Reading, United Kingdom

University of Reading
Reading, United Kingdom

The University of Reading is a public research university in Reading, Berkshire, United Kingdom. The university was established in 1892 as University College, Reading and received its Royal Charter in 1926. It is based on several campuses in, and around, the town of Reading.The university has a long tradition of research, education and training at a local, national and international level. It offers traditional degrees alongside less usual and other vocationally relevant ones. Wikipedia.

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Agency: European Commission | Branch: H2020 | Program: ERA-NET-Cofund | Phase: SC5-02-2015 | Award Amount: 78.28M | Year: 2016

Within the European Research Area (ERA), the ERA4CS Consortium is aiming to boost, research for Climate Services (CS), including climate adaptation, mitigation and disaster risk management, allowing regions, cities and key economic sectors to develop opportunities and strengthen Europes leadership. CS are seen by this consortium as driven by user demands to provide knowledge to face impacts of climate variability and change, as well as guidance both to researchers and decisionmakers in policy and business. ERA4CS will focus on the development of a climate information translation layer bridging user communities and climate system sciences. It implies the development of tools, methods, standards and quality control for reliable, qualified and tailored information required by the various field actors for smart decisions. ERA4CS will boost the JPI Climate initiative by mobilizing more countries, within EU Member States and Associated Countries, by involving both the research performing organizations (RPOs) and the research funding organizations (RFOs), the distinct national climate services and the various disciplines of academia, including Social Sciences and Humanities. ERA4CS will launch a joint transnational co-funded call, with over 16 countries and up to 75M, with two complementary topics: (i) a cash topic, supported by 12 RFOs, on co-development for user needs and action-oriented projects; (ii) an in-kind topic, supported by 28 RPOs, on institutional integration of the research components of national CS. Finally, ERA4CS additional activities will initiate a strong partnership between JPI Climate and others key European and international initiatives (as Copernicus, KIC-Climate, JPIs, WMO/GFCS, Future Earth, Belmont Forum) in order to work towards a common vision and a multiyear implementation strategy, including better co-alignment of national programs and activities up to 2020 and beyond.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: DRS-01-2015 | Award Amount: 14.54M | Year: 2016

The ultimate purpose of ANYWHERE is to empower exposed responder institutions and citizens to enhance their anticipation and pro-active capacity of response to face extreme and high-impact weather and climate events. This will be achieved through the operational implementation of cutting-edge innovative technology as the best way to enhance citizens protection and saving lives. ANYWHERE proposes to implement a Pan-European multi-hazard platform providing a better identification of the expected weather-induced impacts and their location in time and space before they occur. This platform will support a faster analysis and anticipation of risks prior the event occurrence, an improved coordination of emergency reactions in the field and help to raise the self-preparedness of the population at risk. This significant step-ahead in the improvement of the pro-active capacity to provide adequate emergency responses is achievable capitalizing on the advanced forecasting methodologies and impact models made available by previous RTD projects, maximizing the uptake of their innovative potential not fully exploited up to now. The consortium is build upon a strong group of Coordinators of previous key EC projects in the related fields, together with 12 operational authorities and first responders institutions and 6 leading enterprises of the sector. The platform will be adapted to provide early warning products and locally customizable decision support services proactively targeted to the needs and requirements of the regional and local authorities, as well as public and private operators of critical infrastructures and networks. It will be implemented and demonstrated in 4 selected pilot sites to validate the prototype that will be transferred to the real operation. The market uptake will be ensured by the cooperation with a SME and Industry Collaborative Network, covering a wide range of sectors and stakeholders in Europe, and ultimately worldwide.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-21-2016 | Award Amount: 4.26M | Year: 2017

Screening for vision and hearing disorders in children has shown to be highly effective. EU-directive 16620/11 invites EU-member states to give priority to such screening programmes. Early detection and treatment of a lazy eye (prevalence 3%) prevents lifelong visual impairment. Early detection and treatment of hearing impairment (prevalence 0.15%) prevents delayed speech and language development. Across Europe inequity exists in the provision of childhood vision and hearing screening programmes (VAHSPs). High-Income Countries (HICs) have VAHSPs, but they vary with regard to age and frequency of testing, tests used, uptake, screening professionals, referral pathway and funding. This makes it difficult for healthcare providers and policy makers to decide what VAHSP to implement in Low- to Middle-Income Countries (LMICs) and how. In this study, cost-optimised, evidence-based VAHSPs will be implemented in two LMICs, based on collated evidence from existing VAHSPs in Europe. Data on VAHSPs, demography, administration, general screening, screening professions, uptake and treatment availability will be gathered in an established network of professionals in 41 European countries and used in a disease/health system modelling framework to predict benefits and cost in the most optimal health system, taking regional diversity and organisational and resource requirements into account. Model-developed VAHSPs will be tested in the county of Cluj in Romania for vision, and in three counties in Albania for hearing screening. A generic strategy for implementation will be developed by detailed tracking, and from identified requirements, facilitators and barriers. The decision-analytic modelling framework and the strategy for implementation will be packed into a transferable TOOLKIT that will assist healthcare providers and policy makers worldwide in their decisions to introduce or modify VAHSPs, and increase effectiveness, efficiency and equity of child healthcare.

