: i) Project Coordination ii) Review of current knowledge in data collection and methodological practices in assessment and management iii) Identification of data needs, quality, harmonization, methodologies and models for EAF iv) Establishing coordination with the assessment and management international/regional bodies v) Training and capacity building. Symposium. Dissemination component vi) Strengthening the scientific basis of EAF application in Mediterranean and Black Sea fisheries

Agency: European Commission | Branch: H2020 | Program: IA | Phase: MG-3.2-2014 | Award Amount: 12.42M | Year: 2015

The objective of the EBSF_2 project is to validate different innovative solutions that combine efficiency of the bus system with more attractiveness. Such solutions are meant to represent the most innovative in the areas indicated by the Call: the project will proceed to their final validation before their introduction in the market, avoiding pure simulations or large use of prototypes. Following the System Approach, and with the participation of representatives of all key stakeholders categories, these activities will be introduced by the identification of innovation requirements (that will drive the impact assessment), the update of the Bus System Definition (as defined in EBSF). In addition to the impact analysis of the single solutions, the effect of combining key introduction will be evaluated. The European Bus System of the Future Roadmap will be updated with areas for further research and priorities linked to the project topics.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.4.2-2 | Award Amount: 7.70M | Year: 2014

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test for CAD currently available. CT may become the most effective strategy to reduce the ca. 2 million annual negative ICAs in Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD. To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The primary hypothesis will be that CT is superior to ICA for major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) after a maximum follow-up of 4 years in a selected broad population of stable chest pain patients with intermediate pretest likelihood of CAD. The trial will include 23 clinical sites from 18 European countries ensuring broad geographical representation. Comparative effectiveness research of complementing work packages include gender-related analysis, systematic review of evidence, cost-effectiveness analysis, and health-related quality of life. DISCHARGE has the capability to influence current standards and guidelines as well as coverage decisions and will raise awareness among patients, health care providers, and decision-makers in Europe about the effectiveness and cost-effectiveness of coronary CT angiography.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.2.2-3 | Award Amount: 2.81M | Year: 2012

Environmental crime is a threat to environmental, social and economic sustainability and is in conflict with key commitments and strategies of the European Union, including the Europe 2020 Strategy. EFFACE will propose effective and feasible policy options for the EU to combat environmental crime. The recently adopted Environmental Crime Directive, the Ship-Source Pollution Directive, and the new provisions of the Lisbon Treaty have created new instruments and opportunities for increasing the effectiveness of EU measures against environmental crime through harmonisation and co-ordination. However, utilisation of these opportunities suffers from a serious lack of information on environmental crime: e.g. harmonisation measures based on the new Article 83(2) TFEU depend on the availability of reliable information on the impacts of environmental crime. EFFACE will help to address this gap by generating relevant information. Drawing on a combination of quantitative and qualitative approaches and data and an in-depth investigation of different types of environmental crime, EFFACE will provide an assessment of the main costs, impacts and causes of environmental crime in the EU, including those linked to the EU, but occurring outside its territory, complemented by a comprehensive analysis of the status quo in terms of existing instruments, actors and institutions. A SWOT analysis will identify strengths, weaknesses, threats and opportunities associated with the EUs current efforts to combat environmental crime. Feasible policy options for harmonisation and better co-ordination of actors will then be developed with the help of, i.a., typologies of different approaches to harmonisation, sanctioning and strategic enforcement. These policy options will consider the use of policy mixes and innovative approaches to govern such mixes. Stakeholder involvement in EFFACE through interactive policy analysis will promote mutual learning with and among a broad range of stakeholders.

Agency: European Commission | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2011-2 | Award Amount: 2.86M | Year: 2011

The objective of this project is to offer to the SMEs Associations the first integrated management solution for supporting vine growers throughout vineyard life cycle, from planting to harvesting, aiming at addressing quality and production variability issues by means of an advanced Decision Support System (DSS). This DSS will be based on the output of well established and consolidated models applied to viticulture, and will assist the users in day to day management procedures, thanks to a user friendly web interface, assessing for instance the unique watering needs of each single parcel, controlling the growth phase of the grape, along with its vigour and maturity, optimizing at the same time the usage of fertilizers and parasiticides and limiting operators intervention on the soil and on the plant. With the application of information technologies it will be possible to fine tune wine production within the vineyard, maximising the oenological potential of the vineyards, and providing the vine-growers with the following, continuously up to date information: 1)Indication on the type of grape to be grown in the vineyard, being able to differentiate the production in case several zones of the vineyard present different agronomical features; 2)Indication of the ripeness of the grapes; 3) Real time indication, through micro-meteorological stations, of the soil properties, weather forecasts, and other parameters (fertilizing, irrigation, etc.)that can influence both yield but most importantly quality of the harvesting. 4) Indication of soil variability, which is one of the key factors that can affect vine growth fruit development, quality and yield; 5) indications of the zone at risk of fungi or parasites attack; 6) understanding and managing the dynamics of soil, water and phenological stages.

Agency: European Commission | Branch: FP7 | Program: NoE | Phase: HEALTH-2009-2.3.2-1 | Award Amount: 16.97M | Year: 2009

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellence and their ability to contribute to a successful network. The structure of the proposed network significantly evolves prior concepts of network structure introducing new modes of research that have recently emerged. Comprising of 4 research clusters the core activities will include molecular cell biology of the parasite, host immunity, vector biology, population biology and systems biology. One arm of the network activities will be concerned with the timely and effective translation of research respecting the IP rights of partner institutes. The network will also contribute significantly to the production of the next generation of malaria researchers through the operation of an expanded European PhD School for malaria research based at EMBL, students enjoying two supervisors based in different member states. Bespoke training courses for PhD students and network personnel will be offered throughout the duration of the network to maximise individual potential. To create a long term benefit from network activities a limited programme of post-doctoral fellowships within the network will be established. Furthermore, individual career mentoring facilities and an alumni association will continue to guide and engage network graduates. New members will be affiliated annually on a competitive basis with an emphasis on young, emerging Principle Investigators. Through the establishment of an umbrella Foundation and active lobbying of government and non-government funding agencies as well as the establishment of a charitable profile the network will strive to become self-determining.

Agency: European Commission | Branch: FP7 | Program: CP-IP-SICA | Phase: ENV.2009. | Award Amount: 7.77M | Year: 2009

Urban settlements, following the economic crisis of the 70s, entered in a process of regional and urban restructuring to gain a new image at the international level. As a result of the renewed economic success new flows of permanent, semi-permanent, temporary and daily human mobility followed: (i) for consumption (leisure and tourism), (ii) for production (economic migration). The world competition among metropolitan areas highlighted the essential importance of natural and cultural resources. The proposal considers the effects of human mobility on urban settlement growth and restructuring in coastal areas where (i) environment is more fragile and space limited, (ii) every phenomenon is more concentrated and (iii) effects on natural and cultural environment are more acute. Problems are multiplied since the climate change affecting environmental parameters - as sea levels - augments risks of flooding, propagation of pollutants, dislocation of a great number of settlers. Controlling and reducing unwanted consequences is contributing to growing conflicts among stakeholders. An integrated ecosystem approach incorporating social, economic and natural disciplines is essential in understanding and dealing with the complex and dynamic problems facing the coastal city environments. The proposal intends to: (i) identify conflicts, (ii) analyze their quantitative and qualitative effects on the environment, (iii) create models to synthesize the complexity of the different social, economic and environmental systems, (iv) compare the priority of each typology through taxonomy. Outcomes include (i) elaboration of an analysis methodology, (ii) creating tools for appropriate policies, (iii) scenario building, (iv) disseminationexploitation of results for users needs. The project will analyse 8 metropolitan areas of global importance and 8 of local importance in European and Asian countries (Belgium, Portugal, Italy, Sweden, United Kingdom, Israel, India, and Vietnam)

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 3.46M | Year: 2009

Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with pathogenesis of different human diseases, including cancer. NotchIT integrates the research and training activities of the eight different partners, who are all leaders in Notch signaling and related fields, to specifically address three strategic initiatives, which are central to European science and health economy: - the core Notch signaling mechanism with the purpose of constructing a state-of-the-art molecular tool box for Notch signaling and to disseminate this knowledge and reagents at a pan-European level. - the role of Notch signaling in the differentiation and pathology of various cell types with the purpose of using Notch signaling to improve our means to steer stem cell differentiation and to correct aberrant Notch signaling in pathologies. - how Notch signaling can be exogenously controlled through pharmacological approaches, in order to break new ground and to ultimately design new diagnostic and therapeutic protocols. The training component in NotchIT is deeply integrated with the research programme. The partners in NotchIT possess a wide range of expertise and work in operationally diverse environments: Hospitals, Universities, Research Institutes and Industry. This broad knowledge-base, combined with an integrated set of courses, workshops, meetings and cross-laboratory visits, provides an excellent training opportunity for early stage and experienced scientists in the center, and will prepare them for high level positions in academia and industry.

Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-2.2.1 | Award Amount: 10.36M | Year: 2013

Preparing ESNII for HORIZON 2020 The aim of this cross-cutting project is to develop a broad strategic approach to advanced fission systems in Europe in support of the European Sustainable Industrial Initiative (ESNII) within the SET-Plan. The project aims to prepare ESNII structuration and deployment strategy, to ensure efficient European coordinated research on Reactor Safety for the next generation of nuclear installations, linked with SNETP SRA priorities. The ESNII\ project aims to define strategic orientations for the Horizon 2020 period, with a vision to 2050. To achieve the objectives of ESNII, the project will coordinate and support the preparatory phase of legal, administrative, financial and governance structuration, and ensure the review of the different advanced reactor solutions. The project will involve private and public stakeholders, including industry, research and academic communities, with opened door to international collaboration, involving TSO.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: TPT.2011.2-1. | Award Amount: 1.53M | Year: 2011

OPTIMISMs main outcomes is the creation and development of different sets of strategies and methodologies for optimising passenger transport systems based on co-modality ICT solutions. OPTIMISM also takes into consideration the passenger needs and the carbon-neutral objective. The main scope is to provide a scientifically documented insight of the transport system and peoples travel choices via the study of social behaviour, mobility patterns and business models.This will also allow to define future changes in the passengers travel system that would lead to more sustainable method/mode(s) of travelling. OPTIMISM will base its operating principles in three main blocks of activities: 1. Identifying the gaps and harmonisation of data in travel behaviour. This will lead to a unified set of data that will serve as reference material for future exploitation of existing studies and baseline information (or data) 2. Definition of the demand and supply factors that shape the transportation system and mobility patterns. This will aim to give an outlook on future development(s) by modelling and scenario simulation and 3. Defining the potential decarbonisation of the passenger transport system and ensuring the sustainability of the system. The decarbonisation potential and co-benefits of best practice(s)/solutions will be based upon an analysis of ICT and co-modality options with an impact assessment of the research results The OPTIMISM partners will combine and utilise multidisciplinary skills, expertise, and on-going work in the fields of climate friendly transport, foresight, modelling, socio-economics, mobility behaviour, ITS and transport policy development. A network with Pan-European and beyond coverage, has been appointed to lead the dissemination relevant tasks in order to ensure the widespread dissemination of results but also to allow access to various information sources relating to national surveys.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-17-2014 | Award Amount: 6.43M | Year: 2015

Cardiovascular diseases (CVD) cause over 4 million deaths in Europe each year and mass disability: within the coming decades the disability-adjusted life years (DALYs) estimate is expected to rise from a loss of 85 million DALYs in 1990 to a loss of 150 million DALYs globally in 2020. Moreover, patient numbers are expected to rise rapidly in the next decades, due to an ageing society such that the burden of CVD for both patients and the healthcare sector will further rise. Cardiac rehabilitation (CR) is recognised as an effective approach for risk reduction and long term care of patients facing cardiovascular diseases (CVD). However, knowledge on CR in the elderly is limited, while tailoring of CR programmes to the elderly is needed. The reasons for this relates to the following aspects: 1) the elderly account for the majority of cardiac admissions and procedures, yet studies on cardiac rehabilitation have traditionally focused on younger patients, 2) many older patients who would derive benefit from CR interventions, do not participate, 3) there is a lack of commitment and adherence to CR within in the older population with only a minority completing the full programme and 4) a cardiovascular event in elderly patients could be a trigger for disability and dependence. Knowledge is lacking on effective approaches for this specific target group and moreover the specific challenges related to the target group must be addressed. With the ambition to achieve a breakthrough in cardiac care, the main objective of EU-CaRE is thus to obtain the evidence base to improve, tailor and optimise CR programmes regarding sustainable effectiveness, cost-effectiveness and participation level in the elderly. This is achieved through an comparative effectiveness analysis of current conventional cardiac rehabilitation programmes (CR), as well as new innovative mobile telemonitoring guided cardiac rehabilitation (mCR). As such, the project addresses the objectives of call PHC 17.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2011-6;SP1-JTI-ARTEMIS-2011-1 | Award Amount: 12.01M | Year: 2012

The SESAMO project addresses the root causes of problems arising with convergence of safety and security in embedded systems at architectural level, where subtle and poorly understood interactions between functional safety and security mechanisms impede system definition, development, certification, and accreditation procedures and standards. Intense market innovation is being held back by this root cause: the absence of a rigorous theoretical and practical understanding of safety and security feature interaction. The proposed solution is to develop a component-oriented design methodology based upon model-driven technology, jointly addressing safety and security aspects and their interrelation for networked embedded systems in multiple domains (e.g., avionics, transportation, industry control). Key elements of the SESAMO approach are: a methodology to reduce interdependencies between safety and security mechanisms and to jointly ensure their properties constructive elements for the implementation of safe and secure systems procedures for integrated analysis of safety and security an overall design methodology and tool-chain utilizing the constructive elements and integrated analysis procedures to ensure that safety and security are intrinsic characteristics of the system. The relevance of the SESAMO results is guaranteed by the involvement of large partners with significant economic interests in safety and security critical systems in the use case domains: automotive, aerospace, energy, mobile medical, and metropolitan rail transport; a sound group of technology providers (including SMEs); and prestigious research entities (academia and institutes) with deep and complementary multi-domain expertise. SESAMO will enable cost-efficient and systematic design, analysis, development, and assessment of distributed safety and security critical embedded systems. The results will have broad, cross-domain applicability in numerous strategic sectors of European industry. Approved by ARTEMIS-JU on 22/02/2012, Amendment 1 approved by ARTEMIS-JU on 27/02/2014, Amendment 2 approved by ECSEL-JU on 18/02/2015.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 3.60M | Year: 2010

The potential of Mobile wireless Adhoc Networks (MANET) is significantly high. However, MANET applications often happen in infrastructure-less or remote regions where remote connectivity to the outside world has to be provided by some other means. Satellite is one of the solutions to provide this and sometimes the only solution. Current expectations dictate that satellite will be seen not only as a component of an alternative routing path but also as part of a unique (really integrated) system.\n\nThe concept of a hybrid MANET-Satellite network is therefore a natural evolution of considering the problem of providing local and remote connectivity in a highly mobile, dynamic and often remote environment. MONET (Mechanisms for Optimization of hybrid ad-hoc and satellite NETworks) will study the challenges of such composite networks with particular focus on the following:\n\tOptimising network resources and link availability;\n\tProviding Quality of Service (QoS) and Quality of Experience (QoE);\n\tAnd minimizing costs and energy.\n\nIssues such as the re-organisation of MANET to connect to satellite access points, re-organisation of the satellite access points, selection of which satellite access points to use, the use of satellite as a relay between two MANET, the adjustment of routing in accordance with the current network situation and the exchange of cross layer information to improve resource management will be investigated.\nMONET innovates by considering the end-to-end optimization of resource management in a hybrid network, taking into account its impact on both the MANET and satellite segments. MONET architecture will be as terrestrial technology-agnostic as possible. MONET will propose and develop solutions for the optimization of a hybrid MANET-Satellite network, implement prototypes of the most promising algorithms and protocols and test them using COTS hardware in both laboratory and in the field, using several use-case scenarios.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.5-03 | Award Amount: 7.70M | Year: 2012

Water4Crops provides a combination of technical improvements in the field of bio-treatment and agricultural water use within a transdisciplinary identification of novel agri-business opportunities. Water4Crops aims at: a) developing innovative biotechnological wastewater treatments for improved water recycling, b) initiating the co-creation of alternative combinations of bio-treatment, recycling of high value elements, and combinations for bioproducts leading to a better commercialization of biotechnology and agricultural products in Europe and India, c)improving water use efficiency at field level through agronomics, plant breeding and locally adapted new irrigation technologies and accurate crop water requirement measurements techniques. Water4Crops will boost bio-based economy by applying a double track approach. First a comprehensive set of key Green-Economy technologies for: 1) valorization of volatile fatty acids; 2) obtaining: natural antioxidants (polyphenols), biopolymers (PHAs), energy (biomethane); 3) new substances for selective recovery of valuable products from wastewater; 4) tailoring effluent properties from decentralized innovative bioreactors; 5) low bio-sludge production by SBBG Reactors; 6) removal of organopollutants by nanobiocatalysts; 7) reduced clogging of wetlands; 8) virus monitoring detection assays; 9) suitable precision irrigation systems for reclaimed water; 10) new monitoring for increase crop water productivity; 11) understanding the genetic mechanisms regulating drought-adaptive traits across maize, sorghum, millet and tomato; 12) optimized waste water related combinations of species/genotypes x environment x management. Second, new product market combinations will be identified. The co-creation process will be organized by two Mirror cases (Emilia Romagna area in Italy and Hyderabad region in India) within a specific Science-Practice Interface (INNOVA platforms). Developing the new applications and business opportunities with regional enterprises and stakeholder will move India and Europe towards a Green Economy.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.95M | Year: 2015

Photonics, nanotechnology, advanced materials, and advanced manufacturing technologies have been identified as key enabling technologies (KETs) for the EU. Today the photonics global market alone is around 300 billion and Europe has established a strong position with a total share of 20%, directly employing about 290,000 people. However, the shortage of sufficient skilled labour and entrepreneurs capable of handling the highly multi-disciplinary nature of KETs remains a major problem in the EU. Tailoring of semiconductors at the nanoscale is an important enabling technology for a wide range of photonics and electronics applications in diverse areas. In the training network proposed here, a cohort of 15 early stage researchers will be trained in the full range of skills required for a career in photonics, including materials growth, device fabrication, characterisation, design, theory, and commercialisation. A carefully-chosen, well-balanced consortium of 8 academic partners, 2 full industry partners and 7 associated partners are well placed to provide the training in these skills, with European and worldwide reputations as leaders in each field. These skills will be developed within four burgeoning research areas; Semiconductor Metamaterials & Plasmonics, Dilute Nitride semiconductor nanostructures, Hydrogenated Semiconductors and Metamorphic structures. The outcomes of this enabling fundamental research are well focused to deliver advances in sources for secure communications, sensitive detectors for security applications, more efficient solar cells for energy generation, LEDs and sensors for environmental gas and bio-sensing. Each researcher will experience both academic and commercial environments thanks to the strong industrial involvement, resulting in multi-skilled, industry-focused graduates. PROMIS therefore directly addresses the need for additional skilled photonics professionals, as identified by the European Technology Platform, Photonics21.

Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 10.78M | Year: 2009

Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are struggling to cope with the challenges posed by the biology and ecology of mosquito vectors. INFRAVEC aims at bridging the gap between the recent advances in transgenic technology and its implementation as a novel powerful approach for vector control. To this aim, a large European Infrastructure will be established, in which the coordination of efforts, expertise and facilities provided by the individual research groups and institutions will bolster and considerably expand the overall research capabilities of the research community. INFRAVEC will operate, through a number of Networking, Joint Research, Transnational and Service activities, towards the objective of considerably strengthening research capability in Europe by sharing knowledge, resources and technology. INFRAVEC will mainly focus on Anopheles gambiae, the major vector of malaria, and Aedes albopictus, a viral disease vector that is rapidly spreading through Europe. Four Infrastructure facilities will be integrated in the project: 1) the Genetically Modified mosquito laboratory of Imperial College London; 2) the Mosquito Mass-rearing facility at the Centro Agricoltura ed Ambiente (with the support of the International Atomic Energy Agency); 3) the Bioinformatics facility at EMBLEBI, UK; and 4) the Mosquito Confined Release facility at ISRIM. INFRAVEC will provide a formidable research capability to external users and facilitate the performance of five research projects aimed at utilizing basic knowledge of mosquito genetics and biology in an unprecedented effort to develop novel opportunities for mosquito control.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: FI.ICT-2013.1.9 | Award Amount: 36.30M | Year: 2014

FI-WARE has started to materialize as a powerful foundation for the Future Internet. FI-WARE is an innovative, open cloud-based infrastructure for cost-effective creation and delivery of services, at a scale not seen before. FI-WARE is now well under way to successfully achieve its goals of boosting the effectiveness of creating new services of high economic and societal value, reinforcing EU competitiveness and bringing opportunities for high-growth entrepreneurs and SME players.\n\nNow, following an intensive period of research, development and experimentation, the FI-Core Consortium aims to complete the FI-WARE vision and support a truly open innovation ecosystem around FI-Lab, a working instance of FI-WARE that is distributed across multiple datacenters in Europe and is effectively operated using the suite of FI-Ops tools. In this project, the FI-Core consortium will deliver a)Technology extensions, introducing new capabilities to the platform, b) means for platform availability, including the launch of operational FI-Ware nodes across Europe with resources and tools to support them, as well as extensive FI-Ware education and training programs for Web entrepreneurs and SMEs plus c) Processes and tools for platform sustainability, dissemination of current and on-going results, namely FI-WARE, FI-Ops and FI-Lab. These will be a globally competitive foundation for Europes economy.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-28-2015 | Award Amount: 3.33M | Year: 2016

12% of the developed world suffers from congestive heart failure (CHF), which is the most frequent cause of hospitalization in people aged over 65. CHF management involves medications, monitoring of fluid intake and weight, exercise and lifestyle modifications. Since most patients are elderly and suffer from co-morbidities, they have difficulty adhering to the management guidelines, which often leads to poor outcomes. The HeartMan project will develop a personal health system to help CHF patients manage their disease. Its core will be a decision support system that will provide personalised advice to the patients. Its first key feature will be evidence-based predictive models: a short-term model developed in the European project Chiron, and long-term models adapted to focus on modifiable parameters that can improve the patients predicted outcomes. Its second key feature will be the delivery of the advice through a cognitive behavioural therapy based on cognitive dissonance. This is a proven approach that exploits the dissonance between healthy attitudes and unhealthy behaviours to improve the behaviours. It will be augmented by mindfulness exercises, which are expected to make the patients more receptive to the HeartMans advice. The system will also feature advanced health devices and monitoring methods to understand the patients physical and psychological state, and standard-based data management for wide interoperability. In developing the HeartMan system, a human-centred approach will be used. The resulting system will be validated in two trials, which will test its medical effectiveness and usability. The project will also have strong dissemination and exploitation. To ensure industry-standard robustness, the industrial partners will have key role in developing the prototypes, and the documentation necessary for certification as a medical device will be prepared. All the consortium will be involved in IPR management and the building of business models.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SST.2013.2-2. | Award Amount: 15.00M | Year: 2013

