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Potsdam, Germany

Not to be confused with the American university SUNY Potsdam at the State University of New YorkThe University of Potsdam is a German public university in the Berlin-Brandenburg region of Germany. It is situated across four campuses in Potsdam, Brandenburg, including the New Palace of Sanssouci and Babelsberg Park.The University of Potsdam is Brandenburg's largest university and with its numerous extramural institutes, the Potsdam and Berlin area is known as one of the most densely settled research landscapes in Germany. As for the University of Potsdam, more than 8,000 people are working in scholarship and science. As a winner in the competition "Excellence in Teaching" of the Stifterverband für die Deutsche Wissenschaft and the standing conference of the Ministers of Education and Cultural Affairs of the Länder in the Federal Republic of Germany , the University of Potsdam is rigorously implementing its plan to further improve teaching. Wikipedia.

Boese A.D.,University of Potsdam
Journal of Chemical Theory and Computation | Year: 2013

To assess the accuracy of post-Hartree-Fock methods like CCSD(T), MP3, MP2.5, MP2, SCS-MP2, SOS-MP2, and DFT-SAPT, we evaluated several effects going beyond valence-correlated CCSD(T). For 16 small hydrogen bonded systems, CCSD(T) achieves an RMS error of 0.17 kJ/mol in the dissociation energy compared to our best estimate, which is a composite method akin to W4 theory. The error of CCSD(T) is thus much lower than for atomization energies. MP2 is surprisingly accurate for these systems with an RMS error of 1.3 kJ/mol. MP2.5 yields a clear improvement over MP2 (RMS of 0.5 kJ/mol) but still has an error about 3 times as large as CCSD(T) for the absolute RMS and almost 10 times as large for the relative RMS error. Neither SCS-MP2, SOS-MP2, nor DFT-SAPT yield lower errors than MP2. With a ΔCCSD(T) correction to MP2, the basis set limit is readily achieved when employing diffuse functions - without these, the convergence is rather slow. © 2013 American Chemical Society.

Dittmann E.,University of Potsdam | Fewer D.P.,University of Helsinki | Neilan B.A.,University of New South Wales
FEMS Microbiology Reviews | Year: 2013

Cyanobacteria produce an unparalleled variety of toxins that can cause severe health problems or even death in humans, and wild or domestic animals. In the last decade, biosynthetic pathways have been assigned to the majority of the known toxin families. This review summarizes current knowledge about the enzymatic basis for the production of the hepatotoxins microcystin and nodularin, the cytotoxin cylindrospermopsin, the neurotoxins anatoxin and saxitoxin, and the dermatotoxin lyngbyatoxin. Elucidation of the biosynthetic pathways of the toxins has paved the way for the development of molecular techniques for the detection and quantification of the producing cyanobacteria in different environments. Phylogenetic analyses of related clusters from a large number of strains has also allowed for the reconstruction of the evolutionary scenarios that have led to the emergence, diversification, and loss of such gene clusters in different strains and genera of cyanobacteria. Advances in the understanding of toxin biosynthesis and evolution have provided new methods for drinking-water quality control and may inspire the development of techniques for the management of bloom formation in the future. We report the biosynthetic pathways of cyanobacterial toxins and describe the evolutionary scenarios that have led to the emergence, diversification and loss of such gene clusters. © 2012 Federation of European Microbiological Societies.

Shapiro B.,University of California at Santa Cruz | Hofreiter M.,University of York | Hofreiter M.,University of Potsdam
Science | Year: 2014

The publication of partial and complete paleogenomes within the last few years has reinvigorated research in ancient DNA. No longer limited to short fragments of mitochondrial DNA, inference of evolutionary processes through time can now be investigated from genome-wide data sampled as far back as 700,000 years. Tremendous insights have been made, in particular regarding the hominin lineage. With rare exception, however, a paleogenomic perspective has been mired by the quality and quantity of recoverable DNA. Though conceptually simple, extracting ancient DNA remains challenging, and sequencing ancient genomes to high coverage remains prohibitively expensive for most laboratories. Still, with improvements in DNA isolation and declining sequencing costs, the taxonomic and geographic purview of paleogenomics is expanding at a rapid pace. With improved capacity to screen large numbers of samples for those with high proportions of endogenous ancient DNA, paleogenomics is poised to become a key technology to better understand recent evolutionary events.

Kirchner S.,University of Potsdam
Nature Reviews Genetics | Year: 2014

tRNAs, nexus molecules between mRNAs and proteins, have a central role in translation. Recent discoveries have revealed unprecedented complexity of tRNA biosynthesis, modification patterns, regulation and function. In this Review, we present emerging concepts regarding how tRNA abundance is dynamically regulated and how tRNAs (and their nucleolytic fragments) are centrally involved in stress signalling and adaptive translation, operating across a wide range of timescales. Mutations in tRNAs or in genes affecting tRNA biogenesis are also linked to complex human diseases with surprising heterogeneity in tissue vulnerability, and we highlight cell-specific aspects that modulate the disease penetrance of tRNA-based pathologies. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Lederer M.,University of Potsdam
Ecological Economics | Year: 2011

This article compares two carbon governance instruments - the Clean Development Mechanism (CDM) and Reducing Emissions from Deforestation and Degradation (REDD+) - to assess lessons from the former for the latter regarding effectiveness and legitimacy of such instruments. The article argues that the CDM has a relatively high degree of output-oriented legitimacy resulting in effectiveness and some input-oriented legitimacy, with few discernible tradeoffs between them. In contrasting this to REDD+, the hypotheses are advanced that (i) output-oriented legitimacy/effectiveness can again be achieved but that (ii) a higher degree of input-oriented legitimacy is necessary for REDD+ and thus also a certain trade-off between the two forms of legitimacy can be expected. This is shown through comparing the technologies and methodologies, economic rationales, political support, regulatory structures, and environmental impacts of both instruments. © 2011 Elsevier B.V.

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