Nottingham, United Kingdom
Nottingham, United Kingdom

The University of Nottingham is a public research university based in Nottingham, Nottinghamshire, England, United Kingdom. It was founded as University College Nottingham in 1881 and granted a Royal Charter in 1948.Nottingham's main campus, University Park, is situated on the outskirts of the City of Nottingham, with a number of smaller campuses and a teaching hospital located elsewhere in Nottinghamshire. Outside the United Kingdom, Nottingham has campuses in Semenyih, Malaysia and Ningbo, China. Nottingham is organised into five constituent faculties, within which there are more than 50 departments, institutes and research centres. Nottingham has around 44,000 students and 9,000 staff and had a total income of £520 million in 2012/13, of which £100 million was from research grants and contracts.Nottingham is currently ranked 23rd in the UK by the Complete University Guide Table 2015. Several of its subjects have been consistently ranked in the top ten, including Economics, Law, and Pharmacy. A 2014 survey suggested it is the most targeted university by the UK's top employers. In 2012 Nottingham was ranked 13th in the world in terms of the number of alumni listed among CEOs of the Fortune Global 500. It is also ranked 2nd in the 2012 Summer Olympics table of British medal winners. In the 2011 GreenMetric World University Ranking, Nottingham was the world's most sustainable campus.It is a member of the Association of Commonwealth Universities, the Virgo Consortium, the European University Association, the Russell Group, Universities UK, Universitas 21 and participates in the Sutton Trust Summer School programme. Wikipedia.


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Patent
University of Nottingham | Date: 2015-04-08

A capillary refill measurement apparatus (1), comprising a support element (14) configured to receive the weight of a user through their foot, a light source (22) for illuminating a region of the foot that exerts weight onto the support element (14), a light detector (24) arranged to receive light from the illuminated region (36) of the foot and generate an output based on the received light, and a processor (26) configured to determine a capillary refill rate from the output of the light detector (24) when the user adjusts the amount of weight received by the support element (14).


Patent
University of Nottingham | Date: 2014-12-18

This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.


The invention relates to a method for producing functionalised monomers, the method comprising: a) providing a starting material selected from terpenes and terpenoids; b) forming a derivative of the starting material by incorporation of a hydroxyl group; c) esterifying the hydroxyl group of the derivative to introduce a moiety containing a vinyl group, so as to produce a functionalised monomer. The functionalised monomer can be polymerised to obtain a bio-derived polymer.


Patent
University of Nottingham and NewSouth Innovations PTY Ltd | Date: 2015-04-17

Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.


Patent
The Regents Of The University Of California, University of Nottingham and University of Sheffield | Date: 2016-08-05

Provided are methods and compositions for improving the growth characteristics of plants.


Kaloper N.,University of California at Davis | Padilla A.,University of Nottingham
Physical Review Letters | Year: 2014

We propose a very simple reformulation of general relativity, which completely sequesters from gravity all of the vacuum energy from a matter sector, including all loop corrections and renders all contributions from phase transitions automatically small. The idea is to make the dimensional parameters in the matter sector functionals of the 4-volume element of the Universe. For them to be nonzero, the Universe should be finite in spacetime. If this matter is the standard model of particle physics, our mechanism prevents any of its vacuum energy, classical or quantum, from sourcing the curvature of the Universe. The mechanism is consistent with the large hierarchy between the Planck scale, electroweak scale, and curvature scale, and early Universe cosmology, including inflation. Consequences of our proposal are that the vacuum curvature of an old and large universe is not zero, but very small, that wDE-1 is a transient, and that the Universe will collapse in the future. © 2014 American Physical Society.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.2 | Award Amount: 13.04M | Year: 2011

Smart systems consist of heterogeneous subsystems and components providing different functionalities; they are normally implemented as Multi-Package on a Board. To fully exploit the potential of current nanoelectronics technologies, as well as to enable the integration of existing/new IPs and More than Moore devices, smart system miniaturization and Multi-Chip in a Package implementation are unavoidable. Such goals are only achievable if a flexible software platform (i.e., the SMAC platform) for smart subsystems/components design and integration is made available to designers and system integrators.\nThe platform must include methodologies and EDA tools enabling multi-disciplinary and multi-scale modeling and design, simulation of multi-domain systems, subsystems and components at all levels of abstraction, system integration and exploration for optimization of specific metrics, such as power, performance, reliability and robustness.\nKey ingredients for the construction of the SMAC platform include: (1) The development of a cosimulation and co-design environment which is aware (and thus considers) the essential features of the basic subsystems and components to be integrated. (2) The development of modeling and design techniques, methods and tools that, when added to the platform, will enable multi-domain simulation and optimization at various levels of abstraction and across different technological domains.\nThe SMAC platform will allow to successfully address the following grand challenges related to the design and manufacturing of miniaturized smart systems: (1) Development of innovative smart subsystems and components demonstrating advanced performance, ultra low power and the capability of operating under special conditions (e.g., high reliability, long lifetime). (2) Design of miniaturized and integrated smart systems with advanced functionality and performance, including nanoscale sensing systems, possibly operating autonomously and in a networked fashion


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SEC-2013.2.2-2 | Award Amount: 3.99M | Year: 2014

PANDHUB will create an integrated toolbox to aid transport operators and relevant actors in major transport hubs in the development of their current pandemic and dangerous pathogen preparedness and response plans. The project is intended to cover the extraordinary aspects specific to serious natural or man-made pathogen threats in the transport environment by providing accurate, reliable and validated information for the incident threat assessment, preparedness and response phases. The toolbox will include modelling components to simulate the spread of diseases and to evaluate the effects of countermeasures. The impact of these contact tracing and epidemiology tools will be the facilitation of an efficient and rapid response to a cross-border incident, thereby supporting the capability to limit spread and save lives. Co-ordinated and appropriate data collection, collation and analysis tools developed here, will allow swift joined-up epidemiological investigation of a developing situation in order to integrate with, and inform, other technologies and expertise. The capability provided here will largely be achieved through early and close collaboration with transport staff and end-users, and borne out of review and integration of the local and national practical, legal and ethical implications necessarily involved when an incident and its response is multinational. The developed tools will be widely tested through workshops and field exercises. The feedback from these experiments will be used for validation and further development of the tools.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.2.3-01 | Award Amount: 2.88M | Year: 2013

MISW (Mitigation of space weather threats to GNSS services) will tackle the research challenges associated with GNSS (Global Navigation Satellite System) and Space Weather to bring practical solutions right into the forefront of European Industry. Space Weather can affect many modern technologies that we take for granted. One of the most common technologies found across many systems today is navigation and timing provided by the Global Navigation Satellite System (GNSS). The main users of GNSS positioning are reliant on the inherent accuracy that the system can provide but this is not adequate for all applications. Aviation has its own augmentation solution called a Satellite Based Augmentation System (SBAS) and the European version is called EGNOS (European Geostationary Navigation Overlay Service). These systems gather additional information that allows some mitigation of Space Weather Events. However, they are not yet able to work in the most challenging regions and as a consequence Space Weather disturbances to the ionised upper atmosphere (ionosphere) will cause navigation errors that remain uncompensated. MISW will research, develop and apply new solutions to compensate for ionospheric effects on GNSS. Measurements of actual extreme events will allow realistic estimates of the ionospheric delays and errors caused by scintillation. MISW will include the development of new mapping techniques to compensate for ionospheric delay and both system-level and receiver-level solutions to scintillation events. The MISW consortium of leading industry, academia and research organisations will deliver the foundations for the next generation SBAS systems that can be extended across Europe and into Africa, ensuring reliable GNSS services over many decades ahead.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.5.1 | Award Amount: 11.64M | Year: 2013

Obesity and other lifestyle-related illness are among the top healthcare challenges in Europe. Obesity alone accounts for up to 7% of healthcare costs in the EU, as well as wider economy costs associated with lower productivity, lost output and premature death. Obesity in younger age is an alarming predictor for obesity in adulthood, but also entails short term health complications in juvenile age along with greater risk of social and psychological problems.\nKnowing how to stay healthy is not enough to motivate individuals to adopt healthy lifestyles, but relevant progress can be achieved through the use of incentives delivered through a combination of processes and mobile technologies.\nRecognizing the effectiveness of this approach, the PEGASO project will develop a multi-dimensional cross-disciplinary ICT system that will exploit sophisticated game mechanics to motivate behavioral changes towards healthier lifestyles and prevent overweight and obesity in the younger population.\nThe project relies on ICT technologies to implement a framework for the promotion of an health service based on three main features: individual&environmental monitoring, including wearable sensors, mobile phone and multimedia diaries for the acquisition of physical, physiological and behavioural attributes of participants; feedback to the user, presenting personalised healthy options for alternative lifestyles; social connectivity, encouraging involvement in social network experience sharing and social engagement. For the system development, a user centered approach, social and networked games and online education will be used. PEGASO will be tested with over 300 adolescents in three EU member states (Spain, Italy, UK).\nThe development of PEGASO project will mobilize a wide stakeholders ecosystem contributed by National Health Authorities and Research Institutions, Industries and Academia from the ICT and healthcare sectors, as well as food companies and SMEs


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.5 | Award Amount: 10.64M | Year: 2012

In recent years it has become clear that mid-IR imaging spectroscopy has the potential to open a new chapter in bio-medical imaging and offers an effective tool for early cancer diagnosis and improved survival rates. Rather than a search for cancer marker absorption peaks, great progress has been made by analysing the entire bio-molecular mid-IR spectral signature using automated algorithms. However, the lack of suitable sources, detectors and components has restricted the technology to one of academic interest, based on weak thermal sources, low power lasers or synchrotron research tools.For the first time the photonic technology is in place to develop a new mid-IR technology platform on which entirely novel supercontinuum sources (c. 1000x brighter than thermal sources) covering the whole range from 1.5 to 12 m may be built:-Low loss robust chalcogenide fibres for fibre lasers, supercontinuum generation and delivery -Fibre end caps, splicing and fusion technology for soft glass fibres -Crystal technology and novel designs for mid-IR AO modulators based on calomel -Flexible fast AO driver technology to enable high speed HSI acquisition -Low cost T2SL FPA detectors with performance matching state-of-the-art MSL devices -2.9 m Er:ZBLAN and 4.5 m Pr-doped chalcogenide fibre laser pumps -Robust designs for a range of mid-IR SCG sources: a) 1.5-4.5 m from ZBLAN fibre b) 1.5-5.5 m from InF3 fibre c) 3-9 m from 2.9 m pumped PCF chalcogenide fibre d) 4-12 m from 4.5 m pumped step-index chalcogenide fibre.Two specific high impact applications will be addressed: high volume pathology screening (i.e. automated microscope-based examination of samples) and in vivo, remote, real-time skin surface examination (i.e. non-invasive investigation of suspected skin cancer).This project will open the mid-IR to further exploitation, and the technology developed will be transferable to a huge range of applications both in bio-photonics and in wider industry.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-9-2015 | Award Amount: 2.96M | Year: 2015

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part of the regulation of gene expression is implicitly coded in the way in which chromatin is folded. As technology has advanced and information of the folded state of chromatin has emerged, a new branch of genomics (3D/4D genomics) has emerged. Hundreds of laboratories are now defining a young and active community that, though in the end concerned with the same scientific problem, uses many different approaches to study it that individually target radically different length and timescales. The community faces severe practical problems related to: i) how huge, noisy, and diverse data related to widely different size and time scales can be integrated, ii) the lack of standardized analysis and simulation tools, iii) the complete disconnection of associated informatics databases, and iv) the lack of validated and flexible visualization engines. MuG is born at the critical point in the evolution of the field, in a bottom-up approach from the biologist who are suffering severe IT problemes. MuG, supported by European leaders in the field, join three different expertise: biologist with interest in chromatin structure, methods developers and HPC facilities with strong history of supporting Bio-computational problems. We believe that MuG will be a steep-forward in approaching the potential of High Performance Computing to the development of 3D/4D genomics, and will contribute to give a structure to this new and exciting field.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.14M | Year: 2012

The plastic industry contributes around 23% of the total sales in the European chemical industry but is traditionally heavily reliant on petrochemicals for their raw material, additives and reaction media (solvents). REFINE will develop sustainable routes to functional materials (green routes) for various polymer/plastic applications. The network will make use of integrated approaches combining green raw materials, green synthesis (biotechnology) and green processing. This will be complemented by critical life cycle analyses and end-user benchmarking. The network will demonstrate these concepts by targeting selected relevant industrial applications, which are fundamentally dependent upon polymers such as thin film applications (coatings, personal care, etc.). Its leading experts in polymer and material science and biotechnology from 6 academic and research institutions, 2 multinational industrial end-users from different application areas (performance polymers and personal care products) and 1 SMEs will make use of integrated approaches combining green raw materials, green synthesis and green processing. These three elements will systematically be linked in a chain of knowledge approach and complemented through critical life cycle analyses by an SME with specific expertise in ecological process evaluation. The REFINE network will train a new generation of materials researchers, who are aware of the envi-ronmental impact of their work and can apply the tools of sustainability in their future positions (sustainable materials scientists). It will positively impact the employability of its researchers in the bioplastic industry with a predicted growth of >25% by 2020 by giving them a unique combination of skills through scientific, industrial and individual training at the local and network level. REFINE will develop a green technology, which can directly be validated and integrated by industry and thus lead towards a greener and more sustainable society.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Business, Innovation & Skills Financed | Award Amount: 4.54M | Year: 2014

Within the aerospace sector, aftermarket services account for over fifty percent of revenue generated by aero engine manufacturers. Central to this is the ability to inspect and repair high unit cost components, both on-platform and in repair and overhaul facilities, in order to safely return them to operational service. With the drive towards ever-increasingly complex aero-engine architectures, highly engineered components and advanced material systems, many existing repair processes will not be capable of meeting the new aftemarket need. This project will therefore develop and demonstrate three key advanced repair technologies, including the cost-efficient high-integrity repair of blisks, on-platform repair and structural repair of composite components. These repair processes must be capable of being applied to complex geometries and accommodate component variation resulting from service operation.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: EeB.NMP.2012-2 | Award Amount: 8.61M | Year: 2012

The proposed project will develop and demonstrate energy efficient new and innovative technologies and solutions for retrofitting and performance monitoring of a number of typical residential buildings in EU countries. Technologies envisaged for envelope retrofitting include various types of insulation materials. Energy efficient solutions will also be deployed including energy efficient lighting and HVAC, and renewable energy systems. The technologies and solutions will be affordable, durable, easy for installation and compatible with existing building functions and aesthetics as well as energy efficient. The types of building for retrofitting will include detached, semidetached and terrace houses, and flats of different ages. Methods for measurement of building performance before and after retrofitting will include leakage test and thermal imaging to determine the major areas of building envelope for improvement, in addition to smart energy metering for individual technologies and building as a whole. The buildings will be retrofitted to at least the latest national building standards for new buildings. The type and number of technology deployed will be optimised using life cycle energy analysis for each type of building. The work programme will involve development of computer models for optimising technologies and solutions, analysing dynamic energy demand of buildings and predicting microclimate indoors, development and testing of technologies and solutions under laboratory conditions, retrofitting and monitoring residential buildings in different climatic conditions, and a socio-economic analysis. The above outcomes will be delivered through innovative solutions developed by a Consortium comprising leading companies, universities and public institutions from 10 European countries.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.1 | Award Amount: 4.33M | Year: 2012

The BRIDLE project seeks to harness the power and efficiency of diode lasers to develop an affordable direct diode laser source for industrial applications requiring the cutting and welding of sheet metal. Specifically, BRIDLEs diode laser will have a power >2kW from a 100um diameter (NA <= 0.15) optical fibre and efficiency >40%. (This is ~2.5x more powerful, 10x brighter and 1.7x more efficient than the best spectral beam combined diode laser and ~30x times brighter than conventional diode lasers.) BRIDLE will focus on technologies suitable for manufacturability and cost scaling. Along with the increased power and brilliance, this will enable direct diode lasers to penetrate the metal processing market.\n\nBRIDLEs approach is modular, scalable and forward compatible. It begins with high brilliance mini-bars, whose emitters use intracavity filters to achieve 2-3x higher brilliance (~7W @ 0.8-1.5mm.mrad) than the best broad-area emitters (~7W @ 2.7mm.mrad). Fine and coarse spectral beam combining will further increase the brilliance by 5x and 3x increasing the total brilliance by 30-40x. Advanced coherent beam combining techniques will also be pursued to develop phase-coupled mini-bars with a nearly diffraction limited output power of 30W, allowing a further >4x improvement in spatial and spectral brilliance.\n\nBRIDLEs approach is chosen to be compatible with manufacturability and cost scaling requirements. The cost and complexity of the optical system are reduced by integrating optics inside the mini-bars (e.g. mode filters, DBR gratings for fine wavelength-spacing). Efficient, extremely low vertical divergence structures will lead to low-cost smile-insensitive assembly and low-loss optical coupling. The chosen packaging and beam combining techniques allow simple fabrication and good thermal management.\n\nBRIDLEs laser system will be validated for sheet metal cutting. The constituent sub-modules will target additional applications and markets.\n\nThe objectives of the BRIDLE project are of central importance to the photonics and manufacturing industries in Europe. BRIDLE technologies will enable the European diode laser and laser systems industries to maintain a leading global position. The industrial impact will extend across a wide range of industrial sectors, with European applications of this technology in the automotive, aerospace, manufacturing and materials processing sectors giving European manufacturers new advantages in an increasingly dynamic and competitive economic climate.\n\nThrough the exciting new technologies developed in this project, the European laser diode industry will be able to introduce new direct diode lasers into the materials processing markets at a lower cost and with significantly improved performance. European industry and society will be the first to benefit. The BRIDLE project will play a direct and important role in reinforcing economic growth, competitiveness, employment and sustainability.


