Padua, Italy

University of Padua

www.unipd.it
Padua, Italy

The University of Padua is a premier Italian university located in the city of Padua, Italy. The University of Padua was founded in 1222 as a school of law and was one of the most prominent universities in early modern Europe. It is among the earliest universities of the world and the second oldest in Italy. The University of Padua is one of Italy’s leading universities and ranks in the first position in all the recent ranking of Italian large universities. In 2010 the university had approximately 65,000 students and in 2009 was ranked "best university" among Italian institutions of higher education with more than 40,000 students. Wikipedia.

SEARCH FILTERS
Time filter
Source Type

Patent
King Abdulaziz City for Science, Technology and University of Padua | Date: 2016-01-25

The invention provides a white sintered glass-ceramic tile and a method for preparing the white sintered glass-ceramic tile. The white sintered glass-ceramic tile is a single fired tile with a glazed glass-ceramic layer and a porous glass-ceramic layer, wherein each layer is prepared using same starting raw materials. The method includes milling the starting raw materials to obtain a homogenous mixture. The homogenous mixture is melted and poured in water to obtain glass frits. The glass frits are milled and thereafter, sieved to obtain glass frit powder with particle size of below 100 micron (m). A mixture of the glass frit powder and one or more foaming agents is cold pressed to form a porous glass-ceramic layer. Thereafter, the glass frit powder is deposited on the porous glass-ceramic layer to obtain a glazed glass-ceramic layer. Finally, both the layers are fired together.


Patent
University of Padua | Date: 2017-08-02

A pharmaceutical composition to induce bone marrow stem cell mobilization from the bone marrow to peripheral blood in patients suffering from pathological conditions, such as diabetes, or subjected to treatments that impair cell mobilization, or in patients suffering from the so called poor mobilizer condition, which composition comprises at least one therapeutic agent that inhibits production and/or action of the human cytokine oncostatin M (OSM), a macrophage derived factor, that prevents mobilization of stem cells.


Patent
University of Padua, Enzo and Dario | Date: 2017-09-06

The invention relates to a connecting device (1,10,10,10) between construction elements (L, C) for the controlled dissipation of energy comprising at least one plate comprising, in turn, at least a first portion (2, 12, 12,12), said at least first portion (2, 12, 12,12) comprising a plurality of first holes (3,30,30,30) dimensioned and mutually spaced such to create a plurality of first dissipative elements (4,40,40,40) directed in the main development direction of the plate and intended to absorb axial stresses applied on said connecting device (1,10,10,10) and a plurality of second holes (5,50,50,50) dimensioned and mutually spaced such to create a plurality of second dissipative elements (6,60,60,60) directed perpendicularly to the main development direction of the plate and intended to absorb by means of bending mechanisms the axial stresses applied on said connecting device (1,10,10,10); the invention relates also to a building comprising a plurality of connecting devices (1,10,10,10) able to dissipate energy in a controlled way between construction elements (L, C); the invention relates also to the relevant method for the controlled dissipation of energy between construction elements (L,C).


Patent
King Abdulaziz City for Science, Technology and University of Padua | Date: 2017-07-26

The invention provides a white sintered glass-ceramic tile and a method for preparing the white sintered glass-ceramic tile. The white sintered glass-ceramic tile is a single fired tile with a glazed glass-ceramic layer and a porous glass-ceramic layer, wherein each layer is prepared using same starting raw materials. The method includes milling the starting raw materials to obtain a homogenous mixture. The homogenous mixture is melted and poured in water to obtain glass frits. The glass frits are milled and thereafter, sieved to obtain glass frit powder with particle size of below 100 micron (m). A mixture of the glass frit powder and one or more foaming agents is cold pressed to form a porous glass-ceramic layer. Thereafter, the glass frit powder is deposited on the porous glass-ceramic layer to obtain a glazed glass-ceramic layer. Finally, both the layers are fired together.


RATIONALE:: Critical limb ischemia (CLI) is a life-threatening complication of peripheral arterial disease (PAD). In patients who are ineligible for revascularization procedures, there are few therapeutic alternatives, leading to amputations and death. OBJECTIVE:: To provide a systematic review of the literature and a meta-analysis of studies evaluating safety and efficacy of autologous cell therapy for intractable PAD/CLI. METHODS AND RESULTS:: We retrieved 19 randomized controlled trials (RCTs; 837 patients), 7 non-randomized trials (338 patients), and 41 non-controlled studies (1,177 patients). The primary outcome was major amputation. Heterogeneity was high and publication bias could not be excluded. Despite these limitations, the primary analysis (all RCTs) showed that cell therapy reduced the risk of amputation by 37%, improved amputation-free survival by 18% and improved wound healing by 59%, without affecting mortality. Cell therapy significantly increased ABI, TcO2, and reduced rest pain. The secondary analysis (all controlled trials; n=1,175 patients) shows there may be potential to avoid approximately 1 amputation/year for every 2 patients successfully treated. The tertiary analysis (all studies; n=2,332 patients) precisely estimated the changes in ABI, TcO2, rest pain, and walking capacity after cell therapy. Intra-muscular implantation appeared more effective than intra-arterial infusion, and mobilized peripheral blood mononuclear cells (MNCs) may outperform bone marrow-MNCs and mesenchymal stem cells. Amputation rate was improved more in trials wherein the prevalence of diabetes was high. Cell therapy was not associated with severe adverse events. Remarkably, efficacy of cell therapy on all end-points was no longer significant in placebo-controlled RCTs and disappeared in RCTs with a low risk of bias. CONCLUSIONS:: Although this meta-analysis highlights the need for more high quality placebo-controlled trials, equipoise may no longer be guaranteed, because autologous cell therapy has the potential to modify the natural history of intractable CLI. © 2017 American Heart Association, Inc.


