The University of Rochester is a private, nonsectarian, research university in Rochester, New York, United States. The university grants undergraduate and graduate degrees, including doctoral and professional degrees. The university has six schools and various interdisciplinary programs.The University of Rochester is noted for its Eastman School of Music. The university is also home to the Institute of Optics, founded in 1929, the nation's first educational program devoted exclusively to optics. Rochester's Laboratory for Laser Energetics is home to the second most energetic fusion laser in the world.In its history, five university alumni, two faculty, and one senior research associate at Strong Memorial Hospital have been awarded a Nobel Prize; eight alumni and four faculty members have won a Pulitzer Prize, and 19 faculty members have been awarded a Guggenheim Fellowship. Faculty and alumni of Rochester make up nearly one-quarter of the scientists on the board advising NASA in the development of the James Webb Space Telescope, which will replace the Hubble Space Telescope as of 2011. The departments of political science and economics have made a significant and consistent impact on positivist social science since the 1960s; the distinctive, mathematical approach pioneered at Rochester and closely affiliated departments is known as the Rochester school, and Rochester graduates and former affiliates are highly represented at faculties across top economics and political science departments. The University of Rochester, across all of its schools and campuses, enrolls approximately 5,600 undergraduates and 4,600 graduate students. Its 158 buildings house over 200 academic majors. Additionally, Rochester is the largest employer in the Greater Rochester area and the sixth largest employer in the New York. Wikipedia.
University of Rochester | Date: 2017-04-05
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating Staphylococcus aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.
University of Rochester | Date: 2017-02-03
Described are shape memory polymers and methods of making shape memory polymers and actuators from the shape memory polymers.
University of Rochester | Date: 2016-12-03
An ECG clock electrocardiogram based diagnostic device and method is disclosed. The ECG clock provides a clear visual indicator of heart related anomalies such as Long QT syndrome over a longer span of time than can otherwise be assimilated by a medical practitioner. A variable such as QT interval is represented by a variable length radial hand similar to a watch or clock hand. The circular face of the ECG clock represents the diagnostic time interval, typically 24 hours. The resulting output or plot of the ECG clock portrays a circular or polar mapping of the heart related variable such as QT interval over the diagnostic time interval, facilitating rapid diagnosis of volumes of electrocardiogram data by a medical practitioner that has heretofore not been possible.
University of Rochester | Date: 2017-01-13
By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.
University of Rochester | Date: 2016-11-30
A method of forming an image of a region of interest using a pulse-echo imaging device is described. The method includes the steps of transmitting a pulse, discriminating an echo of the pulse by comparison to a plurality of Hermite polynomials, and determining a color for display based on the comparison. A system for forming an image of a region of interest is also described. The system includes a pulse-echo imaging device for transmitting a pulse and a control unit in communication with the pulse-echo imaging device. The control unit is configured to discriminate an echo of the pulse by comparison to a plurality of Hermite polynomials and determine a color for display based on the comparison.
University of Rochester | Date: 2016-12-12
Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent comprising a reactive amino-thiol group connected to the chemical species which is to be covalently linked to the polypeptide, via a linker. Such chemical species can be a functional group, a label or tag molecule, a biological molecule, a ligand, or a solid support. Efficient and catalyst-free methods for C-terminal protein labeling are also provided. The methods expand current capabilities in the area of protein functionalization, providing useful and complementary tools for the isolation, detection, characterization, and analysis of proteins in a variety of in vitro and in vivo applications.
University of Rochester | Date: 2017-02-08
The present invention relates to preparations of induced pluripotent cell-derived oligodendrocyte progenitor cells, and methods of making, isolating, and using these preparations.
Fred Hutchinson Cancer Research Center, Leiden University and University of Rochester | Date: 2017-07-19
The invention provides an agent capable of inhibiting or suppressing the level of DUX4-fl expression in a population of cells in a mammalian subject, for use in a method of treating a mammalian subject suffering from, or at risk for developing, Facioscapulohumeral Dystrophy (FSHD), wherein the agent is a nucleic acid.
University of Rochester | Date: 2017-02-10
The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
University of Rochester | Date: 2017-04-20
Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction with modifications at positions C10 and C9, via chemoenzymatic methods. Recombinant cytochrome P450 polypeptides are also provided for use in the methods. The artemisinin derivatives can be used for the treatment of malaria and other parasitic infections, alone or in combination with other antiparasitic drugs.