Grant
Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2009.4.2 | Award Amount: 7.59M | Year: 2010

The GaLA motivation stems from the acknowledgment of the potentiality of Serious Games (SGs) for education and training and the need to address the challenges of the main stakeholders of the SGs European landscape (users, researchers, developers/industry, educators). A foundational fault issue in this context is the fragmentation that affects the SG landscape.\nGALA aims to shape the scientific community and build a European Virtual Research Centre (VRC) aimed at gathering, integrating, harmonizing and coordinating research on SGs and disseminating knowledge, best practices and tools as a reference point at an international level. The other two key focuses of the project are (1) the support to deployment in the actual educational and training settings and (2) the fostering of innovation and knowledge transfer through research-business dialogue.\nThe NoE organizations aim to integrate their activities and resources in a long-term view structuring the activities along 3 major axes:\n\n\tResearch integration and harmonization.\no\tStrong integration among leading researchers, users and business;\no\tStrong concern on the current standards of education, in order to favour a real uptake and scaling of the educational games initiatives.\no\tAddress sustainability.\n\n\tJoint research activities.\no\tIdentify key issues and address them through multidisciplinary teams (putting always the users learners and teachers - and stakeholders in the centre of the focus) that will be iteratively explored;\no\tPromote Research and Development team forces organized in thematic areas - that will do focused research (e.g. joint PhD and MSc projects on hot SG research projects, joint project proposals) and continuously inform the project about the latest developments in technology and education;\n\n\n\tSpreading of excellence.\no\tDissemination of the NoE achievements as a flagship EU initiative in the TEL area\no\tStrong coordination with EU TEL activities, offering a specialized focus and expertise on SGs.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: SC5-10a-2014 | Award Amount: 3.13M | Year: 2015

Mapping and assessment of ecosystems and their services (ES) are core to the EU Biodiversity (BD) Strategy. They are essential if we are to make informed decisions. Action 5 sets the requirement for an EU-wide knowledge base designed to be: a primary data source for developing Europes green infrastructure; resource to identify areas for ecosystem restoration; and, a baseline against which the goal of no net loss of BD and ES can be evaluated. In response to these requirements, ESMERALDA aims to deliver a flexible methodology to provide the building blocks for pan-European and regional assessments. The work will ensure the timely delivery to EU member states in relation to Action 5 of the BD Strategy, supporting the needs of assessments in relation to the requirements for planning, agriculture, climate, water and nature policy. This methodology will build on existing ES projects and databases (e.g. MAES, OpenNESS, OPERAs, national studies), the Millennium Assessment (MA) and TEEB. ESMERALDA will identify relevant stakeholders and take stock of their requirements at EU, national and regional levels. The objective of ESMERALDA is to share experience through an active process of dialogue and knowledge co-creation that will enable participants to achieve the Action 5 aims. The mapping approach proposed will integrate biophysical, social and economic assessment techniques. Flexibility will be achieved by the creation of a tiered methodology that will encompass both simple (Tier 1) and more complex (Tier 3) approaches. The work will exploit expert- and land cover-based methods, existing ES indicator data and more complex ES models. As a result the outcomes will be applicable in different contexts. The strength of the ESMERALDA consortium lies in its ability to make solutions for mapping and assessment problems available to stakeholders from the start of the project, because our expertise allows us to build on existing research projects and data sharing systems.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 252.00K | Year: 2016

Insects can be accidentally introduced into non-native ecosystems by humans, or expand their geographical range toward the poles as a consequence of global warming. As they invade new environments, exotic species interact with local species, modifying the structure of local food webs. New associations arising from with biological invasions can impact the strength of existing links with effects cascading through trophic levels. When invasive species are herbivores that can attack economically important crops, they can cause serious economic losses. For example, recent invasion of the brown marmorated stink bug (BMSB) (Halyomorpha halys) in Europe and North America has the potential to interfere with local trophic webs and poses a serious threat to several agro-ecosystems. In this project, we will adopt a multidisciplinary approach to study the ecological consequences of BMSB invasions. In particular, we will focus on the effect of alien herbivore invasion on local natural enemies using the following work packages: 1) the impact of exotic herbivores on infochemical communication between plants, herbivores and natural enemies; 2) Learned responses of parasitoids to infochemical evolutionary traps in a climate change context; 3) Contest behaviour of local egg parasitoids for possession of co-evolved and non-coevolved hosts; 4) Patch time allocation of local egg parasitoids after alien herbivore invasion: behavioural and modelling approaches; 5) Molecular aspects of indirect plant defences against invasive and local species 6) Genetic structure of invasive alien herbivores across Europe and North America The proposed research will be of great relevance for the RISE call as it will be an unparalleled opportunity for complementary European and Canadian research groups to join forces, resulting in the development of lasting research collaborations, the transfer of knowledge between research institutions and improving research potential at the European and global levels.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: GALILEO-3-2014 | Award Amount: 1.31M | Year: 2015

Biomass mapping has gained increased interest for bioenergy, climate research and mitigation activities, such as reducing emissions from deforestation and forest degradation, sustainable management of forests and enhancement of forest carbon stocks (e.g. REDD initiative). However, continuous deforestation activity and forest management requires frequent and accurate monitoring which can be expensive and difficult to attain. In Brazil, optical satellite data is typically used by government but even such does not allow accurate enough mapping due cloud coverage, requiring combination of other sources such as in-situ and air-borne measurements. Furthermore, satellite radar signals can penetrate clouds but still today the spatial resolution is not sufficient. In COREGAL, a low cost unmanned fixed-plane Unmanned Aerial Vehicle (UAV) and service for biomass mapping will allow wide scale mapping in the Brazilian context of forest management. A first of a kind combined Position-Reflectometry Galileo receiver will be developed as main sensor for platform positioning and biomass estimation, the latter using reflected GNSS signals (also called GNSS-R) on tree canopies. High positioning accuracy (centimetre level) is required for surface point reflection determination, which is challenging for remote areas where no GNSS infrastructure is available as in the case of many forests in Brazil. However, Galileo AltBOC E5 signals offer unprecedented pseudorange measurement quality which can be used for novel high accuracy positioning. The UAV will be equipped and tested with a COREGAL receiver and optical cameras for aerial mapping and biomass estimation, enabling wide scale low cost mapping: UAV mapping is at least one order of magnitude lower cost than manned air-borne missions while GNSS-R can be seen as bi-static radar replacing expensive, heavy and power consuming radars. The consortium includes universities and companies for successful services and technology exploitation.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.70M | Year: 2015

The growth of cities, impacts of climate change and the massive cost of providing new infrastructure provide the impetus for this proposal entitled Training in Reducing Uncertainty in Structural Safety (TRUSS) which will maximize the potential of infrastructure that already exists. If flaws in a structure can be identified early, the cost of repair will be vastly reduced, and here an effective monitoring system would allow identifying the optimum time to repair as well as improving structural safety. But safety is difficult to quantify and requires a deep understanding of the uncertainty associated to measurements and models for the structure and the loads. TRUSS will gather this understanding by bringing together an intersectoral and multidisciplinary collaboration between 4 Universities, 11 Industry participants and 1 research institute from 6 European countries. The consortium will combine and share expertise to offer training at an advanced level as new concepts for monitoring, modelling and reliability analysis of structures are emerging all the time. TRUSS will make knowledge of structural safety grow by incorporating these emerging technologies (hi-tech monitoring and manufacturing, computing, etc.) into the training programme and it will support job creation by enabling a wider talent pool of skilled and accredited engineering graduates with business, entrepreneurship, communication, project management and other transferrable skills. The training programme will be structured into taught modules combined with original research supported by secondments that will expose 14 fellows to both academia and industry. While developing tools that will reduce uncertainty in structural safety and improve infrastructure management, TRUSS will lay the basis for an advanced doctoral programme that will qualify graduates for dealing with the challenges of an aging European infrastructure stock, thereby enhancing their career prospects in both industry and academia.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: LCE-08-2014 | Award Amount: 15.40M | Year: 2015

The project SENSIBLE addresses the call LCE-08-2014 by integrating electro-chemical, electro-mechanical and thermal storage technologies as well micro-generation (CHP, heat pumps) and renewable energy sources (PV) into power and energy networks as well as homes and buildings. The benefits of storage integration will be demonstrated with three demonstrators in Portugal, UK and Germany. vora (Portugal) will demonstrate storage-enabled power flow, power quality control and grid resilience/robustness in (predominantly low-voltage) power distribution networks under the assumption that these networks are weak and potentially unreliable. Nottingham (UK) will focus on storage-enabled energy management and energy market participation of buildings (homes) and communities under the assumption that the grid is strong (so, with no or little restrictions from the grid). Nuremberg (Germany) will focus on multi-modal energy storage in larger buildings, considering thermal storage, CHP, and different energy vectors (electricity, gas). An important aspect of the project is about how to connect the local storage capacity with the energy markets in a way that results in sustainable business models for small scale storage deployment, especially in buildings and communities. SENSIBLE will also conduct life cycle analyses and assess the socio-economic impact of small-scale storage integrated in buildings distribution networks. By integrating different storage technologies into local energy grids as well as homes and buildings, and by connecting these storage facilities to the energy markets, the project SENSIBLE will have a significant impact on local energy flows in energy grids as well as on the energy utilization in buildings and communities. The impacts range from increased self-sufficiency, power quality and network stability all the way to sustainable business models for local energy generation and storage.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.39M | Year: 2017

TREASURE will provide specialist training in the strategic and emerging area of European GNSS. Collectively, GNSS (Global Navigation Satellite Systems) includes systems such as the US Global Positioning System (GPS) and the Russian GLONASS, as well as the new, under development systems like Chinas Beidou and most importantly Europes Galileo. Galileo is what we call the European GNSS (EGNSS) and is to be fully operational around 2020, therefore the pressing need to invest on research and training right now. This is especially so because GPS has clearly been the frontrunner of all these systems and has dominated the market for two decades now. EGNSS (Galileo) is aimed at changing this market unbalance and is the main focus of this proposal, which concentrates on its use in support of applications demanding high accuracy positioning and navigation. TREASUREs cohort of 13 young researchers will be given gap-bridging innovative training through an exceptional and unique network of industrial, research and academic beneficiaries, with the aim to form a group of outstanding researchers who would not be able to acquire the equivalent set of skills by training at any individual European institution alone. World-class expertise on EGNSS exists in Europe, however multi-disciplinary research skills need expanding to maximise the enormous potential that there is for promotion and exploitation of this technology. TREASURE addresses that need and responds to the much desired involvement of end-users and businesses, by bringing together four top Universities, one research Institute and four leading European companies, with extensive track record and experience in a wide breadth of disciplines to provide the necessary coordinated research training that will enable the ultimate real time high accuracy EGNSS solution.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.91M | Year: 2017

The EU currently is negotiating a controversial Transatlantic Trade and Investment Partnership (TTIP) agreement with the USA, the main features of which will be the abolition of tariffs, the reduction of non-tariff barriers to trade between the EU and the USA and the introduction of a dispute settlement mechanism. The objective of the proposed TTIP Innovative Training Network (TTIP-ITN) is to foster interdisciplinary research into TTIP with a view to create a significantly increased European knowledge base and research capacity on TTIP, thus helping Europe to reap the benefits of TTIP (wealth, jobs, etc.) while addressing its challenges (democracy, accountability, environmental- and labour standards, etc.).The network is an interdisciplinary, intersectoral collaboration pooling world-leading researchers and practitioners from all relevant disciplines of law - EU constitutional, internal market, and external relations law, international trade law, and international law, as well as political science, international relations, business studies, and economics. TTIP-ITN fully integrates non-academic Beneficiaries and Partner Organisations, including think tanks, lobbyists, regulatory bodies, law firms, US academic institutions, and an international organisation. Furthermore, the network will support and enhance the process of converting research results into policy papers through partnership with high-impact policy research units at the forefront of European policy research and policy making. The work package consists of 3 substantive work packages on (1) transatlantic governance, (2) transatlantic regulation, and (3) multilateralism and regionalism. 15 PhD research projects will be supervised by academics of the 11 Beneficiaries with an interdisciplinary training programme covering the legal, political and economic foundations of TTIP and an interdisciplinary and intersectoral programme of secondments involving 22 Partner Organisations.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.94M | Year: 2016

Additive Manufacturing (AM) is a fastgrowing sector with the ability to evoke a revolution in manufacturing due to its almost unlimited design freedom and its capability to produce personalised parts locally and with efficient material use. AM companies however still face technological challenges such as limited precision due to shrinkage and buildin stresses and limited process stability and robustness. Moreover often postprocessing is needed due to the high roughness and remaining porosity. In addition qualified, trained personnel is hard to find. This ITN project will address both the technological and people challenges. To quality assure the parts produced, PAM will, through a close collaboration between industry and academia, address each of the various process stages of AM with a view to implementing good precision engineering practice. To ensure the availability of trained personnel, ESRs will, next to their individual research and complementary skills training, be immersed in the whole AM production chain through handson workshops where they will design, model, fabricate, measure and assess a specific product. The expected impact of PAM thus is: 1. The availability of intersectoral and interdisciplinary trained professionals in an industrial field thats very important for the future of Europe, both enhancing the ESR future career perspectives and advancing European industry. 2. The availability of high precision AM processes through improved layout rules with better use of AM possibilities, better modelling tools for firsttime right processing, possibility for insitu quality control ensuring process stability and, if still needed, optimised postprocessing routes 3. As a result of 1: an increased market acceptance and penetration of AM. 4. Through the early involvement of European industry: a growing importance of the European industrial players in this fastgrowing field. This will help Europe reach its target of 20% manufacturing share of GDP.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.5.3 | Award Amount: 15.53M | Year: 2011

The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of 56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM), brings together the exisiting clinical consortia (EvA FP7, U-BIOPRED IMI and BTS Severe Asthma), and expertise in physiology, radiology, image analysis, bioengineering, data harmonization, data security and ethics, computational modeling and systems biology. We shall develop an integrated multi-scale model building upon existing models. This airway model will be comprised of an integrated micro-scale and macro-scale airway model informed and validated by omic data and ex vivo models at the genome-transcriptome-cell-tissue scale and by CT and functional MRI imaging coupled to detailed physiology at the tissue-organ scale utilising Europes largest airway disease cohort. Validation will be undertaken cross-sectionally, following interventions and after longitudinal follow-up to incorporate both spatial and temporal dimensions. AirPROM has a comprehensive data management platform and a well-developed ethico-legal framework. Critically, AirPROM has an extensive exploitation plan, involving at its inception and throughout its evolution those that will develop and use the technologies emerging from this project. AirPROM therefore will bridge the critical gaps in our clinical management of airways disease, by providing validated models to predict disease progression and response to treatment and the platform to translate these patient-specific tools, so as to pave the way to improved, personalised management of airways disease.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2013.3.5-02 | Award Amount: 1.21M | Year: 2013

The objective of the PreSto GMO ERA-Net project is to clearly map out the steps needed to create and successfully implement an ERA-Net that will coordinate transnational research on the effects of genetically modified organisms (GMOs) in the areas of human and animal health, the environment, and techno- economics and societies. The focus of the ERA-Net will be on GMOs intentionally released into the environment and/or used immediately in feed and food applications. PreSto GMO ERA-Net brings together ministries, agencies, and funding bodies from different Members States and the scientific community to jointly prepare a strategic plan and roadmap for the implementation of the ERA-Net. In addition, the ERA-Net will explicitly take into account the wider views of a diversity of stakeholders and end-users (e.g. non-governmental organisations, industry, farmers). This is intended to strengthen ownership of the ERA-Net among stakeholders in order to encourage participation of different scientific communities in the future joint transnational calls, to enhance collaboration between actors and to increase the accountability of research trajectories and outcomes. The results of the project will form the basis for a robust ERA-Net proposal. In achieving this the project work will (1) promote the accessibility of existing scientific information to interested stakeholders and end-users, (2) lead to the harmonisation of research requirements and capacity building within Europe, (3) complement international developments, (4) contribute to a more efficient use of research funds internationally and (5) identify how strategic collaboration can be used to respond to these future research and training needs through enhancement of durable partnerships.