Rossetto O.,University of Padua | Pirazzini M.,University of Padua | Montecucco C.,University of Padua
Nature Reviews Microbiology | Year: 2014

Botulinum neurotoxins (BoNTs) are produced by anaerobic bacteria of the genus Clostridium and cause a persistent paralysis of peripheral nerve terminals, which is known as botulism. Neurotoxigenic clostridia belong to six phylogenetically distinct groups and produce more than 40 different BoNT types, which inactivate neurotransmitter release owing to their metalloprotease activity. In this Review, we discuss recent studies that have improved our understanding of the genetics and structure of BoNT complexes. We also describe recent insights into the mechanisms of BoNT entry into the general circulation, neuronal binding, membrane translocation and neuroparalysis. © 2014 Macmillan Publishers Limited. All rights reserved.


Stoianov I.,University of Padua | Zorzi M.,University of Padua
Nature Neuroscience | Year: 2012

Numerosity estimation is phylogenetically ancient and foundational to human mathematical learning, but its computational bases remain controversial. Here we show that visual numerosity emerges as a statistical property of images in 'deep networks' that learn a hierarchical generative model of the sensory input. Emergent numerosity detectors had response profiles resembling those of monkey parietal neurons and supported numerosity estimation with the same behavioral signature shown by humans and animals. © 2012 Nature America, Inc. All rights reserved.


Urciuolo A.,University of Padua
Nature communications | Year: 2013

Adult muscle stem cells, or satellite cells have essential roles in homeostasis and regeneration of skeletal muscles. Satellite cells are located within a niche that includes myofibers and extracellular matrix. The function of specific extracellular matrix molecules in regulating SCs is poorly understood. Here, we show that the extracellular matrix protein collagen VI is a key component of the satellite cell niche. Lack of collagen VI in Col6a1(-/-) mice causes impaired muscle regeneration and reduced satellite cell self-renewal capability after injury. Collagen VI null muscles display significant decrease of stiffness, which is able to compromise the in vitro and in vivo activity of wild-type satellite cells. When collagen VI is reinstated in vivo by grafting wild-type fibroblasts, the biomechanical properties of Col6a1(-/-) muscles are ameliorated and satellite cell defects rescued. Our findings establish a critical role for an extracellular matrix molecule in satellite cell self-renewal and open new venues for therapies of collagen VI-related muscle diseases.


The assessment of mitochondrial respiratory chain (RC) enzymatic activities is essential for investigating mitochondrial function in several situations, including mitochondrial disorders, diabetes, cancer, aging and neurodegeneration, as well as for many toxicological assays. Muscle is the most commonly analyzed tissue because of its high metabolic rates and accessibility, although other tissues and cultured cell lines can be used. We describe a step-by-step protocol for a simple and reliable assessment of the RC enzymatic function (complexes I-IV) for minute quantities of muscle, cultured cells and isolated mitochondria from a variety of species and tissues, by using a single-wavelength spectrophotometer. An efficient tissue disruption and the choice for each assay of specific buffers, substrates, adjuvants and detergents in a narrow concentration range allow maximal sensitivity, specificity and linearity of the kinetics. This protocol can be completed in 3 h.


Collini E.,University of Padua
Chemical Society Reviews | Year: 2013

One of the most surprising and significant advances in the study of the photosynthetic light-harvesting process is the discovery that the electronic energy transfer might involve long-lived electronic coherences, under physiologically relevant conditions. This means that the transfer of energy among different chromophores does not follow the expected classical incoherent hopping mechanism, but that quantum-mechanical laws can steer the migration of energy. The implications of such a quantum transport regime, although currently under debate, might have a tremendous impact on our way of thinking about natural and artificial light-harvesting. Central to these discoveries has been the development of new ultrafast spectroscopic techniques, in particular two-dimensional electronic spectroscopy, which is now the primary tool to obtain clear and definitive experimental proof of such effects. This review aims to provide an overview of the experimental techniques developed with the purpose of attaining a more detailed picture of the coherent and incoherent quantum dynamics relevant to energy transfer processes, not limited to the two-dimensional electronic spectroscopy. With the idea of summarizing the experimental and theoretical basic notions necessary to introduce the field, the connection between experimental observables and coherence dynamics will be analysed in detail for each technique, highlighting how electronic coherences could be manifested in different experimental signatures. Similarities and differences among coherent signals as well as advantages and disadvantages of each approach will be critically discussed. Current opinions and debated issues will be emphasised and some possible future directions to address still open questions will be suggested. © 2013 The Royal Society of Chemistry.

Loading University of Padua collaborators
Loading University of Padua collaborators