In 2011, the White Paper on European Transport reasserted how fundamental transport was for society, for the mobility of European citizens and for the growth and vitality of the European economy. CAPACITY4RAIL will deliver research that is innovative, prepares rail for the future and takes into account results from previous research projects and programmes. The project builds on previous useable results and will deliver both technical demonstrations and system wide guidelines and recommendations that will be the basis for future research and investment, increasing the capacities of rail networks in the future. The time used for infrastructure monitoring, maintenance and renewal means down time. New concepts for low maintenance infrastructure, using standardized and plug-and-play concepts will be proposed. Non-intrusive innovative monitoring techniques or self-monitoring infrastructure will be investigated, allowing low or no impact on train operations. The fragility of some key component of the infrastructure system (especially in extreme weather conditions) such as switches may impact the efficiency of the whole system. The resilience of switches to any kind of known failure will be reinforced, as well as the ability of the operation system to recover from incidents. Capacity enhancements will also be achieved by higher speed freight vehicles, allowing an optimized interleaving of freight trains into mixed traffic, and improved planning models for operation. Intermodal integration within the global transport system will be improved through enhanced transhipment of passengers and freight. CAPACITY4RAIL will also look towards 2030/2050, by proposing guidelines for future deployments in the mid-term, recommendations for technologies to de developed and deployed in the long term and investigating the key opportunities for funding these within national and EU funding schemes.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-2.1-2014 | Award Amount: 18.00M | Year: 2015

IN2RAIL is to set the foundations for a resilient, consistent, cost-efficient, high capacity European network by delivering important building blocks that unlock the innovation potential that exists in SHIFT2RAIL: innovative technologies will be explored and resulting concepts embedded in a systems framework where infrastructure, information management, maintenance techniques, energy, and engineering are integrated, optimised, shared and exploited. IN2RAIL will make advances towards SHIFT2RAIL objectives: enhancing the existing capacity fulfilling user demand; increasing the reliability delivering better and consistent quality of service; reducing the LCC increasing competitiveness of the EU rail system. To achieve the above, a holistic approach covering Smart Infrastructures, Intelligent Mobility Management (I2M)and Rail Power Supply and Energy Management will be applied. Smart Infrastructure addresses the fundamental design of critical assets - switches and crossings and tracks. It will research components capable of meeting future railway demands and will utilise modern technologies in the process. Risk and condition-based LEAN approaches to optimise RAMS and LCC in asset maintenance activities will be created to tackle the root causes of degradation. I2M researches automated, interoperable and inter-connected advanced traffic management systems; scalable and upgradable systems, utilising standardised products and interfaces, enabling easy migration from legacy systems; the wealth of data and information on assets and traffic status; information management systems adding the capability of nowcasting and forecasting of critical asset statuses. Rail Power Supply and Energy Management create solutions to improve the energy performance of the railway system. Research on new power systems characterised by reduced losses and capable of balancing energy demands, along with innovative energy management systems enabling accurate and precise estimates of energy flows.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2011.2.4.2-1 | Award Amount: 14.96M | Year: 2012

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke. Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so its social and economic burden will grow with the ageing of the European population. Current treatment options for the 80 to 85% of all strokes due to cerebral ischaemia - around. 900,000 events in Europe every year, or one every 40 seconds - are extremely limited. Systematic review of experimental studies suggests that hypothermia is the most promising intervention identified to date. Therapeutic cooling is effective in reducing ischaemic brain injury following cardiac arrest, and hypothermia is therefore considered by experts the most promising treatment for patients with acute ischaemic stroke, next to reperfusion strategies. The EuroHYP-1 trial is a pan-European, open, randomised, phase III clinical trial which will assess the benefit or harm of therapeutic cooling in 1500 awake adult patients with acute ischaemic stroke. In addition to efficacy and safety, the economic impact of therapeutic hypothermia will be assessed, along with several sub-studies involving imaging, ultrasound, and biomarker methods. The investigators involved in the EuroHYP-1 consortium are leading European experts in statistical design and analysis, therapeutic hypothermia, imaging, health economics, ultrasound, biomarkers, and trial execution (implementation and monitoring). Moreover in addition to these academic experts the consortium also involves European patient and family advocacy groups and small and medium-size enterprises, and the joint endeavours of this extended team will ensure the successful enrolment of patients at eighty hospitals across 25 countries in Europe.

Agency: European Commission | Branch: FP7 | Program: CP-IP-SICA | Phase: HEALTH.2010.2.3.2-4 | Award Amount: 15.40M | Year: 2011

The AvecNet consortium will develop practical solutions to the current limitations of vector control strategies in Africa using a combination of translationally-aware, state of the art science and end user analysis to ensure successful development and uptake of the new and improved approaches to malaria control and elimination. Our carefully balanced, multidisciplinary team of European and African experts includes vector biologists, engineers, epidemiologists, social scientists and leaders of large supranational consortia. These partners are all prominent members of global vector control research programs having unique specialization in Africa-centric projects. Together we have developed a proposal focused specifically to address the three major research challenges that confront efforts to interrupt mosquito-mediated transmission of malaria in Africa: 1. The need for practical strategies to prolong the efficacy of existing insecticide-based vector control methods, 2.The need to develop new interventions that target all major malaria vectors, that are simultaneously effective, socially acceptable and sustainable, 3. The impact of the major demographic and environmental changes occurring in Africa on malaria epidemiology and control. These research activities are cross-linked by specific tasks to reinforce our commitment to ensure sustainability, engage all stakeholders and strengthen research capacity in Africa. Overall, the project will add significant value to the international research effort in vector control by taking forward the state of the art and translating this into new or improved control tools that will be trialled within the time frame of this project. The studies planned in this collaborative project will provide scalable solutions, giving the solid platform upon which ongoing and future vector control programmes can be built.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: Health | Award Amount: 2.25M | Year: 2015

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Information Portal To achieve our aims, EuroStemCell will adopt the highly structured system for coordinated information management established by the FP7 Coordination and Support Action (CSA) also called EuroStemCell. From this, we will implement an ambitious programme of online and direct stakeholder engagement with stem cell research and regenerative medicine, aimed at European citizens at all educational levels. This will include provision of resources tailored specifically for decision-making on stem cell-related questions and an extensive programme of dissemination and capacity building in science communications and public engagement. The proposed work centres on an information hub team, which will link to all project partners and to stakeholders in the stem cell and regenerative medicine arenas and wider society, working with these groupings to implement the project. All outputs will be delivered in 6 European languages, to ensure broad accessibility, and will be rigorously evaluated against measurable objectives throughout the project duration. The proposed consortium comprises leading stem cell labs across Europe, including new member states, together with experts in ethical and societal concerns and evaluating clinical outcomes. It thus provides unparalleled European expertise across the fields of stem cell biology and regenerative medicine and is uniquely placed to maintain and further develop as a world-leading stem cell information resource, thus meeting the challenge outlined in Topic HOA-6-2014.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST.2008.2.5.1 | Award Amount: 5.55M | Year: 2009

The certification of a rail vehicle according to European regulations, Technical Specifications for Interoperability, European Standards and national safety rules represents a significant element of both vehicle cost and time to market. Indeed, a large part of vehicle certification mandates testing for safety, performance and infrastructure compatibility. The new EN standards together with the CR/HS RST and INS TSI define test conditions and limit values for tests for acceptance of running safety parameters. DYNOTRAIN will contribute to the practical implementation of interoperability of railways systems across Europe by checking for inconsistencies and open points in the existing acceptance criteria and by proposing revisions of acceptance criteria in European standards and resolutions to close relevant open points in the TSI. The project aims at decreasing the costs associated with certification without reducing the safety level to enhance the competitiveness of rail traffic. The project is part of the TRIO-TRAIN cluster (Total Regulatory Acceptance for the Interoperable Network) which comprises 3 related projects dealing with key railway interoperability issues: Aerodynamics (AEROTRAIN), Railway Dynamics and Track Interaction (DYNOTRAIN) and Pantograph/Catenary Interaction (PANTOTRAIN) all submitted under the 2nd Call of the FP7. The objective of these projects is to propose an innovative methodology via a computer simulation/virtual homologation that will allow multi-system network and route approval in Europe to become a faster, cheaper and better process for all involved stakeholders. Therefore the success of the TRIOTRAIN cluster will lead to a time reduction for relevant parts of the certification process from 24 to 6 months; an 80% saving in effort for the acceptance of a new vehicle already accepted in an other country and an estimated financial saving of 20-50 Million/year.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: ENV.2011.2.1.5-1 | Award Amount: 8.94M | Year: 2011

The TURaS project aims to bring together urban communities, researchers, local authorities and SMEs to research, develop, demonstrate and disseminate transition strategies and scenarios to enable European cities and their rural interfaces to build vitally-needed resilience in the face of significant sustainability challenges. To ensure maximum impact, the TURaS project has developed an innovative twinning approach bringing together decision makers in local authorities with SMEs and academics to ensure meaningful results and real change are implemented over the duration of the project. 11 local authorities or local development agencies are involved as partners in the project and they will orient research and development from the outset towards the priority sustainability and resilience challenges facing their cities. 9 leading academic research institutions and 6 SMEs will work with these cities helping them to reduce their urban ecological footprint through proposing new visions, feasiblity strategies, spatial scenarios and guidance tools to help cities address these challenges. The specific challenges addressed in TURaS include: climate change adaptation and mitigation; natural resource shortage and unprecedented urban growth. Over the five year duration of the project, the feasibility of these new approaches will be tested in selected case study neighbourhoods and new measures to enable adaptive governance, collaborative decision-making, and behavioural change towards resilient and sustainable European cities will be tested. The impact of these new approaches will be measured and results compared between participating cities before a final set of strategies and tools will be developed for demonstration, dissemination and exploitation in other European cities. SMEs are highly involved in all work packages of the project and specific measures have been put in place to ensure the optimal economic impact of the project is achieved.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA-2007-1.1-02 | Award Amount: 15.27M | Year: 2009

Within the context of the GMES Initiative, the G-MOSAIC Collaborative Project aims at identifying and developing products, methodologies and pilot services for the provision of geo-spatial information in support to EU external relations policies and at contributing to define and demonstrate sustainability of GMES global security perspective. The activities will be devoted to: Investigate the operational exploitation of GMES services as assets supporting security related activities on External Regional Crises Situations; Contribute to identify the Core and Downstream geo-spatial intelligence Services, in the framework of current status of GMES Initiative; Disseminate the knowledge on GMES potential impact on Security related User Community; Contribute to build a political consensus on GMES Services for Security; promote the construction of a European inter-pillar capability for the monitoring services and infrastructures; Assess a sustainable provision and funding model for GMES Security Services; provide recommendations for next sensors for security services. Reference Users are: DG-RELEX (and DGs Development, ECHO, Environment, etc.); Council Entities: EU Military Staff, Situation Centre; National Institutions: Ministries of Foreign Affaires, Intelligence Centres. The proposed service cases, built with the reference users, will support Situation Awareness and Intelligence applications and Crisis Management Operations. In the first domain, the deployed services provide information on major Threat Warning Factors (illegal activities, critical assets monitoring, WMD proliferation control, crisis indicators assessment, extended routes surveillance); these products contribute to understand where, outside of Europe, Regional Crises (state failure, ethnic conflicts, government instability) can occur; In the second domain, for identified Crisis Scenarios, the deployed services support the intervention activities: crisis planning and management, damage assessment, reconstruction and resilience.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.5.2 | Award Amount: 16.43M | Year: 2013

MD-Paedigree is a clinically-led VPH project that addresses both the first and the second actions of part B of Objective ICT-2011.5.2:\n1. it enhances existing disease models stemming from former EC-funded research (Health-e-Child and Sim-e-Child) and from industry and academia, by developing robust and reusable multi-scale models for more predictive, individualised, effective and safer healthcare in several disease areas;\n2. it builds on the eHealth platform already developed for Health-e-Child and Sim-e-Child to establish a worldwide advanced paediatric digital repository.\nIntegrating the point of care through state-of-the-art and fast response interfaces, MD-Paedigree services a broad range of off-the-shelf models and simulations to support physicians and clinical researchers in their daily work. MD-Paedigree vertically integrates data, information and knowledge of incoming patients, in participating hospitals from across Europe and the USA, and provides innovative tools to define new workflows of models towards personalised predictive medicine. Conceived of as a part of the VPH Infostructure described in the ARGOS, MD-Paedigree encompasses a set of services for storage, sharing, similarity search, outcome analysis, risk stratification, and personalised decision support in paediatrics within its innovative model-driven data and workflow-based digital repository. As a specific implementation of the VPH-Share project, MD-Paedigree fully interoperates with it. It has the ambition to be the dominant tool within its purview. MD-Paedigree integrates methodological approaches from the targeted specialties and consequently analyzes biomedical data derived from a multiplicity of heterogeneous sources (from clinical, genetic and metagenomic analysis, to MRI and US image analytics, to haemodynamics, to real-time processing of musculoskeletal parameters and fibres biomechanical data, and others), as well as specialised biomechanical and imaging VPH simulation models.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.2.2 | Award Amount: 25.84M | Year: 2009

The European robotics industry plays a key role in maintaining our continents industrial base. The robotics industry is strong, but fragmented and dispersed. In the future, cutting-edge technology resulting from top-level research will be the decisive factor for success. Europe not only has a powerful robotics industry, but can also boast superb research. By drawing on these resources, ECHORD aims at producing new knowledge through advancing the state of the art in selected research foci and developing novel technology from which new products can be derived. Within ECHORD, opportunities for knowledge advancement and technology transfer between academia and industry will be created across the whole continent. This will be achieved through the solicitation of focused, small-size RTD projects, so-called experiments, which can be rapidly negotiated, funded and executed. Via these experiments, ECHORD will bring about a large-scale introduction of robotic equipment into research institutions. This is expected to result in both tangible and measurable out-comes in terms of the accelerated development of technologies, as well as the deployment of robotics technology into new scenarios for the direct application of research results. For ECHORD, three such scenarios have been defined: human-robot co-working, hyper flexible cells, and cognitive factories. The foremost purpose of the scenarios is to define an environment that is both scientifically challenging to research institutions and commercially relevant to robot manufacturers.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SST.2012.3.1-4. | Award Amount: 15.65M | Year: 2012

European cities face four main mobility problems: congestion, land use , safety and environment. One of the main causes of such problems is the car-ownership rate. The centres of large cities address this issue combining efficient mass transits with car restriction policies but peripheral areas and smaller cities remain dominated by private cars. CityMobil has demonstrated how automating road vehicles can lead to different transport concepts, from partly automated car-share schemes through CyberCars and PRT, to BRT which can make urban mobility more sustainable. However CityMobil has also highlighted three main barriers to the deployment of automated road vehicles: the implementation framework, the legal framework and the unknown wider economic effect. The CityMobil2 goal is to address these barriers and finally to remove them. To smooth the implementation process CityMobil2 will remove the uncertainties which presently hamper procurement and implementation of automated systems. On one hand CityMobil2 features 12 cities which will revise their mobility plans and adopt wherever they will prove effective automated transport systems. Then CityMobil2 will select the best 5 cases (among the 12 cities) to organise demonstrators. The project will procure two sets of automated vehicles and deliver them to the five most motivated cities for a 6 to 8 months demonstration in each city. To change the legal framework CityMobil2 will establish a workgroup with scientists, system builders, cities, and the national certification authorities. The workgroup will to deliver a proposal for a European Directive to set a common legal framework to certify automated transport systems. Finally an industrial study will assess the industrial potential of automated systems on European economy and any eventual negative effect and make a balance of them.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2008-3 | Award Amount: 36.29M | Year: 2009

The mission of the SOFIA project is to create a semantic interoperability platform and selected set of vertical applications to form an embedded system based smart environment. We vision smart environment application and services where all the information user wants, needs and should know from local place is easily available. A key factor in these smart environments will be a common, open way of accessing information of devices in any space. Connecting real physical world with information world enriches the user experience. Simple, local mash-up applications based are build on open data and devices. This is an Internet-like revolution in physical space. Main goal of the project is to make \embedded information\ in the physical world available for smart services - connecting physical world with information world. Common targets are to enable and maintains cross-industry interoperability, to foster innovation while maintaining value of existing legacy and to create new user interaction and interface concepts to enable users to benefit from smart environments. In particular, a major target is multi-vendor interoperability platform as platform for new services. The project addresses three application areas which represent different kind of spaces, in terms of scale and potential applications and services. Spanning from very local personal spaces, to smart housing and further to smart city the project captures the specific aspects of smart spaces and combines the requirements for common solutions. The key outcomes of the project relate to user interaction paradigms for interacting in smart environments, the common interpretability solution between many heterogeneous devices and embedded systems, and on the application development schemes that can mobilise new developers for smart environments.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2007-3.1-3 | Award Amount: 19.08M | Year: 2008

iNTeg-Risk is a large-scale integrating project aimed at improving the management of emerging risks in the innovative industry. This will be achieved by building a new risk management paradigm for emerging risks, which is a set of principles supported by a common language, commonly agreed tools & methods and Key Performance Indicators integrated into a single framework. As main impact, it will reduce time-to-market for the lead market EU technologies and promote safety, security, environmental friendliness and social responsibility as a trade-mark of the advanced EU technologies. The project will improve early recognition and monitoring of emerging risks, seek to reduce accidents caused by them (estimated 75 B/year EU27) and decrease reaction times if major accidents involving emerging risks happen. iNTeg-risk will reach its goals by promoting a EU-wide cross-sectorial life-cycle-based integration across all major disciplines, methods and tools as well as through integration of all relevant stakeholders. The project will be initiated from an empirical basis of 17 individual emerging risk issues (Emerging Risk Representative industrial Applications), and generalize their solutions addressing new technologies, products/materials, production and policies. The solutions will be validated in a second application cycle, and the overall solution made available to stakeholders in the form of the iNTeg-Risk platform: a one-stop shop for EU solutions addressing emerging risks. It will feature issues of early recognition and monitoring of emerging risks, communication, governance, pre-standardization, education & training, dissemination, as well as new tools such as Safetypedia, Atlas of Emerging Risks, Reference Library... The project has a solid industry leadership and involves the leading EU R&D institutions. It is coordinated by the European Virtual Institute for Integrated Risk Management, the EEIG guaranteeing the sustainability of the results after the project.

Boguna M.,University of Barcelona | Castellano C.,CNR Institute for Complex Systems | Castellano C.,University of Rome La Sapienza | Pastor-Satorras R.,Polytechnic University of Catalonia
Physical Review Letters | Year: 2013

We develop an analytical approach to the susceptible-infected-susceptible epidemic model that allows us to unravel the true origin of the absence of an epidemic threshold in heterogeneous networks. We find that a delicate balance between the number of high degree nodes in the network and the topological distance between them dictates the existence or absence of such a threshold. In particular, small-world random networks with a degree distribution decaying slower than an exponential have a vanishing epidemic threshold in the thermodynamic limit. © 2013 American Physical Society.

Monaco S.,University of Rome La Sapienza | Normand-Cyrot D.,University Paris - Sud | Tiefensee F.,University Paris - Sud
IEEE Transactions on Automatic Control | Year: 2011

Two sampled-data design procedures ensuring stabilization of passive systems are described in the general framework of passivity-based control (PBC) strategies. The first one makes reference to some modified output with respect to which passivity under sampling can be preserved. The second one can be interpreted as the sampled-data equivalent to the celebrated continuous-time stabilizing and damping Lg V-controller. A simulated example illustrates the performances. © 2006 IEEE.

Ricotta C.,University of Rome La Sapienza | Moretti M.,Swiss Federal Institute of forest
Oecologia | Year: 2011

Assessing the effects of environmental constraints on community structure often relies on methods that consider changes in species functional traits in response to environmental processes. Various indices have been proposed to measure relevant aspects of community trait composition from different viewpoints and perspectives. Among these, the 'community-weighted mean trait value' (CWM) and the Rao coefficient have been widely used in ecological research for summarizing different facets of functional composition and diversity. Analyzing changes in functional diversity of bee communities along a post-fire successional gradient in southern Switzerland we show that these two measures may be used to describe two complementary aspects of community structure, such as the mean and the dispersion of functional traits within a given species assemblage. While CWM can be adequately used to summarize shifts in mean trait values within communities due to environmental selection for certain functional traits, the Rao coefficient can be effectively applied to analyze patterns of trait convergence or divergence compared to a random expectation. © 2011 Springer-Verlag.

Carradori S.,University of Rome La Sapienza | Carradori S.,University of Chieti Pescara | Petzer J.P.,North West University South Africa
Expert Opinion on Therapeutic Patents | Year: 2015

Introduction: Monoamine oxidase (MAO) inhibitors, despite the initial pharmacological interest, are used in clinic for their antidepressant effect and in the management of Parkinson symptoms, due to the established neuroprotective action. Efficacy and tolerability emerged from large-scale and randomized clinical trials. Areas covered: Thirty-six patents range from April 2012 to September 2014. The number of chemotypes with inhibitory effects on MAO is truly high (40 synthetic compounds, 22 natural products and 6 plant extracts reported and licensed), and the present review is comprehensive of all compounds, which have been patented for their relevance to clinical medicine in this period range (27 patents). Moreover, some of the collected patents deal with new formulations of compounds endowed with MAO inhibitory properties (two patents) and new therapeutic options/drug associations for already known MAO inhibitors (seven patents). Expert opinion: The patents reported in this review showed that the interest in this field is constant and mainly devoted to the study of selective MAO-B inhibitors, used as drugs for the treatment of neurological disorders. The development of novel human MAO inhibitors took advantage of the discovery of new therapeutic targets (cancer, hair loss, muscle dystrophies, cocaine addiction and inflammation), the recognized role of MAOs as molecular biomarkers and their activity in other tissues. © 2015 Informa UK, Ltd.

Pastor-Satorras R.,Polytechnic University of Catalonia | Castellano C.,CNR Institute for Complex Systems | Castellano C.,University of Rome La Sapienza | Van Mieghem P.,Technical University of Delft | And 2 more authors.
Reviews of Modern Physics | Year: 2015

In recent years the research community has accumulated overwhelming evidence for the emergence of complex and heterogeneous connectivity patterns in a wide range of biological and sociotechnical systems. The complex properties of real-world networks have a profound impact on the behavior of equilibrium and nonequilibrium phenomena occurring in various systems, and the study of epidemic spreading is central to our understanding of the unfolding of dynamical processes in complex networks. The theoretical analysis of epidemic spreading in heterogeneous networks requires the development of novel analytical frameworks, and it has produced results of conceptual and practical relevance. A coherent and comprehensive review of the vast research activity concerning epidemic processes is presented, detailing the successful theoretical approaches as well as making their limits and assumptions clear. Physicists, mathematicians, epidemiologists, computer, and social scientists share a common interest in studying epidemic spreading and rely on similar models for the description of the diffusion of pathogens, knowledge, and innovation. For this reason, while focusing on the main results and the paradigmatic models in infectious disease modeling, the major results concerning generalized social contagion processes are also presented. Finally, the research activity at the forefront in the study of epidemic spreading in coevolving, coupled, and time-varying networks is reported. © 2015 American Physical Society. © 2015 American Physical Society.