Grant
Agency: Cordis | Branch: H2020 | Program: CS2-RIA | Phase: JTI-CS2-2014-CFP01-ENG-03-01 | Award Amount: 994.54K | Year: 2016

DevTMF takes the collective technical expertise and experience of working on thermo-mechanical fatigue (TMF) problems related to large aero-engines from three major centres of TMF research, namely Linkping, Swansea and Nottingham Universities in order to perform the activities of this topic. Together, the team will deliver significant technical innovations in following major topics to ensure world-leading competencies in aero engine and aircraft manufacturing sector for Europe: 1. Improvement and development of advanced standard and non-standard cutting-edge TMF experimental methods and harmonisation of the test methods to enable standardisation across the field by performing comprehensive studies into the phenomena for a range of representative parts, 2. Advanced metallurgical assessment of structural disc alloy(s) taking into account the effect of multiple critical variables (e.g. R-ratio, phase, environment, dwell) to determine active damage mechanisms that control the life under TMF operating conditions, and 3. Physically based coupled models, with experimental validation, capable of predicting TMF initiation and propagation lives of components subjected to complex engine cycles and suitable for implementation in the computer programmes used to predict component lives. The project will take the above-described technologies to TRL5. Two business opportunities are addressed by this work: (i) at the end of the project the materials understanding and lifing models will be used to optimise/uprate the performance of existing individual aero engine components and (ii) over a longer timescale influence the development of new disc alloys and ultra efficient future designs (Advance, Ultrafan). The developed TMF technologies will enable industrial aero gas turbines used for aero engines to be operated at higher temperatures and pressures, improving their efficiency and reducing fuel consumption (by 1%) and CO2 emissions. Hence improved competitiveness and marker share.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: FOF-11-2016 | Award Amount: 1.92M | Year: 2016

There is a consensus among industry and policymakers that Europe is currently in the middle of an industrial revolution initiated by the digitisation of industrial processes. Cyber Physical Systems (CPS), the Industrial Internet and the Internet of Things (IoT) connect people, devices, machines and enterprises like never before. For many years companies and research organisations have been addressing these challenges and opportunities both at European level (through the Factories of the Future PPP and related activities) and at national level. The ConnectedFactories project will build upon these activities and consolidate their expert networks, aiming at industrial consensus building across Europe. The ConnectedFactories project will establish and maintain a structured overview of available and upcoming technological approaches and best practices that are needed for mastering this paradigm shift. Present and future needs and challenges of the manufacturing industries will be identified in order to then identify possible scenarios of how digital platforms will enable the digital integration and interoperability of manufacturing systems and processes. Developing these scenarios will require detailed work with companies and other stakeholders through a series of workshops at national and regional level, in order to reach a necessary industrial consensus on aspects such as: innovative technology proposals, business models, aspects, standardization etc while considering the establishment of industrial eco-systems where multi-sided IT platforms create value. This work will enhance the awareness among companies of the use of digital technologies in the manufacturing sector and equip them with knowledge to make informed decisions regarding technology and business model choices. It will reinforce the European manufacturing industries position in the international scene.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 369.99K | Year: 2014

CELLDEX aims to deliver a pleasurable, great tasting chocolate confection with a reduced calorie and sucrose content that will appeal to consumers as an attractive alternative to standard chocolate confections. To achieve this, the project will develop a process to produce a new low calorie bulk sugar replacer from sustainable sources. The new ingredient must out-perform currently available alternatives in providing high quality chocolate confections without undesirable side effects at a reasonble price. The impact of the new ingredient on human physiology will be tested to determine its low calorie credentials and determine the threshold of tolerability. The new ingredient will eventually be available to the food industry and enable the formulation of a range of healthier reduced sugar foods. The availability of tasty but healthy snacks has a role to play in fighting the trend of increasing obesity and type 2 diabetes.


Murchie E.H.,University of Nottingham | Lawson T.,University of Essex
Journal of Experimental Botany | Year: 2013

Chlorophyll fluorescence is a non-invasive measurement of photosystem II (PSII) activity and is a commonly used technique in plant physiology. The sensitivity of PSII activity to abiotic and biotic factors has made this a key technique not only for understanding the photosynthetic mechanisms but also as a broader indicator of how plants respond to environmental change. This, along with low cost and ease of collecting data, has resulted in the appearance of a large array of instrument types for measurement and calculated parameters which can be bewildering for the new user. Moreover, its accessibility can lead to misuse and misinterpretation when the underlying photosynthetic processes are not fully appreciated. This review is timely because it sits at a point of renewed interest in chlorophyll fluorescence where fast measurements of photosynthetic performance are now required for crop improvement purposes. Here we help the researcher make choices in terms of protocols using the equipment and expertise available, especially for field measurements. We start with a basic overview of the principles of fluorescence analysis and provide advice on best practice for taking pulse amplitude-modulated measurements. We also discuss a number of emerging techniques for contemporary crop and ecology research, where we see continual development and application of analytical techniques to meet the new challenges that have arisen in recent years. We end the review by briefly discussing the emerging area of monitoring fluorescence, chlorophyll fluorescence imaging, field phenotyping, and remote sensing of crops for yield and biomass enhancement. © 2013 The Author.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.1.2-05 | Award Amount: 4.80M | Year: 2012

The overall goal of EURoot is to help farmers to face both climate change, which is expected to result in increasingly uneven rainfall, and meet the societal demand for sustainable agriculture with reduced use of water and fertilizers. EURoot objective is to enhance the cereal plant capability to acquire water and nutrients through their roots and maintain growth and performance under stress conditions. Making use of join phenotyping and modelling platforms, EURoot will conduct a suite of experiments designed to better understand and model: i. The genetic and functional bases of root traits involved in soil exploration and resource uptake, ii. The bio-geochemical properties of the soil, including beneficial association with mycorhizal fungi, influencing extraction of nutrient and water by the root system and iii. The plant signalling processes involved in soil environment sensing and responsible for adaptive root system response enhancing soil exploration and resource acquisition. The EURoot project is based on a tripod of interactive WPs addressing specific complementary questions i.e. WP1, genetics of root traits, WP2, root:soil interactions, WP3, root : shoot signalling-, and on two platforms WPs allowing to share innovative phenotyping methods relevant to field conditions and linked to crop performance (WP4) and multi scale modelling (WP5) aiming at integrating root architecture, resource dynamics in the soil and root uptake, and inner plant signalling processes, to design root ideotypes allowing enhanced resource acquisition under stress. Results will be readily translated into screening methods, models and tools (markers, biochemical signatures) to guide the challenging breeding for improved root traits allowing enhanced water and nutrient capture. It will allow the further development of novel cereal cultivars with higher resilience, tolerating erratic rainfalls and reduced fertilizer application, while achieving their yield potential.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2011.2.2-03 | Award Amount: 11.56M | Year: 2012

Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 individuals to investigate: The fuel mediated in utero hypothesis The accelerated postnatal weight gain hypothesis The mismatch hypothesis. Scientific and technical expertise in placental biology, epigenetics and metabolomics will provide understanding at the cellular and molecular level, and refined strategies for intervention in pregnancy and early post natal life to prevent obesity. Using existing cohort studies, ongoing and novel intervention studies and a basic science programme, we will provide the scientific foundations for evidence based recommendations for optimal EarlyNutrition that incorporate long-term health outcomes, focusing on 4 Target Groups: women before pregnancy; pregnant women; infants (incl. breastfeeding); young children. Evidence is produced from animal and placental studies (Theme 1; T1), prospective cohort studies (T2), and randomised controlled trials in pregnant women and infants (T3). T4 covers scientific strategic integration, recommendation development and dissemination, including systematic reviews and behaviour change approaches. A strong multi-disciplinary team of international leaders in the field including collaborators from USA and Australia achieves balance and complementarity. The projects impact comprises definitive evidence on early nutrition effects on health, enhanced EU and global policies, major economic benefits through obesity prevention and value-added nutritional products, and practical recommendations on optimal nutrition in Target Groups. Wide dissemination will be achieved through active engagement with stakeholders.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-03 | Award Amount: 12.00M | Year: 2013

Production diseases compromise health and welfare, generating inefficiencies which impact adversely on profitability, environmental footprint, antibiotic use and product quality. The PROHEALTH project will develop understanding of the multi-factorial dimension of animal pa-thologies linked to the intensification of production and use this to develop, evaluate and disseminate ef-fective control strategies to reduce impact. It will address production diseases of pigs and poultry raised in a wide range of EU intensive systems, using both epidemiological and experimental approaches to consider the extent of, and the risk factors associated with diseases, the influence of genotype and its modification by early life experience, and the dynamic influences of the environment on disease. The mechanisms underlying differences in disease susceptibility will be explored at different levels. Improvement strategies for diseases including neo-natal mortality, gut and respiratory disorders, leg and metabolic disorders will be evaluated in farm scale tests, and data from diverse systems used to model whole-chain socioeconomic implications of disease states and their alleviation. The consortium has expertise in veterinary science and epidemiology, physiology and immunology, ge-netics, nutrition, socioeconomics, welfare and production science of pigs and poultry. The 10 academic, 1 association 4 industry and 7 SME partners cover the full European geographic range to derive meaningful epidemiological data and test interventions across diverse production circumstances. Dissemination activities will encompass all stakeholders in the food chain and establish new e-learning tools. PROHEALTH will deliver novel diagnostics for the propensity to develop production diseases and their occurrence, and multifactorial improvement strategies that can be applied to produce better quality products in a welfare friendly manner and improve competitiveness and sustainability of EU pig & poultry systems


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2011.2.1-02 | Award Amount: 2.44M | Year: 2012

The aim is to investigate the combined effects of hypoxia and sustained recumbency (bedrest), on human physiological systems. The partial pressure of oxygen in the environmental gas inside future planetary habitats will be lower than in atmospheric air. Prolonged exposure to low gravity will result in deconditioning of vital physiological systems, and may consequently constitute a threat to the health of the astronauts. However, it is unknown how prolonged exposure to both reduced gravity and hypoxia will affect health. The new knowledge has also implications for society in general, since chronic hypoxia and bedrest constitutes a model of the basic conditions experienced by patients suffering from respiratory insufficiency restricting them to a physically inactive life style. The challenge of the project lies in the complexity of the experimental interventions where healthy humans are confined to a hypoxic environment during prolonged bedrest. A series of studies will be conducted at the Planica hypoxia facility capable of housing 20 subjects at any simulated altitude. Subjects will remain in horizontal position (bedrest) or be ambulatory, but confined to the facility (ambulation) for 21 days/trial. Each subject will participate in three trials: hypoxic bedrest (simulated altitude 4000m), normoxic bedrest, and hypoxic ambulation. The effects will be investigated in experiments concerning metabolic, cardiorespiratory, musculoskeletal, haematological, immunological and thermoregulatory functions. In addition to the specific objectives, the study will be explorative in the sense that it will collect a broad spectrum of basic data corresponding to that obtained when 21-day bedrest experiments are conducted by ESA/NASA (bedrest core data). Thus, data from the experiments can readily be compared with core data from previous bedrest studies, and hence the added effects of hypoxia should be evident.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-3.2-1 | Award Amount: 15.99M | Year: 2010

The SYNFLOW vision is the paradigm shift from batch-wise large volume processes in pharmaceuticals, fine chemicals and intermediates production comprising many separate unit operations towards highly integrated but yet flexible catalytic continuous flow processing. For this purpose, SYNFLOW develops a unique integrative approach combining molecular understanding of synthesis and catalysis with engineering science in process design and plant concepts, aiming at an efficiency breakthrough in process development and operation. The SYNFLOW mission is to overcome the traditional way of linear process development providing individual solutions for specific products, and to demonstrate the technological, economic and ecological superiority of truly designing processes by application of advanced chemical and engineering knowledge. The SYNFLOW concept is based on the definition of generic challenges with industrial relevance, represented by Case Studies provided by the industrial consortium members. Catalyst development, studies of the underlying chemical target transformations (synthetic methodology), tailored reaction engineering, conceptual process design and process evaluation interact closely in order to substantiate the SYNFLOW vision. Its success will be demonstrated on a relevant production scale as a reference for the entire European Chemical Industry. The SYNFLOW consortium brings together major industrial producers from the Pharmaceuticals, Fine Chemicals and Intermediates sectors, providers of process technology and technical catalyst supply. A number of high-ranked academic partners ensures the availability of comprehensive expertise for the suggested Case Studies. Dissemination of the results is guaranteed by the participation of DECHEMA and Britest. SYNFLOW presents a holistic approach to central challenges of the European Chemical Industries and therefore a highly promising candidate to fulfill the crucial issues of the NMP-2009-3.2-1 call.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.8.1 | Award Amount: 9.94M | Year: 2013

Computer games represent a vast economic market, a key driver of technology, and an increasingly powerful medium for a broad range of applications. The latest wave of innovation for computer games is mobile and, more precisely, location-based. These outdoors mobile experiences are radically different from traditional computer games or their mobile equivalent. They focus the players attention on the real world around them as much as on the digital world of the game, aiming to create a powerful juxtaposition of the two.\nAlthough location-based gaming is an industry on the verge of explosive growth, the creation and deployment of such experiences, especially those involving multiple participants, is simply out of reach for the vast majority of creative industries and authors because of the blend of many cutting-edge technologies they require, their hard to master limitations, and the complex gaming concepts they employ.\nThe first objective of MAGELLAN is to deliver an unprecedented authoring environment based on visual authoring principles in order to enable non-programmers, as well as more advanced users, to cost-effectively author and publish multi-participant location-based experiences. The second objective is to deliver a scalable web platform featuring social networking means and supporting the publication, browsing and execution of a massive number of such experiences. Finally, MAGELLAN will produce a series of guides for authors of location-based experiences that will constitute a reference for interested people as well as a foundational document for future research in the field.\nTo achieve this, MAGELLAN will adopt a holistic approach integrating interdisciplinary research involving a complementary group of world-class experts from multiple scientific and technological domains. A user-centred approach will be adopted in order to place end-users, represented by the 5 SMEs partners and the open User Group members, at the heart of the project.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.1 | Award Amount: 486.75K | Year: 2012

