Ajmer, India

Central University of Rajasthan is an educational institution in Rajasthan, India. The Central University of Rajasthan was established by an Act of Parliament as a new Central University, and is fully funded by the Government of India.The Central Universities Bill 2009 aims at creating one new central university each in Bihar, Gujarat, Haryana, Himachal Pradesh, Jammu and Kashmir, Jharkhand, Karnataka, Kerala, Orissa, Punjab, Rajasthan and Tamil Nadu. It also seeks to convert Guru Ghasidas Vishwavidyalaya in Chhattisgarh, Harisingh Gour Vishwavidyalaya in Sagar and Hemwati Nandan Bahuguna Garhwal University in Uttarakhand into Central universities. Wikipedia.

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Tiwari V.,Central University of Rajasthan | Khokhar M.,Central University of Rajasthan
European Journal of Pharmacology | Year: 2014

Coronary artery disease is one of the leading causes of death worldwide. One of the significant causes of this disease is hypercholesterolemia which is the result of various genetic alterations that are associated with the accumulation of specific classes of lipoprotein particles in plasma. A number of drugs are used to treat hypercholesterolemia like statin, fibrate, bile acid sequestrants, niacin, ezetimibe, omega-3 fatty acids and natural extracts. It has been observed that these drugs show diverse response in different individuals. The present review explains the mechanism of action of these drugs as well as mechanism of its lesser effectiveness or resistance in some individuals. There are various identified genetic variations that are associated with diversity in the drugs response. Therefore, present study helps to understand the ethiology of drug mechanism and resistance developed against drugs used to treat hypercholesterolemia. © 2014 Elsevier B.V.

Tiwari V.,Central University of Rajasthan | Tiwari M.,Central University of Rajasthan
Journal of Proteomics | Year: 2015

Acinetobacter baumannii causes pneumonia, bloodstream infections, urinary tract infections, respiratory infections and meningitis. A. baumannii has developed resistance against most of the antibiotics including carbapenem. Therefore, to battle carbapenem resistance, there is a need to develop antimicrobial drugs with new modes of action. Phosphoproteomics will help identify the differentially phosphorylated protein and its crucial phosphosites which facilitate the elucidation of molecular mechanism of signaling and regulation of carbapenem resistant strain of A. baumannii as compared to carbapenem sensitive strain. This understanding might be useful for the development of new antibiotics against kinases involved in the phosphorylation of identified phosphosites in carbapenem resistant strain of A. baumannii. The proposed antibiotics selectively inhibit carbapenem resistant strain which further avoids its excessive use against carbapenem sensitive strain and thereafter reduces emergence of resistance. © 2014 Elsevier B.V.

Mandal C.C.,Central University of Rajasthan
Frontiers in Endocrinology | Year: 2015

Many epidemiological studies show a positive connection between cardiovascular diseases and risk of osteoporosis, suggesting a role of hyperlipidemia and/or hypercholesterolemia in regulating osteoporosis. The majority of the studies indicated a correlation between high cholesterol and high LDL-cholesterol level with low bone mineral density, a strong predictor of osteoporosis. Similarly, bone metastasis is a serious complication of cancer for patients. Several epidemiological and basic studies have established that high cholesterol is associated with increased cancer risk. Moreover, osteoporotic bone environment predisposes the cancer cells for metastatic growth in the bone microenvironment. This review focuses on how cholesterol and cholesterol-lowering drugs (statins) regulate the functions of bone residential osteoblast and osteoclast cells to augment or to prevent bone deterioration. Moreover, this study provides an insight into molecular mechanisms of cholesterol-mediated bone deterioration. It also proposes a potential mechanism by which cellular cholesterol boosts cancer-induced bone metastasis. © 2015 Mandal.

Haldar S.,Uppsala University | Kanhere D.G.,Central University of Rajasthan | Sanyal B.,Uppsala University
Physical Review B - Condensed Matter and Materials Physics | Year: 2012

We have investigated the electronic and magnetic response of a single Fe atom and a pair of interacting Fe atoms placed in patterned dehydrogenated channels in graphane within the framework of density functional theory. We have considered two channels: "armchair" and "zigzag" channels. Fully relaxed calculations have been carried out for three different channel widths. Our calculations reveal that the response to the magnetic impurities is very different for these two channels. We have also shown that one can stabilize magnetic impurities (Fe in the present case) along the channels of bare carbon atoms, giving rise to a magnetic insulator or a spin gapless semiconductor. Our calculations with spin-orbit coupling shows a large in-plane magnetic anisotropy energy for the case of the armchair channel. The magnetic exchange coupling between two Fe atoms placed in the semiconducting channel with an armchair edge is very weakly ferromagnetic whereas a fairly strong ferromagnetic coupling is observed for reasonable separations between Fe atoms in the zigzag-edged metallic channel with the coupling mediated by the bare carbon atoms. The possibility of realizing an ultrathin device with interesting magnetic properties is discussed. © 2012 American Physical Society.

