University of Qadisiya

College of Science, Iraq

University of Qadisiya

College of Science, Iraq
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Al-Adilee K.J.,University of Qadisiya | Abedalrazaq K.A.,University of Anbar | Al-Hamdiny Z.M.,University of Qadisiya
Asian Journal of Chemistry | Year: 2013

A new ligand containing thiazole and imidazole rings as organic heterocyclic azo dye compound 2-[-2-(6-nitro benzothiazolyl)azo]- imidazole (NBTAI) was prepared by coupling reaction between 6-nitro benzothiazole chloride with imidazole in alkaline alcoholic solution. New six complexes with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) were prepared and characterized by elemental analysis, molar conductance measurements, magnetic moment measurements at room temperature, infrared and electronic spectra. The analytical data show that the metal to ligand ratio [M:L] in all complexes is (1:2). The spectral and analytical data revealed that this ligand behaves as a bidentate chelating agent and the coordination number of all metal ions are found to be six in coordination through the nitrogen N3 atom of azo methine group of heterocyclic imidazole ring and the other nitrogen atom of azo group which is the farthest of imidazole molecule, from two ligands with two molecules and two chloride ions. The results are explained in the light of these analysis.


Al-Masoudi N.A.,University of Basrah | Kadhim R.A.,University of Qadisiya | Abdul-Rida N.A.,University of Qadisiya | Saeed B.A.,University of Basrah | Engel M.,Saarland University
Steroids | Year: 2015

A new class of steroids is being synthesized for its ability to prevent intratumoral androgen production by inhibiting the activity of CYP17 hydroxylase enzyme. The scheme involved the synthesis of chalcone derivative of pregnenolone 5 which was further modified to the corresponding biaryl-chalcone pregnenolone analogs 16-25 using Suzuki-Miyaura cross-coupling reaction. The synthesized compounds were tested for activity using human CYP17α hydroxylase expressed in Escherichia coli. Compounds 21 was the most active inhibitor in this series, with IC50 values of 0.61 μM and selectivity profile of 88.7% inhibition of hydroxylase enzyme. Molecular docking study of 21 was performed and showed the hydrogen bonds and hydrophobic interaction with the amino acid residues of the active site of CYP17. © 2015 Elsevier Inc. All rights reserved.


Esmail E.L.,University of Qadisiya
Meccanica | Year: 2013

This paper presents a MATLAB optimization technique for the determination of the gear ratios of epicyclic-type transmission mechanisms for a given set of velocity ratios. First, all of the feasible clutching sequences are enumerated directly without using complicated techniques. Then, for the transmission mechanism with the associated clutching sequence graph, the overall velocity ratios are derived and expressed in terms of the gear ratios of all the mating gears. Next, following the general trend of increased shift stages and a wider range of velocity ratios, the numbers of teeth of all gears are estimated by MATLAB optimization technique in a single run. Ravigneaux gear mechanisms are used as design examples. The methodology can be applied to any transmission mechanism depending on its kinematic and geometric constraints. New five- and six-velocity automatic transmissions are enumerated from the Ravigneaux gear mechanism. It is a major breakthrough to design a completely satisfactory six-speed automatic transmission from the Ravigneaux gear mechanism since it has only eight links. The new design makes use of the benefits of the Ravigneaux gear train and overcomes the previous art difficulties. This structural design has realized a six-speed automatic transmission, while having minimal number of clutches, and brakes. It is also low cost due to adoption of the conventional available Ravigneaux gear train. © 2013 Springer Science+Business Media Dordrecht.


Al-Masoudi N.A.,University of Basrah | Mahdi K.M.,University of Qadisiya | Abdul-Rida N.A.,University of Qadisiya | Saeed B.A.,University of Basrah | Engel M.,Saarland University
Steroids | Year: 2015

A new series of 17-(N-(arylimino)-5-pregnen-3β-ol derivatives 19-32 as well as carboxylate and acrylate analogues of pregnenolone 37-40 were synthesized and evaluated for their inhibitory activity against human CYP17 hydroxylase expressed in Escherichia coli. Compounds 32 and 37 were the most potent analogues in this series, showing inhibition activity with IC50 = 2.11 and 1.29 μM, respectively. However, the analogue 37 revealed a better selectivity profile (83.21% inhibition of hydroxylase), which is a leading candidate for further development. Molecular docking study of 37 showed binding with the amino acid residues of CYP17 through hydrogen bonds and hydrophobic interaction. © 2015 Published by Elsevier Inc.


A new series of transtion metal complexes of Co(II),Ni(II),Cu(II),Zn(II),Cd(II) and Hg(II) were prepared from the novelazo-schiff base ligand (BIADPI) from by coupling reaction of benzimidazolediazonium chloride with 3-(benzylideneimino)phenol.They have been characterized by elemental analsis (C.H.N),magnetic susceptibility,molar conductance and spectral techniques such us FT-IR, 1H-NMR,electronic spectra and mass spectrometry.The spectral studies of the comlexesreval that the azo-schiff base as a tridentate ligand coordination through the deprotonated phenolic oxygen, N3 of benzimidazole ring and N3 of azo group which is the farthest of benzimidazolemolecule.The molecular structure of the complexes has been optimized by the spectral datas and suggested teterahedral geometry with sp3 hybridisation of Zn(II)-complex and octahedral geometry with sp3d2 hybridization of other metal complexes. All complexes that non-electrolyte and no conductive species exist excepted the Co(III)-complex is 1:1 electrolyte.