We seek to bring together all major European and Israeli research centres in Optimal Control of Quantum Information Processing. This project will coordinate ongoing research activities, best practice dissemination, personnel training and public engagement as well as interaction with public stakeholders and policymakers for 17 established research groups from 15 universities in 6 countries a total of about 60 scientists and 30 PhD students, spanning a variety of nationalities, races, cultures, social backgrounds, genders and career stages.The proposed Consortium will join the forces of multiple EU and Israeli research groups to explore a radical alternative to the currently established information processing technologies quantum information processing, where bits are carried by atoms or elementary particles and dramatic acceleration is believed to be possible for several types of computational tasks. Our specific research area within Quantum Information Processing is optimal control of quantum bits a set of technologies that enable extremely accurate manipulation of quantum bits with minimal expenditure of energy.Within this Coordination Action, we aim to create a vibrant, productive and efficient European research community, to deliver value to the society and to grow a new generation of young European physicists.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SiS.2012.2.2.1-1 | Award Amount: 3.78M | Year: 2013

This project aims to promote a widespread use of inquiry-based science teaching (IBST) in primary and secondary schools. Our major innovation is to connect IBST in school with the world of work making science more meaningful for young European students and motivating their interest in careers in S & T. To this end, we will run training courses in which pre- and in-service teachers will learn about IBST supported by teachers from vocational education, representatives from industry and informal learning. They will develop inquiry tasks in vocational contexts, leading to a large European task repository. Teachers will experience IBST themselves and through iterative cycles of implementation followed by reflection integrate this into their practice. To ensure widespread participation we will use a pyramid model in which we will work with a small number of teachers first each of which will then work with further teachers. Additionally we will develop an innovative interactive e-learning platform. To profit from the international perspective offered by the project teachers will be connected with existing European networks and our own thematic network on IBST through (virtual) meetings, a forum and the task repository. We will adopt a systemic approach to dissemination working with teachers and additionally parents, students, school authorities and policy makers. National and European advisory panels will bring together stakeholders to advise partners throughout the project; dialogue with policy makers will be facilitated by workshops and policy papers. To ensure effectiveness our work will be informed by a detailed analysis of the educational systems in partner nations. We plan to reach more than 65.000 teachers directly and 800.000 teachers indirectly (via stakeholders, media). Throughout, our work will be subject to rigorous evaluation and measures of quality assurance that will be both summative and formative in informing the progress of the project.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 169.32K | Year: 2015

Advances in fit for use manufacturing of biopharmaceutical drug delivery and pharmaceutical systems are now required to fit Quality by Design (QbD) models. These current regulations require excellence to be built into the preparation of emerging products (both material and process) thereby leading to product robustness and quality. In addition, industrial needs (economical and reproducible quality enhancement) are driving manufacturing towards continuous processes over batch type processes which also rely on QbD (for integrity and quality). EHDA technology is a robust process that has been utilised in various formats (e.g. electrospinning, electrospraying, bubbling and even 3D printing) and is favourable due to applicability with the development of stable nanomedicines and biopharmaceuticals, the emergence of this technology is clearly evident in the UK and on the global scale. Attempts in scaling up (for suitable pharmaceutical scale) and in tandem with continuous processes (including controlled manufacturing) have been very limited. There also, now, remains a huge void in the adaptation of sensible QbD (multi-variate) for the current methods developed and also those required by industry. While lab scale research continues with the ongoing development of such processes (e.g. nanomedicines, smart and controlled delivery), the transition to industry or the clinic will have to meet these regulations (and scales) for there to be a real impact, which is now, also, an important aspect of grass root research in the UK. The EHDA network brings together specialists from academia and industry to advance this technology through several means. Firstly, initiating developments towards a real-viable scale for Pharmaceutical production. Secondly, to incorporate developments in lean manufacturing and legislation (e.g. continuous manufacturing, online diagnostics, QbD and adaptable scale). Thirdly, to marry optimised lean technologies with novel and emerging macromolecular therapies and actives. The network has a wide range of activities and initiatives which will lead to significant developments (and collaborations) in an area of increasing global interest (EHDA processes) - but currently only on a viable lab scale to date. This network will be the first of its kind and will serve as the central and pioneering hub in this remit.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.18M | Year: 2016

In the ASPIRE project, whose academic and industrial beneficiaries are world leading in their complementary fields of expertise, the overarching research goal is the measurement of photoelectron angular distributions (PADs) in the molecular frame (MF) of systems of biological relevance. These MF-PADs can be interpreted as electron diffraction patterns, achieved by illuminating the molecule from within, and enable the shapes and motions of individual molecules to be interrogated. Such knowledge is needed for the development of new medicines (the shapes of drug molecules dictate their function) and new materials (efficient solar cells can be constructed if energy dissipation processes in molecules are understood). Progress in this area is highly technologically driven, requiring high repetition rate, short wavelength light sources and fast detectors. The input of private sector beneficiaries is therefore critical to the scientific objectives, as well as to the enhanced training environment. Work packages on advanced light source and detector developments will feed into the overall goal through secondments, regular virtual meetings and face-to-face network meetings. The symbiosis of the developments that will take place in ASPIRE will create a research and training environment that is world-leading and optimally tailored to capitalise, for example, on the investment that has been made in the European XFEL facility. The ESRs will be trained in world-leading laboratories and will benefit from the exchange of best practice among beneficiaries and partners, and from unique training events. ASPIRE will therefore ensure that European research remains competitive in the global market, and that the trained researchers will be uniquely well-placed to contribute to the development of novel instrumentation in the future.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INFRADEV-02-2016 | Award Amount: 4.00M | Year: 2017

Sustainable food security and increasing availability of plant biomass for human nutrition and bioindustries is the key challenge for the coming decades. The analysis of crop performance with respect to structure, function, quality and interaction with the environment (phenotyping) remains the bottleneck for the exploitation of crop genetic diversity required for the enhancement of plant productivity and progress in plant breeding. This requires substantial and concerted action to develop and to increase the availability of phenotyping infrastructures. The European Strategic Forum for Research Infrastructure (ESFRI) has identified Plant Phenotyping as a priority for the European research area and EMPHASIS has been listed on the ESFRI ROADMAP as an infrastructure project to develop and implement a pan-European plant phenotyping infrastructure. The project EMPHASIS-PREP will provide the basis for the establishment the legal framework, the business plan and preparation of an information system for a sustainable and innovative pan-European infrastructure for plant phenotyping within the framework of EMPHASIS. EMPHASIS-PREP will establish a transparent, open and inclusive process, the project partners will foster efficient work in the project in close cooperation with the European plant phenotyping community and all stakeholders. EMPHASIS-PREP includes four major steps: i) mapping (infrastructure, funders, access procedure and models, stakeholder community, e-infrastructure, imaging approaches, legal and governance scenarios); ii) gapping - analysing the gaps and limitations based on the mapping activities; iii) developing strategies to address the gaps; iv) combining the strategies in a business plan for future operation of EPMPHASIS within a corresponding legal framework.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 5.33M | Year: 2012

Neural Engineering is an inherently new discipline that coalesces engineering, physics and neuroscience for the design and development of braincomputer interface systems, cognitive computers and neural prosthetics. For the implementation of future transformative technologies a new breed of young researchers must be trained to integrate ideas and skills from a broad range of disciplines. NETT is composed of seven full network partners and ten associated partners including one international industrial company and eight SMEs. NETT will provide a European focus for the development of those aspects of Complexity Science most relevant to Neural Engineering, and ensure that we do not fall behind research in the US and Japan. We have identified some of the key challenges in this field and designed a set of inter-related multi-disciplinary projects that, by combining the skills of NETT members will generate transformative technologies such as novel speech recognisers, neural- inspired laser networks for information processing and robots with cognitive skills. To address key priority areas of FP7 in multi-disciplinary research, NETT will train ESRs and ERs using a structured, industry-focussed selection of training courses, with leading expertise in mathematics, physics, neuroscience and bioengineering from academia and the private sector. Each ESR will benefit from a secondment to another host country and an internship with an associated partner on problems of genuine real-world relevance. In this way ESRs will acquire a unique set of essential multi-disciplinary skills that will enhance research activity in the ERA and improve their career perspectives in both the public and private sectors. NETT is thus a Marie-Curie ITN whose activities are designed to benefit the development of transformative technologies that could not be developed in isolation, and simultaneously maximise the use of shared resources and facilities for both training and research.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-2.2-2014 | Award Amount: 12.03M | Year: 2015

The ITRAIL -Information Technologies for Shift to rail proposal, first step towards the long term IP4 -IT for an Attractive Railway SHIFTRAIL Innovation Programme, aims at providing a new seamless travel experience, giving access to a complete multimodal travel offer which connects the first and last mile to long distance journeys. This is achieved through the introduction of a ground breaking Technical Enabler based on two concepts: the traveler is placed at the heart of innovative solutions, accessing all multimodal travel services (shopping, ticketing, and tracking) through its travel-companion. An open published framework is providing full interoperability whilst limiting impacts on existing systems, without prerequisites for centralized standardization. This Technical Enabler will be completely settled in the context of the SHIFTRAIL IP4, and ITRAIL is proposing a reduced approach to the scale of a specified use case without weakening any of the key concepts of IP4, such as the usage of Semantic Web technologies, meta planning on distributed data, travel companion with a protected and secured personal wallet stored in the cloud and including the rights to travel. The use case will be defined as a specific instantiation of our open concepts, and will benefit from a completely scalable architecture fully instantiated in IP4. This approach is addressing all the key challenges of the work program, supporting a complete door-to- door intermodal travel offer and proposing a seamless integration of the very diverse existing and future services for planning, one-stop-shop ticketing, and real-time re-accommodation. Moreover, thanks to an Interoperability framework which insulates travel applications from the standards fragmentation in multimodal transport, ITRAIL liberates business-model innovations in the market-place, guaranteeing the economic self-sustainability of these e-services in the long-term.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.4.2-2 | Award Amount: 4.07M | Year: 2011

Background: The efficacy of long-acting -agonists (LABAs) in asthma has been demonstrated but their safety remains an issue, particularly in children. Co-therapy with inhaled corticosteroids (ICs) is recommended in persistent asthma. However, drug-use studies suggest frequently inadequate IC adherence, possibly explaining the occurrence of exacerbations. There is a need for detailed analyses of patterns of use of LABAs and ICs to describe asthma outcomes related to LABAs in monotherapy and at different levels of concomitant ICs, to explore the role of adherence in LABA safety, and to identify populations possibly at risk of adverse LABA-related asthma outcomes. Methods: Summarise available evidence on the risks of LABAs in asthma; develop questionnaires and instruments for the study; identify, in the UK and France, paediatric (6-15) and adult (16-40) patients with persistent asthma treated by LABAs; and link distinct datasets for this group using past and ongoing prescriptions provided by GPs and identified from electronic health records, dispensed therapy identified from claims data, information collected from prescribers, and details on exposures and outcomes collected by computer-assisted telephone interviews with patients over a prospective 24-month period. Analyze the linked datasets to characterise individual asthma care in detail and with high validity, describe patterns of use of LABAs and ICs, and relate these patterns to asthma outcomes. Disseminate results to the scientific community, patients associations, physicians associations, and regulators. Deliverables: Ranking of observed patterns of LABA and IC use according to risk of adverse outcomes due to LABAs. Identification from prescriber and patient data of predictors of patterns of use which put patients at risk. Results for regulators to use regarding recommendations to prescribers and patients on the use of LABAs. Assessment of the potential impact of these recommendations on public health.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SST.2011.5.2-6. | Award Amount: 3.82M | Year: 2011

Europe needs a safe and cost effective transport network to encourage movement of goods and people within the EU and towards major markets in the East. This is central to European transport, economic and environmental policy. Many parts of Europes rail network were constructed in the mid 19th century long before the advent of modern construction standards. Historic levels of low investment, poor maintenance strategies and the deleterious effects of climate change (for example scour of bridge foundations due to flooding and rainfall induced landslides) has resulted in critical elements of the rail network such as bridges, tunnels and earthworks being at significant risk of failure. The consequence of failures of major infrastructure elements is severe and can include loss of life, significant replacement costs (typically measured in millions of Euros) and line closures which can often last for months. The SMART Rail project brings together experts in the areas of highway and railway infrastructure research, SMEs and railway authorities who are responsible for the safety of national infrastructure, The goal of the project is to reduce replacement costs, delay and provide environmentally friendly maintenance solutions for ageing infrastructure networks. This will be achieved through the development of state of the art methods to analyse and monitor the existing infrastructure and make realistic scientific assessments of safety. These engineering assessments of current state will be used to design remediation strategies to prolong the life of existing infrastructure in a cost-effective manner with minimal environmental impact.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2011-1.2.2. | Award Amount: 5.16M | Year: 2011

OpenAIREplus will build a 2nd-Generation Open Access Infrastructure by significantly expanding in several directions the outcomes of the OpenAIRE project, which implements the EC Open Access (OA) pilot. Capitalizing on the OpenAIRE infrastructure, built for managing FP7 and ERC funded articles, and the associated supporting mechanism of the European Helpdesk System, OpenAIREplus will develop an open access, participatory infrastructure for scientific information. It will significantly expand its base of harvested publications to also include all OA publications indexed by the DRIVER infrastructure (more than 270 validated institutional repositories) and any other repository containing peer-reviewed literature that complies with certain standards. It will also generically harvest and index the metadata of scientific datasets in selected diverse OA thematic data repositories. It will support the concept of linked publications by deploying novel services for linking peer-reviewed literature and associated data sets and collections, from link discovery based on diverse forms of mining (textual, usage, etc.), to storage, visual representation, and on-line exploration. It will offer both user-level services to experts and non-scientists alike as well as programming interfaces for providers of value-added services to build applications on its content. Deposited articles and data will be openly accessible through an enhanced version of the OpenAIRE portal, together with any available relevant information on associated project funding and usage statistics. OpenAIREplus will retain its European footprint, engaging people and scientific repositories in almost all 27 EU member states and beyond. The technical work will be complemented by a suite of studies and associated research efforts that will partly proceed in collaboration with different European initiatives and investigate issues of intellectual property rights, efficient financing models, and standards.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-3.4-2014 | Award Amount: 6.93M | Year: 2015

The past decade has seen significant progress on active pedestrian safety, as a result of advances in video and radar technology. In the intelligent vehicle domain, this has recently culminated in the market introduction of first-generation active pedestrian safety systems, which can perform autonomous emergency braking (AEB-PED) in case of critical traffic situations. PROSPECT will significantly improve the effectiveness of active VRU safety systems compared to those currently on the market. This will be achieved in two complementary ways: (a) by expanded scope of VRU scenarios addressed and (b) by improved overall system performance (earlier and more robust detection of VRUs, proactive situation analysis, and fast actuators combined with new intervention strategies for collision avoidance). PROSPECT targets five key objectives: i. Better understanding of relevant VRU scenarios ii. Improved VRU sensing and situational analysis iii. Advanced HMI and vehicle control strategies iv. Four vehicle demonstrators, a mobile driving simulator and a realistic bicycle dummy demonstrator v. Testing in realistic traffic scenarios and user acceptance study The consortium includes the majority of European OEMs (Audi, BMW, DAIMLER, TME and Volvo Cars) currently offering AEB systems for VRU. They are keen to introduce the next generation systems into the market. BOSCH and CONTI will contribute with next generation components and intervention concepts. Video algorithms will be developed by UoA and DAIMLER. Driver interaction aspects (HMI) are considered by UoN and IFSTTAR. Euro NCAP test labs (IDIADA, BAST, TNO) will define and validate test procedures and propose standardization to Euro NCAP and UN-ECE. Accident research will be performed by Chalmers, VTI and BME, based on major in-depth accident databases (GIDAS and IGLAD) and complemented by East Europe data. The work will be done in cooperation with experts in Japan (JARI, NTSEL) and the US (VTTI, UMTRI, NHTSA).


