French Institute of Health, Medical Research, University Paris Diderot, University of Paris 13 and Assistance Publique Hopitaux De Paris | Date: 2016-11-22
The present invention relates to various soluble forms of CD31, including a novel form which is shed by activated platelets and released into the circulation. Methods for detecting said soluble forms of CD31 are disclosed, as are methods of specifically 1 detecting said platelet-derived shed CD31 and the use of such methods as a diagnostic tool.
University of Paris 13 | Date: 2017-04-19
The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.9.7 | Award Amount: 8.27M | Year: 2013
The DIADEMS project aims at exploiting the unique physical properties of NV color centres in ultrapure single-crystal CVD-grown diamond to develop innovative devices with unprecedented performances for ICT applications. By exploiting the atom-like structure of the NV that exhibits spin dependent optical transitions, DIADEMS will make optics-based magnetometry possible.\nThe objectives of DIADEMS are to develop\n- Wide field magnetic imagers with 1 nT sensivities,\n- Scanning probe magnetometer with sensitivity 10 nT and spatial resolution 10 nm,\n- Sensor heads with resolution 1 pT.\n\nTo reach such performances, DIADEMS will:\n- Use new theoretical protocols for sensing,\n- Develop ultrahigh purity diamond material with controlled single nitrogen implantation with a precision better than 5 nm,\n- Process scanning probe tips with diametre in the 20 nm range,\n- Transfer them to AFM cantilever, improve the emission properties of NV by coupling them with photonic cavities and photonic waveguides.\n\nDIADEMS outputs will demonstrate new ICT functionalities that will boost applications with high impact on society:\n- Calibration and optimization of write/read magnetic heads for future high capacity (3 Tbit per square inch) storage disk required for intense computing,\n- Imaging of electron-spin in graphene and carbon nanotubes for next generation of electronic components based on spintronics,\n- Non-invasive investigation of living neuronal networks to understand brain function,\n- Demonstration of magnetic resonance imaging of single spins allowing single protein imaging for medical research.\n\nDIADEMS aims at integrating the efforts of the European Community on NV centres to push further the limits of this promising technology and to keep Europes prominent position.
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INFRAINNOV-02-2016 | Award Amount: 1.99M | Year: 2017
A scientific and technological paradigm change is taking place, concerning the way that very high performance time and frequency reference signals are distributed, moving from radio signal broadcasting to signal transport over optical fibre networks. The latter technology demonstrates performance improvements by orders of magnitude, over distances up to continental scale. Research infrastructures are developing several related technologies, adapted to specific projects and applications. The present project aims to prepare the transfer of this new generation of technology to industry and to strengthen the coordination between research infrastructures and the research and education telecommunication networks, in order to prepare the deployment of this technology to create a sustainable, pan-European network, providing high-performance clock services to European research infrastructures. Further this core network will be designed to be compatible with a global European vision of time and frequency distribution over telecommunication networks, enabling it to provide support to a multitude of lower-performance time services, responding to the rapidly growing needs created by developments such as cloud computing, Internet of Things and Industry 4.0. The project aims at partnership building and innovation for high performance time and frequency (clock) services over optical fibre networks and to prepare the implementation of such a European backbone network.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 4.04M | Year: 2016
Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is the fifth most common cancer worldwide and the third most common cause of cancer mortality. A successful surgical resection of HCC requires complete removal of the tumour while sparing as much healthy tissue as possible. Due to technical and clinical difficulties relatively low percentage of patients are eligible for resection. There is an urgent need to increase the patient eligibility and improve the survival prognosis after liver interventions. HiPerNav will train early stage researchers (biomedical engineers and medical doctors) to become international leading in key areas of expertise through a novel coordinated plan of individual research projects addressing specific bottlenecks in soft tissue navigation for improved treatment of liver cancer. The multi-disciplinary dialogue and work between clinicians and biomedical engineers is crucial to address these bottlenecks. By providing researchers with knowledge and training within specific topics from minimally invasive treatment, biomedical engineering, research methodologies, innovation and entrepreneurship, the link between academic research and industry will be strengthened. This allows for easy transfer of promising results from the research projects to commercially exploitable solutions. The global image guided surgery devices market is promising; it was valued at USD 2.76 billion in 2013 and is projected to expand 6.4% from 2014 to 2022 to reach USD 4.80 billion in 2022. The market for soft-tissue navigation is still in its infancy, mainly due to challenges in achieved accuracy for targeting deformable and moving organs. By providing multi-disciplinary training, the researchers in this consortium of international leading research institutions, universities and industry will initiate true translational research from academic theoretical ideas to the clinical testing of prototype, developed solutions and tools.
