Eugene, OR, United States

University of Oregon

www.uoregon.edu
Eugene, OR, United States

The University of Oregon is a public flagship research university located in Eugene, Oregon. UO was founded in 1876. Since July 2014, UO has been governed by the Board of Trustees of the University of Oregon. The university is classified as having very high research activity and has 19 research centers and institutes. UO was admitted to the Association of American Universities in 1969.UO offers 272 undergraduate and graduate degree programs in a wide range of disciplines. The university is organized into eight colleges: the Robert D. Clark Honors College , the School of Architecture and Allied Arts, the College of Arts and science, the Charles H. Lundquist College of Business, the College of Education, the School of Journalism and Communication, the School of Law, and the School of Music and Dance. Additionally, the Graduate School oversees the university's graduate and certificate programs. Academically, UO is notable because it does not have programs in the fields of engineering or medicine.UO student-athletes compete as the Ducks and are part of the Pacific-12 Conference in the National Collegiate Athletic Association . With nineteen varsity teams, the Oregon Ducks are best known for their football team and track and field program which has helped to make Eugene become known as "Track Town, USA". Wikipedia.


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PubMed | University of Oregon and University of Oxford
Type: Journal Article | Journal: The Journal of biological chemistry | Year: 2016

African trypanosomes and related kinetoplastid parasites selectively traffic specific membrane proteins to the flagellar membrane, but the mechanisms for this trafficking are poorly understood. We show here that KHARON, a protein originally identified in Leishmania parasites, interacts with a putative trypanosome calcium channel and is required for its targeting to the flagellar membrane. KHARON is located at the base of the flagellar axoneme, where it likely mediates targeting of flagellar membrane proteins, but is also on the subpellicular microtubules and the mitotic spindle. Hence, KHARON is probably a multifunctional protein that associates with several components of the trypanosome cytoskeleton. RNA interference-mediated knockdown of KHARON mRNA results in failure of the calcium channel to enter the flagellar membrane, detachment of the flagellum from the cell body, and disruption of mitotic spindles. Furthermore, knockdown of KHARON mRNA induces a lethal failure of cytokinesis in both bloodstream (mammalian host) and procyclic (insect vector) life cycle stages, and KHARON is thus critical for parasite viability.

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