This project will integrate at the highest possible level expertise and technologies to increase the efficiency and decrease the environmental footprint of ruminant production, significantly advancing current knowledge in this sector. The project will exploit state-of-the-art omics technologies to understand how ruminant gastrointestinal microbial ecosystems, or microbiomes, are controlled by the host animal and by the diet consumed, and how this impacts on greenhouse gas emissions, efficiency and product quality. New models and tools will be developed to enable the livestock industry to decrease environmental damage from methane and nitrogen emissions, and to improve efficiency of feed utilisation. A large-scale genetic association study involving 1000 dairy cows will relate feed intake, digestion efficiency, milk production/composition and methane emissions to the ruminal microbiome and host genome, leading to new indicator traits and tools for use in both traditional and genomic selection. Cow-reindeer metagenomic studies will establish how host species influence ruminal microbiology and function. Bovine twins studies will define how the rumen microbiome varies in an identical host genetic background. Nutrition work will assess how dietary oils, nitrogen and carbohydrates affect the ruminal microbiome and product quality. A meta-barcoding 16S rRNA analysis protocol will be developed to investigate ruminal microbiomes more accurately, rapidly and cheaply. Saliva and faeces will be analysed as possible tools for non-invasive assessment of ruminal microbiome and function. A novel method for on-farm methane analysis will be refined for easy application. Results will be publicly available through an online data warehouse that will provide tools to build new queries and create novel information. Transversal work packages include dissemination and industrial liaison, targeted towards the enlarged EU, and candidate and developing countries.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: NMP.2011.2.3-3 | Award Amount: 1.68M | Year: 2012

Most products are produced by means of the established mass production infrastructure. Traditionally, this involves large stocks, high manual labor, large capital investments, high energy use, long distance transportation. Although many advanced new materials have unique functional properties that hold a great promise for innovation, they often need to meet the criteria and characteristics of this established mass production paradigm. This delays the exploitation of the huge potential of whole new classes of materials. Combined with major societal trends and consumer needs like customization, personalization, on-demand fulfillment and the fact that the world is becoming ever more digital and networked, there is a need for a paradigm shift in manufacturing called Digital Fabrication. **Digital Fabrication can be defined as a new kind of industry that uses computer-controlled tools and processes to transform digital designs and materials directly into useful products.** DIGINOVA will establish the current status across material domains and application domains in Europe in order to identify the most promising technology and business propositions for Digital Fabrication. The project consortium, consisting of 4 large companies, 7 SMEs and 9 research institutes will identify and connect main stakeholders through establishment of innovation networks centred around concrete business cases to determine the added value and feasible routes to commercialization. The DIGINOVA consortium has broad research and development experience covering a wide range of materials and applications. The consortium is well equipped to generate international interest and expanding participation in the opportunities it identifies and has a proven track record in drafting roadmaps, establishing networks, involving stakeholders and informing the public at large. The DIGINOVA project will last 24 months and requests EU contribution of 1.265.785.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-07a-2014 | Award Amount: 4.37M | Year: 2015

Tomato is the second most consumed vegetable in the EU and a major dietary source of many nutrients, vitamins and antioxidants. Consumers complaints about the loss of flavour in modern tomatoes, provide an opportunity for the valorisation of traditional tomato varieties, in order to protect them from genetic erosion and the replacement by higher-yielding, pest resistant modern cultivars. Genetic, epigenetic and phenotypic variability and knowledge from farms and in public repositories, will be concentrated in a TRADITOM database and seed repository (O1). The available genetic and phenotypic variability present in TRADITOM varieties, and the genetic and epigenetic differences from modern cultivars will be assessed (O2). For varieties whose cultivation is not sustainable due to unacceptably low yield and/or pathogen resistance, novel F1 hybrids will be generated, retaining the quality characteristics of traditional varieties and incorporating yield and disease resistance traits (O3) Finally, traditional varieties and the impact of traditional cultivation methods will be valorised through a thorough characterization of their composition in term of flavour- and health-related compounds, the identification of consumer preferences, the evaluation of socio-economic factors limiting their market diffusion, and the protection of the most significant case studies through PDO or PGI denominations (O4). TRADITOM is a multidisciplinary translational, multi-actor research project bringing together scientists working in academia, local farmers communities, consumer experts and small seed companies that have preserved the local germplasm, in order to bring to fruition and apply to traditional tomato varieties the enormous knowledge generated on tomato genetics, genomics and metabolomics. This will help the conservation of traditional tomato varieties and enhance the competitive advantage of rural communities based on their production.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.1.1-03 | Award Amount: 3.65M | Year: 2011

The goal of agrobiodiversity conservation, unlike other forms of conservation, is not only the conservation of species and intra-specific genetic diversity related to agriculture, but also to promote its sustainable use in facilitating agricultural production. Although significant progress has been made in the conservation and management of plant genetic resources for food and agriculture (PGRFA) globally and in Europe, there remain two critical areas where progress has been limited: (a) the use of conserved agrobiodiversity by breeders and (b) the systematic conservation of crop wild relative (CWR) and landrace (LR) diversity. Specifically for breeders and CWR / LR diversity conservationists, the status quo is no longer an option as human-induced climate change is threatening the maintenance of the very diversity breeders require to mitigate the adverse impact of climate change. Conventionally, breeders have used their own lines and stocks to generate novel crop varieties, but these materials are relatively genetically uniform and it is now increased recognition that CWR and LR offer the breadth of genetic diversity required by breeders to meet the novel challenges of climate change and rapidly changing consumer demands. Therefore, the aim of PGR Secure is to research novel characterization techniques and conservation strategies for European crop wild relative and landrace diversity, and further, to enhance crop improvement by breeders, as a means of underpinning European food security in the face of climate change. To achieve these goals PGR Secure has four research themes: 1. Investigation of novel characterization techniques, including: (1a) Genomics, phenotyping and metabolomics, (1b) Transcriptomics, (1c) Focused Identification of Germplasm Strategy; 2. CWR and LR conservation, including: (2a) Europe-wide CWR inventory, (2b) Exemplar national CWR inventories, (2c) European CWR strategy, (2d) Europe-wide LR inventory, (2e) Exemplar national LR inventories, (2f) European LR strategy; 3. Facilitating breeders CWR and LR use, including: (3a) Identifying breeders needs, (3b) Meeting breeders needs, (3c) Integration of conservation and user communities, (3d) Pre-breeding - channelling potential interesting germplasm into commercial breeding programmes; and 4. Informatics development, including: (4a) CWR and LR inventory information web availability, (4b) Novel characterization information web availability, (4c) Inter-information system operability. The research requires the integration and collaboration of European policy, conservation and breeding sectors and the products will be disseminated Europe-wide to all appropriate stakeholders. The project, initiated by the European Cooperative Programme for Plant Genetic Resources In Situ and On-Farm Conservation Network will involve 42 European countries, as well as both large and smaller European plant breeding companies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2012.2.2-03 | Award Amount: 14.15M | Year: 2013

The primary goal of PREVIEW is to identify the most efficient lifestyle pattern for the prevention of type-2 diabetes in a population of pre-diabetic overweight or obese individuals. The project comprises two distinct lines of evidence, both embracing European and overseas countries: 1) A multicentre, clinical randomized intervention trial with a total of 2,500 pre-diabetic participants, including children and adolescents, adults and elderly. The duration will be 3 years for the adults and elderly, and 2 years for the children and adolescents. 2) Large population studies using data from all age groups. Focus in both lines of evidence will be on diet (specifically protein and glycemic index) and intensity of physical activity, as well as their interaction with the lifestyle factors, habitual stress and sleeping pattern as well as behavioural, environmental, cultural, and socioeconomic variables. PREVIEW will significantly increase our knowledge on how specific lifestyle factors can help preventing type-2 diabetes. Type-2 diabetes accounts for about 90% of all cases of diabetes, primarily caused by the worldwide obesity epidemic. Diabetes is a costly disease and according to WHO, the direct health care costs of diabetes range from 2.5% to 15% of annual national health care budgets. This worrying trend calls for action and a need for a variety of innovative approaches. PREVIEW aims to be such an innovative attempt including all necessary disciplines and stakeholders, who can contribute to developing new ways for the prevention of this wide-spread life-style related disease. The strategic impact of PREVIEW concerns the massive problems associated with the global diabesity epidemic (obesity and type-2 diabetes) and therefore includes partners from Europe (East, West, North and South) and Australia, New Zealand, and Canada. PREVIEW will thereby contribute to improving health over the life-span of the population in Europe as well as worldwide. Overall the public health and socio-economic impact of PREVIEW is expected to be very significant.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.2.5-01 | Award Amount: 1.30M | Year: 2011

The overall objective of this project is to address the key aspects of the food chain both that determine the transmission of price changes from farm to consumer levels, emphasising the role of competition in the intermediate and retail stages of the food chain and the broader regulatory environment in which firms in food supply chains across the EU compete. Given that the characteristics of the food sector vary considerably throughout the member states of the EU, and the observation that experience resulting from the recent commodity price spikes were significantly different across many countries, a key feature of the project will be to address how the variation in the structure of the food chain across different EU Member States contributes to food price adjustment in individual countries. Further, the project will address on-going developments in the food chain with regard to various aspects of vertical coordination in food supply chains, consolidation in the food sector, how the regulatory environment in which firms compete affects the overall functioning of food supply chains across the EU and the extent to which these issues also impact on SMEs. To this end, the project will address the issue of price adjustment in various dimensions across EU Member States, the selection of Member States reflecting differences in industry structure, the regulatory environment in which firms compete and the experiences they have recently faced with regard to commodity price shocks. In addressing these issues, a selection of different commodity chains (both long and short) will form the basis of the analysis. The research project will be expected to result in significant new insights that address the functioning of food supply chains across the EU Member States that impact on food pricing transparency throughout the EU. To this end, the researchers will interact with stakeholder groups representing interests throughout the food chain in forming a potential Action Plan.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2013.8-1. | Award Amount: 3.21M | Year: 2013

BUTERFLI is a project in response to the invitation to tender from European Commission FP7 within Call FP7-AAT-2013 RTD-Russia. BUTERFLI is the acronym of BUffet and Transition delay control investigated within Europe-Russia cooperation for improved FLIght performances. The Project Topic will focus on experimental and numerical flow control investigations of different phenomena: the buffet on a laminar airfoil, the buffet on a turbulent supercritical airfoil, and the cross-flow instabilities on a swept wing. Different control techniques will be studied: bump design, fluidic control devices, and DBD devices. The Project aims at the improvement of aircraft flight performances. This Project will be carried out in the framework of a EUROPE RUSSIA cooperation. ONERA is the coordinator, and TSAGI will act as Coordinator of the Russian Parties. There are 12 partners, 7 from Europe and 5 from Russia. ONERA (F), IAG-Stuttgart (G), DLR (G), KTH (S), University of Nottingham (UK), EADS UK Ltd. (UK), TsAGI (Russia), MIPT (Russia), JIHT (Russia), ITAM (Russia), Sukhoi Civil Aircraft (Russia), and Erdyn (F). BUTERFLI is splitted into four work packages: WP1 is dedicated to buffet control on 2D turbulent supercritical wing (tangential jet blowing and plasma actuators) WP2 is dedicated to buffet control on 2D laminar wing (bump and perforation blowing) WP3 is dedicated to crossflow instabilities control on swept wing WP4 ensures the scientific coordination of the overall project, and will proposes final roadmaps for the future.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: NMP.2011.4.0-5 | Award Amount: 565.20K | Year: 2012

The need for a transition towards a CO2 neutral biobased economy or bioeconomy, increasing population and globalisation of economies will have the consequence of a need for enhanced supplies of biobased resources. To this end, polysaccharides will be at the central point of the world of tomorrow for sustainable fuel, food, materials and medicine production. EPNOE (European Polysaccharide Network of Excellence) is the short name for the EC Network of Excellence project called Polysaccharides. Established with the help of the European Commission (EC), the European Polysaccharide Network of Excellence (EPNOE) connects the initial 16 EU academic and research institutions and now 26 companies, all being members of the Durable Integrated Structure called EPNOE Association. Activities include research (e.g. EPNOE research Road Map published end of 2010 in Carbohydrate Polymers journal), education (e.g. student mobility or common undergraduate courses), services (e.g. six main academic-industry services), infrastructure (e.g. EPNOE Tool Box) and communication (e.g. sixteen Newsletters issued to 500 subscribers). EPNOE is dedicated to materials made from or with polysaccharides. The general concept at the origin of this proposal is to participate to the improvement of competitiveness of European industry and generate new knowledge in polysaccharides through the expansion of EPNOE leadership in two new areas (Food and Health) and through increasing EPNOE participation and interactions with industry, with a special focus on SMEs.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.45M | Year: 2012

Cleanward aims to develop a novel, safe, user-friendly anti-microbial cleaning system, using titanium dioxide coated ultra-microfibre fabric that will integrate easily into existing contract cleaning equipment: it will achieve log105 microbial removal and the coating will react with water and UV to produce a highly reactive environment: this will kill all harmful micro-organisms quickly and thoroughly without the need for chemical disinfectant all in an isolated, low water volume unit. The cloths will then be available for re-use without running the risk of microbiological cross contamination.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.60M | Year: 2012

The High field Magnetic Resonance (HiMR) Initial Training Network aims to train the future leaders of academic and industrial research in the fundamental science and novel applications of ultra-high field (UHF) in vivo magnetic resonance (MR), in order to address an increasing and currently unmet demand from academia and industry for such specialists. The highly complex and multi-faceted nature of UHF MR means that excellent training can only be provided by immersing ESRs in an environment that integrates different research areas, sectors and groups. The HiMR ITN is centred on a cutting edge, multidisciplinary research program that exploits the complementarities of the participants. This research programme is organised into four themes each focused on a crucial area of development of UHF. The first focuses on improved structural imaging, advancing our understanding of the origins of contrast in MRI scans and developing non-invasive biomarkers for multiple sclerosis. The second theme is centred upon exploiting UHF to develop ultra-high resolution functional MRI (fMRI) which will be very important in basic neuroscience research. It also aims to make fMRI more quantitative, thus encouraging its uptake in the clinic. The third theme aims to exploit the enhanced sensitivity of MR spectroscopy (MRS) at UHF in developing highly specific biomarkers. The final theme will develop novel hardware for both research and in the clinic, and methods of monitoring and correcting motion which limits in-vivo MR resolution. Finally the HiMR ITN will provide a unique opportunity to measure safety outcomes over a large group of workers. The proposed interdisciplinary and intersectoral training program, embedded in this research program, will provide a platform for training ESRs to become specialists in UHF MR, whilst also furnishing them with experience of a broad range of work environments, experimental techniques and theoretical knowledge relevant to the full range of in vivo MR.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: FoF.NMP.2012-5 | Award Amount: 3.63M | Year: 2012

Todays fabrication methods for micro devices can require expensive tooling and long turnaround times, making empirical, performance-based modifications to the design expensive and time consuming. These methods also are limited in their flexibility, so that complex devices, that incorporate on-board valves, separation media, membranes, and recirculating pumps, cannot be developed and adapted without considerable expense in molds and assembly fixtures. This creates a barrier to the development of medium to large series of complex and higher functionality devices, where the cost-benefit ratio of incorporating functionality is too risky for the typical laboratory, diagnostic or medical device developer. To bridge the gap between a high volume production with specialized equipment and a - until today - not efficient production of medium series, SMEs need to find other, more flexible and scalable approaches to produce microsystems in high volumes. The solution proposed by SMARTLAM builds on a modular, flexible, scalable 3D-Integration scenario (3D-I), where novel polymer film materials will be combined with state of the art, scalable 3D printing, structuring and welding technologies. These technologies will be integrated in one production cell allowing for the production of complete 3D Microsystems. A 3D-Integration modeling environment will be set up to support users of the SMARTLAM environment by the design of 3D-I hardware compatible microsystems. Besides the technological challenges SMARTLAM will demonstrate a complete business case. A SME company acting as OEM service provider will be responsible for the real world benchmarking and testing of the SMARTLAM production platform concept. To assess and demonstrate the potential of SMARTLAM, two SME demonstrator partners will take over the role of potential customers, both providing input as well as assessing the 3-DI approach regarding costs, technological capabilities and adaptiveness.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.59M | Year: 2012

The mission of EpiTRAITS is to train young researchers in epigenetic gene regulation and flowering in the model plant Arabidopsis thaliana and the crop plants maize (Zea mays) and barley (Hordeum vulgare). Epigenetic gene regulation confers stability of gene expression patterns through cell divisions while allowing changes in expression in response to environmental or developmental cues. Although changes in epigenetic gene regulation are a major cause for trait variation, no rational strategies have been developed that utilize this knowledge for crop breeding purposes. EpiTRAITS will focus on one of the key plant traits, flowering, which is controlled by various epigenetic mechanisms. The scientific program aims to bridge the gap between fundamental and applied research by translating results from epigenetic research in model organisms to improved technologies for crop breeding and molecular diagnostic tools.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EeB-03-2014 | Award Amount: 5.99M | Year: 2015