Salvati L.,Council of Research in Agriculture | Carlucci M.,University of Rome La Sapienza
Ecological Economics | Year: 2011

This paper analyses the economic performances of the rural system and the level of land sensitivity to degradation in Italy. Three indicators (district value added, share of agriculture on total product, and a composite index of land sensitivity) were used to classify 784 Italian local districts into eight performance classes. Four classes share a combination of high environmental quality (in terms of land degradation), high (or low) economic performances, and high (or low) productivity of the primary sector. The remaining four are characterised by a combination of low (and declining) environmental quality, high (or low) economic performances, and high (or low) productivity of the primary sector. The eight classes were grouped into four 'environmental quality' types and four 'target performance' categories to discriminate among high- and low-performance districts by considering twelve additional variables within a Discriminant Function Analysis (DFA). 148 high environmental performance districts (18% of total) were identified mainly across the Alps and Apennine while 314 districts (41%) were classified in the lowest performance class and concentrated in flat areas of southern Italy. The districts with high environmental performances were characterised, on average, by medium to low district value added, moderately low economic weight of the primary sector, and tourism specialisation. Districts with high economic performances and low environmental performances were characterised by high sensitivity to LD, low district value added, high share of agriculture in total product, and the lowest productivity of labour in all economic sectors. In these districts the risk of entering a downward spiral of rural poverty and environmental degradation is potentially high. © 2011 Elsevier B.V.

Hassoun J.,University of Rome La Sapienza | Croce F.,University of Chieti Pescara | Armand M.,University of Picardie Jules Verne | Scrosati B.,University of Rome La Sapienza
Angewandte Chemie - International Edition | Year: 2011

(Graph Presented). A polymer makes it possible: Use of an advanced polymer electrolyte allowed clarification of the oxygen reaction mechanism in lithium-air solid-state batteries. The related reversible processes are identified to occur at potential values that are the lowest ever reported in the absence of catalyst. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

Neri I.,CNRS Charles Coulomb Laboratory | Metz F.L.,University of Rome La Sapienza
Physical Review Letters | Year: 2012

We present the exact analytical expression for the spectrum of a sparse non-Hermitian random matrix ensemble, generalizing two standard results in random-matrix theory: this analytical expression constitutes a non-Hermitian version of the Kesten-McKay measure as well as a sparse realization of Girko's elliptic law. Our exact result opens new perspectives in the study of several physical problems modelled on sparse random graphs, which are locally treelike. In this context, we show analytically that the convergence rate of a transport process on a very sparse graph depends in a nonmonotonic way upon the degree of symmetry of the graph edges. © 2012 American Physical Society.

D'Elia M.,University of Genoa | Mukherjee S.,Brookhaven National Laboratory | Sanfilippo F.,University of Rome La Sapienza
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2010

We investigate the properties of the deconfining/chiral restoring transition for two flavor QCD in the presence of a uniform background magnetic field. We adopt standard staggered fermions and a lattice spacing of the order of 0.3 fm. We explore different values of the bare quark mass, corresponding to pion masses in the range 200-480 MeV, and magnetic fields up to |e|B∼0.75GeV2. The deconfinement and chiral symmetry restoration temperatures remain compatible with each other and rise very slightly (<2% for our largest magnetic field) as a function of the magnetic field. On the other hand, the transition seems to become sharper as the magnetic field increases. © 2010 The American Physical Society.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.6.1 | Award Amount: 4.66M | Year: 2012

SmartHG will develop economically viable Intelligent Automation Software services gathering real-time data about energy usage from residential homes and exploiting such data for intelligent automation pursuing two main goals: minimise energy usage and cost for each home, support the Distribution Network Operator (DNO) in optimising operation of the grid. SmartHG rests on the following four pillars.\n\nFirst, Internet-based open standard protocols enabling effective communication between: i) home devices (e.g., sensors, smart appliances, local generators, electric vehicles, energy storage) and SmartHG services; ii) SmartHG services and DNO software systems; iii) any pair of SmartHG services. This will enable development of hardware device-independent energy services, possibly on the basis of the services already available.\n\nSecond, user-aware SmartHG services focusing on residential homes. Such services will measure home energy usage and local generation (e.g., from renewable sources), forecast it and actuate home devices (both loads and generators) in order to minimise the home energy bill and usage (local optimisation) with respect to a given price policy computed to attain global (grid level) optimisation.\n\nThird, demand-side aware SmartHG services focusing on the grid. Such services will compute individual (yet fair) price policies for each single home taking into account user preferences while optimizing grid operations. Grid safety for such price policies will be formally verified using model-checking-based techniques. Furthermore, such SmartHG services will increase grid reliability by estimating and controlling (using price policies) voltages and currents in internal unmonitored nodes of the grid.\n\nFourth, SmartHG case studies in Kalundborg and Minsk will enable thorough technical, environmental and economical evaluation of project results.\n\nFinally, SmartHG consortium consists of three highly qualified and multidisciplinary clusters comprising: four research institutions focusing on Computer and Electrical Engineering, four Energy Service SMEs, two DNOs and a municipality. The resulting synergies will ensure the success of the project as well as the wide dissemination and the effective exploitation of the project results.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: AAT-2007-3.5-02 | Award Amount: 26.46M | Year: 2008

The HIRF SE research project has the goal of providing the aeronautics industry with a framework which can be used during the development phase to mitigate the EM aspects. In addition it will provide a considerable reduction in the certification/qualification tests required on air vehicle. The HIRF SE main objectives can be summarized by the two followings items: Full validated and integrated solutions to model, to simulate numerically and to test air vehicles for EM aspects during design and certification; To build (from past and ongoing works) an integrated approach with an open and evolutionary architecture. The HIRF Synthetic Environment expected results can be summarized by the following items: Capability to deal with the increased use of composite materials and structures by the airframe industry. The HIRF SE framework will include the most advanced computational models for the numerical simulation of the EM characteristics and performance of composite materials. Capability to deal with the complete internal and external electromagnetic environment (present and foreseen). The HIRF SE tool will be able to simulate a wide spread typology and number of EM (internal and external) interference sources. To take advantage of a large community to develop and issue a work on modelling of excellence. The result will be to develop and issue a work of excellence on EM modelling by gathering a large team of scientists, academic and industrial engineers, cooperating to build a reference tool of their own. A developed methodology/tool well recognized inside the civil aviation community in accordance with certification bodies. Taking into account the HIRF Synthetic Environment main objectives and the following expected results it is possible to affirm the HIRF SE project addresses the scope of work described in the FP7 Work Programme.

Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2011-IAPP | Award Amount: 1.88M | Year: 2012

The SOS project aims at establishing a strategic longer term industry-academia partnership to face the research challenges related to the development of non-intrusive and pervasive surveillance systems for indoor public areas, based on an innovative combinations of passive radar technology, novel detection and tracking systems in various electromagnetic frequency range, and sensitive data processing. The scientific objective of the underlying research project is to realize a completely new sensor concept for indoor airport areas, by detecting and identifying the presence of hazardous tools, which can be concealed (under clothes or inside bags) by ill-intentioned people, without interfering neither with the normal passenger flows, nor with the normal airport operations. The project intends to study, design and develop the functional prototypes of an innovative multisensor based system, integrating active and passive radar sensors and highly complex data-fusion. The SOS project involves academic and industrial researchers, who will have the opportunity to share complementary and multidisciplinary knowledge on different radar technologies and data-fusion, in order to foster integration of these technology as well as future joint RTD. Through a dedicated Transfer of Knowledge (ToK) programme they will share their own expertise, will acquire new knowledge in complementary and intersectoral fields and will integrate their new know-how back to their home institutions. The research teams will be complemented by new recruited experienced researchers with advanced competence in the field of detection, sensitive data processing and passive tracking radar systems. The SOS system will foster globally the security level in public spaces such as airports, establish long term industry academic collaboration through a joint 10 year RTD roadmap and reach out to the general public through airport bill-boards on the benefits of RTD in this area for passengers.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2007.5.2 | Award Amount: 1.28M | Year: 2008

The project GAP focuses on the area of Patient safety and risk assessment of the challenge 5 of FP7-ICT. It addresses, via specific workshops and studies, all aspects of risk prediction, evaluation of risk factors, evaluation and management tools designed for the preparation of means that allows an intervention in real situations. The project will evaluate insofar as possible all current solutions resulting from civil and military research on computerized decision-making on the topic of crisis management and, more specifically, major health crises. The results of the project will add to the decision-making potential of the unit of information collection on health crises (Emergency Operations Facility of the Directorate General of Health and Consumer Protection) which brings together a range of computerized tools for the collection and transmission of information (H.E.O.F). The primary goal of this project is to bring together the emergent concepts which will permit us in the near future to predict, study, control and remedy the most complex of crises, those that jeopardise health. The challenge is to build a genuine system of health and social defence, and its components (concept, organisation, personnel, equipment, training..), at the European and world levels. The project results should facilitate the creation of this system. At the same time, the partners are aware of the importance of the political decision and commitment. For this reason , GAP is driven from High level representatives of HealthCare Ministries of EU countries and Associated States (Israel). \nThe consortium and the experts associated with the Support Action GAP represent both of the complementary poles of excellence for the successful execution of this mission.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 11.57M | Year: 2011

Recent progress in physical Human-Robot Interaction (pHRI) showed that active and safe workspace sharing becomes possible in principle. Inspired by these results, SAPHARI will perform a fundamental paradigm shift in robot development in the sense that we place the human as the centre of the entire design. We address all essential aspects of safe, intuitive physical interaction between humans and complex, human-like robotic systems in a strongly interconnected manner. While encompassing safety issues based on biomechanical analysis, human-friendly hardware design, and interaction control strategies, the project will develop and validate perceptive and cognitive key components that enable robots to track, understand and predict human motions in a weakly structured dynamic environment in real-time. Apart from developing the necessary capabilities for interactive autonomy, we will tightly incorporate the human safety also at the cognitive level. This will enable the robots to react or physically interact with humans in a safe and autonomous way. Biomechanical knowledge and biologically motivated variable compliance actuators will be used to design bimanual manipulation systems close to human properties and performance. Planning motions and tasks of such complex systems in real-time require new concepts, including tight coupling of control and planning, that lead to new reactive action generation behaviours. Moreover, self explaining interaction and communication frameworks will be developed to enhance the system usability. The project focuses on two industrial use cases that explicitly require contacts and force exchange in human-robot co-work, as well as on professional service scenarios in hospitals, in which a medical staff and an assisting robot interact closely during daily work. Results of this project are expected to strongly impact all applications where interactive robots can assist humans and release them from dangerous or routine tasks.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.2.1 | Award Amount: 11.09M | Year: 2013

Using a proven-in-practice user-centric design methodology, TRADR develops novel S&T for human-robot teams to assist in disaster response efforts, over multiple missions: The novel S&T makes experience persistent. Various kinds of robots collaborate with human team members to explore the environment, and gather physical samples. Throughout this collaborative effort, TRADR enables the team to gradually develop its understanding of the disaster area over, multiple possibly asynchronous missions (persistent environment models), to improve team members understanding of how to work in the area (persistent multi-robot action models), and to improve team-work (persistent human-robot teaming).

Agency: European Commission | Branch: H2020 | Program: IA | Phase: LCE-02-2016 | Award Amount: 15.84M | Year: 2017

inteGRIDy aims to integrate cutting-edge technologies, solutions and mechanisms in a scalable Cross-Functional Platform connecting energy networks with diverse stakeholders, facilitating optimal and dynamic operation of the Distribution Grid (DG), fostering the stability and coordination of distributed energy resources and enabling collaborative storage schemes within an increasing share of renewables. inteGRIDy will: a) Integrate innovative smart grid technologies, enabling optimal and dynamic operation of the distribution systems assets within high grid reliability and stability standards b) Validate innovative Demand Response technologies and relevant business models c) Utilize storage technologies and their capabilities to relieve the DG and enable significant avoidance of RES curtailment, enhancing self-consumption and net metering d) Enable interconnection with transport and heat networks, forming Virtual Energy Network synergies ensuring energy security e) Provide modelling & profiling extraction for network topology representation, innovative DR mechanisms and Storage characterization, facilitating decision making in DGs operations f) Provide predictive, forecasting tools & scenario-based simulation, facilitating an innovative Operation Analysis Framework g) Develop new business and services to create value for distribution domain stakeholders and end users/prosumers in an emerging electricity market. inteGRIDy will impact on: a) operations by reconfigurable topology control & supervision b) market by providing new services c) customer by enhanced engagement through DR mechanisms d) transmission by novel forecasting scenarios for the MV/LV areas e) part of the production incorporating innovative storage targeting the optimum use of RES f) environment by CO2 reduction inteGRIDy approach will be deployed and validated in 6 large-scale and 4 small-scale real-life demonstration covering different climatic zones and markets with different maturity.

Agency: European Commission | Branch: FP7 | Program: CP-IP-SICA | Phase: HEALTH.2010.2.3.4-1 | Award Amount: 16.04M | Year: 2010

To contribute to the development of vaccines against Shigella and ETEC for children of the developing world, STOPENTERICS will provide novel solutions by imposing a two-fold paradigm switch: (i) to break the dogma of serotype-specificity by inducing a cross-protective immunity (ii) to improve the immunogenicity of Shigella glycoconjugates by using synthetic oligosacharides mimicking the lipopolysaccharide O-antigen. The possibilities offered by genomics/proteomics and bacterial outer membrane blebs (OMB) will be exploited to identify virulence proteins conserved throughout Shigella or ETEC isolates. For ETEC, the development of a safe, immunogenic ST (heat stable) toxoid is a priority. State-of-the-art glycochemistry and sugar-protein carrier conjugation will allow engineering optimal Shigella glycoconjugates with focus on the five most prevalent serotypes. The ultimate aim is to optimize chances for the best coverage by combining cross-protective and serotype-specific antigens, thus ensuring the development of efficient multivalent vaccines that will help reduce the burden of diarrheal diseases. At all stages of the R & D process, candidate antigens will be considered in light of immunomonitoring data obtained in naturally-infected individuals, and volunteers undergoing vaccine trials. Regarding the latter, Phase-1 clinical trials with two vaccine candidates are planned as proofsof-concept of (i) a synthetic oligosaccharides approach mimicking Shigella O-antigens, and (ii) a Shigella OMB-based vaccines to be tested after validation of preclinical studies. STOPENTERICS is a unique combination of laboratories, platforms, vaccinology centres from academia and industry in the North and the South, integrated to successfully develop new vaccines, from R&D toward clinical trials. By promoting high-standard training capacity for young investigators, it will foster a new generation of researchers in neglected infectious diseases.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2010.3.1.3-1 | Award Amount: 4.92M | Year: 2011

The recycling of end-of-life concrete into new concrete is one of the most interesting options for reducing worldwide natural resources use and emissions associated with the building materials sector. The production of the cement used in concrete, for example, is responsible for at least 5% of worldwide CO2 emissions. On-site reuse of clean silica aggregate from old concrete saves natural resources and reduces transport and dust, while the re-use of the calcium-rich cement paste has the potential to cut carbon dioxide emissions in the production of new cement by a factor of two. In order to achieve this goal, a new system approach is studied in which automatic quality control assesses and maintains high standards of concrete demolition waste from the earliest stage of recycling, and novel breaker/sorting technology concentrates silica and calcium effectively into separate fractions at low cost (Figure 1.1). Finally, the smaller calcium-rich fraction, which is typically also rich in fine organic residues, is converted into new binding agents by thermal processing, and mixed with the aggregate into new mortar. Next to technological advances, certification and design guidelines are developed to use the recycle concrete in a responsible and optimal way. The project aims to develop three innovative technologies for recycling end-of-life concrete, integrate them with state-of-the-art demolition and building processes and procedures, and test the new system approach on two Dutch concrete towers involving 70,000 tons of concrete. A special feature of this large case study is a new type of government contract which links the recycling of the towers to the re-use of the recycled materials in new buildings. The results of the project will be used to determine which kinds of strategies and policies are most effective to facilitate an efficient transition towards optimal value recovery from Construction and Demolition Waste and sustainable building.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 3.97M | Year: 2010

Space-time phenomena giving rise to fronts and interfaces are central issues in many contexts of Science and Technology. A selection of some of the most challenging ones, most often of multi-disciplinary character, will be pursued by a team of 10 Full Partner Members (8 universities of different countries and two industries, Guigues Environnement (France) and Siemens (Germany)) with the help of 4 Associate Partners. The project is divided into three general Work Packages A: Image Processing, B: Patterns in Complex Reaction-Diffusion Systems and C: Interfaces, Control and Inverse Methods in Technology Problems. The training of 42 ESR is proposed with a interdisciplinar orientation: besides the presence of the two mentioned industries with special interest in work packages B and C, respectively, most of the mathematicians implied in this ITN in the field of image processing are collaborating with researchers from other fields as in the case of the Technion Computer Sciences and Electrical Engineering departments. The presence of two industrial partners will also broaden the range of applications of the training techniques used in the FIRST. The Guigues and Simens partners, are in the supervisory board of the ITN, and are involved in the training programme through complementary skills seminars. Most of the ESRs will be trained in at least two different universities. The list of structured training courses refers not only to a set of postgraduate courses available in the PhD programmes but to some specialized courses which will be organized for the FIRST ITN. The benefit to the European scientific community will be significant: the training will not only produce researchers with broad backgrounds qualified for academic careers. It will also produce individuals with an understanding of science and with an excellent perspective for a career outside academia.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.4-1 | Award Amount: 3.94M | Year: 2008

This medium-sized collaborative project will document and monitor the natural course and study the pathophysiology of Primary Antibody Deficiencies (PAD). PADs are rare inborn errors of the immune system with an estimated incidence of <1:25.000. The defective immunity in patients with PAD causes an increased susceptibility to recurrent infections of the respiratory- and gastro-intestinal tract as well as ill defined co-morbidity including granulomatous disease, lymphocytic organ infiltration and (paradoxically) autoimmunity. Our consortium cares for more than 1000 PAD patients, representing approx. 50% of the patients registered in Europe, many of them being children. We propose to: 1. Combine clinical and research data in a central online registry, complemented by a sample repository (WP1) 2. Elucidate the genetic cause of PADs by linkage analysis and candidate gene approaches (WP2) 3. Establish in vitro models for B cell differentiation steps that are defective in PADs such as in vitro class switch recombination, and siRNA knockdown models for PAD screening (WP3) 4. Create mouse models of PAD by using several technology platforms including knock-in and knock-out mice, shRNA mediated gene knock-down and humanised mice (WP4) 5. Perform translational research by taking the observations from the patients into the basic research projects and transfer these results back to the patients (WP5) The study of these immunodeficiencies represent an experiment of nature, uniquely enabling researchers to study the detrimental effects of mutations in specific genes involved in the immune system. Basic research results are translated into the development of new technologies, new knowledge, and new therapeutic tools. The clinical results will improve the diagnosis, management and quality of life of PAD patients, leading to future developments of new tests, preventive measures and treatment protocols.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2007-2.3-1 | Award Amount: 15.47M | Year: 2008

Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and remodel the ECM to create pores into which angiogenic endothelial cells migrate. This observation, that physiological angiogenesis proceeds in response to solid-phase cues motivates our approach, namely creating bioactive resorbable materials as scaffolds that contain bound molecular signals to induce physiological angiogenesis in situations of tissue repair and regeneration. In some of our scaffold materials, porosity is inherent by virtue of fabrication, and in others porosity is created by cell-associated proteolysis as it is in physiological angiogenesis. All materials will be designed so as to be injectable or implantable into the human body. In some work, the final injectable/implantable material will comprise only materials and bioactive biomolecular signals, and in other cases it will also comprise cells. Thus, the concept of ANGIOSCAFF is to create materials that are bioresponsive (to environmental signals including pH and redox potential, and to cellular signals such as proteases), that are bioactive (by virtue of bound peptide or recombinant protein adhesion ligands and bound and releasable growth factors), and that are capable of carrying cellular therapeutics. To realize ANGIOSCAFF, we have assembled a team comprising both industrial and academic expert groups in biomaterials design and development, experts in the science and application of angiogenesis, in imaging in animal models, and in applications demanding biomaterials-based, angiogenesis-demanding tissue engineering therapies, including repair of bone, skin, cardiac muscle, skeletal muscle and nerve.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: Fission-2008-2.2.1 | Award Amount: 11.87M | Year: 2009

The suggested Collaborative Project (CP) addresses key viability and performance issues to support the development of a fourth generation European Sodium Fast Reactor (ESFR). This innovative system is mainly developed for competitive electricity generation and offer interesting potential characteristics in terms of safety, environmental impact, resource utilisation and waste minimisation (e.g. potential for Minor Actinides management). The objectives of the CP-ESFR look for the improvement, vis--vis of current nuclear systems, of the safety level, the guarantee of a financial risk comparable to that of the other means of energy production and a flexible and robust management of the nuclear materials. The corresponding technical requirements in terms of Systems performance; Operation, maintenance and procedures; Safety design & analysis and licensing issues; Physical protection &Proliferation resistance; Functional requirements for provisions; Fuel cycle Constructability; Decommisioning; Systems economy are based among others - upon the results of the 6th FP Specific Support Action EISOFAR (Roadmap for a European Innovative SOdium cooled FAst Reactor). The schedule for this four years project fit with the principle for an industrial deployment of ESFR technology around 2040 with the preliminary deployment of a demonstrator by 2020-2025. Following the requirements above, and considering the context as it is described, the Collaborative Project is tentatively structured into six main technical sub projects (SPs): 1)Consistency and assessment & international relationships 2)Fuel, fuel element, core & fuel cycle 3)Safety and Security 4)Energy Conversion System Components & materials 5)Reactor system (including handling) 6)Education & training A specific Management activity will insure the whole consistency.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: MG-3.6-2016 | Award Amount: 3.00M | Year: 2016

SaferAfrica project aims at establishing a Dialogue Platform between Africa and Europe focused on road safety and traffic management issues. It will represent a high-level body with the main objective of providing recommendations to update the African Road Safety Action Plan and the African Road Safety Charter, as well as fostering the adoption of specific initiatives, properly funded. The involvement of Development Banks will ensure the identification of available resources and the definition of suitable schemes of funding. The activity of the Platform will also focus on the reinforcement of the endogenous African capabilities through the dissemination of the EU know-how. Twinning Programs will be set up, besides the conduction of different training activities. Local contexts will be duly taken into account and studies on specific risk factors as well as transferability analysis of measures already tested elsewhere will be conducted. The project activities will be oriented to the Safe System approach and grouped in four pillars: Road Safety Knowledge and Data; Road Safety and Traffic management Capacity Review; Capacity Building and Training; Sharing of Good Practices. The platform will work at two levels. A decision making level, run by a Management Board basing its actions on information provided and activities carried out by a technical level, with established Working Groups addressing specific topics. The Management Board will be constituted by prominent institutions like EC, the African Union Commission, Financial Institutions, Regional Economic Communities (UN). The technical level will involve government and research institutions, international and stakeholders organizations (e.g. NGOs), with a fair balance between African and EU partners, even for what concerns responsibilities (e.g. Euro-African work package co-leadership). The Dialogue Platform is intended to constitute a stable body, able to orient road safety policies beyond the project end.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2010.5.2-1 | Award Amount: 5.07M | Year: 2011

