Buchoux S.,University of Picardie Jules Verne
Bioinformatics | Year: 2017
When studying biological membranes, Molecular Dynamics (MD) simulations reveal to be quite complementary to experimental techniques. Because the simulated systems keep increasing both in size and complexity, the analysis of MD trajectories need to be computationally efficient while being robust enough to perform analysis on membranes that may be curved or deformed due to their size and/or protein-lipid interactions. This work presents a new software named FATSLiM ('Fast Analysis Toolbox for Simulations of Lipid Membranes') that can extract physical properties from MD simulations of membranes (with or without interacting proteins). Because it relies on the calculation of local normals, FATSLiM does not depend of the bilayer morphology and thus can handle with the same accuracy vesicles for instance. Thanks to an efficiency-driven development, it is also fast and consumes a rather low amount of memory. © The Author 2016. Published by Oxford University Press. All rights reserved.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.66M | Year: 2016
The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimers disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2\ ion; it is expressed almost ubiquitously; interacts with multiple G subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling. The objectives of CaSR Biomedicine are: 1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general. 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders. 4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area. Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).
Agency: European Commission | Branch: FP7 | Program: JTI-CS | Phase: JTI-CS-2013-1-SGO-02-072 | Award Amount: 599.96K | Year: 2013
The SAVER project addresses the task of power conversion with battery charging. To overcome the low power quality of passive converters, the SAVER concept consists of two parts, an AC/DC converter and a Li-ion battery, and allows key advantages such as smaller passive components, lower weight, higher efficiency and higher power density. The converter moves from passive to high-frequency active switching with forced cooling. It also will implement zero current zero voltage switching instead of hard switching methods. Moving from passive to active switching also brings with it the ability to integrate other types of control within the embedded processing power, required for the control loop execution. This brings with it the opportunity of embedding battery constraints, such as battery charging and monitoring. The other important development within SAVER is the Li-ion battery. Improving the power delivery capability of batteries is very important for the development of more electrical aircraft, and only Li-ion can deliver all of the requirements - but not without stringent safety measures. SAVER will not only allow the characterization of Li-ion batteries for aerospace use, but also advise on all aspects regarding Li-ion usage such as safety, optimization, monitoring, battery management systems, simulation as well as testing (cycling, temperature and impedance analysis). In addition to the hardware design and prototyping, the work includes a detailed technology study, covering topics such as power converters, battery chargers and applicable aerospace standards. These results will be used to deliver an architecture down-selection and help define specifications. SAVER will aid European aircraft manufacturers in testing and validating advanced power electronic converters and Li-ion technology for aerospace use; advancing more electrical aircraft and putting them at the forefront of industry.
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.88M | Year: 2013
The realization of efficient, cheap, reliable, scalable and portable terahertz (THz) radiation sources and detectors is one of the important objectives in modern applied physics. THz emitters and detectors have potential applications in biology, medicine, security and nondestructive in-depth imaging. However none of the existing THz devices satisfy the application requirements. The project consortium, which includes teams from the leading European universities: Durham, Vilnius, Paris-7, Exeter, St. Petersburg, Prague, Amiens, University of Iceland, Swiss Company Alpes laser and several industrial associated partners, proposes a broad range of new approaches aiming to bridge the terahertz gap: (i) Polariton-based THz emission using microcavities in the strong coupling regime, (ii) New types and concepts of semiconducting materials for short pulsed THz emission, (iii) Carbon nanotubes and graphene as THz emitters and detectors, (iv) Application of Ferroelectric and Multiferroic materials for THz devices. To achieve this objective, we are planning to educate and train a team of collaborating young physicists and device engineers able to conduct research and exploit its application in this new area.
