The University of Rochester is a private, nonsectarian, research university in Rochester, New York, United States. The university grants undergraduate and graduate degrees, including doctoral and professional degrees. The university has six schools and various interdisciplinary programs.The University of Rochester is noted for its Eastman School of Music. The university is also home to the Institute of Optics, founded in 1929, the nation's first educational program devoted exclusively to optics. Rochester's Laboratory for Laser Energetics is home to the second most energetic fusion laser in the world.In its history, five university alumni, two faculty, and one senior research associate at Strong Memorial Hospital have been awarded a Nobel Prize; eight alumni and four faculty members have won a Pulitzer Prize, and 19 faculty members have been awarded a Guggenheim Fellowship. Faculty and alumni of Rochester make up nearly one-quarter of the scientists on the board advising NASA in the development of the James Webb Space Telescope, which will replace the Hubble Space Telescope as of 2011. The departments of political science and economics have made a significant and consistent impact on positivist social science since the 1960s; the distinctive, mathematical approach pioneered at Rochester and closely affiliated departments is known as the Rochester school, and Rochester graduates and former affiliates are highly represented at faculties across top economics and political science departments. The University of Rochester, across all of its schools and campuses, enrolls approximately 5,600 undergraduates and 4,600 graduate students. Its 158 buildings house over 200 academic majors. Additionally, Rochester is the largest employer in the Greater Rochester area and the sixth largest employer in the New York. Wikipedia.
University of Rochester and University of Kansas | Date: 2016-11-21
University of Rochester | Date: 2016-10-19
A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patients vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.
University of Rochester | Date: 2016-09-26
The present invention provides compositions and methods for providing controllable local delivery of a therapeutic agent to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with osteoporosis, bone cancer or bone fracture. The invention provides a therapeutic agent that is tethered to a polymer to form a therapeutic-tethered macromer, where the therapeutic agent is controllably released from the conjugate by degradation of the tether. In certain embodiments, the therapeutic agent is an inhibitor of GSK3. In certain embodiments, the composition of the invention is specifically targeted to a site in need of bone formation or treatment.
University of Rochester | Date: 2016-09-12
A responsive construction toy is disclosed. The responsive construction toy, also known as LumenLinks, comprises at least one active rod and at least one connector. The active rod has an optics end and a push-pull transducer. The active rod illuminates with varying intensity and color to signify magnitude and direction of force on the active rod. Three dimensional structures such as trusses, buildings, and towers can be built by connecting active rods and connectors. When a structure is built, the forces on each active rod can be visually interpreted, thus providing an educational toy that has both tangible and concrete elements as well as responsiveness and feedback.
University of Rochester | Date: 2015-04-01
Methods and compositions are provided for generating macrocyclic peptides constrained by side-chain-to-C-terminus non-peptidic tethers for use as functional and structural mimics of -helical motifs, including in therapeutic applications. These methods can be used to produce libraries of conformationally constrained peptidomimetics to identify compounds with desired activity properties.
University of Rochester | Date: 2016-09-08
A microfabricated device and method having a substrate with an array of curvilinear cavities that is used for high throughput single cell screening. The substrate of the device is preferably fabricated in a low elastic modulus polymer such as polydimethylsiloxane. The architecture of the cavity forms a small volume micro-niche that seeded cells can rapidly condition to promote survival and proliferation which can be monitored for hours to days to weeks. The cavity architecture allows independent assays to be conducted with minimal influence from nearest neighbor cavities. Methods are disclosed to use the device to, for example, screen single cells by clonal proliferation, clonal morphology, secreted factors, secretion rate, surface markers, and cell functional characteristics including but not limited to migration, drug resistance, the ability to block or promote signaling pathways, or to enhance opsonization.
University of Rochester | Date: 2016-08-05
Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the receiving comprises setting a plurality of resistances on the plurality of cells, wherein each of the plurality of resistances are based on the first data. The method further includes receiving, by the resistive memory array, a second data, wherein the receiving comprises applying at least one of a current and a voltage based on the second data on the plurality of cells. The method still further includes determining, by the resistive memory array, an initial unknown value, the initial value based on the first data and the second data.
University of Rochester | Date: 2016-09-02
Disclosed herein are systems and methods for removing reverberation from signals. The systems and methods can be applicable to audio signals, for example, to voice, musical instrument sounds, and the like. Signals such as the vowel sounds in speech and the sustained portions of many musical instrument sounds can be composed of a fundamental frequency component and a series of harmonically related overtones. The systems and methods can exploit the intrinsically high degree of mutual correlation among the overtones. When such signals are passed through a reverberant channel, the degree of mutual correlation among the partials can be reduced. An inverse channel filter for the removal of reverberation can be found by employing an adaptive filter technique that maximizes the cross-correlation among signal overtones.
University of Rochester | Date: 2017-04-05
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating Staphylococcus aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.
Presgraves D.C.,University of Rochester
Nature Reviews Genetics | Year: 2010
All plant and animal species arise by speciation ĝ€" the evolutionary splitting of one species into two reproductively incompatible species. But until recently our understanding of the molecular genetic details of speciation was slow in coming and largely limited to Drosophila species. Here, I review progress in determining the molecular identities and evolutionary histories of several new 'speciation genes' that cause hybrid dysfunction between species of yeast, flies, mice and plants. The new work suggests that, surprisingly, the first steps in the evolution of hybrid dysfunction are not necessarily adaptive. © 2010 Macmillan Publishers Limited. All rights reserved.