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Matias E.F.F.,University of Region of Cariri | Santos K.K.A.,University of Region of Cariri | Costa J.G.M.,Leo Sampaio College | Coutinho H.D.M.,University of Region of Cariri
Asian Biomedicine | Year: 2010

Background: Although broad-band ultraviolet (UV)-A has been described as a therapeutic option for various skin diseases, there are few studies investigating the efficacy of UV-A irradiation in treating diseases related to infectious agents. Objective: Evaluate the light-enhanced antibacterial activity of Brazilian medical plants, Croton campestris A (Euphorbiaceae), Ocimum gratissimum L. (Lamiaceae), and Cordia verbenaceae DC (Boraginaceae). Methods: Hexane extracts of Croton campestris A., Ocimum gratissimum L., and Cordia verbenaceae DC were assayed using a UV-A exposure method against strains of Staphylococcus aureus and Escherichia coli. Assays were performed in triplicate with and without exposure to UV-A radiation to test for light-activated or lightenhanced antibacterial activity. Results: All extracts showed activity against the S. aureus strain. Extracts of O. gratissimum and C. verbenaceae were the most active after exposure to UV-A light, with an increase in antibacterial activity of 140 and 100%, respectively. No extract showed light-activated antibacterial activity against E. coli. Conclusion: C. campestris, O. gravissimum and C. verbenaceae showed light-enhanced antibiotic activity. This suggests that phytochemical investigations may be warranted.

Santos A.K.L.,University of Region of Cariri | Costa J.G.M.,University of Region of Cariri | Menezes I.R.A.,University of Region of Cariri | Cansancao I.F.,Federal University of Ceará | And 3 more authors.
Pharmacognosy Magazine | Year: 2010

Background: This study evaluates the radical-scavenging activity of five plants used as food and medicines in the northeastern region of Brazil. Materials and Methods: Spectrophotometric analysis of the plants′ ethanol extracts was carried out. The antioxidant activity was determined by the DPPH (2,2-diphenyl-1 picrylhydrazyl) test. The antioxidant capacity was measured using ascorbic acid as a positive control. Results: All tested plant extracts showed an antioxidant activity, but the highest activity was observed with the extracts of Momordica charantia and Eugenia jambolana. Conclusions: Therefore, these species must be studied as a putative source of products for use in the prevention and treatment of diseases in which oxidants or free radicals are implicated.

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