SiteChar will facilitate the implementation of CO2 storage in Europe by improving and extending standard site characterisation workflows, and by establishing the feasibility of CO2 storage on representative potential CO2 complexes suitable for development in the near term. Reasonable estimates of the theoretical capacities of storage sites have been undertaken in previous studies. We will develop a workflow to undertake site characterisation, assessment of risks and development of monitoring plans necessary to reach the final stage of licensing. We will perform detailed site-specific techno-economic analyses and evaluate injection strategies, based on credible and realistic sources of CO2. We will undertake in-depth activities to enhance public awareness. The SiteChar workflow will be tested at a range of onshore and offshore, open and structural traps and depleted hydrocarbon reservoirs, located across Europe. Site characterisation will be placed in an economic context. A key innovation will be the development of internal dry-run licence applications for 2 sites, tested by relevant regulatory authorities. This iterative process will refine the storage site characterisation workflow and identify gaps in site-specific characterisation needed to secure storage licenses under the EC Directive, as implemented in host member states. In addition, we will address critical points of the workflow, such as screening of multiple options, fault geomechanics, reactive flow simulation, the presence of geological heterogeneity, trapping mechanisms, a Framework for Risk Assessment and Management and sensitivity analysis. These studies will be conducted through a strong collaboration of experienced industrial and academic research partners. SiteChar will produce practical guidelines for site characterisation and advance a portfolio of sites to a (near-) completed feasibility stage, ready for detailed front-end engineering and design.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SST.2008.4.2.1. | Award Amount: 7.31M | Year: 2010

Evidenced based approaches lie at the heart of the most successful road safety polices and accident and other road safety data is a key component. No single set of data can support all road safety questions and the European Road Safety Observatory has been developed as a focus for a range of data and information types. One part of the Observatory includes a series of data protocols and collection methodologies for a range of data types including national level and in-depth accident data, exposure data and safety performance indicators. Although it is a substantial step forward the ERSO remains the first stage and further development is needed. This proposal addresses the needs for further improvement of the Observatory by enhancing, structuring and applying the data and information it contains. DaCoTA WP3 aims to continue the efforts made in previous projects by gathering, consolidating and standardizing the available road safety data and information, through the exploitation of all available sources, in a systematic and comprehensive way. New data on road safety management processes will be gathered from a selection of key EU Member States together with data concerning exposure and indicators. This will be assembled and structured using, for example, the approaches developed within the Sunflower project. DaCoTA will identify, train and further support new teams across the Member States to conduct detailed accident investigations for safety purposes. It will develop new approaches to evaluate the casualty reduction effectiveness of new technologies and will develop new innovative approaches to gather routine data on normal driving behaviour. Key factors of the proposal include a highly skilled and experienced team to develop the safety information resources, the involvement of industry stakeholders as partners within the project and the close liaison with Member States through enhanced national experts groups.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.8.2 | Award Amount: 3.09M | Year: 2008

In the near future, it is reasonable to expect that new types of systems will appear, designed or emerged, of massive scale, expansive and permeating their environment, of very heterogeneous nature, and operating in a constantly changing networked environment. We expect that most such systems will have the form of a large society of networked artifacts that are small, have limited sensing, signal processing, and communication capabilities, and are usually of limited energy. Yet by cooperation, they will be organized in large societies to accomplish tasks that are difficult or beyond the capabilities of todays conventional centralized systems. The scale and nature of these systems requires naturally that they are pervasive and are expected to operate beyond the complete understanding and control of their designers, developers, and users. These systems or societies should have particular ways to achieve an appropriate level of organization and integration that is achieved seamlessly and with appropriate levels of flexibility. The aim of this project is to establish the foundations of adaptive networked societies of small or tiny heterogeneous artifacts. We indent to develop an understanding of such societies that will enable us to establish their fundamental properties and laws, as well as, their inherent trade-offs. We will approach our goal by working on a usable quantitative theory of networked adaptation based on rigorous and measurable gains. We also indent to apply our models, methods, and results to the scrutiny of large-scale simulations and experiments, from which we expect to obtain valuable feedback. The foundational results and the feedback from simulations and experiments will form a unifying framework for adaptive nets of artifacts that hopefully will enable us to come up with a coherent working set of design rules for such systems. In a nutshell, we will work towards a science of adaptive organization of pervasive networks of small or tiny artifacts.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SEC-2007-3.3-01 | Award Amount: 4.94M | Year: 2009

The project aims to improve the detection of manned and unmanned platforms by exploiting the treatment of more accurate information of cooperative as well as non-cooperative flying objects, in order to identify potentially threats. The scope will be reached by managing the 3D position data in region including extended border lines and large areas, 24 hours a day and in all weather conditions, derived from enhanced existing Primary Surveillance Radar (PSR), together whit conventional data and information coming via various passive radar technique in order to extend the airspace coverage and to enhance the target recognition capability of the surveillance systems. Thus, the security could be enhanced in large areas, at sustainable costs, by improving the recognition of non-cooperative target through more accurate information on its characteristics and/or more accurate positioning. The final objective of the research consists of study, design and realization of a simple demonstrator of a low cost, interoperable, radar based, system able to identify, all kinds of non-cooperative threat with the contribution of data coming from: - an innovative three-dimensional PSR - conventional sensors (Primary radar, Secondary radar, ADBS, etc) - a network composed by a multitude of multi-operational passive, bistatic and high resolution radar. The system core will performs mainly an opportune Fusion of the such data and an accurate control of Consistency enhancing the early warning alerts capacities of final user based on a detailed 3D map of the area under surveillance with additional information on the nature of the target and on the alert level selected considering the track, the direction and a trajectory prediction of the target performed by the included Decision Support module.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 3.45M | Year: 2010

Currently, femtocells and macrocells are seen as isolated networks, competing for the resources available in the common spectrum band, at the cost of injecting interference to the whole system. FREEDOM project will face key technical and industrial concerns about the foreseen mid-term massive deployment of femtocells by adopting a new approach based on cooperative/coordination paradigms, enabled by the limited ISP backhaul link. The project will not disregard the approach of isolated networks because it is met when there is not enough backhaul link connecting the femtocells and macrocell. In order to guarantee a strong focus and efficiency, FREEDOM will focus on: advanced interference-aware cooperative PHY techniques; improvement of the control plane procedures for seamless connectivity and system-level and hardware feasibility evaluation of the proposed femto-based network architecture.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: FoF-06-2014 | Award Amount: 8.05M | Year: 2015

In nearly every sector of industrial manufacturing polishing techniques are used. But often manual polishing is the only option because the tasks are too complex to be automated. Therefore in SYMPLEXITY Symbiotic Human-Robot Solutions for Complex Surface Finishing Operations will be developed. The main SYMPLEXITY Objectives are SO 1 Accurate and cognitive industrial robot systems enabling safe human-robot collaboration for surface finishing operations SO 2 Easy to use interfaces for planning, control and re-planning of shared finishing tasks SO 3 Collaboration oriented process technology for abrasive finishing, laser and fluid jet polishing SO 4 Integrated and autonomous sensing system for objective identification of surface properties SO 5 Introduction of developed collaborative finishing solutions into manufacturing industry In SO5 the results of the first 4 objectives will be combined to 3 demonstrator human-robot collaboration cells, one for each of the investigated process technologies. The 3 demonstrator cells will be tested in operational environment at 3 end-users. SYMPLEXITY is the consistent continuation of 3 recent EU projects that achieved TRL 4-5: COMET Plug-and-produce COmponents and METhods for adaptive control of industrial robots SAPHARI Safe and Autonomous Physical Human-Aware Robot Interaction poliMATIC Polishing processes and tools development SYMPLEXITY will bring together the results and key partners of these 3 projects to achieve TRL7 and thereby support the European Industry to win the competition in the global market with higher quality, efficient manufacturing and economic production, based on human robot collaboration for polishing complex shaped metallic surfaces. Relevant branches are tool making, medical engineering, aeronautics and automotive industry. Case studies show, that for many applications todays >90% of manual work can be converted in 80 % of robotic work under human control and 20 % of manual work.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA.2010.1.1-05 | Award Amount: 2.49M | Year: 2011

Within the framework of the FP7 3 call several policies are related to the maritime surveillance for safety purposes as border surveillance, traffic safety, fishery control and environmental protection and monitoring (i.e. sea platform infrastructures and sea ports). Within all these policies the detection and the tracking of small vessels assumes a central strategic issue. A common tool, useful for monitoring the maritime borders and in particular maritime routings and traffic and the management of pollution, is proposed. In this program a Simulator for a Moving Target Indication System will be implemented. The heritage of the FP7 2 call is taken into account concerning the Operational Scenarios, the EU Techniques and Technologies and possible contributions from planned or on-going Space Missions. The SIMTISYS program will assure to the European Service Providers a useful and powerful tool for detection and tracking of small vessel in defined Scenarios.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.1 | Award Amount: 4.58M | Year: 2012

Femtocell networks are currently seen as a new communication paradigm for the ever increasing ubiquitous wireless traffic demands. Being pervasive by nature, its proximity to the subscriber opens a new world of possibilities for the development of applications. Among them, cloud computing services demanded by smartphones could be moved from large server farms to HeNBs, provided that these are equipped with computational and storage resources, thus improving user experience on latency and download/upload speed. TROPIC addresses this scenario by exploiting advanced MP2MP communications schemes, innovative virtualization procedures, and a cross-layer approach to the allocation of resources understood in a wide sense: radio, computational/storage capacity and energy. TROPIC work programme includes the definition and characterization of the system level building blocks and their required interfaces for the implementation of a full system emulator and the development of a proof of concept platform.

Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2011-IAPP | Award Amount: 1.60M | Year: 2012

BRAINVECTORS aims devising new gene therapy(GT)-based treatments for Parkinsons and other neurodegenerative diseases, in substitution of current systemic treatments, by delivering neurotrophic factors (GDNF) into the CNS with new vectors derived from adeno-associated (AAV), canine adenoviruses (CAV) and lentiviruses (LV) with inducible gene expression. Although AAV, CAV and LVV are considered acceptable in terms of bio-safety, their immune response must be well characterized in order to further develop these vectors for clinical trials. Furthermore, the possibility to switch-off the expression of neurotrophic factors in case of adverse effects represents a significant pharmacological progress of the gene therapy approach for Parkinsons disease. BRAINVECTORS will: - devise new inducible gene expression cassettes with increased sensitivity of transactivators and inducers reducing thus the dose of drugs necessary to obtain GDNF expression in brain; - characterise the immune responses induced by the components of GDNF-AAV, -CAV and -LVV in rodent models for Parkinsons disease by using biomarker-based immunological screening. The project is based upon a network of 12 participants of public academic institutions and private non-profit organisations and SMEs in France, Germany, Italy, Netherland, Portugal, Spain, Sweden and Switzerland. Some of them are traditionally linked together in developing vectors backbones, vector production technologies and Parkinsons animal models. Others have strong immunological background, pioneering the biomarkers-based immuno-technologies for GT vectors, and have R&D expertise/facilities on/for animal cell technologies cGMP for biopharmaceuticals. 142 p-m will be involved during 48 months in R&D and TOK activities with 72 p-m of recruited postdocs and 70 p-m of seconded staff.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-1.4-5 | Award Amount: 4.33M | Year: 2008

Formidable challenges remain to prevent and treat successfully neurodegenerative diseases. Traditional pharmacological approaches, as well as those using stem cells, have made progress but their impact remain limited. As suggested by clinical results in Canavan and Parkinsons disease, gene transfer offers substantial potential. However, this strategy of therapeutic intervention also brings unique obstacles - in particular the need to address feasibility, efficacy and safety. BrainCAV's foundation is the potential of canine adenovirus type 2 (CAV-2) vectors, which preferentially transduce neurons and undergo a very efficient long-distance targeting via axonal transport. Moreover, the episomal long-term expression leads to safe, efficient neuron-specific gene delivery. We proposed a structured translational approach that spans basic research through pre-clinical model feasibility, efficacy and safety. To provide a proof-of-principle of the effectiveness of CAV-2, we tackle mucopolysaccharidosis type VII, a global, orphan disease commonly affecting children, and Parkinson's disease, a focal degeneration of dopaminergic neurones commonly affecting aged population. To develop and execute this project, BrainCAV brings together an interdisciplinary combination of partners with unique expertise that will take CAV-2 vectors to the doorstep of clinical trials.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.3.5-01 | Award Amount: 3.91M | Year: 2011

MINOTAURUS will deliver innovative bio-processes (bioaugmentation, enzyme technology, rhizoremediation with halophytes, and bioelectrochemical remediation), which are all based on the concept of IMMOBILIZATION OF BIOCATALYSTS (microorganisms and enzymes), to eliminate emerging and classic organic pollutants. The immobilization-based technologies will be applied to engineered (ex-situ) and natural systems (in situ) for the bioremediation of groundwater, wastewater, and soil. The selection and adaptation of modern physico-chemical, biological, and ecotoxicological monitoring tools combined to a rational understanding of engineering and enzymology/microbial physiology aspects is a pertinent approach to open the black-box of the our technologies. The reliable process-monitoring will constitute a solid basis to develop and refine our biodegradation kinetics models, which will be the mean to improve the predictability of performances to be achieved with our technologies. A key strength of MINOTAURUS is the possibility of direct implementation of our technologies at five EU reference sites that are confronted with pollutants (two technologies will be tested on-site during the first year). We will deliver not only a set of tools, techniques and processes which will enhance the ability of our communities to respond to the challenges of organic pollutants but also frameworks for structuring and making evidence-based decisions for the most sustainable and appropriate bioremediation measures. MINOTAURUS consortium consists of fifteen partners from eight European and Europe-associated countries. Eight research & education institutions, five SMEs covering the whole chain of our bioremediation approaches (production/monitoring of biocatalysts, bioremediation, and engineering), one large end-user installing wastewater treatment plants, and one environmental agency will work together with the support of an advisory board mainly consisting of environmental decision-makers

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: SST-2007-4.1-04;SST-2007-4.1-01 | Award Amount: 722.88K | Year: 2008

ESTEEM aims at contributing to the coordination of research activities and policies between the EU and the Neighbouring Countries on transport issues. More specifically, its aim is to strengthen and enhance the links between Maghreb and the neighbouring EU countries namely Italy, France and Spain - in order to identify strategic priorities and topics for high quality researches on safety and security in transport system and infrastructure. The project has been outlined by a consortium consisting of seven organizations with different but complementary field of expertise related to transportation. Each partner represents a country of the selected area of intervention, which means a well-balanced geographical distribution and a consequent higher number and range of potential beneficiaries to be reached. The proposal is structured according to the following method: the state of the art on safety and security related research in the selected region will be analyzed; specific sub-areas will be identified according to the main needs in the domain of transport system safety and security; surveys will be conducted on each sub-area in order to identify priority research actions to be undertaken; a series of workshops will be organized in order to validate the surveys results, with the aim of identifying specific topics and defining potential guidelines and roadmaps for future research; an ad hoc network will be set up with the aim of fostering collaboration among the participant and disseminating the projects results to an as wide as possible range of stakeholders. Relevant stakeholders and other interested entities will be invited to join the network, hence improving collaborations at all levels. Co-ordination of research activities and policies on transport related topics will be in this way ensured across the whole Mediterranean area as well as a long lasting impact and sustainability.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-5.2-2014 | Award Amount: 4.41M | Year: 2015

Urban areas represent the greatest challenges for freight transport and service trips, both in terms of goods distribution and service allocation performance, and environmental impacts (air emission, traffic congestion, road safety, accidents and noise). The salient scope of the proposal is the enabling of knowledge and understanding of freight distribution and service trips by providing guidance for implementing effective and sustainable policies and measures. This guidance will support the choice of the most optimal and applicable solutions for urban freight and service transport, and will facilitate stakeholder collaboration and the development, field testing and transfer of best governance and business models. This shall be achieved through: - the targeted understanding of urban freight and service trips, fostered by data collection on city logistics, - field testing and implementation of representative city logistics measures, - the development and application of a modular, integrated, evaluation framework for the assessment of these measures - the development of a typology between cities and potential city logistics components, and - the provision of guidance to cities, shaping consistent implementation channels for successful solutions, all according to the local needs and constraints. These activities will be accompanied by the production of practical tools that could support the take-up impact of NOVELOG project to wider international city and industrial networks and beyond the projects lifetime. NOVELOG will contribute to the European Commissions research and policy agenda through the generation of sound knowledge that introduces a new approach to guidance strategies that supports a more sustainable urban environment.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2007-2.2-01 | Award Amount: 1.99M | Year: 2009

It is the aim of SHRINK SMART to study the role of policies and governance systems in different types of shrinking urban regions. It is based on comparative case studies from seven urban regions throughout Europe with a focus on disadvantaged urban regions in Eastern and Southern Europe that will provide a basis for analyzing different trajectories of shrinkage, understanding main challenges for urban planning and elaborating alternatives for urban governance. Firstly, the impact of shrinkage for urban and regional development that are caused by population losses will be identified focusing on different fields; the main challenges will be elaborated in a comparative perspective. Secondly, the relation between local institutional structures and modes of decision making on the one hand and the challenges of shrinkage on the other will be analysed. Here, the focus will be on strategies and instruments, on the relation of public and private actors and on institutional frameworks and cross-scale interactions. As a result, different trajectories of shrinkage processes within Europe will be defined and a set of policy recommendations for different constellations of shrinking cities will be developed. Furthermore, with the aim of providing practicable knowledge for decision-makers, SHRINK SMART will engage in extensive dissemination activities and develop a set of tools and policy recommendations. Summarizing, SHRINK SMART embarks on the following key objectives: to identify main challenges caused by shrinkage for urban and regional development, to develop an analytical framework for understanding the challenges of development in different types of shrinking urban regions, to draw lessons and develop sustainable and transferable policy-recommendations, to establish a network of experts on the phenomenon of shrinking urban regions, to discuss the findings with practitioners and policy-makers in order to improve transferability of knowledge into action.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 2.33M | Year: 2015

This cross-disciplinary Marie Curie Innovative Training Network builds upon the transformative opportunities created by existing X-ray sources and new sources soon to be operative in Europe. These opportunities include using ultrafast X-ray sources to extract time-dependent structural information from proteins; and revolutionary possibilities created by X-ray Free Electron Laser radiation for an entirely new regime of pre-damage serial femtosecond crystallography. No lag should exist between building new sources and training the next generation of scientists well versed in using these facilities. Our research training will yield new scientific insights on fundamental properties of protein structure and dynamics: one of the most challenging problems in structural biology; and technological advancements in diverse fields from pharmacology to nanotechnology. X-probe creates close interdisciplinary collaboration between structural biologists, physical chemists, beamline engineers, software developers, and industrial partners. The rapidly changing state-of-the-art demands that young researchers are trained to meet these new experimental, technical and analysis challenges at the forefront of structural biology and photochemistry. X-probes interdisciplinary and intersectorial training network incorporates four leading European X-ray facilities (ESRF, MAXIV Laboratory, European XFEL, SwissFEL); three academic laboratories at the forefront developing X-ray tools to probe protein dynamics; and both large and small industrial partners. Four principal scientists in X-probe are female. X-probe builds close cooperation between traditionally separate fields of research at the very cutting edge of structural biology and creates a visionary training network that would not be possible within any of the individual partner states.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: SiS.2011.1.0-1 | Award Amount: 4.48M | Year: 2012

The objective of the R&Dialogue project is to create mechanisms for effectively tackling the scientific and technology related challenges faced by society by proactively bringing together different actors with complementary knowledge and experiences. The Mobilisation and Mutual Learning Action Plan (MMLAP) therefore forges partnerships between research organisations and different societal actors. It develops forms of dialogue and cooperation between science and society at different stages of the research process. The partners pool experiences and knowledge and better focus their respective efforts to develop a common approach to the issues at stake. In doing so the MMLAP contributes to sharing innovation more widely and efficiently and to optimizing the role of research and technology in tackling societal challenges. The objective of this project is to organise a dialogue between R&D organisations (RDOs) and civil society organisations (CSOs) that results in a joint vision of CSOs and RDOs on the development of renewable energies and CCS for a low carbon society and identification of actions to improve the dialogue and associated mutual learning. Our task will thus be to create a mechanism for dialogue between research and Civil Society Organisations (CSOs ) to develop a common approach on issues regarding the low-carbon society. This common approach can be used by international, national and local policy makers, CSOs, industry and research. It will result in an Action Plan signed by all participating organisations.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2009. | Award Amount: 4.78M | Year: 2009

SYNER-G is research project which has the following main goals: (1) To elaborate appropriate, in the European context, fragility relationships for the vulnerability analysis and loss estimation of all elements at risk, for buildings, building aggregates, utility networks (water, waste water, energy, gas), transportation systems (road, railways, harbors) as well as complex medical care facilities (hospitals) and fire-fighting systems. (2) To develop social and economic vulnerability relationships for quantifying the impact of earthquakes. (3) To develop a unified methodology, and tools, for systemic vulnerability assessment accounting for all components (structural and socio-economic) exposed to seismic hazard, considering interdependencies within a system unit and between systems, in order to capture the increased loss impact due to the interdependencies and the interactions among systems and systems of systems. The methodology and the proposed fragility functions will be validated in selected sites (urban scale) and systems and it will implemented in an appropriate open source and unrestricted access software tool. Guidelines will be prepared and the results and outputs will be disseminated in Europe and world wide with appropriate dissemination schemes. SYNER-G is integrated across different disciplines with an internationally recognized partnership from Europe, USA and Japan. The objectives and the deliverables are focused to the needs of the administration and local authorities, which are responsible for the management of seismic risk, as well as the needs of the construction and insurance industry. URL:

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2008.5.2.2. | Award Amount: 5.24M | Year: 2009

The overall objective of project is to contribute to improve the security in the airport area and, thus, on board of departing aircrafts by: detecting and identifying, without interfering neither with the normal passengers flows, nor with the normal airport operations, the presence of hazardous materials or tools, concealed (under clothes or inside bags) by ill-intentioned people circulating inside airports and that could deliver attacks; tracking the movements of those threatening people concealing those forbidden items, so that they can easily be localized by security operators. The project intends to study, design and develop the functional prototype of an innovative multi-sensor based system integrating active and passive radar sensors, able to survey wide airport areas without requiring the passengers cooperation by detecting hazardous materials/tools and tracking threatening people or containers; the system will increase the security level not only in the gate area (behind metal detector), but also at a preliminary stage, starting from the airport arriving/departure halls. The approach to be followed foresees two separate and integrated controls: 1. one at the Terminal accesses (between sliding or revolving doors, etc ..) equipped with innovative active devices, not interfering with passengers transit and able to detect and identify dangerous tools (guns, knifes, non-metallic weapons, explosives, etc.) concealed under clothes or inside bags, without requiring passengers to remove their clothes or to empty out their bags; 2. the other in the airport halls before the gate area equipped with new passive RF sensors not interfering with passengers transit and able to track suspicious people/containers. The integrated controls information will be managed in a secure way within the airport information networks allowing security operators to face threats in the most suitable way, minimizing the risk to other people inside the Terminal area.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA-2007-2.2-02 | Award Amount: 6.56M | Year: 2009

In Space Propulsion 1 was set up to improve the fundamental knowledge and the techniques which are necessary to allow Europe to implement new ambitious space programs involving cryogenic propulsion. It concentrates on liquid oxygen, liquid hydrogen, and liquid methane propellants, and the anticipated progress will address - LOX methane combustion - heat and propellant management - materials tribology, compatibility, and hydrogen embrittlement.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.04M | Year: 2013

