Pittsburgh, PA, United States

University of Pittsburgh

Pittsburgh, PA, United States

The University of Pittsburgh is a state-related research university located in Pittsburgh, Pennsylvania. It was founded on the edge of the American frontier as the Pittsburgh Academy in 1787, and evolved into the Western University of Pennsylvania by alteration of its charter in 1819. After surviving two devastating fires and various relocations within the area, the school moved to its current location in the Oakland neighborhood of the city and was renamed to the University of Pittsburgh in 1908. For most of its history Pitt was a private institution, until it became part of the Commonwealth System of Higher Education in 1966.The university is composed of 17 undergraduate and graduate schools and colleges located at its urban Pittsburgh campus, home to the university's central administration and 28,766 undergraduate, graduate, and professional students. The university also includes four additional undergraduate schools located at campuses within Western Pennsylvania: Bradford, Greensburg, Johnstown, and Titusville. The 132-acre Pittsburgh campus comprises multiple historic buildings of the Schenley Farms Historic District, most notably its 42-story gothic revival centerpiece, the Cathedral of Learning. The campus is situated adjacent to the flagship medical facilities of its closely affiliated University of Pittsburgh Medical Center , as well as the Carnegie Museums of Pittsburgh, Schenley Park, and Carnegie Mellon University.The university has an annual operating budget of approximately $2 billion that includes nearly $900 million in research and development expenditures. A member of the Association of American Universities, Pitt is the sixth largest recipient of federally sponsored research funding among U.S. universities in 2013 and is a major recipient of research funding from the National Institutes of Health. It is the second largest non-government employer in the Pittsburgh region behind UPMC. Pitt has been placed among the top public universities in the United States in both domestic and international rankings, and has been listed as a "best value" in higher education by multiple publications.Pitt students have access to various arts programs throughout the campus and city, and can participate in approximately 350 student organizations. Pitt's varsity athletic teams, collectively known as the Pittsburgh Panthers, compete in Division I of the NCAA, primarily as members of the Atlantic Coast Conference. Wikipedia.

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University of Pittsburgh and Wake forest University | Date: 2017-02-10

The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within the patient.

University of Pittsburgh | Date: 2017-03-01

Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.

University of Pittsburgh | Date: 2017-01-25

The invention relates to magnesium-polymer composites, methods for their preparation and applications for their use. The composites include a combination of magnesium particles and polymer matrix. The polymer can include, but is not limited to, poly(lactic co-glycolic) acid. In certain embodiments, the composites of the invention are particularly useful for forming medical devices for implantation into a body of a patient. In certain other embodiments, the magnesium-polymer composites are useful for wound healing compositions for administration to an exterior surface of a body of a patient.

A universal, modular, temperature controlled MRI phantom for calibration and validation for anisotropic and isotropic imaging comprises an outer insulating shell configured to be received within an MRI chamber; an inner shell received within the outer insulating shell; a fluid conduits adjacent the inner shell for receiving temperature controlling fluid or gas cycling there-through; and a series of stacked layers of frames containing test points for the MRI phantom, each layer including at least one fiducial and including at least some anisotropic imaging test points in at least one frame and at least one isotropic imaging test point in at least one frame. The anisotropic imaging comprises hollow tubular textile fibers, wherein each hollow tubular fiber has an outer diameter of less than 50 microns and an inner diameter of less than 20 microns, wherein at least some hollow tubular fibers are filled with a fluid.

University of Pittsburgh, Mayo Foundation For Medical Education And Research, Sakuma, Holditch and Koide | Date: 2017-04-19

This document relates to methods and materials for increasing viral vector infectivity. For example, methods and materials for using spliceosome inhibitors (e.g., U2 snRNP spliceosome inhibitors such as meayamycin B or pladienolide derivative E7107) to increase viral vector (e.g., adeno-associated virus-based vector) infectivity are provided.

University of Pittsburgh | Date: 2017-01-17

Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.

University of Pittsburgh | Date: 2017-03-29

It is disclosed herein that microperoxidases are capable of binding carbon monoxide (CO) with high affinity and displacing CO from hemoglobin, thereby acting as CO scavengers. The present disclosure provides methods of treating carboxyhemoglobinemia (or CO poisoning) in a subject by administering a therapeutically amount of an isolated or recombinant microperoxidase. Methods of removing CO from hemoglobin in blood or tissue by administering a therapeutically amount of an isolated or recombinant microperoxidase are also described. Methods of determining the effectiveness of a microperoxidase for removing CO from hemoglobin are further described.

Robbins P.D.,Scripps Research Institute | Morelli A.E.,University of Pittsburgh
Nature Reviews Immunology | Year: 2014

Extracellular vesicles, including exosomes, are small membrane vesicles derived from multivesicular bodies or from the plasma membrane. Most, if not all, cell types release extracellular vesicles, which then enter the bodily fluids. These vesicles contain a subset of proteins, lipids and nucleic acids that are derived from the parent cell. It is thought that extracellular vesicles have important roles in intercellular communication, both locally and systemically, as they transfer their contents, including proteins, lipids and RNAs, between cells. Extracellular vesicles are involved in numerous physiological processes, and vesicles from both non-immune and immune cells have important roles in immune regulation. Moreover, extracellular vesicle-based therapeutics are being developed and clinically tested for the treatment of inflammatory diseases, autoimmune disorders and cancer. Given the tremendous therapeutic potential of extracellular vesicles, this Review focuses on their role in modulating immune responses, as well as their potential therapeutic applications. © 2014 Macmillan Publishers Limited. All rights reserved.

Grace A.A.,University of Pittsburgh
Nature Reviews Neuroscience | Year: 2016

The dopamine system is unique among the brain's modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion. Dopamine neurons exhibit several activity patterns-including tonic and phasic firing-that are determined by a combination of endogenous pacemaker conductances and regulation by multiple afferent systems. Emerging evidence suggests that disruptions in these regulatory systems may underlie the pathophysiology of several psychiatric disorders, including schizophrenia and depression. © 2016 Macmillan Publishers Limited.

McClung C.A.,University of Pittsburgh
Biological Psychiatry | Year: 2013

Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression, bipolar disorder, and other mood disorders. These hypotheses include disruptions in monoamine transmission, hypothalamus-pituitary-adrenal axis function, immune function, neurogenesis, mitochondrial dysfunction, and neuropeptide signaling (to name a few). Nearly all people suffering from mood disorders have significant disruptions in circadian rhythms and the sleep/wake cycle. In fact, altered sleep patterns are one of the major diagnostic criteria for these disorders. Moreover, environmental disruptions to circadian rhythms, including shift work, travel across time zones, and irregular social schedules, tend to precipitate or exacerbate mood-related episodes. Recent studies have found that molecular clocks are found throughout the brain and body where they participate in the regulation of most physiological processes, including those thought to be involved in mood regulation. This review will summarize recent data that implicate the circadian system as a vital regulator of a variety of systems that are thought to play a role in the development of mood disorders. © 2013 Society of Biological Psychiatry.

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