Hamley I.W.,University of Reading
Angewandte Chemie - International Edition | Year: 2014

The self-assembly of different classes of peptide, including cyclic peptides, amyloid peptides and surfactant-like peptides into nanotube structures is reviewed. The modes of self-assembly are discussed. Additionally, applications in bionanotechnology and synthetic materials science are summarized. Building biotubes: The self-assembly of peptide nanotubes from different classes of peptide, including cyclic peptides, amyloid peptides, and surfactant-like peptides, is reviewed. Their applications in bionanotechnology and synthetic materials science are summarized. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Wheeler T.,University of Reading | Von Braun J.,University of Bonn
Science | Year: 2013

Climate change could potentially interrupt progress toward a world without hunger. A robust and coherent global pattern is discernible of the impacts of climate change on crop productivity that could have consequences for food availability. The stability of whole food systems may be at risk under climate change because of short-term variability in supply. However, the potential impact is less clear at regional scales, but it is likely that climate variability and change will exacerbate food insecurity in areas currently vulnerable to hunger and undernutrition. Likewise, it can be anticipated that food access and utilization will be affected indirectly via collateral effects on household and individual incomes, and food utilization could be impaired by loss of access to drinking water and damage to health. The evidence supports the need for considerable investment in adaptation and mitigation actions toward a "climate-smart food system" that is more resilient to climate change influences on food security.

McGuffin L.J.,University of Reading
Nucleic acids research | Year: 2013

Once you have generated a 3D model of a protein, how do you know whether it bears any resemblance to the actual structure? To determine the usefulness of 3D models of proteins, they must be assessed in terms of their quality by methods that predict their similarity to the native structure. The ModFOLD4 server is the latest version of our leading independent server for the estimation of both the global and local (per-residue) quality of 3D protein models. The server produces both machine readable and graphical output, providing users with intuitive visual reports on the quality of predicted protein tertiary structures. The ModFOLD4 server is freely available to all at:

Shepherd T.G.,University of Reading
Nature Geoscience | Year: 2014

The evidence for anthropogenic climate change continues to strengthen, and concerns about severe weather events are increasing. As a result, scientific interest is rapidly shifting from detection and attribution of global climate change to prediction of its impacts at the regional scale. However, nearly everything we have any confidence in when it comes to climate change is related to global patterns of surface temperature, which are primarily controlled by thermodynamics. In contrast, we have much less confidence in atmospheric circulation aspects of climate change, which are primarily controlled by dynamics and exert a strong control on regional climate. Model projections of circulation-related fields, including precipitation, show a wide range of possible outcomes, even on centennial timescales. Sources of uncertainty include low-frequency chaotic variability and the sensitivity to model error of the circulation response to climate forcing. As the circulation response to external forcing appears to project strongly onto existing patterns of variability, knowledge of errors in the dynamics of variability may provide some constraints on model projections. Nevertheless, higher scientific confidence in circulation-related aspects of climate change will be difficult to obtain. For effective decision-making, it is necessary to move to a more explicitly probabilistic, risk-based approach. © 2014 Macmillan Publishers Limited. All rights reserved 704.

Tailleux R.,University of Reading
Annual Review of Fluid Mechanics | Year: 2013

Lorenz's theory of available potential energy (APE) remains the main framework for studying the atmospheric and oceanic energy cycles. Because the APE generation rate is the volume integral of a thermodynamic efficiency times the local diabatic heating/cooling rate, APE theory is often regarded as an extension of the theory of heat engines. Available energetics in classical thermodynamics, however, usually relies on the concept of exergy and is usually measured relative to a reference-state maximizing entropy at constant energy, whereas APE's reference state minimizes potential energy at constant entropy. This review seeks to shed light on the two concepts; it covers local formulations of available energetics, alternative views of the dynamics/thermodynamics coupling, APE theory and the second law of thermodynamics, APE production/dissipation, extensions to binary fluids, mean/eddy decompositions, APE in incompressible fluids, APE and irreversible turbulent mixing, and the role of mechanical forcing on APE production. Copyright © 2013 by Annual Reviews. All rights reserved.

Hamley I.W.,University of Reading
Chemical Reviews | Year: 2012

A study was conducted to investigate the role of the amyloid β (Aβ)-peptide in Alzheimer's disease (AD) and fibrillization. The aim was to introduce relevant key findings on physicochemical properties. Key aspects of the biology and biochemistry associated with the role of Aβ in AD were also investigated along with developments in potential therapies and biomarkers. The aggregation of the amyloid β-peptide into oligomers or fibrils was implicated as a key process associated with progression of AD. A marked decrease or absence of tau expression appeared to reduce the neurotoxic effects of Aβ, while proteins including non-β-amyloid component (NAC) were codeposited along with Aβ in plaques. NAC comprised of residues 61-95 of a-synuclein, which was involved in amyloidoses with Lewy bodies such as Parkinson's disease.

Agency: GTR | Branch: BBSRC | Program: | Phase: Research Grant | Award Amount: 1.54M | Year: 2017

The AFTP comprises an elite partnership of research institutions that have the scientific credentials to provide training in the technical skills and innovation needs of the UK agriculture and food industries on a global stage. The primary role of the AFTP is to deliver University-accredited and recognised high-level training that up-skills staff employed within the agrifood sector and disseminates the quality and technical advancements of UK research. This remit makes a major contribution to the commitment of BBSRC, as outlined in its 2015/16 delivery plan, to support world class training in the biosciences and provide the skills necessary for delivering continuing innovation in the bioeconomy to generate benefits for society within the UK and worldwide.

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