Built2Spec brings together a new and breakthrough set of technological advances for self-inspection and quality assurance that will be put into the hands of construction stakeholders to help meeting EU energy efficiency targets, new build standards, and related policy ambitions. B2S will expand upon a cloud based construction support platform, conceived following the most advanced integrated design and delivery framework for the building sector and hosting applications that facilitate worksite activities and quality compliance by putting knowledge in hands of contractors, in the form of shared design specifications and 3D models, installation guidelines, information on regulatory frameworks, and help from construction experts on smartphones and tablets. New self-inspection technologies managed within the platform and developed in the project include: Special IR camera in smartphones coupled with new mathematical reverse models for on-the-fly analysis of existing buildings envelope thermal properties Rapid BIM modelling via instant 3D capture with smartphones, passed via the cloud to the refurbishment team back-office, allowing accurate instant energy efficiency evaluation, quality check and streamlined quotation process Portable, innovative low pressure air tightness technique allowing testing of occupied buildings Smart sensor-embedded construction elements (identification, structural performance, and building environment parameters) Portable single device for Indoor Air Quality tests offering multi-gas capabilities targeting the most harmful gas pollutants A novel lightweight portable sound source for on-site acoustic tests to regulation compliance The B2S system will be integrated into the operations of SME contractors, large construction firms, and end user clients directly within the consortium and work program activities, assuring systematic and scientific performance measures, feedback and powerful exploitation and dissemination strategies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SSH.2012.4.2-1 | Award Amount: 8.27M | Year: 2013

FRAME, a 4-year multidisciplinary project, represents a consortium of 19 internationally recognized and globally networked human rights institutes from across Europe and strategic regions around the world. Through FRAME, more than 100 leading researchers and practitioners - with a strong gender balance - aim to provide the necessary building blocks for a coherent EU human rights policy comprised of: (i) a sound knowledge base taking account of the factors, concepts, institutions and instruments underlying human rights protection; (ii) appraisal of the EUs full potential to contribute to global human rights governance through its relationship with multiple actors and its manifold policies; and (iii) a set of indicators, tools and policy proposals geared to strengthen human rights implementation in EU policy-making. Through 4 research clusters, FRAME offers creative solutions to enhance the coherence and effectiveness of EU human rights policy. Cluster 1: Factors examines the key factors facilitating or hindering human rights protection, the concepts of human rights, democracy and the rule of law and the human rights protection institutions and instruments at global, regional and national level. Cluster 2: Actors addresses the EUs human rights engagement with the UN, regional multilateral organizations, regional and strategic partnerships with third countries and non-state actors, as well as the relationship between EU institutions and the Member States. Cluster 3: Policies hones the fostering of human rights in EU policies on development and trade, human rights violations in conflicts, freedom, security and justice and external human rights and democratization action. Cluster 4: Tools develops indicators, tools and policy proposals, including policy benchmarking, to monitor and improve the effectiveness of EU human rights policy. FRAMEs vital impact on human rights research, education and policy innovation will continue beyond the projects lifetime.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 4.00M | Year: 2011

CADMAD aims to make a foundational breakthrough in the way computers and computer-aided design and manufacturing is employed in DNA-based research and development, making a radically new use of information technologies in biology and biotechnology.Biology and biotechnology research involves DNA programming, which is akin to computer programming. Researchers modify and combine DNA of interest in a programmatic way to uncover its function, to improve its function, or to create new functions. Whereas the composition and editing of computer programs is as easy as using a word-processor, the design, construction and editing of DNA in a programmatic fashion is still a slow, expensive, labour-intensive wet-lab process.CADMADs vision is to replace the labour-intensive DNA processing carried out today by tens of thousands of skilled wet-lab workers around the world, by high-throughput computer-aided design and manufacturing of DNA, which would be fundamentally more efficient than plain de novo DNA synthesis by effectively reusing existing DNA. Computed-aided design and manufacturing of semiconductor chips has enabled the computer revolution, the Internet revolution, and the mobile phone revolution. Computer-aided design and manufacturing of DNA may similarly enable a revolution in biology and biotechnology, in which high-throughput computer-aided and robotically executed experiments replace manual wet-lab work, resulting in accelerated progress in key areas of research and development.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: AAT.2012.1.4-2. | Award Amount: 30.14M | Year: 2012

Future aero engines will need to be more efficient and contribute to the reduction on environmental impact of air transportation. They must reach some standards of performance by reducing emissions and creating some savings on operation costs. EIMG consortium has launched since several years some initiatives to develop future engines in the frame of the European Committee research programmes. Within different project such as DREAM, VITAL, NEWAC or LEMCOTEC, EIMG is ensuring the development of innovative technologies in order to further reduce the fuel burn, emissions and noise. In order to ensure the technological breakthrough, future aero-engines will have higher overall pressure ratios (OPR) to increase thermal efficiency and will have higher bypass ratios (BPR) to increase propulsive efficiency. These lead to smaller and hotter high pressure cores. As core engine technologies have been addressed in the previous project, E-BREAK project will ensure the mandatory evolution of sub-systems. It is indeed required for enabling integration of engine with new core technologies to develop adequate technologies for sub-systems. E-BREAK will aim to adapt sub-systems to new constraints of temperature and pressure. The overall picture of these initiatives bring all technology bricks to a TRL level ensuring the possibility to integrate them in a new aero engines generation before 2020. In its 2020 vision, ACARE aims to reduce by 50% per passenger kilometer CO2 emissions with an engine contribution targeting a decrease by 15 to 20% of the SFC. NOX emissions would have to be reduced by 80 % and efforts need to be made on other emissions. E-BREAK will be an enabler of the future UHOPR integrated engine development, completing efforts done in previous or in on-going Level 2 programs.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.8. | Award Amount: 7.16M | Year: 2012

The ability to quantitatively analyze plant phenotypic traits (from single cells to plant and stand level) and their dynamic responses to the environment is an essential requirement for genetic and physiological research, and the cornerstone for enabling applications of scientific findings to bioeconomy. Whereas molecular profiling technologies allow today the generation of a large amount of data with decreasing costs largely due to automation and robotics, the understanding of the link between genotype and phenotype has progressed more slowly. Insufficient technical and conceptual capacity of the plant scientific community to probe existing genetic resources and unravel environmental effects limits faster progress in this field. The development of robust and standardized phenotyping applications depends on the availability of specialised infrastructure, technologies and protocols. Europe has become a key driver in defining innovative solutions in academic and industrial settings. However, the existing initiatives at the local or member-state level represent a fragmented research landscape with similar goals. The aim of this project is to create synergies between the leading plant phenotyping institutions in Europe as a nucleus for the development of a strong European Plant Phenotyping Network (EPPN). The project fosters the development of an effective European infrastructure including human resources, expertise and communication needed to support transnational access to user communities. Joint research activities will adapt and develop novel sensors and methods for application in plant phenotyping. Innovative phenotyping concepts integrating mechanistic, medium- and high throughput as well as field phenotyping will be developed and made available to the community. This project will strengthen Europes leading role in plant phenotyping research and application through the creation of a community of research institutes, universities, industry and SMEs.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-3-2014 | Award Amount: 4.70M | Year: 2015

Quantum Simulators provide new levels of understanding of equilibrium and out-of-equilibrium properties of many-body quantum systems, one of the most challenging problems in physics. The main objective of the RYSQ project is to use Rydberg atoms for quantum simulations, because their outstanding versatility will allow us to perform a great variety of useful quantum simulations, by exploiting different aspects of the same experimental and theoretical tools. By implementing not only one but a whole family of Rydberg Quantum Simulators, the project will address both the coherent and incoherent dissipative dynamics of many-body quantum systems, with potential applications in the understanding and design of artificial light harvesting systems, large quantum systems with controlled decoherence, and novel materials. This will be achieved by building upon a novel generic approach to quantum simulation, where Rydberg atoms allow both digital (gate) and analog (interaction) simulations. In addition to solving problems in fundamental and applied science, the project will build up core competences for quantum science and technologies in mainstream engineering, by using innovative methods for communication, dissemination and exploitation of results. In summary, RYSQ plans (A) to develop a collection of novel experimental and theoretical tools for Rydberg quantum simulators, and (B) to use them as a basis for implementing many important applications of quantum simulations. The project is structured in such a way to allow for efficient exchanges within the consortium, and to maximize the overall outcome of the work.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.2.4.5-2 | Award Amount: 7.93M | Year: 2012

Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in joint space width (JSW). However, radiographic evidence is seen only after significant cartilage degradation has already taken place. The early stages of the disease may remain latent and asymptomatic for many years. Therefore, there is an acute need for reliable biomarkers and diagnostic tests that can facilitate earlier diagnosis of OA, and inform the prognosis, monitoring and therapeutic strategies for chronic and disabling forms of this disease. However, there is currently a lack of reliable, quantifiable and easily measured biomarkers that provide an earlier diagnosis of OA, inform on the prognostic of the disease and monitor and predict responses to therapeutic modalities. Biomarkers of tissue turnover in joints can reflect disease relevant biological activity and provide valuable information that may be useful diagnostically and therapeutically, potentially enabling a more rational and personalized approach to healthcare management. The proliferation of omic technologies has facilitated rapid progress in biomarker research. Combinations of omic technologies are dominating the biomarker research arena and are playing increasingly important roles in the identification, validation and qualification of new biomarkers. The aim of the D-BOARD consortium is to bring together leading academic institutions and European Small and Medium Enterprises (SMEs) to focus on the identification, validation and qualification of new combination biomarkers and the development of diagnostic tests capable of subclinical disease diagnosis for degenerative and inflammatory diseases of joints.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.95M | Year: 2015

Photonics, nanotechnology, advanced materials, and advanced manufacturing technologies have been identified as key enabling technologies (KETs) for the EU. Today the photonics global market alone is around 300 billion and Europe has established a strong position with a total share of 20%, directly employing about 290,000 people. However, the shortage of sufficient skilled labour and entrepreneurs capable of handling the highly multi-disciplinary nature of KETs remains a major problem in the EU. Tailoring of semiconductors at the nanoscale is an important enabling technology for a wide range of photonics and electronics applications in diverse areas. In the training network proposed here, a cohort of 15 early stage researchers will be trained in the full range of skills required for a career in photonics, including materials growth, device fabrication, characterisation, design, theory, and commercialisation. A carefully-chosen, well-balanced consortium of 8 academic partners, 2 full industry partners and 7 associated partners are well placed to provide the training in these skills, with European and worldwide reputations as leaders in each field. These skills will be developed within four burgeoning research areas; Semiconductor Metamaterials & Plasmonics, Dilute Nitride semiconductor nanostructures, Hydrogenated Semiconductors and Metamorphic structures. The outcomes of this enabling fundamental research are well focused to deliver advances in sources for secure communications, sensitive detectors for security applications, more efficient solar cells for energy generation, LEDs and sensors for environmental gas and bio-sensing. Each researcher will experience both academic and commercial environments thanks to the strong industrial involvement, resulting in multi-skilled, industry-focused graduates. PROMIS therefore directly addresses the need for additional skilled photonics professionals, as identified by the European Technology Platform, Photonics21.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SiS.2011.1.3.1-1 | Award Amount: 964.55K | Year: 2011

MEDOANET will focus on national and regional coordination of Open Access strategies, policies and structures in six Mediterranean countries Greece, Italy, France, Spain, Portugal and Turkey. It will do so by means of strengthening, expanding and systematizing the activities of an already active regional network of partners from Mediterranean Europe. MEDOANET will identify and map existing strategies, structures and policies of the six countries into an online Mediterranean Open Access Tracker, and, most significantly, it will identify and systematically engage significant policy makers and other stakeholders with the ability to affect change in policies, in a top-down approach. This will increase awareness of key issues at the policy level, fostering the conditions for coordinated policies at national and institutional levels that are currently largely lacking in these Mediterranean countries. National Task Forces will be formed and national workshops will serve as forums to debate the course of action in each country in a coordinated fashion. A European workshop will bring together key policy makers from the six countries and other European experts and will contribute towards regional coordination across the partner countries and beyond. The project will further produce guidelines for policy makers, namely research policy makers, public research funders, such as National Research Councils, and institution administrators, such as rectors - common for all the countries. A European conference will serve to place the project outcomes in a wider context, as well as bring together stakeholders from the six Mediterranean countries and the rest of Europe in an effort to further coordinate discourse towards policy actions that will strengthen the Open Access paradigm. To benefit from the valuable experience and expertise in Northern Europe, the consortium will also include three strategic partners from the region.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: SC5-17-2015 | Award Amount: 5.73M | Year: 2016

Currently within the EUs Earth Observation (EO) monitoring framework, there is a need for low-cost methods for acquiring high quality in-situ data to create accurate and well-validated environmental monitoring products. The aim of the LandSense project is to build a far reaching citizen observatory for Land Use and Land Cover (LULC) monitoring that will also function as a technology innovation marketplace. LandSense will deploy advanced tools, services and resources to mobilize and engage citizens to collect in-situ observations (i.e. ground-based data and visual interpretations of EO imagery). Integrating these citizen-driven in-situ data collections with established authoritative and open access data sources will help reduce costs, extend GEOSS and Copernicus capacities, and support comprehensive environmental monitoring systems. New LandSense services (LandSense Campaigner, FarmLand Support, Change Detector and Quality Assurance & Control) will be deployed in three demonstration cases that will address critical LULC issues in the areas of urbanization, agricultural land use and forest/habitat monitoring. Policy-relevant campaigns will be implemented in close collaboration with multiple stakeholders to ensure that citizen observations contribute to EU-wide environmental governance and decision-making. There will be numerous pathways to citizen empowerment via the LandSense Engagement Platform, i.e. tools for discussion, online voting collaborative mapping, as well as events linked to various campaigns involving public consultation. Simultaneously, to improve Europes role in the business of in-situ monitoring, LandSense will create sustainable business models to support market uptake and innovation of its novel added-value products and services.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2011.2.4.2-1 | Award Amount: 14.96M | Year: 2012

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke. Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so its social and economic burden will grow with the ageing of the European population. Current treatment options for the 80 to 85% of all strokes due to cerebral ischaemia - around. 900,000 events in Europe every year, or one every 40 seconds - are extremely limited. Systematic review of experimental studies suggests that hypothermia is the most promising intervention identified to date. Therapeutic cooling is effective in reducing ischaemic brain injury following cardiac arrest, and hypothermia is therefore considered by experts the most promising treatment for patients with acute ischaemic stroke, next to reperfusion strategies. The EuroHYP-1 trial is a pan-European, open, randomised, phase III clinical trial which will assess the benefit or harm of therapeutic cooling in 1500 awake adult patients with acute ischaemic stroke. In addition to efficacy and safety, the economic impact of therapeutic hypothermia will be assessed, along with several sub-studies involving imaging, ultrasound, and biomarker methods. The investigators involved in the EuroHYP-1 consortium are leading European experts in statistical design and analysis, therapeutic hypothermia, imaging, health economics, ultrasound, biomarkers, and trial execution (implementation and monitoring). Moreover in addition to these academic experts the consortium also involves European patient and family advocacy groups and small and medium-size enterprises, and the joint endeavours of this extended team will ensure the successful enrolment of patients at eighty hospitals across 25 countries in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2011.2.1.5-1 | Award Amount: 8.94M | Year: 2011