Al-Masoudi N.A.,University of Basrah | Kassim A.G.,University of Qadisiya | Abdul-Reda N.A.,University of Qadisiya
Nucleosides, Nucleotides and Nucleic Acids | Year: 2014

A series of 4-Amino-5-((4-chlorophenyl)diazenyl)-6-(alkylamino)-1- methylpyrimidin-2-one deri- vatives 7-16 were prepared by nucleophilic displacement of 6-chloro-pyrimidine 6 by various amines. 4-Amino-5-((aryl-4-yl) diazenyl)-6-Aryl-1-methylpyrimidin-2-one analogs 19-27, as well as 4-Amino-5-((aryl-[1,1′-biphenyl]-4-yl)diazenyl)-6-Aryl-1-methylpyrimidin- 2-one 29-31 and 4-Amino-6-Aryl-1-methylpyrimidin-2-one 34-34, were synthesized via Suzuki cross-coupling reaction, using Pd(PPh3)4 as a catalyst and arylboronic acids as reagents. All compounds were evaluated for their antiviral activity against the replication of HIV-1 and HIV-2 in MT-4. Compounds 6, 16, 27, and 29 showed a 50% effective concentration of >2.15, >3.03, >2.29, and >1.63 μM, respectively, but no selectivity was observed (selectivity index < 1). Two of the newly synthesized pyrimidines 12 and 29 exhibited moderate kinesin Eg5 inhibition. © 2014 Copyright Taylor & Francis Group, LLC.


Dawood H.I.,University Malaysia Perlis | Dawood H.I.,University of Qadisiya | Mohammed K.S.,University Malaysia Perlis | Rahmat A.,University Malaysia Perlis | Uday M.B.,Imperial College London
Transactions of Nonferrous Metals Society of China (English Edition) | Year: 2015

The effect of small tool pin profiles on the microstructures and mechanical properties of 6061 aluminum alloy joints using friction stir welding (FSW) technique was investigated. Three different tool pin profiles: threaded tapered cylindrical (T1), triangular (T2) and square (T3) were used to produce the joints. The results indicate that the weld joints are notably affected by joining with different tool pin profiles. The triangular tool pin profile produces the best metallurgical and mechanical weld properties compared with other tool pin profiles. Besides, the lowest tensile strength and microhardness are obtained for the joint friction stir welded with square tool pin profile. It is observed that the smaller tool pin profile and shoulder diameter lead to narrow region of heat affected zone (HAZ) and a desired level of softening. The fracture surface examination shows that the joints are also affected when welding with different types of tool pin profiles. The fracture surface shows that the triangular specimen fails with a ductile fracture mode during the tensile test, while the brittle fracture modes are observed in the joints fabricated with other tool pin profiles (T1 and T3). © 2015 The Nonferrous Metals Society of China.


Khan I.,University of Nottingham | Khan I.,Quaid-i-Azam University | Hameed S.,Quaid-i-Azam University | Al-Masoudi N.A.,Am Tannenhof 8 | And 3 more authors.
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences | Year: 2015

A new series of fused 1,2,4-triazoles, namely 6-aryl-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 3a-h and 4a-f as well as 6-aryl-3-(furan-2-yl)- 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines 5a-h, were synthesized by the condensation of 4-amino-5-(furan-2- yl)-4H-1,2,4-triazole-3-thiol (2) with substituted aromatic acids and phenacyl bromides, respectively. The structures of the newly synthesized compounds were established using spectroscopic analysis, while that of 3e was confirmed independently by a single-crystal X-ray structure determination. The compounds were evaluated for their antiviral activity against the replication of HIV-1 and HIV-2 in MT-4 cells using an MTT assay. In a docking study, 4b interacted with several amino acids in the reverse transcriptase (RT) binding site of HIV-1. Some new analogues were selected for evaluation of their Eg5 inhibitory activity using an in vitro malachite green ATPase assay. The QSAR of these new analogues was studied as well.


PubMed | University of Qadisiya, University of Basrah and Saarland University
Type: | Journal: Steroids | Year: 2015

A new class of steroids is being synthesized for its ability to prevent intratumoral androgen production by inhibiting the activity of CYP17 hydroxylase enzyme. The scheme involved the synthesis of chalcone derivative of pregnenolone 5 which was further modified to the corresponding biaryl-chalcone pregnenolone analogs 16-25 using Suzuki-Miyaura cross-coupling reaction. The synthesized compounds were tested for activity using human CYP17 hydroxylase expressed in Escherichia coli. Compounds 21 was the most active inhibitor in this series, with IC50 values of 0.61M and selectivity profile of 88.7% inhibition of hydroxylase enzyme. Molecular docking study of 21 was performed and showed the hydrogen bonds and hydrophobic interaction with the amino acid residues of the active site of CYP17.


PubMed | University of Niš and University of Qadisiya
Type: | Journal: Computational and mathematical methods in medicine | Year: 2015

Geometrically accurate and anatomically correct 3D models of the human bones are of great importance for medical research and practice in orthopedics and surgery. These geometrical models can be created by the use of techniques which can be based on input geometrical data acquired from volumetric methods of scanning (e.g., Computed Tomography (CT)) or on the 2D images (e.g., X-ray). Geometrical models of human bones created in such way can be applied for education of medical practitioners, preoperative planning, etc. In cases when geometrical data about the human bone is incomplete (e.g., fractures), it may be necessary to create its complete geometrical model. The possible solution for this problem is the application of parametric models. The geometry of these models can be changed and adapted to the specific patient based on the values of parameters acquired from medical images (e.g., X-ray). In this paper, Method of Anatomical Features (MAF) which enables creation of geometrically precise and anatomically accurate geometrical models of the human bones is implemented for the creation of the parametric model of the Human Mandible Coronoid Process (HMCP). The obtained results about geometrical accuracy of the model are quite satisfactory, as it is stated by the medical practitioners and confirmed in the literature.

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