The Digital Scholarly Editions Initial Training Network (DiXiT) is concerned with one of the most dynamic and pioneering research areas at the intersection of the humanities and computer sciences focused on digital scholarly editions. While the digital turn has challenged the theoretical understanding of and the methodological approach to the core research activity in most of the humanities, there is hardly any university institution which is able to provide the infrastructure and the resources in order to train the next generation of young scholars and researchers in all subjects and methods of this quickly developing field according to the needed standards. Therefore, only an international training network can provide this infrastructure and the scholarly resources for doctoral training and supervision. For this reason ten leading European institutions from universities and academies closely collaborating with the private sector and cultural heritage institutions intend to form one of the most innovative training networks for a new generation of scholars in the field of digital scholarly editing. DiXiT training programme offers a combination of network-wide training modules (Camps & Conventions) and local specialist training in connection with individual research projects, which not only will stand out in Europe, but will be able to compete with the worldwide leading centres and networks in the field of Digital Humanities research, cultural heritage, software and publishing industries. Moreover, DiXiT will help to create a training trajectory for the emerging supra-disciplinary field of Digital Humanities and thus anchoring it in an institutionalized, structured education scheme. The participating SMEs have a genuine interest in the achievement of the objectives of DiXiT because they actually need to recruit new professions in the domain of digital scholarly editions, with international and cross-disciplinary preparation, which is still not fully available on the professional market. This provides sound basis and guarantees a concrete approach to the exploitation and sustainability plan of the project.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.47M | Year: 2013

Non-coding RNA (ncRNA) is a new research field in rapid development. It holds the potential to explain many fundamental biological phenomena and there is a vast prospective for the development of ncRNA-derived diagnostic and therapeutic tools. Hence, biotech and pharmaceutical companies are actively looking into this unexplored territory for novel targets. Therefore, there is a substantial and unmet need for the training of scientists in ncRNA biology, methodology and exploitation. The regions encompassing protein coding potential (exons) in humans only amount to 2% of the genome. New sequencing techniques have evidenced that mammalian genomes are pervasively transcribed and have revealed the existence of multiple classes of ncRNAs. Although our knowledge on the multitude of transcripts produced by the non-coding 98% of the genome is still very sketchy, pivotal roles have been established for ncRNAs in organismal development and homeostasis, in cellular proliferation, differentiation and apoptosis and in a broad range of human pathologies. Hence, there is a need to educate young scientists in this emerging and important research field. Aside from increasing our collective understanding of essential biological phenomena, ncRNA also constitute a vast and largely unexplored territory for the development of novel therapeutics and diagnostics. Accordingly, we propose to form a European RNA training network, RNATRAIN. This network will be devoted to educating the next generation of European researchers focusing on the functions and importance of ncRNAs in multidisciplinary projects in which the ncRNAs are studied in the context of development, differentiation and disease. Towards this, a group of 9 top-quality European research laboratories and 3 companies from 8 countries will train, to the best level, a cohort of early-stage researchers using cutting-edge technologies to dissect the functions and potentials of ncRNAs through integrated multidisciplinary projects.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2009.5.2.1 | Award Amount: 5.26M | Year: 2010

Although significant leakage from CO2 storage sites is not expected, if it did occur there could be adverse environmental consequences, which are not well constrained. The objective of RISCS is to provide fundamental research on environmental impacts, necessary to underpin frameworks for the safe management of CO2 storage sites. To achieve this, RISCS will quantitatively assess environmental impacts from exposure to known CO2 fluxes. The assessments will be based on field laboratory experiments, measurements at natural leakage sites and numerical simulations, for both marine and terrestrial ecosystems. This will provide new constraints on the impacts of CO2 leakage on humans and onshore and offshore ecosystems. RISCS will provide the underpinning information necessary to: 1. Rigorously evaluate the safety of different storage sites 2. Carry out Environmental Impact Assessments (EIAs) over different timescales 3. Design storage sites to minimise hazards 4. Help to design near surface monitoring strategies 5. Refine storage licence applications and conditions 6. Develop a framework to communicate the safety of storage to key stakeholders This approach will meet the requirements of OSPAR and the EC Directive both in ensuring environmental protection and the planning of near surface monitoring programmes. The US EPA has recently published rules for CO2 storage, and a Vulnerability Evaluation Framework for geological sequestration of CO2. RISCS will build on this approach, creating a similar framework addressing European needs. In order to meet these objectives we have assembled a team with very specific and focussed expertise, enabling us to assess both northern and southern European impacts scenarios, onshore and offshore. To maintain a full external perspective on the research, from both scientific and public acceptance viewpoints, we have enlisted leading CCS experts from CSLF partner countries, two NGOs, the IEA GHG programme and industry.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.3.4-2 | Award Amount: 8.64M | Year: 2014

This proposal builds on the proven methodology developed in the SEtTReND FP7 project to develop inhibitors of schistosome HME as lead compounds for new drugs. We will employ a target-based strategy for the development of novel drug leads against schistosomiasis, leishmaniasis, Chagas disease and malaria by targeting histone modifying enzymes (HME), in particular those involved in acetylation/deacetylation and methylation/demethylation. The principal objectives of A-PARADDISE are: - The identification of HMEs from Leishmania sp. and Trypanosoma cruzi and the molecular characterization and functional characterization of selected potential targets, - Phenotypic screening of Leishmania, T. cruzi, S. mansoni and P. falciparum using HME class inhibitors, inhibitors developed specifically against S. mansoni and P. falciparum HMEs. This will permit us to obtain a comprehensive view of inhibitor classes and chemical scaffolds of interest, - Production of recombinant Leishmania and T. cruzi HME proteins, structural studies. Selected, validated target enzymes will be produced, crystallized and analysed by X-ray diffraction. Assays will be optimized to permit testing of inhibitors, - High-throughput and structure-based (in silico) screening of selected HMEs. Inhibitors selected will be further screened by phenotypic assays on the parasites in vitro, - Optimisation of inhibitor structures by chemical synthesis based on molecular modelling studies (inhibitors of all origins), - Transcriptomic analysis of drug-treated parasites to verify target specificity and mechanism of action (all parasites), - Pharmacological and toxicological studies (in vitro and in vivo) of selected inhibitors, in vivo testing of compounds in parasite-infected mice. The overall objective of the A-PARADDISE project is to develop optimized epigenetic inhibitors for further testing and optimisation as drug candidates against the four parasites studied.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA.2009.1.1.01 | Award Amount: 4.22M | Year: 2010

The decision to propose EVOSS (a downstream service uniquely related to volcanic hazard monitoring) was driven by 9 institutional End Users from the EU, the Caribbean and Africa, with objective technical needs in managing 6 volcano observatories and having responsibility in current major unrests at 11 volcanoes worldwide, some of which in remote areas subjected to complex operational conditions. EVOSS, stems from the unique ensemble of phenomena, parameters and forerunners involved in volcanic unrests, and the need for responses scaled to the vastly variable intensities, durations and extent of possible eruptive activity. It capitalises on results achieved within projects GlobVolcano and PROMOTE of ESA, currently running. Its main goal is to implement the spaceborne support to volcano monitoring capacity by a substantial amount, acting at supra-regional scale and including multi-parameter tracking with temporal resolutions (multispectral EO) and spatial resolutions (Radar EO) hitherto unachieved. EVOSS, is centred on the development or the finalization of advanced data processing techniques for Gas/Ash, Thermal (high-temperature) and Ground deformation, underlain by robust theory and brought seamlessly to the End User for use in surveillance routine and emergency decision. EVOSS was designed for acting from sustained unrest on, with adaptive task scaling up to handing over the surveillance to spaceborne observation during events of outstanding areal impact, that may lead to withdraw personnel from the field or to evacuate the observatory. The integration of space-borne data in groundbased monitoring arrays (if they exist) is done at the local level. In EVOSS, the concept is voluntarily restricted to EU and Africa but can be readily extended globally by exploiting the combined potential of geostationary multispectral and Radar LEO observations, to enhance the quality and speed of the response of Observatories to multi-hazard and trans-national events.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.5-01 | Award Amount: 12.44M | Year: 2013

KillSpill delivers innovative (bio)technologies, which can be integrated to the real sequences of state-of-the-art actions used currently to cleanup oil spills. The catalogue of KillSpill products & technologies is based on a review of technology & knowledge gaps in approaches of oil spill disasters and brings appropriate tools for 1st response, follow-up, and longer-term actions, specifically tailored to the versatility of oil spills. KillSpill develops chemicals & biochemicals to be used for 1st response actions to disperse/emulsify oil and materials enabling the containment and sorption of oil, preparing the field for the follow-up actions. KillSpill develops (Bio)technologies aiming at intensified biodegradation processes by bioaugmentation/biostimulation as follow-up and longer term actions in aerobic/slight anoxic compartments. KillSpill develops (bio)technologies adapted for the remediation of anoxic/anaerobic fresh & chronically polluted sediments. KillSpill compiles knowledge on dispersion/sorption and biodegradation processes to produce multifunctional products, which are suited for follow-up and longer term actions. The multifunctional products address the necessity for integrated bioremediation (bioavailability, metabolic requirements, etc.) and are efficient along the whole redox gradient from surface water to sediments. The products/technologies are field-tested in open sea oil spills and large mesocosms to unravel the champions products & technologies. The (bio)tools are benchmarked with existing solutions using cutting-edge analytics, biosensors, and omics and checked for eco-efficiency to merit green label. KillSpill consortium is multidisciplinary and gathers 33 partners from 12 EU and EU-associated countries and USA; 18 research & academic institutions, 14 SMEs, and 1 association of oil spill companies work together with the support of a high level advisory board to cover the whole chain of oil spill (bio)remediation.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: WATER-1b-2015 | Award Amount: 9.77M | Year: 2016

SMART-Plant will scale-up in real environment eco-innovative and energy-efficient solutions to renovate existing wastewater treatment plants and close the circular value chain by applying low-carbon techniques to recover materials that are otherwise lost. 7\2 pilot systems will be optimized fore > 2 years in real environment in 5 municipal water treatment plants, inclunding also 2 post-processing facilities. The systems will be authomatisedwith the aim of optimizing wastewater treatment, resource recovery, energy-efficiency and reduction of greenhouse emissions. A comprehensive SMART portfolio comprising biopolymers, cellulose, fertilizersand intermediates will be recoveredand processed up to the final commercializable end-products. The integration of resource recovery assets to system-wide asset management programs will be evaluated in each site following the resource recovery paradigm for the wastewater treatment plant of the future, enabled through SMART-Plant solutions. The project will prove the feasibility of circular management of urban wastewater and environmental sustainability of the systems, to be demonstrated through Life Cycle Assessment and Life Cycle Costing approaches to prove the global benefit of the scaled-up water solutions. Dynamic modeling and superstructure framework for decision support will be developed and validated to identify the optimum SMART-Plant system integration options for recovered resources and technologies.Global market deployment will be achieved as right fit solution for water utilities and relevant industrial stakeholders, considering the strategic implications of the resource recovery paradigm in case of both public and private water management. New public-private partnership models will be explored connecting the water sector to the chemical industry and its downstream segments such asthe contruction and agricultural sector, thus generating new opportunities for funding, as well as potential public-private competition.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: GALILEO-1-2015 | Award Amount: 4.17M | Year: 2016

SKYOPENER will increase the use of Remotely-Piloted Aircraft Systems (RPAS) for civilian applications by contributing to the European RPAS Steering Groups roadmap for the integration of civil RPAS into the European Aviation System. SKYOPENER will provide a whole operational process and a system that will demonstrate higher capability through Communication, Navigation and Surveillance innovations in RPAS. The SKYOPENER system will be designed, in the first instance, for specific operations for tactical RPAS, that are under 25kilos but subject to national aviation authority regulation, operating at Very Low Level of operation (under 500ft). SKYOPENER will include live trials in Switzerland for which we will gather stakeholders implicated in the operations of RPAS including RPAS operators, civil aviation authorities, air navigation service providers, RPAS manufacturers, satcom service providers etc. The newly developed system will be the result of the integration of a range of components which will combine technologies such as GNSS, satcom and security tools. GNSS will be used for the safety navigation of RPAS. The project will provide a command and control link that uses communication through multi-band satellite and radio and will address the redundancy issue of communication systems It will also feature a surveillance system with detect and avoid functions that will be based on GNSS, system wide information management and satcom. Such a system will be less costly, less complex, lighter and easier to roll out than those that are currently using mode-S transponders. SKYOPENER project brings together a seven partner team with a range of expertise and skills. Additionally we will include in the project a stakeholder group which will advise on the requirements of the project, witness the trial operations and support in the dissemination of results from the project. The range of partners, stakeholders and European associations give SKYOPENER a European scope.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2009-IRSES | Award Amount: 3.25M | Year: 2011

The High Energy Physics (HEP) European scientific community has developed cutting-edge, large-scale facilities that make it a world leader. Particle Physics Programmes in Europe are attracting participation of groups from non-European countries, in particular from Latin America. In the reciprocal direction, the Pierre Auger Observatory for High Energy Cosmic Rays, recently established in Argentina, receives a large European participation. The Latin American HEP community is composed of about 1000 physicists and engineers, more than a half young physicists, graduates and PhDs. In Europe, Latin American physicists collaborate with Research Institutions, Universities and with the European Laboratory for Particle Physics (CERN). Current trend is to increase participation in CERN, in view of the start-up of the Large Hadron Collider (LHC). Large scale LA-Europe collaboration is recent, however, and needs to be consolidated. The EPLANET program will support visits from Argentina, Brazil, Chile and Mexico to CERN and other European Institutions and from European countries to the AUGER Observatory, with short exchanges (1-2 months) for senior and longer exchanges (2-12 months) for junior investigators, for a total of about 1800 months. Visits will be used to perform research on the LHC and AUGER experiments, inside well established groups. Scientific results thereby obtained will parallel advanced training and acquisition of new techonologies in accelerator and detector physics, medical physics and ICT. EPLANET will foster the community and develop internal Latin-American collaboration to reach the critical scientific mass and profit from the educational, technological and industrial impact of HEP. The detachment of European senior and junior scientists in Latin-America will strengthen research partnership between Latin America and Europe. EPLANET will foster a sustainable collaboration between Europe and Latin America in HEP and associated technologies.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-3.4-2014 | Award Amount: 5.79M | Year: 2015

The objective of SafetyCube is to develop an innovative road safety Decision Support System (DSS) that will enable policy-makers and stakeholders to select and implement the most appropriate strategies, measures and cost-effective approaches to reduce casualties of all road user types and all severities. At the core of the project will be a novel and comprehensive analysis of accident causation factors combined with newly estimated data on the effectiveness and cost-effectiveness of safety measures, not just in relation to reduction of fatalities but also the number of injured. An operational framework will be established to provide future access to the DSS once the project is completed. The project has four sub-objectives: 1. To develop new analysis methods for (a) Priority setting, (b) Evaluating the effectiveness of measures (c) Monitoring serious injuries and assessing their socio-economic costs (d) Cost-benefit analysis taking account of human and material costs 2. To apply these methods to safety data to identify the key accident causation mechanisms, risk factors and the most cost-effective measures for fatally and seriously injured casualties 3. To develop an operational framework to ensure the project facilities can be accessed and updated beyond the completion of SafetyCube 4. To enhance the European Road Safety Observatory and work with road safety stakeholders to ensure the results of the project can be implemented as widely as possible The project outputs will be framed according to the specific policy and stakeholder areas infrastructures, vehicles and road users so that the measures developed in the project can be most readily applied. A systems approach will ensure effective coordination between these areas. The close involvement of road safety stakeholders of all types at national and EU levels and wider will enable the DSS to be focussed on the most appropriate policy-making procedures and ensure the project outputs have global reach.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA.2010.1.1-05 | Award Amount: 6.99M | Year: 2011

Taking benefit from the previous and on-going efforts in the GMES context, the DOLPHIN project intends to develop the key technological and operational gap-filling innovations, leading in the mid-term to a full and sustainable operational exploitation of Earth Observation Satellites capabilities in the EU and MS maritime policies applications. DOLPHIN aims at developing new tools providing effective improvements of the state-of-the-art capabilities in Maritime Surveillance with respect to Users real needs in particular through filling their present technological gaps. The identification of these technological gaps is made easier by the fact that the DOLPHIN partners have developed a solid experience through a number of past and on going initiatives, such as LIMES, MARISS, MarCoast, EMSA CSN, in which a wide European Users community in the Maritime Surveillance sector has already taken an active part in identifying application needs and technological gaps. DOLPHIN will respond to the specific Users need, focused on Users missions, through the development of Decision Support Modules (DSM) which will integrate innovative Software Tools, aiming at filling the identified technological gaps according to specific policy-driven requirements and scenarios. Five policy areas have been selected as being in most need of improvement: Border Surveillance, Traffic Safety, Environmental Protection, Fisheries Control and Search and Rescue. Each policy area has categories of users that are quite different, so each policy area will be addressed through a specific DSM. Users will play an important role in the consolidation of the operational scenarios, to ensure that they are significant and representative of the complexity of the requirements. They will also be involved in the validation of the Operational Scenarios, when modules will be integrated in operational Services Chains and their actual effectiveness will be measured on the basis of the given definition.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2010-6 | Award Amount: 12.83M | Year: 2011

The nSHIELD project is, at the same time, a complement and an improvement of pSHIELD, a pilot project funded in ARTEMIS Call 2009 as the first investigation to build the SHIELD Architectural Framework for SPD. The roadmap proposed in this pilot project aims at addressing Security, Privacy and Dependability (SPD) in the context of Embedded Systems (ESs) as built in rather than as add-on functionalities, proposing and perceiving with this strategy the first step toward SPD certification for future ES. Within this scope, the role of nSHIELD will be to realize, demonstrate and validate this roadmap. The leading concept is to demonstrate composability of SPD technologies. Starting from current SPD solutions in ESs, the project will develop new technologies and consolidate the ones already explored in pSHIELD in a solid basement that will become the reference milestone for a new generation of SPD-ready ESs. SHIELD will approach SPD at 4 different levels: node, network, middleware and overlay. For each level, the state of the art in SPD of single technologies and solutions will be improved and integrated (hardware and communication technologies, cryptography, middleware, smart SPD applications, etc.). The SPD technologies will be enhanced with the composable functionality that are being studied and designed in pSHIELD, in order to fit in the SHIELD architectural framework. To achieve these challenging goals the project aims to create an innovative, modular, composable, expandable and high-dependable architectural framework, concrete tools and common SPD metrics capable of improving the overall SPD level in any specific application domain, with minimum engineering effort. The whole ESs lifecycle will be supported to provide the highest cross-layer and cross-domain levels of SPD and guaranteeing their maintenance and evolution in time In order to verify these important achievements, the project will validate the SHIELD integrated system by means of fourt scenarios

Agency: European Commission | Branch: FP7 | Program: CP | Phase: GC-SST.2010.7-8. | Award Amount: 42.31M | Year: 2011

Green eMotion aims at enabling mass deployment of electromobility in Europe. To achieve this, major players from industry, the energy sector, municipalities as well as universities and research institutions have joined forces to develop and demonstrate a commonly accepted and user-friendly framework consisting of interoperable and scalable technical solutions in connection with a sustainable business platform. The Smart Grids development, innovative ICT solutions, different types of electric vehicles (EV) as well as urban mobility concepts will be taken into account for the implementation of this framework. Green eMotion will connect ten ongoing regional and national electromobility initiatives leveraging on the results and comparing the different technology approaches to ensure the best solutions prevail for the EU single market. A virtual marketplace will be created to enable the different actors to interact and to allow for new high-value transportation services as well as EV-user convenience in billing (EU Clearing House). Furthermore, the project will contribute to the improvement and development of new and existing standards for electromobility interfaces. The elaborated technological solutions will be demonstrated in all participating demonstration regions to prove the interoperability of the framework. Green eMotion will facilitate the understanding of all stakeholders about the parameters which influence the achievement of best possible results for society, environment as well as economy and thus ensure transfer of best practices. As a result, policy makers, urban planners and electric utilities will receive a reference model for a sustainable rollout of electromobility in Europe. The commitment of industry players ensures the focus of the project on the market after demonstration. By proving efficient and user-friendly solutions which are also profitable for businesses, the Green eMotion framework plans to accomplish EU wide acceptance of all stakeholders.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2013.7.3.1 | Award Amount: 7.50M | Year: 2013

The anticipated mass roll-out of electric vehicles (EVs) in Europe and the continuously increasing number of distributed energy resources (DER) are posing major challenges to Europes Distribution System Operators (DSOs) with regard to ensuring a secure and reliable energy supply and network operation. Despite ongoing research and demonstration activities in this field, particularly the development of new and the revision of existing planning rules and operational principles of DSOs still require extensive R&D efforts. The overall objective of PlanGridEV is therefore to develop new network planning tools and methods for European DSOs for an optimized large-scale roll-out of electromobility in Europe whilst at the same time maximizing the potential of DER integration. The project will also identify gaps in current network operation procedures and update tools and methods to address local load and congestion issues, leveraging on the possibilities of managing EV as controllable loads. For the validation activities the project will rely on existing infrastructures of the four involved DSOs. Taking into account improved methods for network operation, regulatory frameworks and business models, PlanGridEV will bring about an evolution of current grid planning rules and investment strategies. The comprehensive approach takes into account requirements and constraints of all relevant stakeholders, particularly through an effective cooperation between Original Equipment Manufacturers (OEMs) and DSOs accompanied by leading scientific and technological research partners in the consortium. The project will have considerable impact on the environmental, economic, scientific and societal level by enabling a more cost-effective network planning and increasing the overall hosting capacity of European distribution networks. PlanGridEV will leverage on previous research results, coordinate with on-going initiatives and ensure a successful market uptake of the developed solutions.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2009-6 | Award Amount: 5.39M | Year: 2010


Parisi G.,University of Rome La Sapienza | Zamponi F.,Laboratoire Of Physique Theorique
Reviews of Modern Physics | Year: 2010

Hard spheres are ubiquitous in condensed matter: they have been used as models for liquids, crystals, colloidal systems, granular systems, and powders. Packings of hard spheres are of even wider interest as they are related to important problems in information theory, such as digitalization of signals, error correcting codes, and optimization problems. In three dimensions the densest packing of identical hard spheres has been proven to be the fcc lattice, and it is conjectured that the closest packing is ordered (a regular lattice, e.g., a crystal) in low enough dimension. Still, amorphous packings have attracted much interest because for polydisperse colloids and granular materials the crystalline state is not obtained in experiments for kinetic reasons. A theory of amorphous packings, and more generally glassy states, of hard spheres is reviewed here, that is based on the replica method: this theory gives predictions on the structure and thermodynamics of these states. In dimensions between two and six these predictions can be successfully compared with numerical simulations. The limit of large dimension is also discussed where an exact solution is possible. Some of the results presented here were published, but others are original: in particular, an improved discussion of the large dimension limit and new results on the correlation function and the contact force distribution in three dimensions. The main assumptions that are beyond the theory presented are clarified and, in particular, the relation between static computation and the dynamical procedures used to construct amorphous packings. There remain many weak points in the theory that should be better investigated. © 2010 The American Physical Society.