French National Center for Scientific Research and University of Paris 13 | Date: 2015-06-24
The present invention concerns a process for the production of boron phosphide BP comprising the reduction of boron phosphate BPO_(4) with at least one alkaline earth metal (EA) according to Equation (1): BPO_(4) + 4 EA BP + 4 EA(O)(1)
Cahiez G.,University of Paris 13 |
Moyeux A.,University of Paris 13
Chemical Reviews | Year: 2010
Cobalt-catalyzed cross-coupling reactions are very efficient for the elaboration of Csp2-Csp2 bonds and are especially interesting for couplings involving alkyl halides. Kharasch described the first cobalt-catalyzed alkenylation of aromatic Grignard reagents in 1943. In 1998, Cahiez reinvestigated the cobalt-catalyzed alkenylation of aromatic Grignard reagents. Recently, Hayashi described the cobalt-catalyzed cross-coupling between alkenyl triflates and alkenyl Grignard reagents. In 1983, Uemura described the cross-coupling between diaryltellurides (Ar2Te) and aromatic organomagnesium reagents in the presence of cobalt salts. The reaction affords poor yields, and a substantial amount of homocoupling product accruing from the Grignard reagent is produced. Iron-catalyzed cross coupling between aryl Grignard reagents and functionalized secondary alkyl bromides generally failed whereas excellent yields are obtained under cobalt catalysis.
Signorotti L.,University of Paris 13
Proceedings. Biological sciences / The Royal Society | Year: 2014
Prenatal olfactory learning has been demonstrated in a wide variety of animals, where it affects development and behaviour. Young ants learn the chemical signature of their colony. This cue-learning process allows the formation of a template used for nest-mate recognition in order to distinguish alien individuals from nest-mates, thus ensuring that cooperation is directed towards group members and aliens are kept outside the colony. To date, no study has investigated the possible effect of cue learning during early developmental stages on adult nest-mate recognition. Here, we show that odour familiarization during preimaginal life affects recognition abilities of adult Aphaenogaster senilis ants, particularly when the familiarization process occurs during the first larval stages. Ants eclosed from larvae exposed to the odour of an adoptive colony showed reduced aggression towards familiar, adoptive individuals belonging to this colony compared with alien individuals (true unfamiliar), but they remained non-aggressive towards adult individuals of their natal colony. Moreover, we found that the chemical similarity between the colony of origin and the adoptive colony does not influence the degree of aggression, meaning that the observed effect is likely to be due only to preimaginal learning experience. These results help understanding the developmental processes underlying efficient recognition systems.
Agency: Cordis | Branch: H2020 | Program: MSCA-IF-EF-CAR | Phase: MSCA-IF-2014-EF | Award Amount: 185.08K | Year: 2015
Many organisms, including humans, group together and perform collective actions such as birds forming coordinated flocks to evade predators, forage or roost. Some, as social insects, have evolved complex societies in which the unit of selection is not the individual, as in most vertebrates, but the colony. Yet, in both there is evidence of consistent behavioural variability among both individuals and groups. The study of collective behaviour - coordinated actions resulting in emergent properties at the group level - and the study of animal personality - between individual differences that are consistent over time and contexts - have progressed tremendously in the last two decades and are converging in their search for the link between individuality and collectivity, a fundamental and timely issue in biology. The GROUPIND project aims to investigate the relationship between individual personality and group personality by using ants and starlings as study organisms, both of which showing distinct collective behaviour and marked individual behavioural variability. The project will use a comparative approach to address the following objectives: (1) To characterize, also upon experimental manipulation, the composition of personalities in the group and understand how this relates to personality at the group level. Are group personalities an average of individual personalities within the group? Do they result from different distributions of individual personalities? Are there keystone individuals that exert a disproportionate influence on the group personality? (2) To understand how diversity of individual personalities contributes to decision making and to the ecological success at the group level, and how this would feed back at the individual level. By bridging two major fields of study, this project will shed new light on the ability of groups to function effectively, unravelling the consequences that personality differences can exert on social life and its evolution.
Agency: Cordis | Branch: H2020 | Program: MSCA-IF-EF-ST | Phase: MSCA-IF-2014-EF | Award Amount: 185.08K | Year: 2015
This research proposal is in mathematics, its content is part of algebraic topology and homotopy theory. It aims at deepening our understanding of the homotopy theory of cosimplicial unstable (co-)algebras over the Steenrod algebra and its relation to the homotopy theory of cosimplicial spaces. This is achieved by new methods developed recently by the ER (Dr. Biedermann) and coauthors and by methods from Goodwillie calculus. Specifically, there are three closely related parts/work packages: 1. Prove a general vanishing theorem of higher obstructions for realizing a map on homology as a map of spaces. The theorem is known to hold in rational homotopy and in the mod p Massey-Peterson case. 2. Find an algebraic description of the first obstruction living in Andre-Quillen cohomology (AQC) to the existence of a realization of unstable coalgebras. 3. Define natural operations on AQC of unstable coalgebras with general coefficients. As part of the risk management we describe two further fallback projects: 4. Study the Goodwillie tower of the identity functor of simplicial unstable algebras and relate its layers to AQC. 5. Describe the algebra of homotopy operations on simplicial commutative algebras for odd primes p. These projects are parts of a program of the ER to investigate realization problems and rigidity results associated to singular (co-)homology. A longterm goal (beyond the time frame of the fellowship) is to develop a deformation theory of unstable (co-)algebras over the Steenrod algebra and their realizing homotopy types in the mod p case.