Rochester, NY, United States

University of Rochester

www.rochester.edu
Rochester, NY, United States

The University of Rochester is a private, nonsectarian, research university in Rochester, New York, United States. The university grants undergraduate and graduate degrees, including doctoral and professional degrees. The university has six schools and various interdisciplinary programs.The University of Rochester is noted for its Eastman School of Music. The university is also home to the Institute of Optics, founded in 1929, the nation's first educational program devoted exclusively to optics. Rochester's Laboratory for Laser Energetics is home to the second most energetic fusion laser in the world.In its history, five university alumni, two faculty, and one senior research associate at Strong Memorial Hospital have been awarded a Nobel Prize; eight alumni and four faculty members have won a Pulitzer Prize, and 19 faculty members have been awarded a Guggenheim Fellowship. Faculty and alumni of Rochester make up nearly one-quarter of the scientists on the board advising NASA in the development of the James Webb Space Telescope, which will replace the Hubble Space Telescope as of 2011. The departments of political science and economics have made a significant and consistent impact on positivist social science since the 1960s; the distinctive, mathematical approach pioneered at Rochester and closely affiliated departments is known as the Rochester school, and Rochester graduates and former affiliates are highly represented at faculties across top economics and political science departments. The University of Rochester, across all of its schools and campuses, enrolls approximately 5,600 undergraduates and 4,600 graduate students. Its 158 buildings house over 200 academic majors. Additionally, Rochester is the largest employer in the Greater Rochester area and the sixth largest employer in the New York. Wikipedia.

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Patent
University of Rochester | Date: 2017-04-05

The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating Staphylococcus aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.


Patent
University of Rochester | Date: 2017-04-19

Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.


Patent
University of Rochester | Date: 2017-02-03

Described are shape memory polymers and methods of making shape memory polymers and actuators from the shape memory polymers.


Patent
Georgetown University and University of Rochester | Date: 2017-03-29

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one sample from the subject to determine a value of the subjects exosomal profile or combined biomarker profile (lipids plus exosomal cargo) and comparing the value of the subjects exosomal or combined biomarker profile with the value of a normal exosomal or biomarker profile, respectively. A change in the value of the subjects exosomal or combined biomarker profile, including a change in the subjects exosomal or combined biomarker profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.


Patent
Fred Hutchinson Cancer Research Center, University of Rochester and Leiden University | Date: 2017-01-25

Embodiments provide methods and compositions related to determining or predicting the presence or risk of developing DUX-4-related diseases such as muscular dystrophy. In particular, methods and compositions may be provided by identifying patients with Facioscapulohumeral muscular dystrophy (FSHD). Methods and compositions are based, in part, on the discovery that expression of certain biomarkers in patients or subjects can determine the presence or risk of developing DUX-4-related diseases such as muscular dystrophy, or particularly FSHD. Further disclosed are DUX-4 biomarkers that can be used for the methods.


A method and apparatus for determining the progressive potential of a disease is disclosed. The forward to backward, propagating second harmonic generation signal derived from a second harmonic generation instrument is used to assess the collagen microstructure of imaged body tissue by way of numerical values that are in turn used to determine the progressive or metastatic potential of the disease. The disease may, for example, be a cancer such as breast, cancer, lung fibrosis, colorectal adenocarcinoma, or the like. The apparatus may include in vivo instruments or laboratory diagnostic instruments with methods disclosed herein.


Patent
Georgetown University and University of Rochester | Date: 2017-04-05

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subjects gene expression profile with the value of a normal gene expression profile. A change in the value of the subjects gene expression profile, above or below normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.


Patent
University of Rochester | Date: 2017-02-08

Methods and compositions are provided for generating macrocyclic peptides constrained by side-chain-to-C-terminus non-peptidic tethers for use as functional and structural mimics of -helical motifs, including in therapeutic applications. These methods can be used to produce libraries of conformationally constrained peptidomimetics to identify compounds with desired activity properties.


Patent
Georgetown University and University of Rochester | Date: 2017-04-05

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subjects metabolite profile and comparing the value of the subjects metabolite profile with the value of a normal metabolite profile. A change in the value of the subjects metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.


Patent
Georgetown University and University of Rochester | Date: 2017-03-08

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subjects lipidomic profile, and also analyzing the gene expression profile from leukocytes and comparing the value of the subjects biomarker profile (lipidomic profile plus gene expression profile) with the value of a normal biomarker profile. A change in the value of the subjects biomarker profile, including a change in the subjects biomarker profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

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