University of Picardie Jules Verne and Mersen France Amiens Sas | Date: 2014-06-23
A method for monitoring the quality of a communication channel supported by a sliding contact, the method comprising the following steps: controlling (401) the application of a continuous electrical signal onto one of the elements of the sliding contact, receiving (402) a plurality of values (V(n)) of electrical signals measured on the other of the elements of the sliding contact, estimating (408) from said plurality of measured values, a variance parameter value, comparing (409) the variance parameter value with a threshold (THR) and, on the basis of the result of the comparison, generating a signal (CHANNEL_OK, CHANNEL_NOK) representative of the quality of the communication channel.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 864.00K | Year: 2017
Increased longevity with a high quality of life is desirable not only for personal life-satisfaction but also for reducing healthcare costs and for increasing the socioeconomic contributions of individuals in countries with ageing population demographics. Lifelong lifestyle has an important impact on health status in older age and adequate nutrition plays a key role in maintaining cellular functions within normal limits. Microelements such as zinc (Zn) and copper (Cu) are essential for life and are involved in the normal functioning of thousands of proteins. The dysregulation of these metals leads to perturbed homeostasis, disease and diminished quality of life. In this study, the molecular mechanisms by which ageing affects Zn and Cu absorption and excretion will be determined, and the consequent impact on metal flux and transport kinetics will be expressed by mathematical modelling. The project output will include a predictive model for the impact of ageing on Zn and Cu homeostasis, informing intervention with dietary advice or supplementation to improve longevity. The consortium combines intersectoral and interdisciplinary expertise from 3 EU and 2 partner countries with established links and clear potential for knowledge exchange and transfer of skills. The consortium objectives are: 1. To determine the impact of dietary Zn and Cu on the microbiota and also age-related changes in the microbiota composition on the absorption of Zn and Cu. 2. To understand the influence of senescence on the regulation of Zn and Cu flux into and out of key cells controlling their homeostasis (gut mucosal cells, pancreatic acinar cells and hepatocytes) and its impact on the expression of related genes such as transporters. 3. To determine how senescence affects the transporter proteins, channels and chaperones involved in regulating Zn and Cu trafficking through the key absorptive and excretory cells affecting body metal homeostasis.
French National Center for Scientific Research, University of Picardie Jules Verne, University Of Technology Of Varsovie and University of Rome La Sapienza | Date: 2014-12-01
A pentacyclic anion salt is provided for use thereof in electrolyte compositions. The compound has an inorganic, organic or organometallic cation M of valency m (1m3) and m anions corresponding to the formula (I) in which R_(f )is a CFZZ group in which Z is F or a perflouroalkyl group having from 1 to 3 carbon atoms, and Z is an H, F or Cl group, an optionally fluorinated or perfluorinated alkoxy group having from 1 to 5 carbon atoms, an optionally fluorinated or perfluorinated oxaalkoxy group having 1 to 5 carbon atoms or an optionally fluorinated or perfluorinated alkyl group having from 1 to 5 carbon atoms; Z being other than F when Z is F. An electrolyte composition comprises said salt in solution in a liquid solvent or a polymer solvent.
Agency: European Commission | Branch: FP7 | Program: JTI-CS | Phase: JTI-CS-2013-2-SGO-02-076 | Award Amount: 1.48M | Year: 2014
The development of a more electrical aircraft is a technological transition applied or envisioned for almost all the systems in the aircrafts and helicopters. Together with the electrification of aircraft actuation systems, also the implementation of an electric propulsion can lead to many advantages in terms of reduced specific consumption, noise reduction, weight and volume saving. Anyway this transition is mainly limited by the reliability, lifespan and some safety aspects of electric system. In this context, the objective of this CfP is the design of a motor-drive for aircraft electric propulsion mainly characterized by high reliability, safety and high power-to-weight/power-to-volume ratio. To fulfill this objective, a high performance multi-phase permanent magnet motor drive with modular integrated architecture and fault tolerant capabilities is proposed. Such a system will integrate the electromechanical design with the power and control electronics by mean of a compact double stacks stator architecture. The basic objective is to provide integrated and optimized redundancies in order to fulfill the high power-to-volume/power-to-weight ratio requirements. The integrated system will also benefits from the features of Silicon Carbon (SiC) devices to achieve high performance and reliable power electronics stage since they offer faster switching speeds (up to 100kHz), low losses, the ability to function at high operating temperatures (250), and therefore the flexibility to further improve the converter system design over a very wide frequency range.
Sipre and University of Picardie Jules Verne | Date: 2014-05-28
The present invention relates to a novel method for synthesising, without a solvent, N-alkyl-glycosyl(di)amine derivatives represented by the following general formula (I): The invention also concerns the use of N-alkyl-glycosyl(di)amine derivatives represented by the general formula (I), and N-alkyl-glycosyl(di)ammonium quaternary salts represented by the general formula (II) and N-alkyl-glycamine derivatives represented by the general formula (III) obtained from N-alkyl-glycosyl(di)amine derivatives represented by the general formula (I), as antibacterial and/or antifungal agents against phytopathogens.
Chadli M.,University of Picardie Jules Verne |
Karimi H.R.,University of Agder
IEEE Transactions on Fuzzy Systems | Year: 2013
This paper deals with the observer design for Takagi-Sugeno (T-S) fuzzy models subject to unknown inputs and disturbance affecting both states and outputs of the system. Sufficient conditions to design an unknown input T-S observer are given in linear matrix inequality (LMI) terms. Both continuous-time and discrete-time cases are studied. Relaxations are introduced by using intermediate variables. Extension to the case of unmeasured decision variables is also given. A numerical example is given to illustrate the effectiveness of the given results. © 2012 IEEE.