Tiwari V.,Central University of Rajasthan | Tiwari M.,Central University of Rajasthan
Frontiers in Microbiology | Year: 2014

Acinetobacter baumannii is an opportunistic pathogen causing pneumonia, respiratory infections and urinary tract infections. The prevalence of this lethal pathogen increases gradually in the clinical setup where it can grow on artificial surfaces, utilize ethanol as a carbon source. Moreover it resists desiccation. Carbapenems, a β-lactam, are the most commonly prescribed drugs against A. baumannii. Resistance against carbapenem has emerged in Acinetobacter baumannii which can create significant health problems and is responsible for high morbidity & mortality. With the development of quantitative proteomics, a considerable progress has been made in the study of carbapenem resistance of Acinetobacter baumannii. Recent updates showed that quantitative proteomics has now emerged as an important tool to understand the carbapenem resistance mechanism in Acinetobacter baumannii. Present review also highlights the complementary nature of different quantitative proteomic methods used to study carbapenem resistance and suggests to combine multiple proteomic methods for understanding the response to antibiotics by Acinetobacter baumannii. © 2014 Tiwari and Tiwari.

Prajapat J.K.,Central University of Rajasthan | Aouf M.K.,Mansoura University
Computers and Mathematics with Applications | Year: 2012

In this paper we investigate a majorization problem for a subclass of p-valently analytic function involving a generalized fractional differintegral operator. Some useful consequences of the main result are mentioned and relevance with some of the earlier results are also pointed out. © 2011 Elsevier Ltd. All rights reserved.

Prajapat J.K.,Central University of Rajasthan
Mathematical and Computer Modelling | Year: 2012

We obtain subordination and superordination preserving properties for a new generalized multiplier transformation operator, defined for multivalent functions in the open unit disk. A differential sandwich-type theorem for these multivalent functions, and some consequences are also presented. © 2011 Elsevier Ltd.

Mini S.,Central University of Rajasthan | Udgata S.K.,University of Hyderabad | Sabat S.L.,University of Hyderabad
IEEE Sensors Journal | Year: 2014

Network lifetime plays an integral role in setting up an efficient wireless sensor network. The objective of this paper is twofold. The first one is to deploy sensor nodes at optimal locations such that the theoretically computed network lifetime is maximum. The second is to schedule these sensor nodes such that the network attains the maximum lifetime. Thus, the overall objective of this paper is to identify optimal deployment locations of the given sensor nodes with a pre-specified sensing range, and to schedule them such that the network lifetime is maximum with the required coverage level. Since the upper bound of the network lifetime for a given network can be computed mathematically, we use this knowledge to compute locations of deployment such that the network lifetime is maximum. Further, the nodes are scheduled to achieve this upper bound. In this paper, we use artificial bee colony algorithm and particle swarm optimization for sensor deployment problem followed by a heuristic for scheduling. A comparative study shows that artificial bee colony algorithm performs better for sensor deployment problem. The proposed heuristic was able to achieve the theoretical upper bound in all the experimented cases. © 2013 IEEE.

Pareek N.,Umeå University | Pareek N.,Central University of Rajasthan | Gillgren T.,Umeå University | Jonsson L.J.,Umeå University
Bioresource Technology | Year: 2013

Protein adsorption onto eight lignocellulosic substances (six lignin preparations and two hemicelluloses) was investigated at pH 4.8 and at two different temperatures (4. °C and 45. °C). The kinetics of the adsorption of cellulase, xylanase, and β-glucosidase were determined by enzyme activity measurements. The maximum adsorption capacities, the affinity constants and the binding strengths varied widely and were typically higher for the lignins than for the carbohydrates. As indicated by BET and gel permeation chromatography, different substances had widely different surface area, pore size, weight average molecular weight, and polydispersity index, but these properties were difficult to relate to protein binding. In most cases, an increase in temperature from 4. °C to 45. °C and a low content of carboxylic acid groups, as indicated by Fourier-Transform Infra-Red (FTIR) spectroscopy, resulted in increased protein adsorption capacity, which suggests that hydrophobic interactions play an important role. © 2013 The Authors.

Tiwari V.,Central University of Rajasthan | Roy R.,Central University of Rajasthan | Tiwari M.,Central University of Rajasthan
Frontiers in Microbiology | Year: 2015

Bacterial pathogens cause a number of lethal diseases. Opportunistic bacterial pathogens grouped into ESKAPE pathogens that are linked to the high degree of morbidity, mortality and increased costs as described by Infectious Disease Society of America. Acinetobacter baumannii is one of the ESKAPE pathogens which cause respiratory infection, pneumonia and urinary tract infections. The prevalence of this pathogen increases gradually in the clinical setup where it can grow on artificial surfaces, utilize ethanol as a carbon source and resists desiccation. Carbapenems, a β-lactam, are the most commonly prescribed drugs against A. baumannii. The high level of acquired and intrinsic carbapenem resistance mechanisms acquired by these bacteria makes their eradication difficult. The pharmaceutical industry has no solution to this problem. Hence, it is an urgent requirement to find a suitable alternative to carbapenem, a commonly prescribed drug for Acinetobacter infection. In order to do this, here we have made an effort to review the active compounds of plants that have potent antibacterial activity against many bacteria including carbapenem resistant strain of A. baumannii. We have also briefly highlighted the separation and identification methods used for these active compounds. This review will help researchers involved in the screening of herbal active compounds that might act as a replacement for carbapenem. © 2015 Tiwari, Roy and Tiwari.

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