Troyes, France

The University of Reims Champagne-Ardenne is a French university, in the Academy of Reims. It was officially established in 1967, as the successor of Rheims University, one of the most important European universities of the Middle Ages, which was established in 1548 and closed in 1793. Wikipedia.


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Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-11-2015 | Award Amount: 6.00M | Year: 2016

The business model currently under development for second generation ethanol is a replication of the model used for first generation which is plants with massive annual production capacities. Such high production rates require high capital investment and huge amounts of biomasses (250-350,000 tons per year) concentrated in small radius catchment areas to afford transportation costs (50 km). Under such conditions, opportunities for installing plants in most rural areas in Europe and worldwide are scarce. The objective of the project is to develop an alternative solution for the production of 2G ethanol, competitive at smaller industrial scale and therefore applicable to a large amount of countries, rural areas and feedstocks. The target is to reach technical, environmental and economical viabilities in production units processing at least 30,000 tons equivalent dry biomass per year. This approach will definitely enlarge the scope of biomass feedstocks exploitable for the production of biofuel and create better conditions for the deployment of production sites, to the benefit of rural areas in Europe and worldwide. The main concept underpinning the project relies on a new biomass conversion process able to run all the steps from the pretreatment of the raw material to the enzymatic pre-hydrolysis in one-stage-reactor under mild operating conditions. This new process recently developed to TRL 4, offers the most integrated and compact solution for the conversion of lignocellulosic biomass for the production of ethanol developed so far, and it will lead to reduced capital and operation expenditures. The new process will be developed to TRL 5 in the project with the goal of achieving satisfactory technical, environmental and economical performances in relevant operation environment. The project will investigate and select business cases for installations of demonstration/first-of-a-kind small-scale industrial plants in different European and Latino American countries.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: ISIB-02-2014 | Award Amount: 2.00M | Year: 2015

Building on a methodology for innovation-driven research previously developed and tested, the WINETWORK project has the ambition to stimulate collaborative innovation in the wine sector. The project will implement a methodology that has been successful in promoting demand-driven innovations in previous regional and European projects. This approach is mainly based on the interactions between a network of facilitator agents, several regional technical working groups and one European scientific working group. A participatory approach is used to translate results from science and practical knowledge into technical datasheets that are used to prepare materials adapted to end-users. A bottom-up approach is also used to identify a demand-driven innovation agenda. In the WINETWORK project, the approach will be implemented in ten regions from seven countries representing more than 90% of the EU wine production. The main topic addressed in the network concern the control and the fight against diseases that jeopardise the future production potential of the EU (Grapevine Trunk Diseases and Flavescence Dore). As they represent a threat for the economic viability of the entire sector, these topics have been previously identified as a priority by winegrowers, scientists and decision-makers. As many winegrowers are testing innovative and sustainable approaches to fight these diseases, it is very beneficial to capture these ideas and to share them between EU countries. Innovative practices will be synthesized, tailored and translated to become fully accessible to innovation support services and to winegrowers. The project will then deliver a vast reservoir of existing scientific and practical knowledge related to sustainable vineyard management. It will also provide a methodology that will support all agriculture sectors to enhance innovation-driven research. WINETWORK involves 11 partners of excellence representing the entire innovation chain, from science to farmers.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.3.1-1 | Award Amount: 7.73M | Year: 2013