Munoz M.A.,University of Granada | Juhasz R.,Hungarian Academy of Sciences | Castellano C.,University of Rome La Sapienza | Odor G.,Research Institute for Technical Physics and Materials Science
Physical Review Letters | Year: 2010

Quenched disorder is known to play a relevant role in dynamical processes and phase transitions. Its effects on the dynamics of complex networks have hardly been studied. Aimed at filling this gap, we analyze the contact process, i.e., the simplest propagation model, with quenched disorder on complex networks. We find Griffiths phases and other rare-region effects, leading rather generically to anomalously slow (algebraic, logarithmic,...) relaxation, on Erdos-Rényi networks. Similar effects are predicted to exist for other topologies with a finite percolation threshold. More surprisingly, we find that Griffiths phases can also emerge in the absence of quenched disorder, as a consequence of topological heterogeneity in networks with finite topological dimension. These results have a broad spectrum of implications for propagation phenomena and other dynamical processes on networks. © 2010 The American Physical Society.

Cava E.,University of Washington | Cava E.,University of Rome La Sapienza | Fontana L.,University of Washington | Fontana L.,University of Salerno
Aging | Year: 2013

Calorie Restriction (CR) without malnutrition slows aging and increases average and maximal lifespan in simple model organisms and rodents. In rhesus monkeys long-term CR reduces the incidence of type 2 diabetes, cardiovascular disease and cancer, and protects against age-associated sarcopenia and neurodegeneration. However, so far CR significantly increased average lifespan only in the Wisconsin, but not in the NIA monkey study. Differences in diet composition and study design between the 2 on-going trials may explain the discrepancies in survival and disease. Nevertheless, many of the metabolic and hormonal adaptations that are typical of the long-lived CR rodents did not occur in either the NIA or WNPRC CR monkeys. Whether or not CR will extend lifespan in humans is not yet known, but accumulating data indicate that moderate CR with adequate nutrition has a powerful protective effect against obesity, type 2 diabetes, inflammation, hypertension, cardiovascular disease and reduces metabolic risk factors associated with cancer. Moreover, CR in human beings improves markers of cardiovascular aging, and rejuvenates the skeletal muscle transcriptional profile. More studies are needed to understand the interactions between CR, diet composition, exercise, and other environmental and psychological factors on metabolic and molecular pathways that regulate health and longevity. © Cava and Fontana.

Koukopoulos A.,Centro Lucio Bini | Sani G.,University of Rome La Sapienza | Ghaemi S.N.,Tufts University
British Journal of Psychiatry | Year: 2013

The DSM system has never acknowledged a central position for mixed states; thus, mixed depressions have been almost completely neglected for decades. Now, DSM-5 is proposing diagnostic criteria for depression with mixed features that will lead to more misdiagnosis and inadequate treatment of this syndrome. Different criteria, based on empirically stronger evidence than exists for the DSM-5 criteria, should be adopted.

Sardellitti S.,University of Rome La Sapienza | Barbarossa S.,University of Rome La Sapienza | Swami A.,ARL
IEEE Transactions on Signal Processing | Year: 2012

Consensus algorithms have generated a lot of interest due to their ability to compute globally relevant statistics by only exploiting local communications among sensors. However, when implemented over wireless sensor networks, the inherent iterative nature of consensus algorithms may cause a large energy consumption. Hence, to make consensus algorithms really appealing in sensor networks, it is necessary to minimize the energy necessary to reach a consensus, within a given accuracy. We propose a method to optimize the network topology and the power allocation over each active link in order to minimize the energy consumption. We consider two network models: a deterministic model, where the nodes are located arbitrarily but their positions are known, and a random model, where the network topology is modeled as a random geometric graph (RGG). In the first case, we show how to convert the topology optimization problem, which is inherently combinatorial, into a parametric convex problem, solvable with efficient algorithms. In the second case, we optimize the power transmitted by each node, exploiting the asymptotic distributions of the eigenvalues of the adjacency matrix of an RGG. We further show that the optimal power can be found as the solution of a convex problem. The theoretical findings are corroborated with extensive simulation results. © 2006 IEEE.

Maharaj E.A.,Monash University | D'Urso P.,University of Rome La Sapienza
Information Sciences | Year: 2011

Traditional and fuzzy cluster analyses are applicable to variables whose values are uncorrelated. Hence, in order to cluster time series data which are usually serially correlated, one needs to extract features from the time series, the values of which are uncorrelated. The periodogram which is an estimator of the spectral density function of a time series is a feature that can be used in the cluster analysis of time series because its ordinates are uncorrelated. Additionally, the normalized periodogram and the logarithm of the normalized periodogram are also features that can be used. In this paper, we consider a fuzzy clustering approach for time series based on the estimated cepstrum. The cepstrum is the spectrum of the logarithm of the spectral density function. We show in our simulation studies for the typical generating processes that have been considered, fuzzy clustering based on the cepstral coefficients performs very well compared to when it is based on other features. © 2010 Elsevier Inc. All rights reserved.

Cozzolino A.,University of Rome La Sapienza | Rossi S.,Cranfield University | Conforti A.,European Investment Fund
Journal of Humanitarian Logistics and Supply Chain Management | Year: 2012

PurposeThe purpose of this paper is to identify the specific stages of the humanitarian logistics process in which the agile and lean principles are needed. Design/methodology/approachTo achieve this purpose, the authors propose an original conceptual framework and apply it to evidence from a “best practice” case study in the humanitarian sector: the United Nations World Food Programme and its efforts in the Darfur (Sudan) crisis. FindingsAlthough several previous works introduced the agile principle as suitable for disaster relief, when and how to embrace the agile and lean principles remained unclear. This paper demonstrates the proper combination of the agile and lean principles in disaster relief phases. The correspondence is based on the coincidence of the objectives that arises in every stage and that each principle is capable of achieving. Research limitations/implicationsFurther empirical research is needed to support the framework and to enrich the results that arise from this first explorative work. Practical implicationsThe proposed framework is targeted at leading actors involved in the operation and planning of humanitarian logistics when a crisis emerges. This approach, which is based on the combination of the agile and lean principles, is not exclusive to the humanitarian sector. This perspective may be useful to create business logistics that address disruptions to traditional supply chain flows and other forces that disrupt logistics, production and information handling. Originality/valueThe paper clarifies how agility and leanness should be emphasised in specific stages of the humanitarian logistics process, to reach a higher level of effectiveness and efficiency when planning disaster relief. © 2012, © Emerald Group Publishing Limited.

Camici P.G.,San Raffaele Scientific Institute | D'Amati G.,University of Rome La Sapienza | Rimoldi O.,CNR Institute of Molecular Bioimaging and Physiology
Nature Reviews Cardiology | Year: 2015

Obstructive disease of the epicardial coronary arteries was recognized as the cause of angina pectoris >2 centuries ago, and sudden thrombotic occlusion of an epicardial coronary artery has been established as the cause of acute myocardial infarction for >100 years. In the past 2 decades, dysfunction of the coronary microvasculature emerged as an additional mechanism of myocardial ischaemia that bears important prognostic implications. The coronary microvasculature (vessels <300 μm in diameter) cannot be directly imaged in vivo, but a number of invasive and noninvasive techniques, each with relative advantages and pitfalls, can be used to assess parameters that depend directly on coronary microvascular function. These methods include invasive or noninvasive measurement of Doppler-derived coronary blood flow velocity reserve, assessment of myocardial blood flow and flow reserve using noninvasive imaging, and calculation of microcirculatory resistance indexes during coronary catheterization. These advanced techniques for assessment of the coronary microvasculature have provided novel insights into the pathophysiological role of coronary microvascular dysfunction in the development of myocardial ischaemia in different clinical conditions. © 2015 Macmillan Publishers Limited.

Rocco M.V.,Polytechnic of Milan | Colombo E.,Polytechnic of Milan | Sciubba E.,University of Rome La Sapienza
Applied Energy | Year: 2014

Objective: This paper presents a theoretical reassessment of the Extended Exergy Accounting method (EEA in the following), a comprehensive exergy-based analytical paradigm for the evaluation of the total equivalent primary resource consumption in a generic system.Our intent in this paper was to rigorously review the EEA theory and to highlight its double "valence" as a resource quantifier and to clarify its operative potential. On the one side, EEA can be properly regarded as a general "costing" theory based on a proper knowledge of the cumulative exergy consumption of different supply chains, economic systems and labour market: it is indeed the only method that translates externalities (capital, labour and environmental remediation) into cumulative exergetic costs and thus allows for their rigorous inclusion in a comprehensive resource cost assessment. Indeed, the extended exergy cost eec reflects both the thermodynamic "efficiency" of the production chain and the "hidden" resource costs for the society as a whole.From another, perhaps even more innovative, perspective, EEA can be viewed as a space and time dependent methodology since economic and labour costs can only be included in the Extended Exergy balance via their exergy equivalents (via two rigorously defined postulates). Since the equivalent exergy cost of the externalities depends both on the type of society and on the time window of the analysis, the extended exergy cost eec reflects in a very real sense both the thermodynamic "efficiency" of the machinery and the "conversion efficiency" of the specific society within which the analysis is performed.We argue that these two intrinsic features of the EEA method provide both additional insight in and more relevant information for every comparative analysis of energy conversion systems, both at a global and a local level.In the paper, traditional and advanced exergy analysis methods are briefly discussed and EEA theoretical foundations and details for its application are described in detail. Methods: The method converts not only material and energy flows, but externalities as well (labour, capital and environmental costs) into flows of equivalent primary exergy, so that all exchanges between the system and the environment can be completely accounted for on a rigorous thermodynamic basis.The current emphasis decision makers and by public opinion alike seem to be placing on sustainability generates the need for continue research in the field of systems analysis, and a preliminary review confirms that exergy may constitute a coherent and rational basis for developing global and local analysis methods. Moreover, extended exergy accounting possesses some specific and peculiar characteristics that make it more suitable for life-cycle and cradle-to-grave (or well-to-wheel) applications. Results: Taxonomy for the classification of exergy-based methods is proposed.A novel assessment of the EEA method is provided, its advantages and drawbacks are discussed and areas in need of further theoretical investigation are identified. Conclusions: Since EEA is a life-cycle method, it is argued that it represents an improvement with regard to other current methods, in that it provides additional insight into the phenomenological aspects of any "energy conversion chain". The paper demonstrates that the Extended Exergy cost function can be used within the traditional and very well formalized Thermoeconomic framework, replacing the economic cost function in order to evaluate and optimize the consumption of resources of a system in a more complete and rational way. Practical implications: This paper contains some specific proposals as to the further development of the EEA method, to increase its effectiveness and to improve its practical applicability for system analysis. Suggestions are made on how to include an EEA discussion in the current debate about sustainable development. © 2013 Elsevier Ltd.

Durso P.,University of Rome La Sapienza | Maharaj E.A.,Monash University
Fuzzy Sets and Systems | Year: 2012

Crisp and fuzzy clustering methods based on a combination of univariate and multivariate wavelet features are considered for the clustering of multivariate time series. The performance of each of these methods is evaluated for stationary and variance nonstationary multivariate time series with different error correlation structures. The main outcomes of the simulation studies are are as follows: the superior performance of this approach for both the crisp and fuzzy cluster methods compared to some of the other approaches for clustering multivariate time series; the very good performance of the fuzzy relational method, overall, to cluster longer time series when all of them do not appear to group exclusively into well separated clusters. We consider an application to multivariate greenhouse gases time series and show that the crisp and fuzzy clustering methods considered are well validated. © 2011 Elsevier B.V. All rights reserved.

Helmrich A.,University of Strasbourg | Helmrich A.,University of Bern | Ballarino M.,University of Strasbourg | Ballarino M.,University of Rome La Sapienza | And 2 more authors.
Nature Structural and Molecular Biology | Year: 2013

To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA-and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses. © 2013 Nature America, Inc. All rights reserved.

Busardo F.P.,University of Rome La Sapienza | Jones A.W.,Linköping University
Current Neuropharmacology | Year: 2015

The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous system depressant and is often encountered during forensic investigations of living and deceased persons. The sodium salt of GHB is registered as a therapeutic agent (Xyrem®), approved in some countries for the treatment of narcolepsy-associated cataplexy and (Alcover®) is an adjuvant medication for detoxification and withdrawal in alcoholics. Trace amounts of GHB are produced endogenously (0.5-1.0 mg/L) in various tissues, including the brain, where it functions as both a precursor and a metabolite of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Available information indicates that GHB serves as a neurotransmitter or neuromodulator in the GABAergic system, especially via binding to the GABA-B receptor subtype. Although GHB is listed as a controlled substance in many countries abuse still continues, owing to the availability of precursor drugs, γ -butyrolactone (GBL) and 1,4-butanediol (BD), which are not regulated. After ingestion both GBL and BD are rapidly converted into GHB (t½ ~1 min). The Cmax occurs after 20-40 min and GHB is then eliminated from plasma with a half-life of 30-50 min. Only about 1-5% of the dose of GHB is recoverable in urine and the window of detection is relatively short (3-10 h). This calls for expeditious sampling when evidence of drug use and/or abuse is required in forensic casework. The recreational dose of GHB is not easy to estimate and a concentration in plasma of ~100 mg/L produces euphoria and disinhibition, whereas 500 mg/L might cause death from cardiorespiratory depression. Effective antidotes to reverse the sedative and intoxicating effects of GHB do not exist. The poisoned patients require supportive care, vital signs should be monitored and the airways kept clear in case of emesis. After prolonged regular use of GHB tolerance and dependence develop and abrupt cessation of drug use leads to unpleasant withdrawal symptoms. There is no evidence-based protocol available to deal with GHB withdrawal, apart from administering benzodiazepines. © 2015 Bentham Science Publishers.

Cesana M.,Polytechnic of Milan | Cuomo F.,University of Rome La Sapienza | Ekici E.,Ohio State University
Ad Hoc Networks | Year: 2011

Cognitive radio networks (CRNs) are composed of cognitive, spectrum-agile devices capable of changing their configurations on the fly based on the spectral environment. This capability opens up the possibility of designing flexible and dynamic spectrum access strategies with the purpose of opportunistically reusing portions of the spectrum temporarily vacated by licensed primary users. On the other hand, the flexibility in the spectrum access phase comes with an increased complexity in the design of communication protocols at different layers. This work focuses on the problem of designing effective routing solutions for multi-hop CRNs, which is a focal issue to fully unleash the potentials of the cognitive networking paradigm. We provide an extensive overview of the research in the field of routing for CRNs, clearly differentiating two main categories: approaches based on a full spectrum knowledge, and approaches that consider only local spectrum knowledge obtained via distributed procedures and protocols. In each category we describe and comment on proposed design methodologies, routing metrics and practical implementation issues. Finally, possible future research directions are also proposed. © 2010 Elsevier B.V. All rights reserved.

Grzonka S.,Albert Ludwigs University of Freiburg | Grisetti G.,University of Rome La Sapienza | Burgard W.,Albert Ludwigs University of Freiburg
IEEE Transactions on Robotics | Year: 2012

Recently, there has been increased interest in the development of autonomous flying vehicles. However, as most of the proposed approaches are suitable for outdoor operation, only a few techniques have been designed for indoor environments, where the systems cannot rely on the Global Positioning System (GPS) and, therefore, have to use their exteroceptive sensors for navigation. In this paper, we present a general navigation system that enables a small-sized quadrotor system to autonomously operate in indoor environments. To achieve this, we systematically extend and adapt techniques that have been successfully applied on ground robots. We describe all algorithms and present a broad set of experiments, which illustrate that they enable a quadrotor robot to reliably and autonomously navigate in indoor environments. © 2006 IEEE.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 288.00K | Year: 2016

This project explores strong-gravity phenomena involving black holes in the context of high-energy physics applications and astrophysical observations including gravitational waves. The proposed studies can be loosely classified into four groups with considerable overlap. (i) Fundamental fields in strong gravity. Fundamental fields coupled to curvature are essential for cosmological models, for explaining the nature of dark matter or to extend the Standard Model of particle physics. In addition, scalar fields are often used as proxy for other, more complex interactions. Through numerical, perturbative and analytical modeling, we will explore the dynamics and wave emission of neutron stars and black holes in dark-matter environments and infer bounds on axion-like particles. (ii) Stability of black holes. The physical stability of black-hole solutions with or without the presence of fundamental matter fields will be studied. Such solutions represent possible end states of the dynamical processes and their importance critically relies on whether they form long-term stable spacetimes. (iii) Modified theories of gravity. Modifications and extensions of general relativity are being explored for a variety of reasons ranging from cosmological observations to attempts to unify general relativity with quantum mechanics. We will explore observable effects of various such theories in astrophysical systems with a particular focus on gravitational-wave and electromagnetic signatures, that could allow us to test general relativity against modified theories of gravity. (iv) High-energy collisions. The gravitational interaction of ultrarelativistic collisions will be modeled numerically and perturbatively to probe the possibility of black-hole formation in the framework of TeV gravity scenarios.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-23-2014 | Award Amount: 6.93M | Year: 2015

The subject of this proposal is a robot assistant that is trained to understand maintenance tasks so that it can either pro-actively or as a result of prompting, offer assistance to maintenance technicians performing routine and preventative maintenance. Conceptually the robots task is to provide a second pair of hands to the maintenance engineer, such that once the robot has been trained it can predict when and how it can usefully provide help. The robots behavioural repertoire is learnt in a training phase that includes the monitoring of maintenance technician activity, the construction of a knowledge base that describes the context of a task, and a theory of action that enables dynamic behaviour generation. The result is a set of competencies coupled with an ability to recognise the state of a task and an understanding of how these competencies can be usefully deployed given the state. The scope of work includes the construction of a robot assistant, the systems that facilitate the training, the actual training on a number of representative tasks, perceptual systems that facilitate activity recognition, and validation of the systems ability to usefully contribute to tasks in collaboration with a maintenance engineer. Assessment of the system will test its ability to recognise when it doesnt know something as well as its ability to generalise its knowledge to previously unseen tasks.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 1.51M | Year: 2015

The joint Exchange programme is based on a research proposal finalized to examine how smart specialization strategies (S3) to regenerate local economic areas can be implemented, according to the new agenda of Europe 2020. This can be largely achieved by incorporating a place-based dimension. The main aim is to identify and prescribe the implementation S3 in terms of spatial, social and environmental factors. The programme will map out local needs and opportunities in a variety of contexts which could drive regional policy interventions. The resulting S3 will not only emphasize Key Enable Technologies, but will also empower the local innovation process. Elements gained from the preceding CLUDs project such as tacit knowledge, embedded social networks, and innovative milieu will ensure that the proposed S3 for each area is successful. The proposal intends to apply a Multidisciplinary Approach to Plan Smart Specialization Strategies in a prospective to enhance Local Economic Development (MAPS-LED). The MAPS-LED place-based framework will include two important drivers: 1. Cluster policy, 2. Innovative milieu in terms of the local value chains based on the urban-rural linkages The MAPS-LED project will be built in order to connect three important key-factors: Governance; Localization; Territorial network. The S3 in a MAPS-LED perspective will be visualized through appropriate designated areas, overcoming the constraints determined by the locally-bounded concept of the district through the rationale of the networks and flows activated by governance dynamics. The proposal exploits and moves forward the findings of the CLUDs project (research network of four EU and two US universities) funded by IRSES 2010, by expanding the concept of social and environmental added value embedded in some innovative urban regeneration approaches to the larger regional context. The result will be to build on the strong existing CLUDs research network and its Intl Doctorate URED.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.5-2 | Award Amount: 3.76M | Year: 2012

The recycling business is traditionally dominated by SMEs. In the last 5 years a general trend in the electronics recycling sector to bigger companies is very visible. Multinational, multi-sector companies are buying several smaller recyclers every year. Hence the previous project HydroWEEE (03/200902/2012) dealt with the recovery of rare and precious metals from WEEE. The idea has been to develop a mobile plant using hydrometallurgical processes to extract metals like yttrium, indium, lithium, cobalt, zinc, copper, gold, silver, nickel, lead, tin in a high purity. By making this plant mobile several SMEs can benefit from the same plant. By making the processes universal several fractions (lamps, CRTs, LCDs, printed circuit boards and Li-batteries) can be treated in the same mobile plant in batches. This reduces the minimum quantities and necessary investments. In addition these innovative HydroWEEE processes produce pure enough materials that can be directly used for electroplating and other applications. The objective of HydroWEEE Demo is to build 2 industrial, real-life demonstration plants (1 stationary and 1 mobile) in order to test the performance and prove the viability of the processes from an integrated point of view (technical, economical, operational, social) including the assessment of its risks (incl. health) and benefits to the society and the environment as well as remove the barriers for a wide market uptake. Finally the previously developed processes of extracting yttrium, indium, lithium, cobalt, zinc, copper, gold, silver, nickel, lead, tin will be improved and new processes to recover additional metals which are still in this fractions (Cerium, Platinum, Palladium, Europium, Lanthanum, Terbium, ) as well as the integrated treatment of solid and liquid wastes will be developed. Summarized HydroWEEE Demo will boost European competitiveness by applying novel processes for improved resource efficiency by extracting rare and precious metals.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-15-2015 | Award Amount: 12.49M | Year: 2016

To meet the ambitious EC target of an 80% reduction in greenhouse gas emissions by 2050, CO2 Capture and Storage (CCS) needs to move rapidly towards full scale implementation with geological storage solutions both on and offshore. Onshore storage offers increased flexibility and reduced infrastructure and monitoring costs. Enabling onshore storage will support management of decarbonisation strategies at territory level while enhancing security of energy supply and local economic activities, and securing jobs across Europe. However, successful onshore storage also requires some unique technical and societal challenges to be overcome. ENOS will provide crucial advances to help foster onshore CO2 storage across Europe through: 1) Developing, testing and demonstrating in the field, under real-life conditions, key technologies specifically adapted to onshore storage. 2) Contributing to the creation of a favourable environment for onshore storage across Europe. The ENOS site portfolio will provide a great opportunity for demonstration of technologies for safe and environmentally sound storage at relevant scale. Best practices will be developed using experience gained from the field experiments with the participation of local stakeholders and the lay public. This will produce improved integrated research outcomes and increase stakeholder understanding and confidence in CO2 storage. In this improved framework, ENOS will catalyse new onshore pilot and demonstration projects in new locations and geological settings across Europe, taking into account the site-specific and local socio-economic context. By developing technologies from TRL4/5 to TRL6 across the storage lifecycle, feeding the resultant knowledge and experience into training and education and cooperating at the pan-European and global level, ENOS will have a decisive impact on innovation and build the confidence needed for enabling onshore CO2 storage in Europe.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.74M | Year: 2016

PDZnet will create an innovative European PhD training network focusing on unraveling PDZ domain-mediated signaling networks. The emphasis will be on signaling nodes essential for the development of cancer and diseases of the nervous system, conditions that affect millions of Europeans and are major societal challenges. PDZ domains are protein and lipid recognizing modules that play a central role in trafficking and organizing diverse cell signaling assemblies, thereby allowing information to be transmitted from receptors, ion channels and transporters in the cell membrane. PDZ domain mediated interactions are emerging as conceptually novel and promising drug targets, with exciting opportunities for the development of novel therapies, especially within cancer and brain diseases. We will establish a European multidisciplinary platform integrating a plethora of complementary life science disciplines that range from chemical development of inhibitors to studies in live animals. The network encompasses 8 academic and 2 industrial beneficiaries as well as one industrial and one academic partner, which are all committed to promote frontline research, innovation and educational activities within the study of PDZ domain-mediated signal transduction pathways related to brain diseases and cancer. This interdisciplinary network will establish an outstanding training opportunity for Early Stage Researchers, who will be integrated in projects unraveling intracellular PDZ domain interactomes to provide pertinent information for discovering drug-related interactions. In a comprehensive and integrated training effort, involving a combination of scientific and transferable skills, the students will receive an interdisciplinary, intersectoral and innovative doctoral training from experienced industrial and academic leaders in well-reputed European Institutions.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 3.10M | Year: 2012

