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Pavia, Italy

The University of Pavia is a university located in Pavia, Lombardy, Italy. It was founded in 1361 and has nine faculties. Wikipedia.

Donati S.,University of Pavia
Laser and Photonics Reviews | Year: 2012

In this review, self-mixing interferometry (SMI), a new configuration of interferometry, is discussed. SMI has practical advantages compared to standard interferometry, for example SMI does not require any optical part external to the laser chip and can be employed in a variety of measurements. Applications range from the traditional measurements related to optical pathlength - like displacement, small-amplitude vibrations, velocity - to sensing of weak optical echoes - for return loss and isolation factor measurements, CD readout and scroll sensing - and also, a special feature because of the interaction with the medium, measurements of physical parameters, like the laser linewidth, coherence length, and the alfa factor. Because it is also a coherent detection scheme, the SMI works close to the quantum limit of the received field, typically -90 dBm, so that minimum detectable amplitudes of 100 pm/√Hz are currently achieved upon operation on diffusive targets, whereas a corner cube allows half-wavelength counting mode - or 0.5 μm resolution - on a dynamic range up to 2 m and more. With its compact setup, the SMI is easy to deploy in the field and can interface a variety of experiments - from MEMS testing to rotating machines vibration testing to pickup of biological motility. The illustration shows a double-channel, differential SMI incorporated in a thermomechanical test equipment to trace the mechanical hysteresis cycle of the beads of a motor-engine brake. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Tartara L.,University of Pavia
Journal of the Optical Society of America B: Optical Physics | Year: 2015

A detailed experimental investigation about the propagation of a fundamental soliton interacting with a weak dispersive pulse at an optical event horizon is presented. The results show that the soliton is either redshifted or blueshifted depending on the wavelength of the dispersive pulse. As a consequence of such a wavelength shift, the soliton is either stretched or compressed. The results thus demonstrate the possibility of controlling the propagation of an intense optical pulse by means of a less powerful pulse. © 2015 Optical Society of America. Source

Laforenza U.,University of Pavia
Molecular Aspects of Medicine | Year: 2012

Water transport through the human digestive system is physiologically crucial for maintaining body water homeostasis and ensure digestive and absorptive functions. Within the gastrointestinal tract, water recirculates, being secreted with the digestive juices and then almost entirely absorbed by the small and large intestine. The importance of aquaporins (AQPs), transmembrane water channel proteins, in the rapid passage of water across plasma membranes in the gastrointestinal tract appears immediately evident. Several AQP isoforms are found in gastrointestinal epithelia, with AQP1, 3, 7, 10 and 11 being the most abundantly expressed in the whole gut. On the other hand, AQP4 and 8 are located selectively in the stomach and colon, respectively. Here we review AQP expression and localization at the tissue, cellular and subcellular level in gastrointestinal epithelia, and their modification in various gut diseases. © 2012 Elsevier Ltd. All rights reserved. Source

We studied mutations of MPL exon 10 in patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF), first investigating a cohort of 892 consecutive patients. MPL mutation scanning was performed on granulocyte genomic DNA by using a high-resolution melt assay, and the mutant allele burden was evaluated by using deep sequencing. Somatic mutations of MPL, all but one involving codon W515, were detected in 26/661 (4%) patients with ET, 10/187 (5%) with PMF, and 7/44 (16%) patients with post-ET myelofibrosis. Comparison of JAK2 (V617F)-mutated and MPL-mutated patients showed only minor phenotypic differences. In an extended group of 62 MPL-mutated patients, the granulocyte mutant allele burden ranged from 1% to 95% and was significantly higher in patients with PMF or post-ET myelofibrosis compared with those with ET. Patients with higher mutation burdens had evidence of acquired copy-neutral loss of heterozygosity (CN-LOH) of chromosome 1p in granulocytes, consistent with a transition from heterozygosity to homozygosity for the MPL mutation in clonal cells. A significant association was found between MPL-mutant allele burden greater than 50% and marrow fibrosis. These observations suggest that acquired CN-LOH of chromosome 1p involving the MPL location may represent a molecular mechanism of fibrotic transformation in MPL-mutated myeloproliferative neoplasms. Source

University of Pavia | Date: 2013-03-28

A two-photon excited fluorescence microscope including a laser source configured to emit a light beam and an optical arrangement configured to receive the light beam from the laser source. The optical arrangement is configured to shape the light beam so that, at an output of the microscope, the light beam is substantially collimated in a first transverse direction perpendicular to the propagation direction of the light beam at the microscope output and is focused in a second transverse direction perpendicular to the first transverse direction and to the propagation direction, thereby forming a line parallel to the first transverse direction.

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