Felinger A.,University of Pecs
Journal of Chromatography A | Year: 2011
The recently developed pellicular packing materials show high efficiency and have attracted great interest. The improved mass-transfer kinetics of the core-shell particles is due to the shorter diffusion path of the molecules within the stationarity phase. In this study we show how the diffusion time of the molecules visiting the stationary phase depends on the geometry of the porous shell stationary phase. The mean escape time of diffusion is calculated on the basis of a random walk model. © 2010 Elsevier B.V.
Hideg E.,University of Pecs |
Jansen M.A.K.,University College Cork |
Strid A.,Orebro University
Trends in Plant Science | Year: 2013
Ultraviolet-B (UV-B) radiation has long been perceived as a stressor. However, a conceptual U-turn has taken place, and UV-B damage is now considered rare. We question whether UV-stress and UV-B-induced reactive oxygen species (ROS) are still relevant concepts, and if ROS-mediated signaling contributes to UV-B acclimation. Measurements of antioxidants and of antioxidant genes show that both low and high UV-B doses alter ROS metabolism. Yet, there is no evidence that ROS control gene expression under low UV-B. Instead, expression of antioxidant genes is linked to the UV RESISTANCE LOCUS 8 pathway. We hypothesize that low UV-B doses cause 'eustress' (good stress) and that stimuli-specific signaling pathways pre-dispose plants to a state of low alert that includes activation of antioxidant defenses. © 2012 Elsevier Ltd.
Antihypertensive efficacy of triple combination perindopril/indapamide plus amlodipine in high-risk hypertensives: Results of the PIANIST study (Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients)
Toth K.,University of Pecs
American Journal of Cardiovascular Drugs | Year: 2014
Objective: Our objective was to evaluate a triple-drug antihypertensive strategy for blood pressure control in patients with difficult-to-treat hypertension. Design: The Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients (PIANIST) trial was an observational, 4-month, open-label study. Patients and interventions: A total of 4,731 patients at high or very high cardiovascular risk with hypertension that was not properly controlled despite antihypertensive therapy, and for whom study treatment (fixed-dose perindopril 10 mg/indapamide 2.5 mg + amlodipine 5 or 10 mg) was consistent with their existing therapeutic plan, were included. Outcomes: One-sample t tests and Chi-squared tests were performed to evaluate changes in blood pressure. Results: Mean baseline office blood pressure (OBP) was 160.5 ± 13.3/93.8 ± 8.7 mmHg. After 4 months of therapy, OBP decreased by 28.3 ± 13.5/13.8 ± 9.4 to 132.2 ± 8.6/80.0 ± 6.6 mmHg (p < 0.0001). Blood pressure targets were reached by 72.0 % of patients and by 81 and 91 % of patients previously treated with an angiotensin-converting enzyme inhibitor/hydrochlorothiazide or an angiotensin receptor blocker/ hydrochlorothiazide, respectively. Changes in OBP were 18.7 ± 8.3/9.7 ± 7.2 mmHg for grade 1 (n = 1,679), 30.4 ± 10.1/14.7 ± 8.6 mmHg for grade 2 (n = 2,397), and 45.4 ± 15.1/20.7 ± 12.1 mmHg for grade 3 patients (n = 655; all p < 0.0001). In patients who underwent ambulatory blood pressure monitoring (n = 104), 24-h mean blood pressure decreased from 147.4 ± 13.8/82.1 ± 11.9 to 122.6 ± 9.1/72.8 ± 7.4 mmHg (p < 0.0001). Ankle edema was infrequent (0.2 % of patients). Conclusion: Triple combination perindopril/indapamide/amlodipine was effectively and safely administered to a large population of high- and very high-risk hypertensive patients who had not reached target OBP values with previous treatment. © 2014 Springer International Publishing.
Kollar L.,University of Pecs |
Keglevich G.,Budapest University of Technology and Economics
Chemical Reviews | Year: 2010
Homogeneous catalysis reactions of some 3, 4, 5, 6, and 7-membered P-heterocyclic ligands of unprecedented structure, are reviewed. A highly stable polycyclic phosphirane can be synthesized in a few steps from dibenzosuberone, which is found to act as a relatively good electron donor. The radical ring-opening polymerization of methylphosphirane, phosphetane, and phospholane, is found to be the fastest with phosphetanes, reflecting the compromise between the strain in the transition structure and the strain released by the partially broken bond. Phospholes of related structure react readily with maleic acid derivatives such as amides and anhydrides. P-Chloro-2-phospholenes are reacted with amino acid esters, resulting in the corresponding 1-L-α-amino acid derivatives of phospholene oxides as chiral P-N phospholenes.
Gabriel R.,University of Pecs
British Journal of Clinical Pharmacology | Year: 2013
Diabetic retinopathy, a common complication of diabetes, develops in 75% of patients with type1 and 50% of patients with type2 diabetes, progressing to legal blindness in about 5%. In the recent years, considerable efforts have been put into finding treatments for this condition. It has been discovered that peptidergic mechanisms (neuropeptides and their analogues, activating a diverse array of signal transduction pathways through their multiple receptors) are potentially important for consideration in drug development strategies. A considerable amount of knowledge has been accumulated over the last three decades on human retinal neuropeptides and those elements in the pathomechanisms of diabetic retinopathy which might be related to peptidergic signal transduction. Here, human retinal neuropeptides and their receptors are reviewed, along with the theories relevant to the pathogenesis of diabetic retinopathy both in humans and in experimental models. By collating this information, the curative potential of certain neupeptides and their analogues/antagonists can also be discussed, along with the existing clinical treatments of diabetic retinopathy. The most promising peptidergic pathways for which treatment strategies may be developed at present are stimulation of the somatostatin-related pathway and the pituitary adenylyl cyclase-activating polypeptide-related pathway or inhibition of angiotensinergic mechanisms. These approaches may result in the inhibition of vascular endothelial growth factor production and neuronal apoptosis; therefore, both the optical quality of the image and the processing capability of the neural circuit in the retina may be saved. © 2012 The British Pharmacological Society.