The HRC POWER project proposes a radically new approach combining novel advanced materials and an innovative hybridization technology to make breakthroughs at materials and concept levels: very high temperature operation up to 1300C with high Carnot efficiency, round-the-clock operation for 95% ACF, high flexibility / dispatchability, low water consumption. Novel materials will consist of advanced absorber metamaterials based on self organized structure and advanced infrared selective emitter refractory crystals. Novel technology / concept will consist of specific micro-combustor operating at very high temperature. This concept is a radically new path for renewable energy hybridization in a solid state device able to provide high quality thermal energy from solar and H2 or Biogas sources to thermal / electrical solid state converters. The main objectives of the HRC POWER project are to develop novel functional materials for advanced building blocks (solar, combustion and hybrid modes), novel high temperature joining technologies (integration of the building blocks) and to realize the proof of concept of this fully new technology, going from the architecture design to the performance assessment.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.9.5 | Award Amount: 2.27M | Year: 2014

We aim at laying the foundations of a novel paradigm in optical sensing by introducing molecule-specific strong light-matter interaction at mid-infrared wavelengths through the engineering of plasmonic effects in group-IV semiconductors.The key enabling technology is the novel germanium-on-silicon material platform: heavily-doped Ge films display plasma frequencies in the mid-infrared range. This allows for the complete substitution of metals with CMOS-compatible semiconductors in plasmonic infrared sensors, with enormous advantages in terms of fabrication quality and costs. Moreover, the mid-infrared range offers the unique opportunity of molecule specificity to target gases in the atmosphere, analytes in a solution or biomolecules in a diagnostic assay.We will develop sensing substrates containing infrared antennas and waveguides with antenna-enhanced detectors. Antennas and waveguides will be made of heavily-doped Ge to fully exploit plasmonic effects: high field concentration to increase sensitivity, resonant coupling to vibrational lines for chemical specificity, deeper integration to decrease costs. To achieve our goals we will rely on semiconductor growth by chemical vapor deposition, electromagnetic simulations, micro/nanofabrication of devices and advanced infrared spectroscopy. We aim at studying the fundamental properties of new materials and devices in order to assess their potential for sensing.Impacts of the proposed research go far beyond transforming optical sensing technology. Lab-on-chip disposable biosensors with integrated readout for medical diagnostics would radically cut healthcare costs. The possibility of actively tuning electromagnetic signals by electrical and/or optical control of the plasma frequency in semiconductors holds promises for dramatic opto-electronic integration. Finally, plasmonic semiconductor antennas will impact on photovoltaics, light harvesting and thermal imaging.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA-2007-2.1-01 | Award Amount: 6.66M | Year: 2009

The ULISSE project is conceived by a network of centers already operative in space experimentation. This network is mainly based on the European USOCs including a number of research centers and companies. The USOCs (User Support and Operation Centers) are a network of centres engaged by the European Space Agency (ESA) in various EU countries to support the operations for scientific experiments on board the International Space Station. ESA recognised the unique expertise of the USOCs in space experimentation; in fact, USOCs personnel has a sound scientific background, participate in research projects and realise a large number of space experiments, consolidating experience on scientific space payloads and related operations. In addition, USOCs have well-established liaisons with the scientific community, with national public institutions and with European industries. These competences and resources make the USOCs network particularly able to generate value from space experiments. The ULISSE project proposes to exploit this network of competences and resources to complement the on-going activities of payload operations on the ISS with new initiatives aimed at increasing the return of scientific space activities. For this purpose, ULISSE intends to pursue the valorisation and exploitation of ISS scientific data and of the already available data from previous space experiments as well as data from other space platforms, increasing the involvement of specialized community and the awareness of general public. ULISSE will provide scientific and technical data concerning most scientific disciplines, as Life Sciences including Space Medicine and Exobiology, Biotechnology, Material and Fluid Sciences. The data will be integrated with specific services and tools for their exploitation through a middleware platform. The project will include dissemination activities: scientific as well as divulgative publications, public events, educational activities on space research.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-23-2014 | Award Amount: 4.78M | Year: 2015

To feed a growing world population with the given amount of available farmland, we must develop new methods of sustainable farming that increase yield while reducing reliance on herbicides and pesticides. Precision agricultural techniques seek to address this challenge by monitoring key indicators of crop health and targeting treatment only to plants that need it. This is a time consuming and expensive activity and while there has been great progress on autonomous farm robots, most systems have been developed to solve only specialized tasks. This lack of flexibility poses a high risk of no return on investment for farmers. The goal of the Flourish project is to bridge the gap between the current and desired capabilities of agricultural robots by developing an adaptable robotic solution for precision farming. By combining the aerial survey capabilities of a small autonomous multi-copter Unmanned Aerial Vehicle (UAV) with a multi-purpose agricultural Unmanned Ground Vehicle, the system will be able to survey a field from the air, perform targeted intervention on the ground, and provide detailed information for decision support, all with minimal user intervention. The system can be adapted to a wide range of crops by choosing different sensors and ground treatment packages. This development requires improvements in technological abilities for safe accurate navigation within farms, coordinated multi-robot mission planning that enables large field survey even with short UAV flight times, multispectral three-dimensional mapping with high temporal and spatial resolution, ground intervention tools and techniques, data analysis tools for crop monitoring and weed detection and user interface design to support agricultural decision making. As these aspects are addressed in Flourish, the project will unlock new prospects for commercial agricultural robotics in the near future.

Agency: European Commission | Branch: FP7 | Program: CSA | Phase: ICT-2011.2.1 | Award Amount: 2.02M | Year: 2013

Robot competitions have proved to be an effective instrument to foster scientific research and push the state of the art in a field. Teams participating in a competition must identify best practice solutions covering a wide range of functionalities and integrate them into practical systems. These systems have to work in the real world, outside of the usual laboratory conditions. The competition experience helps to transfer the applied methods and tools to successful and high-impact real-world applications. Other effects of robot competitions are that young students are attracted to science and engineering disciplines, and that the relevance of robotics research is demonstrated to citizens. However, some limitations can emerge as competitions mature: the effort required to enter the competition grows and may present a barrier for the participation of new teams; a gap between benchmarking complete systems in competitions and benchmarking subsystems in research may develop and limit the usefulness of the competition results to industry.\n\nThe goal of RoCKIn is to speed up the progress towards smarter robots through scientific competitions. Two challenges have been selected for the competitions due to their high relevance and impact on Europes societal and industrial needs: domestic service robots (RoCKIn@Home) and innovative robot applications in industry (RoCKIn@Work). Both challenges have been inspired by activities in the RoboCup community, but RoCKIn improves and extends them by introducing new and prevailing research topics, like natural interaction with humans or networking mobile robots with sensors in ambient environments, in addition to specifying concrete benchmark criteria for assessing progress.\n\nThe RoCKIn project\n\tdesigns open domain testbeds for competitions targeting the two challenges and usable by researchers worldwide,\n\tdevelops methods for benchmarking through competitions that allow to assess both particular subsystems as well as the integrated system,\n\torganizes two robot competition events, each of them based on the two challenges and testbeds,\n\torganizes camps open to student participants, so as to help new teams getting involved in the competitions, and\n\texecutes dissemination activities to target stakeholders in industry and academia, as well as the general public.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH-2010-2.2-1 | Award Amount: 3.34M | Year: 2011

EUBORDERRREGIONS will investigate the manifold consequences of increasing cross-border interaction for the development of regions at the EUs external borders and, in this way, contribute to scientific and policy debate on the future of economic, social and territorial cohesion within the EU. Importantly, the project will contextualise development issues in selected EU Borderlands with regard to interaction between the EU and countries of the immediate neighbourhood. Within the context of these challenges, the regions at issue here are struggling to define new opportunities for social and economic development and are also attempting to create greater capacities for territorial cooperation with other regions. Despite all criticisms levelled at the European Commission, the EU as market and political institution has been absolutely essential in preparing the ground for greater economic and political interaction. Much will therefore depend on how EU policies and policy discourses translate into political capital for local/regional cross-border cooperation in the new borderlands. At the same time, the issue of capacity building and exploitation of the benefits of strategic cross-border co-operation must be clearly addressed at the local and regional level.As such, these border regions will be treated as interfaces between development dynamics and policy frameworks operating within the EU, on the one hand, and in neighbouring countries, on the other. In doing this, the project will also contribute to the state of the art of policy-oriented research on regional development and cohesion within Europe.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-FCH | Phase: SP1-JTI-FCH.2010.2.2;SP1-JTI-FCH.2010.2.3 | Award Amount: 4.93M | Year: 2011

Sustainable decentralized hydrogen production requires development of efficient fuel-flexible units adaptable to renewable sources. CoMETHy aims at developing a compact steam reformer to convert reformable fuels (methane, bioethanol, glycerol, etc.) to pure hydrogen, adaptable to several heat sources (solar, biomass, fossil, refuse derived fuels, etc.) depending on the locally available energy mix. The following systems and components will be developed: a structured open-celled catalyst for the low-temperature (< 550C) steam reforming processes a membrane reactor to separate hydrogen from the gas mixture the use of an intermediate low-cost and environmentally friendly liquid heat transfer fluid (molten nitrates) to supply process heat from a multi fuel system. Reducing reforming temperatures below 550C by itself will significantly reduce material costs. The process involves heat collection from several energy sources and its storage as sensible heat of a molten salts mixture at 550C. This molten salt stream provides the process heat to the steam reformer, steam generator, and other units. The choice of molten salts as heat transfer fluid allows: improved compactness of the reformer; rapid and frequent start-up operations with minor material ageing concerns; improved heat recovery capability from different external sources; coupling with intermittent renewable sources like solar in the medium-long term, using efficient heat storage to provide the renewable heat when required. Methane, either from desulfurized natural gas or biogas, will be considered as a reference feed material to be converted to hydrogen. The same system is flexible also in terms of the reformable feedstock: bioethanol and/or glycerol can be converted to hydrogen following the same reforming route. The project involves RTD activities ion the single components, followed by proof-of-concept of the integrated system at the pilot scale (2 Nm2/h of hydrogen) and cost-benefit analysis.

Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 792.00K | Year: 2015

The aim of the Personalized pREvention of Chronic DIseases consortium (PRECeDI) is to provide high-quality, multidisciplinary knowledge through training and research in Personalized Medicine (PM), with specific reference to prevention of chronic diseases. There is a large consensus that PM is a driver of innovation for research and health care, and also for the health care system and industry as a whole. In order to harness the potential of this new concept, the PRECeDI consortium provides a cohesive framework for training staff from academic and non-academic (NA) institutions on research topics related to PM, with specific reference to the prevention of chronic diseases where there is a lack of substantial evidence, though the potential is huge. The acquisition of skills from staff will come from dedicated secondments aimed at training on research topics not available at the home institutions, and attendance to courses, workshops, seminars, conferences. The goal of secondment is to enable staff to make informed decisions for appropriately serve health care systems, new biotech industries and policy makers at the dawn of the post-genomic era PRECeDI is a multidisciplinary group of institutions working on different facets of PM, from basic research, to economic evaluations, health service organization, and ethical, social, and policy issues. The consortium is embedded in existing cooperation structures, such as the PerMed project and the Erasmus Mundus ERAWEB II program, with additional leading SMEs in Europe and Canada as beneficiaries. The consortium consists of 8 beneficiaries and 3 partners, of which 7 are academic institutions and 4 NA, including 2 SMEs. During 4-years, 23 ESRs and 7 ERs will be seconded to 11 institutions, where researchers will be supported by a team of leading EU scientists in PM-related disciplines. In the long run, PRECeDI will foster the integration of PM in the field of prevention, thus contributing to better health for Europes citizen

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2010-IRSES | Award Amount: 722.40K | Year: 2011

The proposal is based on a research project integrated with a higher education agenda finalized to explore a new approach in delivering and implementing integrated urban policies and programmes. The proposal intends to explore the potential of a new tool for renovating degraded public spaces and improving the attractiveness and accessibility of deprived urban areas by focusing on the high potential of local commercial activities. The exploration is oriented to the implementation of an innovative tools: CLUDs, Commercial Local Urban Districts, aimed at emphasizing the strategic role of small retails -handcraft and typical food- in reinforcing the sense of community, reducing transportation costs and contributing to the creation of attractive urban environment, thus producing increase of private investments. The CLUDs are designated areas, reflecting the rationale of Economic Opportunity Zones. In particular, the thematic specification of the CLUDs is related to local small retail associations that can be occurred on typical local production. The implementation of the programme is based on a networking of four EU universities (Reggio Calabria, Salford, Aalto, Rome) and two USA universities (Boston and San Diego), which all hold the leading positions in planning education, training and research in their countries. Partners will exchange staff members, early stage and Experienced researchers, around yearly seminars/meetings, workshops, and a final international symposium. The core of this network activity regards: Joint research and training activities on two main topics - public/private partnership (PPP) and urban regeneration; an international symposium on PPP in urban regeneration process. The expected result is to bring together an international and interdisciplinary group of research team for the purpose of forming an excellent centre of synergy in research and innovation transfer in the field of PPP applied to urban regeneration actions and policies.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2011-IRSES | Award Amount: 168.60K | Year: 2012

Numerical relativity, the gauge/gravity duality and trans-Planckian scattering have been tremendously active and successful areas in gravitational/high energy physics in recent years. They are strongly motivated by direct experimental connections: gravitational wave detection, probing strong interactions at the Large Hadron Collider (LHC) and at the Relativistic Heavy Ion Collider (RHIC) and even black hole production at the LHC. Numerical relativity methods, applied to black holes, will be essential (and powerful) in studying these high energy physics topics. Such merging is a new born field, pioneered by the proponents. It involves a strong numerical effort, requiring access to supercomputing facilities, expertise in theoretical and phenomenological modeling in high energy physics and contact with research teams working on dedicated experiments in particle accelerators. The necessary numerical relativity techniques have only very recently reached a state of sufficient maturity, which, together with the ongoing scientific runs at LHC and the beginning of science runs for advanced LIGO in the near future make this research programme extremely timely. This action will be instrumental in mainting the existing collaboration and synergies between the proponents, and stimulating European leadership in this flourishing research field.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.27M | Year: 2011

In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/specification and how these are corrupted in disease are largely unknown. The focus of Hem-ID is a highly integrated approach to study the functional interactions between the genetic regulatory circuits orchestrated by transcription factors TFs-, (that direct the progressive cell type specification) and epigenetic mechanisms (that establish the cellular memory that fixes cell fate decisions during differentiation) in physiological hematopoiesis and in leukemia with the final goal of formulating novel diagnostic/prognostic markers and therapeutic approaches in treating leukemias. HEM_ID will: -Decipher Modular Networks assembled by master TFs controlling hematopoietic self renewal and differentiation and the molecular dynamics of TFs/DNA interactions by unique biophysical approache -Identify epigenetic modifiers (new relevant loci, -epiQTLs, DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias. The strength of Hem-ID ITN lies in the high quality multidisciplinary -but strictly integrated- expertise and technological platforms covering the complete pathway from basic research to its clinical exploitation- contributed from both public Institutions and Private sector and made available to Hem-ID Fellows. Besides research, an integrated training program of scientific and complementary activities will be offered to HEM-ID Fellows that will complement and strengthen their career development.

Agency: European Commission | Branch: FP7 | Program: JTI-CP-FCH | Phase: SP1-JTI-FCH.2011.2.3 | Award Amount: 3.44M | Year: 2012

Through development and scale up activities on materials and reactors for the integration of advanced biomass steam gasification and syngas purification processes, UNIfHY aims to obtain continuous pure hydrogen production from biomass, increase well-to-tank efficiency and contribute to a sustainable energy portfolio, exploiting results achieved in past R&D EU projects on hot gas catalytic conditioning. The project is based on the utilization of plant components of proven performance and reliability and well established processes (UNIQUE coupled gasification and gas conditioning technology, Water-Gas Shift, WGS, system and Pressure Swing Adsorption, PSA, system), thus targeting up to 20 years plant durability with availability>95%. The project benefits from the already existing laboratories and UNIQUE gasifiers in order to maximize results (technology development at process-, system- and industrial-scale) with minimum risk and budget requirement (laboratories, pilot and industrial gasifier already available). New materials for atmospheric pressure WGS are realized and utilized to develop reactors, integrated with a tailored PSA in a portable purification unit, connected downstream small-to-medium scale (up to 1 MWth) UNIQUE gasifiers in order to yield pure hydrogen. The result will be two UNIfHY prototype units for continuous production of hydrogen (up to 500 kg/day). Thanks to the high level of thermal integration and to the reuse of purge gas in the process, conversion efficiency in hydrogen higher than 70% is expected. Finally, the gas conditioning system cost becomes 30% as that of a standard free-standing conditioning system, due to remarkable plant integration: reforming of both tar and methane and particulates abatement is carried out directly in the freeboard of the biomass gasifier, providing investment cost savings greater than 50%, a simplified plant layout with reduction of space and components up to 50% and a hydrogen production cost not exceeding 4/kg.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.3-3 | Award Amount: 11.33M | Year: 2014

The project eartH2Observe brings together the findings from European FP projects DEWFORA, GLOWASIS, WATCH, GEOWOW and others. It will integrate available global earth observations (EO), in-situ datasets and models and will construct a global water resources re-analysis dataset of significant length (several decades). The resulting data will allow for improved insights on the full extent of available water and existing pressures on global water resources in all parts of the water cycle. The project will support efficient and globally consistent water management and decision making by providing comprehensive multi-scale (regional, continental and global) water resources observations. It will test new EO data sources, extend existing processing algorithms and combine data from multiple satellite missions in order to improve the overall resolution and reliability of EO data included in the re-analysis dataset. The usability and operational value of the developed data will be verified and demonstrated in a number of case-studies across the world that aim to improve the efficiency of regional water distribution. The case-studies will be conducted together with local end-users and stakeholders. Regions of interest cover multiple continents, a variety of hydrological, climatological and governance conditions and differ in degree of data richness (e.g. the Mediterranean and Baltic region, Ethiopia, Colombia, Australia, New Zealand and Bangladesh). The data will be disseminated though an open data Water Cycle Integrator portal to ensure increased availability of global water resources information on both regional and global scale. The data portal will be the European contributor to the existing GEOSS water cycle platforms and communities. Project results will be actively disseminated using a combination of traditional methods (workshops, papers, website and conferences) and novel methods such as E-learning courses and webinars that promote the use of the developed dataset.

Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: ENV.2007. | Award Amount: 1.68M | Year: 2008

HEREPLUS will: 1) involve coordination among epidemiologists, biostatisticians, environmental scientists, GIS specialists in order to realize the full potential of GIS technology in environmental health research; 2) develop risk maps relating to human health, and O3 and PM concentrations using the ArcGis approach, taking into account existing and validated epidemiological models, for selection of important and problematic large European urban areas such as Rome, Madrid, Dresden, Athens; 3) improve the knowledge of the potential role of different urban vegetation types for mitigating the O3 and PM pollution levels, and provide best practices regarding the selection of no-VOCs emitting species and management of large green areas located in different neighbouring urban areas; 4) furnish guidelines for municipal managers and administrators deputed to establish urban-environmental measures which combine risk maps, urban vegetation as a sink for ozone and PM, and minimization of sanitary costs, all based on results and knowledge achieved by the project activities as a whole. These guidelines will take the form of best practices recommendations and designs for municipal laws that may be used as a base-line for municipal administrations; 5) disseminate guidelines and best practice indications at a European level, through international workshops and a conclusive report. Specific cardio-respiratory disease, such as asthma, bronchitis, COPD exacerbation, ischemic heart disease, and the morbidity and mortality for these diseases, associated to O3 and PM, will be considered in HEREPLUS. HEREPLUS will produce the above mentioned risk maps starting from pre-existent environmental and health data, by development of new epidemiological and statistical approach, also in support for the implementation of Global Earth Observation System of Systems (GEOSS) initiative and the Environment and Health Action Plan.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: SPA-2007-2.2-02 | Award Amount: 2.99M | Year: 2009

AEROFAST main goal is to invest and improve the AEROCAPTURE transportation mean. An important step to allow for human expansion into the solar system is to develop advanced transportation systems to move humans and cargo between GEO and LEO, and also returning them from the Moon or from Mars. Typically such vehicle must rely on aerocapture to be mass effective: using atmospheric drag to slow space vehicles is regarded as one of the largest contributors to making both lunar and Martian missions affordable. In the coming decades aerocapture will become one of the core capabilities for planetary transportation. This technology allows for large amount of mass saved (up to 30 %) at launch and is fully adapted to large weight missions (Sample return missions and manned missions): for an insertion into a low Mars orbit with propulsion, 41% of the initial mass is put on final orbit whereas with an aerocapture manoeuvre 82% of the initial mass is put into final orbit. Today the technology readiness level of such an aerocapture mission is roughly 2 to 3 in Europe. AEROFAST goal is to prepare for a flight demonstration on a planet with atmosphere (earth or even more attractive Mars) and to reach TRL 3 to 4 in the frame of this FP7 first call.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-23-2014 | Award Amount: 4.24M | Year: 2015

COMANOID investigates the deployment of robotic solutions in well-identified Airbus airliner assembly operations that are laborious or tedious for human workers and for which access is impossible for wheeled or rail-ported robotic platforms. As a solution to these constraints a humanoid robot is proposed to achieve the described tasks in real-use cases provided by Airbus Group. At a first glance, a humanoid robotic solution appears extremely risky, since the operations to be conducted are in highly constrained aircraft cavities with non-uniform (cargo) structures. Furthermore, these tight spaces are to be shared with human workers. Recent developments, however, in multi-contact planning and control suggest that this is a much more plausible solution than current alternatives such as a manipulator mounted on multi-legged base. Indeed, if humanoid robots can efficiently exploit their surroundings in order to support themselves during motion and manipulation, they can ensure balance and stability, move in non-gaited (acyclic) ways through narrow passages, and also increase operational forces by creating closed-kinematic chains. Bipedal robots are well suited to narrow environments specifically because they are able to perform manipulation using only small support areas. Moreover, the stability benefits of multi-legged robots that have larger support areas are largely lost when the manipulator must be brought close, or even beyond, the support borders. COMANOID aims at assessing clearly how far the state-of-the-art stands from such novel technologies. In particular the project focuses on implementing a real-world humanoid robotics solution using the best of research and innovation. The main challenge will be to integrate current scientific and technological advances including multi-contact planning and control; advanced visual-haptic servoing; perception and localization; human-robot safety and the operational efficiency of cobotics solutions in airliner manufacturing.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.5 | Award Amount: 2.89M | Year: 2010

