The University of Padua is a premier Italian university located in the city of Padua, Italy. The University of Padua was founded in 1222 as a school of law and was one of the most prominent universities in early modern Europe. It is among the earliest universities of the world and the second oldest in Italy. The University of Padua is one of Italy’s leading universities and ranks in the first position in all the recent ranking of Italian large universities. In 2010 the university had approximately 65,000 students and in 2009 was ranked "best university" among Italian institutions of higher education with more than 40,000 students. Wikipedia.
Urciuolo A.,University of Padua
Adult muscle stem cells, or satellite cells have essential roles in homeostasis and regeneration of skeletal muscles. Satellite cells are located within a niche that includes myofibers and extracellular matrix. The function of specific extracellular matrix molecules in regulating SCs is poorly understood. Here, we show that the extracellular matrix protein collagen VI is a key component of the satellite cell niche. Lack of collagen VI in Col6a1(-/-) mice causes impaired muscle regeneration and reduced satellite cell self-renewal capability after injury. Collagen VI null muscles display significant decrease of stiffness, which is able to compromise the in vitro and in vivo activity of wild-type satellite cells. When collagen VI is reinstated in vivo by grafting wild-type fibroblasts, the biomechanical properties of Col6a1(-/-) muscles are ameliorated and satellite cell defects rescued. Our findings establish a critical role for an extracellular matrix molecule in satellite cell self-renewal and open new venues for therapies of collagen VI-related muscle diseases. Source
Collini E.,University of Padua
Chemical Society Reviews
One of the most surprising and significant advances in the study of the photosynthetic light-harvesting process is the discovery that the electronic energy transfer might involve long-lived electronic coherences, under physiologically relevant conditions. This means that the transfer of energy among different chromophores does not follow the expected classical incoherent hopping mechanism, but that quantum-mechanical laws can steer the migration of energy. The implications of such a quantum transport regime, although currently under debate, might have a tremendous impact on our way of thinking about natural and artificial light-harvesting. Central to these discoveries has been the development of new ultrafast spectroscopic techniques, in particular two-dimensional electronic spectroscopy, which is now the primary tool to obtain clear and definitive experimental proof of such effects. This review aims to provide an overview of the experimental techniques developed with the purpose of attaining a more detailed picture of the coherent and incoherent quantum dynamics relevant to energy transfer processes, not limited to the two-dimensional electronic spectroscopy. With the idea of summarizing the experimental and theoretical basic notions necessary to introduce the field, the connection between experimental observables and coherence dynamics will be analysed in detail for each technique, highlighting how electronic coherences could be manifested in different experimental signatures. Similarities and differences among coherent signals as well as advantages and disadvantages of each approach will be critically discussed. Current opinions and debated issues will be emphasised and some possible future directions to address still open questions will be suggested. © 2013 The Royal Society of Chemistry. Source
University of Padua | Date: 2013-11-22
In a method for distributing execution of a problem to a plurality of K (wherein K2) workers, a pair of identifiers (k, K) is transmitted to each worker, wherein k uniquely identifies each worker and wherein K indicates the total number of workers. Each worker applies a first rule deterministically and autonomously without communicating between the workers. The first rule is the same for each worker. The first rule splits the problem in m parts, wherein mK. Each worker applies a second rule deterministically and autonomously without communicating between the workers. The second rule assigns each of the m parts to one of the K workers. The second rule is the same for each worker. Each worker processes exactly the parts that have been assigned thereto, thereby generating a unit of output. Each of the units of output from each worker is merged.
University of Padua | Date: 2015-07-28
The present invention relates to the expression of two genes, CyclinG The invention also illustrates how CyclinG
University of Padua | Date: 2014-07-15
Administration of monoamine oxidase inhibitors is useful in the prevention and treatment of heart failure and incipient heart failure.