The University of Rochester is a private, nonsectarian, research university in Rochester, New York, United States. The university grants undergraduate and graduate degrees, including doctoral and professional degrees. The university has six schools and various interdisciplinary programs.The University of Rochester is noted for its Eastman School of Music. The university is also home to the Institute of Optics, founded in 1929, the nation's first educational program devoted exclusively to optics. Rochester's Laboratory for Laser Energetics is home to the second most energetic fusion laser in the world.In its history, five university alumni, two faculty, and one senior research associate at Strong Memorial Hospital have been awarded a Nobel Prize; eight alumni and four faculty members have won a Pulitzer Prize, and 19 faculty members have been awarded a Guggenheim Fellowship. Faculty and alumni of Rochester make up nearly one-quarter of the scientists on the board advising NASA in the development of the James Webb Space Telescope, which will replace the Hubble Space Telescope as of 2011. The departments of political science and economics have made a significant and consistent impact on positivist social science since the 1960s; the distinctive, mathematical approach pioneered at Rochester and closely affiliated departments is known as the Rochester school, and Rochester graduates and former affiliates are highly represented at faculties across top economics and political science departments. The University of Rochester, across all of its schools and campuses, enrolls approximately 5,600 undergraduates and 4,600 graduate students. Its 158 buildings house over 200 academic majors. Additionally, Rochester is the largest employer in the Greater Rochester area and the sixth largest employer in the New York. Wikipedia.
University of Rochester | Date: 2017-04-05
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating Staphylococcus aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.
Xerox and University of Rochester | Date: 2016-04-26
The quality of surgeries in captured videos is modeled in a learning network. For this task, a dataset of surgical video is given with a corresponding set of scores that are labeled by reviewers, to learn a model for quality assessment of surgical procedures. A learned model is then used to automatically assess quality of a surgical procedure, which omits the need for professional experts to manually inspect such videos. The quality assessment of surgical procedures can be performed off-line or in real-time as the surgical procedure is being performed. Surgical actions in surgical procedures are also localized in space and time to provide a feedback to the surgeon as to which action can be improved.
In.Sight and University of Rochester | Date: 2016-12-20
Methods and systems for manufacturing a wavefront-guided scleral lens prosthetic device customized for an eye of a patient include obtaining a first scleral lens prosthetic device with a central optic zone configured to vault over the eyes cornea and a peripheral haptic zone configured to align with the eyes sclera, collecting measurements of any offset and/or rotation of the first scleral lens prosthetic device relative to the eyes pupil and of any aberrations, particularly higher-order aberrations, generating a wavefront-guided profile from the measurements, and fabricating a second scleral lens prosthetic device with the profile on a surface of a central optic zone configured to vault over the eyes cornea and a peripheral haptic zone customized to align with the eyes sclera.
University of Rochester | Date: 2016-12-20
Embodiments of the present invention are generally directed to materials processing methods using femtosecond duration laser pulses, and to the altered materials obtained by such methods. The resulting nanostructured (with or without macro- and micro-structuring) materials have a variety of applications, including, for example, aesthetic applications for jewelry or ornamentation; biomedical applications related to biocompatibility; catalysis applications; and modification of, for example, the optical and hydrophilic properties of materials including selective coloring.
University of Rochester | Date: 2017-02-03
Described are shape memory polymers and methods of making shape memory polymers and actuators from the shape memory polymers.
University of Rochester | Date: 2016-11-23
Described herein are compositions and methods relating to biomarkers used to diagnose brain injury in a subject who has experienced a head trauma. The biomarkers described herein can be used to diagnose, monitor the onset, monitor the progression, and assess the recovery of brain injury. The biomarkers can also be used to establish and evaluate treatment plans.
University of Rochester | Date: 2016-12-12
Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent comprising a reactive amino-thiol group connected to the chemical species which is to be covalently linked to the polypeptide, via a linker. Such chemical species can be a functional group, a label or tag molecule, a biological molecule, a ligand, or a solid support. Efficient and catalyst-free methods for C-terminal protein labeling are also provided. The methods expand current capabilities in the area of protein functionalization, providing useful and complementary tools for the isolation, detection, characterization, and analysis of proteins in a variety of in vitro and in vivo applications.
University of Rochester | Date: 2017-04-19
Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.
Georgetown University and University of Rochester | Date: 2017-03-29
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one sample from the subject to determine a value of the subjects exosomal profile or combined biomarker profile (lipids plus exosomal cargo) and comparing the value of the subjects exosomal or combined biomarker profile with the value of a normal exosomal or biomarker profile, respectively. A change in the value of the subjects exosomal or combined biomarker profile, including a change in the subjects exosomal or combined biomarker profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
Presgraves D.C.,University of Rochester
Nature Reviews Genetics | Year: 2010
All plant and animal species arise by speciation ĝ€" the evolutionary splitting of one species into two reproductively incompatible species. But until recently our understanding of the molecular genetic details of speciation was slow in coming and largely limited to Drosophila species. Here, I review progress in determining the molecular identities and evolutionary histories of several new 'speciation genes' that cause hybrid dysfunction between species of yeast, flies, mice and plants. The new work suggests that, surprisingly, the first steps in the evolution of hybrid dysfunction are not necessarily adaptive. © 2010 Macmillan Publishers Limited. All rights reserved.