The TURaS project aims to bring together urban communities, researchers, local authorities and SMEs to research, develop, demonstrate and disseminate transition strategies and scenarios to enable European cities and their rural interfaces to build vitally-needed resilience in the face of significant sustainability challenges. To ensure maximum impact, the TURaS project has developed an innovative twinning approach bringing together decision makers in local authorities with SMEs and academics to ensure meaningful results and real change are implemented over the duration of the project. 11 local authorities or local development agencies are involved as partners in the project and they will orient research and development from the outset towards the priority sustainability and resilience challenges facing their cities. 9 leading academic research institutions and 6 SMEs will work with these cities helping them to reduce their urban ecological footprint through proposing new visions, feasiblity strategies, spatial scenarios and guidance tools to help cities address these challenges. The specific challenges addressed in TURaS include: climate change adaptation and mitigation; natural resource shortage and unprecedented urban growth. Over the five year duration of the project, the feasibility of these new approaches will be tested in selected case study neighbourhoods and new measures to enable adaptive governance, collaborative decision-making, and behavioural change towards resilient and sustainable European cities will be tested. The impact of these new approaches will be measured and results compared between participating cities before a final set of strategies and tools will be developed for demonstration, dissemination and exploitation in other European cities. SMEs are highly involved in all work packages of the project and specific measures have been put in place to ensure the optimal economic impact of the project is achieved.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-17-2014 | Award Amount: 5.99M | Year: 2015

Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occurrence in the elderly. The elderly have been strongly underrepresented in previous stroke trials and treatment guidelines have no recommendations specific to this important group. Elderly patients are at the highest risk of complications after stroke, such as infections, fever, and dysphagia. These complications are strongly and independently associated with a higher risk of death or dependency. We will perform a pragmatic, randomised, open clinical trial with blinded outcome assessment in 3800 patients with acute stroke aged 66 years or older, to assess whether pharmacological prevention of infections and fever, and early management of dysphagia, will reduce the risk of death, poor functional outcome, and poor quality of life, and lead to reductions in the costs of stroke care throughout Europe. Patients will be randomised using a factorial design to preventive treatment for 4 days with ceftriaxone, paracetamol, and/or metoclopramide, or to standard care alone. The primary outcome is functional outcome at 3 months, assessed with the modified Rankin Scale (mRS), and analysed with ordinal logistic regression. The study will have 90% power to detect a statistically significant shift towards a favourable outcome, assuming a 5% absolute increase in the proportion of patients with a good outcome (mRS 0 to 2) in the intervention group, compared with controls. This simple, safe, and generally available treatment strategy has the potential to lead to an annual reduction of over 25 000 elderly Europeans being dead or dependent as a result of stroke, at very low costs.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-2.1-2014 | Award Amount: 18.00M | Year: 2015

IN2RAIL is to set the foundations for a resilient, consistent, cost-efficient, high capacity European network by delivering important building blocks that unlock the innovation potential that exists in SHIFT2RAIL: innovative technologies will be explored and resulting concepts embedded in a systems framework where infrastructure, information management, maintenance techniques, energy, and engineering are integrated, optimised, shared and exploited. IN2RAIL will make advances towards SHIFT2RAIL objectives: enhancing the existing capacity fulfilling user demand; increasing the reliability delivering better and consistent quality of service; reducing the LCC increasing competitiveness of the EU rail system. To achieve the above, a holistic approach covering Smart Infrastructures, Intelligent Mobility Management (I2M)and Rail Power Supply and Energy Management will be applied. Smart Infrastructure addresses the fundamental design of critical assets - switches and crossings and tracks. It will research components capable of meeting future railway demands and will utilise modern technologies in the process. Risk and condition-based LEAN approaches to optimise RAMS and LCC in asset maintenance activities will be created to tackle the root causes of degradation. I2M researches automated, interoperable and inter-connected advanced traffic management systems; scalable and upgradable systems, utilising standardised products and interfaces, enabling easy migration from legacy systems; the wealth of data and information on assets and traffic status; information management systems adding the capability of nowcasting and forecasting of critical asset statuses. Rail Power Supply and Energy Management create solutions to improve the energy performance of the railway system. Research on new power systems characterised by reduced losses and capable of balancing energy demands, along with innovative energy management systems enabling accurate and precise estimates of energy flows.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2013.7.1 | Award Amount: 8.74M | Year: 2013

Traditionally, the European manufacturing industry is characterized by innovative technology, quality processes and robust products which have leveraged Europes industrialization. However, globalization has exposed Europes industry to new emerging and industrialized manufacturing markets and the current economic challenges have decelerated the internal boost and investment, respectively. Hence, new ICT infrastructures across Europe need to be established to re-enforce global competitiveness.\nThe motivating idea behind CloudFlow is to open up the power of Cloud Computing for engineering WorkFlows (CloudFlow). The aim of CloudFlow is to enable engineers to access services on the Cloud spanning domains such as CAD, CAM, CAE (CFD), Systems and PLM, and combining them to integrated workflows leveraging HPC resources. Workflows are of key importance in todays product/production development processes were products show ever increasing complexity integrating geometry, mechanics, electronics and software aspects. Such complex products require multi-domain simulation, simulation-in-the-loop and synchronized workflows based on interoperability of data, services and workflows.\nCloudFlow is an SME-driven IP incorporating seven SMEs: Missler (CAD/CAM), JOTNE (PLM), Numeca (CAE/CFD), ITI (Systems), Arctur (HPC), Stellba Hydro (hydraulic machines/hydro turbines) and CARSA (business models and security). Four renowned research institutions complement the consortium: DFKI, SINTEF, University of Nottingham and Fraunhofer.\nCloudFlow will build on existing standards and components to facilitate an as-vendor-independent-as-possible Cloud engineering workflows platform. Open Cloud Computing Interface (OCCI), STEP (for CAD and CAE data) and WSDL (for service description and orchestration) are amongst the core standards that will be leveraged. The key aspects (from a technical and a business perspective) are: Data, Services, Workflows, Users and Business models including Security aspects.\nCloudFlow will conduct two Open Calls for external experiments investigating the use of the CloudFlow infrastructure in new and innovative ways, outreaching into the engineering and manufacturing community and engaging external partners. Each of these two Open Calls will look for seven additional experiments to gather experience with engineering Cloud uses and gaining insights from these experiments.\nCloudFlow is striving for the following impacts: a) increasing industrial competitiveness by contributing to improve performance (front-loading, early error detection, time-to-market, ...) and innovation (co-use of models, early virtual testing) and b) improving in innovation capabilities by enabling more engineers to gain insights and to create innovation by accessing new tools and easing the use of Cloud Infrastructures.\nAll in all, CloudFlow wants to contribute to a wider adaption of Cloud infrastructures and making them a practical option for manufacturing companies.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 4.50M | Year: 2013

Centre vision: The EPSRC Centre for Innovative Food Manufacturing will meet the challenges of UK and global food security through developing world-leading technologies, tools and leaders, tailored to the specific needs of food products. With a turnover of £76.2bn (20% of the UK total), Food and drink is the largest manufacturing sector in the UK employing around 400,000 people. With an anticipated rapid growth in better value products and in products designed for the nations Health and Wellness, in particular for the ageing population, food manufacturing requires innovation in increased productivity - to produce more from less - to preserve natural resources such as water and energy, to minimise waste generation and to decrease the trade deficit in the sector. Crucially this will enable the UK food sector to be at the forefront of the next generation of sustainable production which are more natural and healthier., and to develop more resilient supply chains leading to state of the art manufacturing capability, in an increasingly competitive landscape. The proposed research focuses on identifying not only new sources of raw material but also on reducing the demand on existing resources through a simultaneous improvement of food products, manufacturing methods and supply networks. In this context, some of the key research questions are: How do we fully valorise biomass (including waste re-use) as new sources of raw material in food production?; How can we design and manufacture products with the high nutritional values using fewer raw materials?; How do we improve the efficiency of food production processes (e.g. through smart monitoring technologies; process intensification / flexible manufacturing) to consume fewer resources (materials, energy and water) across the supply chain?; How can we eliminate the production and post-production waste caused by inefficient supply and manufacturing activities and /or relationships? The scope of the proposed research focuse on the manufacturing activities from post-farm gate to supermarket shelf, and will be considered under two specific Grand Challenges (GC): 1) Innovative materials, products and processes and 2) Sustainable food supply and manufacture. These research challenges closely align with the EPSRC call for Centres for Innovative Manufacturing, in particular the three areas of Resource Efficiency in Manufacturing: processes and technologies towards complete reuse of key materials and components; the need to dramatically reduce energy demand, including the incorporation of smart energy monitoring and management technologies; optimisation of material and product re-use, re-manufacturing and recycling, Innovative Production Processes: manufactured foods being complex formulated systems, and Complex Multifunctional Products: food is a high volume product assembled using processes which operate from the nano- (raw material) to the macro-scales (packaged goods). The proposed EPSRC Centre brings together world leading expertise in the areas of biomaterial science, formulation engineering and sustainable manufacturing. Loughborough and Nottingham are involved in the current EPSRC Centres and will ensure complementarities with other EPSRC research portfolios. The Centre will deliver demonstrable tools, methods and specific technologies, will develop academic and industrial leaders, and will provide evidence to support future policy making, thus ensuring the long-term competitiveness and security of the UK and global food supply chain. The proposal benefits from the interest and support of a wide range of stakeholders from ingredient producers and manufacturers to retailers and governmental organisations and has exploitation opportunities as the research challenges fit with the strategic themes in the new TSB High Value Manufacturing Strategy 2012-2015.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.4 | Award Amount: 4.50M | Year: 2011

Product and production engineering in companies are typically fragmented across different functional units, distributed across companies along the value chain, requiring input from experts from a variety of disciplines using different methods and tools. This leads to a high coordination effort to synergise work and information transfer as well as to sub-optimal decisions and unused knowledge and experiences. The resulting waste in engineering processes results in an unnecessary lengthening of time-to-market and time-to-production of new products and to a loss of competitiveness of European companies.\namePLM will offer a radically new and extensible approach to collaborative engineering, leveraging state-of-the art research on semantics, heuristics and visualization. The objectives are to\n-Engineer an ontology that serves as an\n-interoperable model and\n-integrating element for an open engineering system: the amePLM Platform\n-Develop an open engineering platform based on existing tools and libraries, by special consideration of open-source software\n-Research and develop tools to assist in product and process development, analysis, virtual testing and optimization based on heuristic methods and simulation that operate on knowledge represented by information which is structured by means of an ontology\n-Devise a visualization module to enable cross-disciplinary collaboration and remote consultation approaches\nThe solution development will be accomplished through a user-centric approach by 2 leading edge high tech software providers, guided and validated by industrial cases from 3 SME and 2 international companies. The research needed for the innovative amePLM-solutions is performed by 5 leading universities and Fraunhofer.\nThe knowledge-driven amePLM-platform will drastically accelerate product and production engineering by integrated workflows, capturing and reuse of knowledge and experiences and by facilitating cross-disciplinary knowledge-sharing and collaboration.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.21M | Year: 2013

Extended lifespan is a new and permanent feature of human life globally. The demographic for population growth of persons over 60 years is predicted to expand by 70% and 400% respectively in developed and less developed regions during the coming decades. Ageing, is accompanied by cognitive decline and greater risk of depression and anxiety. Major drug companies have recently cutback significantly on development of drugs against brain disorders due to lack of new avenues of research. Thus the responsibility falls on academic labs to make breakthroughs to improve brain health. This consortium gathers experts on molecular mechanisms of age-associated pathologies including depressive disorders and anxiety, and neurodegeneration. Specifically, they focus on identification of stress-regulated molecules provoking neuronal death and hindering neurogenesis, and monitoring the consequences of these processes in human brain. The groups combine biological and medical imaging techniques with behavioral studies and proteomics to define molecular mechanisms of ageing and neurogenesis. Using biotechnology, they will create new tools to isolate neurogenic cells from aged brain, thus aiding research strategies an early stage. Four leading imaging infrastructures from across Europe selected from the ESFRI Eurobioimaging Proof-of Concept list have been selected as partners to facilitate this training and research program. Confocal and high-content imaging is used to define ageing pathways, proteomics and genomics to visualize effectors of pathological ageing, transgenic mice to study neurogenesis and MRI/MRS to identify and localize new depression-related parameters in select patient populations. This multi-faceted approach aims to (i) identify druggable targets and identify reagents to interfere with pathways contributing to depression and anxiety, and (ii) produce novel tools to image depression-associated events in brain, facilitating earlier diagnosis and intervention.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2010.2.3-1 | Award Amount: 14.80M | Year: 2012

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art biomaterials and to design highly performing bioinspired materials learning from natural processes. By this outcome driven project comprising first class academic and industrial participants the project will create scientific and technical excellence and through links with these SMEs will strengthen the technological capacity and their ability to operate competitively on an international market. BIODESIGN will (i) perform a careful retrospective-analysis of previous outcomes from clinical studies performed with humans through animal modelling in a reverse engineering approach applied to an in-vitro to the molecular design level, (ii) develop new strategies for a more rational design of ECM mimetic materials serving both as gels and load carrying scaffolds, (iii) link novel designs to adequate and more predictive in-vitro methods allowing significant reduction in development time and use of animals and (iv) evaluate these concepts for musculoskeletal and cardiac regeneration. By the development of safe, ethically and regulatory acceptable, and clinically applicable materials this project will promote harmonization while at the same time creating awareness in society of the benefits of these innovations as one of the key points is to improve health and quality of life of the patients. BIODESIGN will stimulate technological innovation, utilization of research results, transfer of knowledge and technologies and creation of technology based business in Europe. It will also support the development of world-class human resources, making Europe a more attractive to top researchers.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SSH.2011.5.1-1 | Award Amount: 10.40M | Year: 2012

The central objective of ANTICORRP is to investigate and explain the factors that promote or hinder the development of effective anticorruption policies and impartial government institutions. ANTICORRP directly addresses the objective in the Work Program by examining what the causes of corruption are, how corruption can be conceptualized, measured and analysed, what the impact of corruption on societies is and how policy responses can be tailored as to deal effectively with this phenomenon. The starting point for this project is the following: The knowledge about the very negative impact that corruption has on a great number of factors that are important for human well-being (economic prosperity, population health, life satisfaction, gender equality, social trust, political legitimacy, etc.) is now well established. At the same time, knowledge about how corruption can be successfully fought by political means is much less developed. While this project concentrates on corruption in Europe, ANTICORRP also has a global scope. The project will identify general global trends concerning corruption and select over-performing and under-performing countries in terms of their progress towards less corrupt governance regimes and conduct more detailed qualitative analyses of these cases. The project includes participants from anthropology, criminology, economics, gender studies, history, legal studies, political science, public policy and administration and sociology at twenty-one units in sixteen European countries. Research will be conduced using a various set of methods including historical case-studies, large-scale surveys and ethnographical approaches. The project will strive to ensure that the research findings are spread to policy makers and the general public by using high profile multimedia and data visualisation tools as well as research-to-policy workshops at different levels and for different target audiences.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: CULT-COOP-08-2016 | Award Amount: 2.44M | Year: 2017

A main challenge with the development of virtual museums is establishing meaningful user experiences that allow for personal, complex and emotional encounters with art and cultural heritage. The GIFT project suggests creating meaningful personalization through digital gifting and emotional appropriation: Designs for allowing visitors to create their own museum tours as digital mixtapes, and to play with technologies that measure emotional responses to artwork as a playful reappropriation of museum spaces. We aim to accommodate the complex ways in which users may confront art and heritage content, and engage users to participate and share experiences that are emotionally poignant and personally profound. Through multidisciplinary, practice-based research we will develop, test and validate two ground-breaking prototypes for digital encounters with cultural heritage. From this process we will develop a framework with theory, tools, design guidelines and best practice recommendations for creating meaningful personalization of hybrid virtual museum experiences. The GIFT consortium includes leading artists and researchers with a long history of successful collaborations, who will be working with a panel of 10 lead users from prominent European museums, to develop theoretical and practical advances with great impact for the cultural heritage sector and European society. By enabling more engaging hybrid virtual/physical museum experiences, we will contribute to increasing citizens curiosity and engagement. The hybrid format will also help make both virtual museum experiences as well as physical visits more engaging and attractive, thus contributing to economic growth through ticket sales as well as digital sales. By providing frameworks that help non-technical experts in the heritage sector to build and experiment with meaningful personalization of digital cultural heritage, the project gives the sector tools to build and innovate further.