Important progress has been made in the field of HPV-disease prevention with the development and implementation of HPV vaccines and HPV DNA screening. In the CoheaHr project, the (cost-) effectiveness of different European preventive strategies will be compared. The goal is to build a reliable and comparable evidence base on the (cost-) effectiveness of these policies implemented under country-specific preventive services conditions. To achieve this goal, a set of specific tasks will be carried out. Three randomized trials will be performed in organised screening settings to determine: i) whether self-collection of specimens for HPV DNA testing is an effective and feasible alternative for physician-based sampling, ii) whether screening intervals can be extended in women vaccinated at young age, iii) whether vaccinating women two years before entering the screening programme will favour the use of HPV screening. The first and third randomized trials are multi-country trials whereas the second trial will be carried out in a cohort of Finnish women vaccinated in 2007. For unvaccinated, 25-45 year old women participating in screening, acceptability and general feasibility of HPV vaccination will be studied in a multi-country demonstration survey. Comparisons by transmission models are included to provide long-term projections for cancer incidence and mortality. Furthermore, the establishment of a standardised joint European data warehouse will be continued and extended for (continuous) evaluation of comparative effectiveness of screening and vaccination policies in Europe. Finally, there will be an ongoing effort for producing systematic reviews and meta-analyses which provide a sustainable resource for evidence. CoheaHr will provide a strong evidence base which enable policy and other decision makers to make informed decision-making on HPV prevention strategies, thereby contributing to strengthening health systems and health services interventions in Europe.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: SSH.2013.5.2-1 | Award Amount: 6.39M | Year: 2014

Using an innovative interdisciplinary approach, MIME will generate an organised body of policy-relevant propositions addressing the full range of questions raised in the call. Our aim is to identify the language policies and strategies that best combine mobility and inclusion. MIME emphasises complementarity between disciplines, and brings together researchers from sociolinguistics, political science, sociology, history, geography, economics, education, translation studies, psychology, and law, who all have longstanding experience in the application of their discipline to language issues. The diverse concepts and methods are combined in an analytical framework designed to ensure their practice-oriented integration. MIME identifies, assesses and recommends measures for the management of trade-offs between the potentially conflicting goals of mobility and inclusion in a multilingual Europe. Rather than taking existing trade-offs as a given, we think that they can be modified, both in symbolic and in material/financial terms, and we argue that this objective can best be achieved through carefully designed public policies and the intelligent use of dynamics in civil society. Several partners have been involved in successful FP6 research, and key advances achieved there will guide the MIME project: languages are viewed as fluid realities in a context of high mobility of people, goods, services, and knowledge, influencing the way in which skills and identities are used and constantly re-shaped. The project integrates these micro-level insights into a macro-level approach to multilingual Europe. MIME results will be made widely available through a creative approach to dissemination, including training modules and the MIME Stakeholder Forum, allowing for sustained dialogue between academics, professional associations and local/regional authorities. The project culminates in a consensus conference where recommendations based on the project findings are adopted.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2013-IAPP | Award Amount: 2.19M | Year: 2013

MICROSMETICS aims to discover and carry to the stage of development innovative products in the area of cosmeceuticals originating from global biodiversity using emerging and state of the art technologies in the field of biotechnology, natural products chemistry and applied microbiology. These objectives will be implemented through an extended and balanced scheme of researchers exchanges and recruitments, in both directions and via a mutual scientific project developed on the needs and interests of both Industrial and Academic sectors, exploiting the existing complimentary expertise. More specifically, MICROSMETICS scientific concept involves the discovery of novel natural products originating from global microbial biodiversity. Already existing culture collections will be exploited incorporating modern high throughput platforms (in silico & in vitro) for the rational and targeted selection of the most promising strains. Advanced analytical approaches and techniques will be applied for the efficient, accelerated and advantageous isolation and identification of natural constituents as well as the quality assessment of the lead products. A broad spectrum of bioassays and novel analytical approaches will be incorporated for the evaluation of anti-ageing, more specifically anti-oxidant, skin-protecting, and skin-whitening activity of all derived products. Attention will be given to the selection and optimisation of fermentation technologies used for the production of final lead products to ensure sustainability. Within this frame, core scientific knowledge and lead compounds for further development are expected to be produced creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different dynamics and orientation. MICROSMETICS aspires to comprise a successful model of long-lasting collaboration between Industry and Academia for sustainable exploitation of existing know-how and produced knowledge.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2016 | Award Amount: 2.84M | Year: 2016