The CLAM project aims at developing a collaborative embedded monitoring and control platform for submarine surveillance by combining cutting edge acoustic vector sensor technology, underwater wireless sensor network protocols, collaborative situation-aware reasoning and distributed signal processing techniques for horizontal and vertical linear sensor arrays. The result will be a cooperative, flexible and robust underwater sensing, reasoning and communication platform for online surveillance of submarine environments accommodating pervasively deployed heterogeneous sensor nodes deployed at different water depths, enabling sensing and actuating devices to exchange data, autonomously network together, and collaboratively and locally asses their observation environment and act upon. Horizontal and vertical collaboration between sensor arrays in form of collaborative routing and beam forming, sensor fusion and distributed processing and reasoning enables fine-grained monitoring of the submarine environment and collaborative event detection as well as transmission of the network information to the monitoring stations.\nCLAMs consortium has experience and knowledge needed to deliver, exploit, and commercialize a complete solution right from the sensor node platform design, collaborative communication and networking protocols, adaptive, robust and scalable collaborative data processing and reasoning, up to the application requirements and market analysis. Participation of the international, external advisory board in this project indicates that the demand and potential market for such monitoring platforms goes beyond Europe. This can offer Europe a great opportunity in becoming an international leader in this emerging area which is still very much in its infancy.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.8.1 | Award Amount: 3.49M | Year: 2008

CATHERINE will provide a new unconventional concept for local and chip-level interconnects that will bridge ICT beyond the limits of CMOS technology.The main goals of CATHERINE are:G1) to develop an innovative cost-effective and reliable technological solution for high-performance next-generation nanointerconnects.G2) to develop proof-of-concept nanointerconnects to assess and verify the new proposed solution The expected results of CATHERINE are then summarized by the following points:R1) definition of all causal relations within the design-chain microstructure characteristics fabrication process functional propertiesR2) development of multiscale multiphysics simulation models for the prediction of the multifunctional performance of the interconnect and for the EMC analysisR3) development of electromagnetic and multifunctional test procedures and experimental characterization methods R4) manufacturing and testing of proof-of-concept samples of nanointerconnects at laboratory level. The final project product will be:P1) integrated data-base for nanointerconnect designP2) proof-of-concept nanointerconnect The new bottom-up approach proposed by CATHERINE consists in realizing CNT-based nano-interconnects for integrated circuit exploiting two different techniques: (i) a template-based CVD technique that allow high control of the growth of perfect aligned arrays of CNTs. The CNTs are synthesized within the pores of properly designed alumina nanostructures. CNTs wall thickness is controlled by the reaction time, the CNT length by the thickness of alumina nanostructures, the CNT external tube diameter by the nanostructures pore size; (ii) CVD growth of CNTs and carbon nanofibers (CNFs) on substrate patterned with nano-imprint lithography. Both techniques do not require electron beam lithography (EBL) for CNTs growth or substrate preparation. The resulting process is cost-effective and can be easily implemented at industrial scale.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.5.2 | Award Amount: 5.62M | Year: 2014

MR-guided Focused Ultrasound Surgery (MRgFUS) combines high intensity focused ultrasound for thermal ablation of diseased tissue with MR imaging to visualise the tumour and surrounding anatomy and to provide MR thermal feedback.\nHowever, MRgFUS treatment of the liver and other abdominal organs present tremendous technological challenges, including motion due to breathing and shielding of the target by the rib cage.\nTo tackle these challenges, the VPH project FUSIMO has set out to develop a planning system for MRgFUS capable to deal with moving abdominal organs.\nTRANS-FUSIMO will translate the FUSIMO demonstrator into a clinically applicable system spanning the full clinical workflow of planning, conduction and assessment as well as learning from the procedure:\n1) Extension of the FUSIMO demonstrator to support conduction and assessment of the intervention under breathing motion\n2) Interfacing state-of-the-art FUS hardware and imaging devices to build an integrated real-time-capable system for liver FUS\n3) Improving model components for optimized clinical workflow, real-time applicability and validated outcome prediction\n4) Allowing training and learning using the FUSIMO software system by building a case and result database\n5) Conduction of pre-clinical (phantoms, cadaver, animal) experiments of the FUSIMO system\nIn a clinical trial, the feasibility of using the integrated system for neoadjuvant MRgFUS to achieve prolonged survival will be investigated.\nAs a final project result, the integrated system will be close to certification status and subsequent commercialization. With such an integrated real-time system, FUS can become a commercially and clinically competitive alternative to current surgical and minimal-invasive oncological interventions, thus providing a non-invasive treatment, reducing side-effects, and healthcare costs.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.8.2 | Award Amount: 3.66M | Year: 2013

Mapping and digitizing archeological sites is an important task to preserve cultural heritage and to make it accessible to the public. Current systems for digitizing sites typically build upon static 3D laser scanning technology that is brought into archeological sites by humans. This is acceptable in general, but prevents the digitization of sites that are inaccessible by humans. In the field of robotics, however, there has recently been a tremendous progress in the development of autonomous robots that can access hazardous areas. ROVINA aims at extending this line of research with respect to reliability, accuracy and autonomy to enable the novel application scenario of autonomously mapping of areas of high archeological value that are hardly accessible.\n\nROVINA will develop methods for building accurate, textured 3D models of large sites including annotations and semantic information. To construct the detailed model, it will combine innovative techniques to interpret vision and depth data. ROVINA will furthermore develop advanced techniques for the safe navigation in the cultural heritage site. To actively control the robot, ROVINA will provide interfaces with different levels of robot autonomy. Already during the exploration mission, we will visualize relevant environmental aspects to the end-users so that they can appropriately interact and provide direct feedback. Our system will allow experts, virtual tourists and potentially construction companies to carefully inspect otherwise inaccessible historic sites. The International Council on Monuments and Sites will exploit the 3D models and technology. The ROVINA consortium is targeted at developing novel methods that will, besides the indicated goal, also open new perspectives for applications where autonomy and perception matters, such as robotics. To simplify the exploitation, all components developed in this project will be released as open source software as well as under a commercial license.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.5.3 | Award Amount: 4.68M | Year: 2011

In recent years, High-Intensity Focused Ultrasound and Focused Ultrasound (FUS) have become frequent tools for non-invasive benign tumour therapy. Applications in the treatment of fibroadenoma of uterus has become commercial and passed FDA clearance in 2004 and sonication of bone metastasis has obtained a CE mark. Other tumours are under preclinical (prostate, kidney) and clinical (breast, brain and liver) evaluation. However, treating tumours with focused ultrasound is still challenging in terms of reliable therapy planning, monitoring and outcome prediction especially in moving organs with a complex blood supply. It is important to understand that the processes involved in FUS therapy are multi-level ranging from organ morphology, perfusion and motion, down to microscopic and cellular level. The relation within and between these levels is not well understood.\nFUSIMO will develop, implement and validate a multi-level model for moving abdominal organs for use with FUS and Magnetic resonance-guided focused ultrasound surgery. The overall model will consist of several sub-models, which interact and describe aspects in a hierarchical manner. The integrated model will consist of;\n- Abdominal organ model to simulate motion and the influence on ultrasound application\n- Target organ/tumour model to capture organ/tumour physiology, and organ/tumour reaction to therapy\n- Microscopic tissue model to simulate direct heat ablation, model energy distribution, tissue heating and cooling\n- Model to evaluate first steps to simulate drug delivery, microbubble distribution and dynamics\nThe FUSIMO developments in the field of hardware and software will be combined into an integrated system, which will allow both abdominal FUS application to moving organs, and also other treatment modalities such as radio frequency, laser or cryotherapy or other types of interventions based on particles or fields in radiation therapy.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2007.1.1 | Award Amount: 5.64M | Year: 2008

Dynamic spectrum allocation has become a key research activity in wireless communications field and in particular a key technology for The Network of the Future objective proposed in ICT Work Programme 2007.\n\nFollowing these current trends towards dynamic spectrum allocation, the SENDORA project will focus on developing innovative techniques based on sensor networks, that will support the coexistence of licensed and unlicensed wireless users in a same area. The SENDORA project ideas stem from recent fundamental works on cognitive radio technology.\nThe capability to detect spectrum holes, without interfering with the primary network currently in use, is the actual major difficulty faced by the cognitive radio. The innovative concept proposed in SENDORA project consists in developing a sensor network aided cognitive radio technology which will allow to solve this issue, thanks to the introduction of sensor networks and associated networking capabilities.\n\nThe sensor network aided cognitive radio proposed and studied in SENDORA project will address many different advanced techniques, but will also propose an analysis of the potential exploitation of these techniques. First, scenarios of interest will be defined and will provide the technical activities with requirements to cover. Different types of scenarios will be proposed, corresponding to real needs, mainly identified by the potential integrators of the solutions. On the technical point of view, novel spectrum sensing techniques will be first proposed to be able to identify spectrum holes. Corresponding information management and exploitation will be studied to achieve the co-existence of cognitive radios with primary licensed technology without generating harmful interferences. The design, dimensioning and networking of the wireless sensor network will be deeply addressed. Finally, a proof-of-concept demonstration will be developed to assess the theoretical research.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST.2008.2.5.1 | Award Amount: 4.04M | Year: 2009

The certification of a rail vehicle according to European regulations, Technical Specifications for Interoperability, European Standards and national safety rules represents a significant element of both vehicle cost and time to market. Indeed, a large part of vehicle certification mandates testing for safety, performance and infrastructure compatibility. AEROTRAIN will help meet the business scenarios listed in the ERRAC SRRA 2002 and 2007 by aiding the spread of European homologation and acceptance procedures to speed up interoperable product approvals while squeezing out risk through improved safety management. In the field of aerodynamics a recent EN focuses on common definitions and descriptions of the aerodynamic phenomena and measurement procedures. Due to the application to all types of rail traffic it has not converged yet to one method per phenomenon but allows variations arising from national rules. The focus of the project is therefore on using the TSI route to consolidate the methodologies allowing the free exchange of certification data. The project is part of the TRIO-TRAIN cluster (Total Regulatory Acceptance for the Interoperable Network) which comprises 3 related projects dealing with key railway interoperability issues: Aerodynamics (AEROTRAIN), Railway Dynamics and Track Interaction (DYNOTRAIN) and Pantograph/Catenary Interaction (PANTOTRAIN) all submitted under the 2nd Call of the FP7. The objective of these projects is to propose an innovative methodology via a computer simulation/virtual homologation that will allow multi-system network and route approval in Europe to become a faster, cheaper and better process for all involved stakeholders. Therefore the success of the TRIOTRAIN cluster will lead to a time reduction for relevant parts of the certification process from 24 to 6 months; an 80% saving in effort for the acceptance of a new vehicle already accepted in an other country and an estimated financial saving of 20-50 Million/year.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.2.4.4-1 | Award Amount: 7.82M | Year: 2012

This application aims at a European marketing application for an orphan indication of the biopharmaceutical interferon-beta (IFN-beta) (EU3/07/505), to treat acute lunge injury (ALI) and acute respiratory distress syndrome (ARDS). Despite the much improved mechanical ventilation techniques and improved supportive therapies, ARDS kills 35-40 % of the 175.000 annual European patients. This condition has no approved pharmacological treatment in Europe. The applicant, Faron Pharmaceuticals, has recently finished a clinical phase I/II study with ALI/ARDS patients to obtain initial safety and pharmacokinetics for IFN-beta. Moreover, the study demonstrated very significant drop in all cause mortality of the IFN-beta treated patients at the day 28, the only accepted efficacy measurement as the primary end point for the treatment of ALI/ARDS. The pharmacological effect of IFN-beta is based on its ability to increase the de novo synthesis of endothelial cell surface anti-inflammatory molecule CD73, which can locally produce the enzymatic end product adenosine. Adenosine, in turn, increases endothelial barrier function and prevents the key step of ALI/ARDS process vascular leakage. Faron and its clinical network will conduct a pan-European pivotal phase III study for further safety and pharmacokinetics of IFN-beta. If phase II reduction in all cause mortality of the IFN-beta treated ARDS patients can be replicated in a bigger study, the data would allow a marketing application for European regulatory authorities but also a much improved understanding what clinical parameters and biomarkers can attribute to the outcome of this deadly process in lungs. We also anticipate to harmonize European ARDS treatment and to create ARDS specific analytics for future ARDS diagnosis and treatment efficacy. ARDS patients represent massive cost burden to hospitals, societies and insurance companies. New medication for ALI/ARDS is much hoped and most welcome by intensive care doctors.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.12M | Year: 2009

The recycling business is traditionally dominated by SMEs. In the last 2-3 years a general trend in the electronics recycling sector to bigger companies is very visible. Multinational, multisector companies are buying several smaller recyclers every year. This trend is caused by 2 factors: Many countries transposed the WEEE- and Battery Directives in a way relying heavily on collective systems. Also the big secondary raw material processors are more interested in few big contracts instead of a lot of small contracts as this brings down their administrative costs. Therefore it is close to impossible to sell materials with a high metal concentration for SMEs at the moment. Therefore the HydroWEEE project deals with the recovery of base and precious metals from WEEE including lamps and spent batteries by hydrometallurgical processes. The idea is to develop a mobile plant using hydrometallurgical processes to extract metals like Copper (Cu), Manganese (Mn), Zinc (Zn), Yttrium (Y), Indium (In), in a high purity (above 95%). By making this plant mobile (in a container) several SMEs can benefit from the same plant at different times and therefore limit the necessary quantities of waste as well as investments. In addition this new HydroWEEE process will produce pure enough materials that they can be directly used by end-users for electroplating. Because of this 2 levels of intermediaries from today (bigger recyclers and secondary material processors) will be bypassed. This will make the SMEs much more competitive than today and reverse the general trend to bigger companies. The HydroWEEE consortium has 9 partners from 4 countries - 3 EU Member States (Austria, Romania, Italy) and a Western Balkan Country (Serbia). All in all it has been calculated that HydroWEEE generates a turnover in excess of 100 million and about 150 interesting work places within the SMEs approximately 100 times the total cost of the project or 130 times the EU-funding

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT-2007-6.1-02;AAT-2007-6.2-01 | Award Amount: 10.35M | Year: 2008

Lacpat II is a logical follow-up of the previous EC-project which has as objective to reduce antipodal flights to less than 2 to 4 hours. Among the several studied vehicles, only two novel aircraft for a Mach 5 and 8 flight are retained in the present proposal. Starting from the available Mach 5 vehicle and its related precooled turboramjet, assumed performance figures of different components will now be assessed in more detail, i.e.: Intake design and performance Environment friendly design of combustor Nozzle design and performance Structural analysis Once available, the vehicle performance will be re-assessed. The outcome will allow the definition of a detailed development roadmap. Though the cruise flight of the Mach 8 vehicle based on a scramjet seemed feasible, the acceleration based on an ejector rocket was not. Integrated design of airframe and engine throughout the whole trajectory is the prime focus now to guarantee a successful design. A turbo-based engine will replace the former ejector rocket to assure better performance and fuel consumption during acceleration. Important points to be addressed to realize these goals are: - proper development and validation of engine-airframe integration tools and methodology - high-speed airbreathing cycle analysis - off- and on-design behaviour of engine and airframe - dedicated experiments to evaluate the design in various operation points Validated tool development should give solid confidence to propose a fully integrated vehicle to comply with the mission goals. Once defined, a roadmap will be defined with a step-wise approach to future development. Finally, for vehicles flying at high speeds and high altitudes, limited know-how is available on the environmental impact. The influence of NOx and H2O onto the ozone layer and the formation of contrails with its direct and indirect effects will be investigated for both vehicles.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2007. | Award Amount: 4.68M | Year: 2008

Conventional techniques for site characterization are time consuming, cost intensive, and do not support decision making. Therefore, new techniques for step by step site characterization strategy with smart feed back loops are necessary. These will be able to support a future soil framework directive. Advanced geophysical site characterization techniques combined with new types of vegetation analysis will be developed. Based on these non-invasive surveys, the extension of sources, contamination levels (THP, BTEX, PAH, CHC, explosives, heavy metals and radio nuclides) and soil heterogeneities will be localized first. Hot spots will then be investigated by new direct push probing systems integrated with geophysical & hydrogeological methods and combined with chemical & isotopic contaminant analysis for source localization and identification (environmental forensics). The actually occurring bioprocesses, such as contaminant degradation or precipitation/mobilization processes, will be assessed using biosensors, in situ microcosms, and stable isotope and biomarker analysis. These new techniques and tools will be evaluated against best practice of conventional methods. Therefore, they will be applied at fully equipped and characterized European reference sites available in the project and will be provided to consultants and SMEs for application. Integrated statistical analysis and modelling at different stages of the step by step approach will result in an improved view of soil and subsurface contamination and will provide a sound basis for risk assessment and decision.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2007. | Award Amount: 3.85M | Year: 2008

The European consumption of plastics increased from 24,6 Mtons in 1993 to 39,7 Mtons in 2003 and its growth rate exceeds that of the economy as a whole. At the same time, polymer recyclers and manufacturing industries have a problem buying feed materials and secondary polymers of sufficient volume and quality, as a result of the pull of China and India on all raw material resources. The alternative of using more primary plastics has a range of environmental impacts and needs more resources (about two kg oil for one kg plastic). The polymer resources in complex wastes, such as WEEE, household waste and ASR (ACEA: 7.5 million tons of shredder residue in the EU17 in 2002), are largely unused, because of the problem to produce high-purity products from such sources at acceptable costs. Today just one million out of 14 million ton polyolefins yearly sold in Europe is being recycled. W2Plastics aims to develop cost-effective and clean technology based on Magnetic Density Separation (MDS) and Ultrasound process control to recover high-purity polyolefins from complex wastes. A substantial effort is spent on making the new technologies fit in between the state-of-the-art technology of waste processors and the demands of the compounding and manufacturing industries by defining standards and best practices as well as effective quality-control tools (hyperspectral imaging). The integrated set of technologies and standards aims at changing the status of complex wastes to a resource of high-purity polyolefins for a wide range of industries. The development of such technology is in line with the European legislation (COM/2001/0031, 99/31/EC, 2000/53/EC, 2002/96/EC, 2003/108/EC) aiming at fostering the development environmental friendly technologies to reduce the environmental impact of human activities, to protect the environment, to minimize depletion of resources and to promote at the same time) business opportunities and improved competitiveness of European industry and SMEs

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 3.27M | Year: 2008

Effective and efficient vibration and acoustic analysis, modelling and design methods are required to produce world-leading products with good noise and vibration performance. Noise and vibration levels must remain within safe limits, there are issues regarding human comfort and a need for robust, optimal, efficient designs. There is also an increasing trend towards virtual design and prototyping, to reduce costs and development times. For all these reasons good analysis and modeling tools are essential. Ideally such tools would be applicable over the whole frequency range of interest, which is the audio-frequency range for automotive and aerospace structures, for instance. In practice, specific methods are applicable in a limited frequency region. Finite element analysis (FEA) is a low frequency method which is both well developed and well established. At high frequencies statistical energy analysis (SEA) is a valuable, but less well-established, tool. There is however a mid-frequency gap in our modelling capabilities: too high for FEA, too low for SEA. This is important, since it strongly affects product performance and competitiveness, and forms the target for this ITN. Substantial challenges exist in this mid-frequency range. New analysis approaches are essential to produce world-leading products. This ITN brings together academic and industrial partners who will together host researchers, drawing together skills and expertise in a range of different technical approaches. The industrial partners bring specific applications, behind which are generic difficulties associated with the mid-frequency region. The academic partners bring a diverse range of potential research approaches and the capability of research training, provision of courses and dissemination to the wider community. Together they can develop and promote research, knowledge and application of mid-frequency vibration and acoustics analysis techniques within EU industry.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SPA.2012.1.1-04 | Award Amount: 2.84M | Year: 2012

PREFER aims at responding to major fire prevention needs in Southern Europe. All reports on the state of Europes forests indicate that the broad Mediterranean area is systematically affected by uncontrolled forest fires with large impact on ecosystems, soil erosion, slope instability, desertification trends, and local economies as a whole, whit a negative mid-to-long term prospect because of Climate Change. In this scenario, the need to improve the information and the intelligence support to forest fire prevention is widely recognized to be relevant. Fire prevention is still the most cost-effective strategy when compared to firefighting and extinguishing that are costly, local, and triggered only in response to already ongoing crises. PREFER intends to contribute to responding to such a pragmatic need of Southern Europes forests by : 1) providing timely multi-scale and multi-payload information products based on exploitation of all available spaceborne sensors within the project time frame (the next 3 years) ; 2) offering a portfolio of EO products focused both on Pre-crisis and Post-crisis forest fire emergency cycle in the EU Mediterranean area; 3) preparing the exploitation of new spaceborne sensors available by 2020 (e.g. : Sentinels) and 4) contributing to the definition of User requirements for the new EO missions. PREFER capitalizes on the experience gained in the last decade by the Partners, in the frame of European and national applied research programs focusing on the management of forest fire hazards with spaceborne observation means. It will set up a regional service, able to process and distribute the information to end users, developed and maintained by a regional R&D cluster of core users, industries and research institutes. Through the exploitation of the synoptic character of spaceborne EO data, the regional service is intended to stimulate further the coordination between countries on forest fires prevention in the EU Mediterranean region.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SST.2008.2.5.1 | Award Amount: 3.53M | Year: 2009

The current interoperability approval process for new High Speed and Conventional railway vehicles in Europe is a very long and costly process. The Technical Specifications for Interoperability provide common regulations for the homologation of new rolling stock but do not directly eliminate the current burdens regarding new vehicle approval on each network. In this context, the pantograph/catenary system represents one of the major barriers to rolling stock interoperability. Indeed, each country has developed its own overhead line equipment leading to different catenary designs with variations in mechanical properties. A unified approval method is a key subject that must be addressed to provide a competitive railway system. Hence, PANTOTRAIN proposes to transfer the pantograph/catenary certification from current line testing towards laboratory testing and simulation. This will improve pantograph interoperability, increase train performances on the existing infrastructure and achieve considerable costs and time savings for the homologation of new pantographs The project is part of the TRIO-TRAIN cluster (Total Regulatory Acceptance for the Interoperable Network) which comprises 3 related projects dealing with key railway interoperability issues: Aerodynamics (AEROTRAIN), Railway Dynamics and Track Interaction (DYNOTRAIN) and Pantograph/Catenary Interaction (PANTOTRAIN) all submitted under the 2nd Call of the FP7. The objective of these projects is to propose an innovative methodology via a computer simulation/virtual homologation that will allow multi-system network and route approval in Europe to become a faster, cheaper and better process for all involved stakeholders. Therefore the success of the TRIOTRAIN cluster will lead to a time reduction for relevant parts of the certification process from 24 to 6 months; an 80% saving in effort for the acceptance of a new vehicle already accepted in an other country and an estimated financial saving of 20-50 Million/year

De Giacomo G.,University of Rome La Sapienza | Vardi M.Y.,Rice University
IJCAI International Joint Conference on Artificial Intelligence | Year: 2013

In this paper we look into the assumption of interpreting LTL over finite traces. In particular we show that LTLf, i.e., LTL under this assumption, is less expressive than what might appear at first sight, and that at essentially no computational cost one can make a significant increase in expressiveness while maintaining the same intuitiveness of LTLf. Indeed, we propose a logic, LDLf for Linear Dynamic Logic over finite traces, which borrows the syntax from Propositional Dynamic Logic (PDL), but is interpreted over finite traces. Satisfiability, validity and logical implication (as well as model checking) for LDLf are PSPACE-complete as for LTLf (and LTL).