The Directive 2009/128/EC sets rules in EU for the sustainable use of pesticides to reduce the risks and impacts of pesticide use on peoples health and the environment. Among the listed actions there is the promotion of low pesticide-input management including non-chemical methods. In parallel several chemical active ingredients have been banned because of toxicity concerns. The result is that growers are left with few control tools against pests. On the other hand most of the available alternative control methods have several limitations, especially in term of efficacy. Several new ideas are not reaching the industry and are confined in the academic would. The concept behind this EIT is to explore new approaches to identify new cutting edge solutions for pest control based on new non classical approaches in strict collaboration with industrial partner and to train 10 highly skilled early stage researchers (ESR) through a doctoral programme that integrates 5 academic research with concept-driven product development in 5 EU companies with a strong curriculum in development and innovation within a large interdisciplinary environment. Microorganisms are often used so far as replacement of chemical active ingredients. The innovative aspect of this EID is to base the new pest control solutions on interactions of microorganisms with plants and insects rather than using them as plant protection products. Microorganisms unsurpassed inclination towards the association with eukaryotic macro-organisms determines traits and qualities in the host that harbours them. Microbial symbionts ability to profoundly transform their living habitat paves the way for unexplored outlooks in the ability to use microbial symbioses as sustainable and renewable tools to improve production and quality in agriculture. Microorganisms are key players in shaping several insects semiochemicals, in particular kairomones indicating a food source or oviposition site for some insect species.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.4-2 | Award Amount: 12.85M | Year: 2013

The thermal properties of nanostructured materials are of fundamental importance to modern technology, but at present reproducible metrological definitions, tools and methods do not exist. This is because the mechanisms of heat transport at the nanoscale are entirely different to those at the macro scale. The project will place nanothermal metrology on a solid basis by an integrated physics-based experimental and modelling effort to: Define a common terminology for nanothermal measurement Realise standard materials and devices for measurement and calibration of nanothermal measurements Develop new instruments and methods for traceable nanothermal measurement Develop calibrated and validated thermal models covering the range from atomic to macro-scale Apply these tools to selected representative industrial problems Assess the tools for suitability for adoption as potential standards of measurement including their traceability and reproducibility The objectives will be achieved by a team comprising physicists, materials scientists, modellers, instrumentalists, microscopists, industrial partners (including SMEs and OEMs) and National Measurement Institutes. The outputs of QUANTIHEAT will be embodied in highly characterised reference samples, calibration systems, measurement tools, numerical modelling tools, reference measurements and documented procedures. The availability of calibrated numerical modelling tools will facilitate the rapid digital thermal design of new nanosystems without the need for extensive prototyping. Their validation against experiment over all length scales will provide a solid basis for the deployment of new nanostructured materials, devices and structures having optimised performance without the need for excessively conservative design. Standardization is a key driver of industrial and scientific progress: QUANTIHEAT is expected to constitute a de-facto standard for a key area of physical measurement at the nanoscale worldwide.


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, University of Rouen and University of Reims Champagne Ardenne | Date: 2015-10-21

The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.


Patent
Airbus, University of Reims Champagne Ardenne and French National Center for Scientific Research | Date: 2015-02-11

A sizing composition for reinforcing fibres is provided which makes it possible to improve the adhesion of these fibres with respect to an organic matrix that forms, with them, a part made of a composite material and that results from the chain transfer polymerization of a curable resin. The sizing composition includes a polybutadiene prepolymer comprising at least two epoxide functions, a cross-linking agent comprising at least two reactive functions, at least one of which is a thiol function; and a catalyst comprising at least one tertiary amine function. The sizing composition may be used in the following fields of use: aeronautical, aerospace, railway, naval and motor vehicle industries, for example, for the production of structural, engine, passenger compartment or body work parts; arms industry, for example, for the production of parts incorporated into the composition of missiles or missile launch tubes; sports and leisure goods industry, for example, for the production of goods intended for water sports and board sports.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 567.00K | Year: 2015

Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.

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