The only lands on Earth that have not been explored in any depth by science are those that have been lost to the oceans. Global warming at the end of the last Ice Age led to the inundation of vast landscapes that had once been home to thousands of people. These lost lands hold a unique and largely unexplored record of settlement and colonisation linked to climate change over millennia. Amongst the most significant is Doggerland. Occupying much of the North Sea basin between continental Europe and Britain it would have been a heartland of human occupation and central to the process of re-settlement and colonisation of north Western Europe during the Mesolithic and the Neolithic. Within this submerged landscape lies fragmentary yet valuable evidence for the lifestyles of its inhabitants including the changes resulting from both the encroaching sea and the introduction of Neolithic technologies. This inundated landscape cannot be explored conventionally, however pioneering work by the applicants research group has led to the rediscovery of Doggerland through the creation of the first detailed topographic maps relating to human occupation in the Early Holocene. Within this project world-leading innovators in the fields of archaeo-geophysics, molecular biology and computer simulation will develop a ground-breaking new paradigm for the study of past environments, ecological change and the transition between hunter gathering societies and farming in north west Europe. It will: 1) use the latest seismic reflectance data available to generate topographical maps of the whole of early Holocene Doggerland that are as accurate and complete as possible. 2) reconstruct and simulate the palaeo-environments of Doggerland using ancient DNA extracted directly from sediment cores. 3) explore the Mesolithic landscapes and also identify incipient Neolithic signals indicating early contact and development within the region of Doggerland.


Grant
Agency: Cordis | Branch: FP7 | Program: ERC-AG | Phase: ERC-AG-PE3 | Award Amount: 1.94M | Year: 2011

The 0MSPIN project consists of an extensive integrated theoretical, experimental and device development programme of research opening a radical new approach to spintronics. Spintronics has the potential to supersede existing storage and memory applications, and to provide alternatives to current CMOS technology. Ferromagnetic matels used in all current spintronics applications may make it impractical to realise the full potential of spintronics. Metals are unsuitable for transistor and information processing applications, for opto-electronics, or for high-density integration. The 0MSPIN project aims to remove the major road-block holding back the development of spintronics in a radical way: removing the ferromagnetic component from key active parts or from the whole of the spintronic devices. This approach is based on exploiting the combination of exchange and spin-orbit coupling phenomena and material systems with zero macroscopic moment. The goal of the 0MSPIN is to provide a new paradigm by which spintronics can enter the realms of conventional semiconductors in both fundamental condensed matter research and in information technologies. In the central part of the proposal, the research towards this goal is embedded within a materials science project whose aim is to introduce into physics and microelectronics an entirely new class of semiconductors. 0MSPIN seeks to exploit three classes of material systems: (1) Antiferromagnetic bi-metallic 3d-5d alloys (e.g. Mn2Au). (2) Antiferromagnetic I-II-V semiconductors (e.g. LiMnAs). (3) Non-magnetic spin-orbit coupled semiconductors with injected spin-polarized currents (e.g. 2D III-V structures). Proof of concept devices operating at high temperatures will be fabricated to show-case new functionalities offered by zero-moment systems for sensing and memory applications, information processing, and opto-electronics technologies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP-SICA | Phase: ENV.2009.2.2.1.4 | Award Amount: 8.83M | Year: 2010

Many efforts have been deployed for developing Integrated Coastal Zone Management (ICZM) in the Mediterranean and the Black Sea. Both basins have, and continue to suffer severe environmental degradation. In many areas this has led to unsustainable trends, which have impacted, on economic activities and human well-being. An important progress has been made with the launch of the ICZM Protocol for the Mediterranean Sea in January 2008. The ICZM Protocol offers, for the first time in the Mediterranean, an opportunity to work in a new way, and a model that can be used as a basis for solving similar problems elsewhere, such as in the Back Sea. The aim of PEGASO is to build on existing capacities and develop common novel approaches to support integrated policies for the coastal, marine and maritime realms of the Mediterranean and Black Sea Basins in ways that are consistent with and relevant to the implementation of the ICZM Protocol for the Mediterranean. PEGASO will use the model of the existing ICZM Protocol for the Mediterranean and adjust it to the needs of the Black Sea through three innovative actions: - Constructing an ICZM governance platform as a bridge between scientist and end-user communities, going far beyond a conventional bridging. The building of a shared scientific and end users platform is at the heart of our proposal linked with new models of governance. -Refining and further developing efficient and easy to use tools for making sustainability assessments in the coastal zone (indicators, accounting methods and models, scenarios, socio-economic valuations, etc). They will be tested and validated in 10 sites (CASES) and by the ICZM Platform, using a multi-scale approach for integrated regional assessment. -Implementing a Spatial Data Infrastructure (SDI), following INSPIRE Directive, to organize local geonodes and standardize spatial data to support information sharing on an interactive visor, to make it available to the ICZM Platform, and to disseminate all results of the project to all interested parties and beyond. -Enhancing regional networks of scientists and stakeholders in ICPC countries, supported by capacity building, to implement the PEGASO tools and lessons learned, to assess the state and trends for coast and sea in both basins, identifying present and future main threats agreeing on responses to be done at different scales in an integrated approach, including transdisciplinary and transbondary long-term collaborations.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SSH.2011.1.1-1 | Award Amount: 3.59M | Year: 2012

LLLightinEurope LifeLong Learning, Innovation, Growth and Human capital Tracks in Europe Among all Europeans between 24 and 65 years old who had a tertiary educational degree in 2010, 82.8% were working. In the same age group, 68.3% who completed secondary schooling were working. Only 46% of those who did not complete secondary schooling were working. It is apparent that if Europe wants to be working, higher education is the necessary foundation for being competitive in the labor market. Since this is not only true for generations of future workers currently in school, but equally so for those who are today in their 30s, 40s and 50s, Lifelong Learning must be essential to continued employability. The cumulative investment necessary to generate higher education degrees alone for adults over the next two decades across Europe may be 3.5 trillion euros or about 1.4% of European GDP per year. Even higher investments are required in non-formal and informal Lifelong Learning. To help guide this investment, this research project will find answers to the following urgent questions: 1. How do successful enterprises actively employ Lifelong Learning for their competitive advantage? 2. Which public policy environments facilitate Lifelong Learning for such enterprises and entrepreneurs? 3. How does Lifelong Learning interact with and promote innovativeness on the enterprise level? 4. How much of which skills do European adults actually have? 5. What are the actual learning mechanisms in adult life that lead to these skills? 6. What are the causal effects of these skills on growth, competitiveness and social cohesion? The research consortium includes nine universities and research institutes from four academic disciplines macro-econometrics, innovation dynamics, educational systems, psychometrics to establish empirically proven answers. All outputs of the project (models, reports and tools) are designed to guide, support and facilitate best practice and strategy among public policy officials, enterprise strategists, individual citizens and fellow scientists.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.07M | Year: 2013

The design, construction, maintenance, use and end-of-life management of road pavements and railways is associated with a number of important impacts on the environment; namely the consequences of energy consumption, unsustainable use of materials/resources, waste generation and release of hazardous substances into the environment. It is estimated that over 80% of all these environmental impacts are defined during the design phase of a product, including road pavements and railways. SUP&R (Sustainable Pavement & Rail) ITN,through a coherent research and training approach involving close collaboration between research institutions and industrial stakeholders across Europe, will allow this step change in the sustainability of road and rail infrastructure to be addressed by targeting the following overall aim: To setup a multidisciplinary and multi-sectoral network in order to form a new generation of engineers versed in sustainable technologies and to provide, to both academia and industry, design procedures and sustainability assessment methodologies to certify the sustainability of the studied technologies to the benefit of the European community SUP&R ITN includes an intensive four year training programme which will be international, multi-disciplinary and multi-sectoral. The young researchers will be trained through individual research projects, with a strong collaborations of partners from the private sector that will allow to jointly investigated strategies to overcome the existing barriers and deliver long-term benefits in terms of: 1. Eco-designed road and rail infrastructure that maximises the recycling of waste materials and ensures best performance characteristics to suit the diverse set of European environments; 2. Reduced installation, maintenance and operating costs as well as long term sustainable solutions; 3. A bespoke sustainability assessment tool, tailored to needs of product development in the road pavement and rail infrastructure sector.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.88M | Year: 2012

Scanning probe microscopy(SPM) has now evolved to the point where not only is imaging and manipulation with single atom resolution achievable but the state of the art in the field involves sub-molecular and sub-atomic resolution: individual chemical bonds can be resolved, their properties measured, and their spatial symmetry exploited. SPM is, however, increasingly a victim of its own success. The wide availability of commercial instruments means that the technique is now very commonly seen as a routine imaging and characterisation tool. This unfortunately engenders a mindset amongst young researchers where they see an SPM as a black box and typically have a superficial understanding of the operating principles, theoretical principles, and current (or ultimate) limits of the technique. In turn, this black box mentality has severe implications for the health and competitiveness of the SPM - and, by extension nanoscience and nanotechnology - sectors in the ERA which rely fundamentally on creative innovation. ACRITAS directly counters this decline in the skills base and creativity of young researchers by providing an exciting and challenging environment for SPM training, spanning the public and private sectors and redefining the state of the art. A defining aspect of the network is its integration of scanning probe groups whose research is carried out under what might be termed `extreme conditions (ultrahigh vacuum, cryogenic temperatures) with teams of scientists who focus on interactions and control in biologically relevant environments. Although both communities use the same types of experimental techniques, there has traditionally been rather little communication between the two, largely because of different disciplinary biases. ACRITAS will act as a new and important bridge between the physical- and life sciences in advanced SPM and will thus be unique in the training it provides in a field which underpins a vast amount of 21st century science


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 233.34K | Year: 2013

Imagine an epidemic is doubling in size every six days soon after the first cases are announced. If you know cases are all infectious for six days then a back-of-the envelope calculation tells you that each case infects on average a further three before recovering and vaccine coverage of 67% or greater is needed to contain the outbreak. But if you dont know anything about how long people with the disease are contagious for, then this simple calculation cannot be made without additional information. This project aims to quantify that uncertainty, so that when a measurement of the duration of infectiousness is made then we will be able to assess how infectious the disease associated with a particular outbreak is likely to be. Also, when you have a cold then it is is convenient to describe your disease state categorically, which is to say that you will say Im coming down with a cold, Im in the middle of a cold, or Im just getting better from a cold, rather than my viral titre is probably 3 on a logarithmic scale. It is also often convenient for scientific epidemiologists to take a categorical approach to disease state, and this project proposes to find a reliable method for deciding what the relevant categories should be.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.75M | Year: 2017

Cancer is considered as the second leading cause of death worldwide. It is important to develop methodologies that improve understanding of the disease condition and progression. Over the past few years, single cell biology has been performed using micro/nano robotics for exploration of the nanomechanical and electrophysiological properties of cells. However, most of the research so far has been empirical and the understanding of the mechanisms and thus possible for cancer therapy are limited. Therefore, a systematic approach to address this challenge using advanced micro/robotics techniques is timely and important to a wide range of the technologies where micro/nano manipulation and measurement are in demand. The proposed Micro/nano robotics for single cancer cells (MNR4SCell) project focuses on the staff exchange between the 8 world recognised institutions of EU and China, and the share of knowledge and ideas, and further the development of the leading edge technologies for the design, modelling, and control of micro/nano robotics and their applications in single cancer cell measurement, characterisation, manipulation, and surgery. This project meets the objectives and requirements of the Marie Skodowska-Curie Actions: Research and Innovation Staff Exchange (RISE). The ultimate goal of MNR4SCell is to establish long-term international and multidisciplinary research collaboration between Europe and China in the challenging field of micro/nano robotics for single cancer cells in the characterisation, diagnosis and targeted therapy. The synergistic approach and knowledge established by MNR4SCell will serve as the building blocks of the micro/nano robotics and biomedical applications, and thus keep the consortiums leading position in the world for potential major scientific and technological breakthroughs in nanotechnology and cancer therapy.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2011.1.4-1 | Award Amount: 9.56M | Year: 2012

It is vital that nanomanufacturing routes facilitate an increase in production whilst being green, sustainable, low cost and capable of producing high quality materials. Continuous hydrothermal synthesis is an enabling and underpinning technology that is ready to prove itself at industrial scale as a result of recent breakthroughs in reactor design which suggest that it could now be scaled over 100 tons per annum. Academic specialists with international reputations in reactor modelling and kinetics and metrology will develop the know how needed to scale up the current pilot scale system. Selected project partners with expertise in sustainability modelling and life cycle assessment will quantify the environmental impact and benefits of a process that uses water as a recyclable solvent, whilst producing the highest quality, dispersed and formulated products. In addition to scale up production, the process will be improved through case studies with industrial end users in four key areas printed electronics with SOVY; surface coatings with CRF, PPG and SOVY; healthcare and medical with ENDOR and CERA; hybrid polymers and materials with TopGaN and REPSOL. Further value will be added to the Project by working on new materials that have been identified as key future targets but cannot be currently made, or made in significant quantities. The consortium is founded on the principle that the whole value chain (from nanoparticle production to final product) must be involved in the development of the technology. This will not only inform the development stages of the production process but also maximise market pull, rather than simply relying on subsequent technology push.


Grant
Agency: Cordis | Branch: FP7 | Program: JTI-CP-FCH | Phase: SP1-JTI-FCH.2011.3.4 | Award Amount: 2.73M | Year: 2012

The project (TriSOFC) aims to develop and evaluate the performance of the first-of-its-kind LT-SOFC tri-generation system for low carbon buildings. The system is based on the integration of LT-SOFC stack and a novel liquid desiccant unit. A 1.5kW low-cost durable LT-SOFC tri-generation prototype system will be designed optimised, constructed and tested. The tri-generation system incorporates additional components including a fuel processor, to generate reformate gas if natural-gas used as fuel, and equipment for the electrical, mechanical and control balance of plant (BoP). With high efficiency, low-cost and longterm duration in mind, all these components will be first tested in the laboratory for further optimisation and miniaturisation. The performance of the tri-generation system will be tested using the Creative Energy Homes (low/zero carbon homes) at the University of Nottingham, UK. The tri-generation system will be used primarily in the low carbon homes/buildings. The system will be tested using natural-gas but it could be modified for use with other clean/renewable energy fuels (e.g. alcohol, biomass liquid fuel and biodiesel). The system has the potential to reduce CO2 emission by 70% compared to a traditional energy production system comprising of separate condensate power plant, boiler and compressor-driven cooling units. The successful development of the proposed project will promote LT-SOFC applications for provision of power, heat and cooling. The commercialisation of the system will bring economic and environmental benefits to the EU.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: FoF.NMP.2012-3 | Award Amount: 5.42M | Year: 2012

There is an increasing pressure on European SMEs to deliver high quality, often customised products using cost effective manufacturing processes and systems while competing in the global market. One of the key production processes in high labour cost areas such as Europe is assembly of final products in sectors such as automotive, aerospace, pharmaceutical and medical industries. They all require systems that can: be installed quickly, achieve high volumes at shorter time intervals, perform with minimum interruptions and be reconfigured for new products with minimum cost. PRIME aims to create new solutions for deployment by SMEs of highly adaptive, reconfigurable self-aware plug and produce assembly systems, which will use multi-agent control, dynamic knowledge sharing, integrated monitoring, and innovative human-machine interaction mechanisms. These next generation assembly systems equipped with PRIME technology will be able to proactively support rapid reconfiguration, adaptation, error-recovery, and operational performance improvement. This will lead to a dramatic cost and time reduction of deploying and maintaining complex assembly systems on demand and improve their effectiveness. The PRIME vision will be achieved by enhancing todays assembly systems with standardised plug and produce process and control solutions and interfaces to allow rapid reconfiguration and deployment, performance monitoring, self-awareness and evolutionary system adaptation. Based on this, the overall system performance will be monitored against production objectives and bottlenecks, thus errors and sub-optimal behaviour can be identified and assigned to the responsible stations. This will enable optimisation and adaptation of the assembly processes and associated system behaviour within a human centred environment. Furthermore, methods will be developed to integrate existing legacy system modules within the plug-and-produce environment using standardised interfacing.


The EU manufacturing sector is vitally important to the EU economy, contributing ~17.1% of GDP and accounted for some 22 million jobs (2007) . EU exports have expanded by 4.7% p.a. over 2000-2008 and in some sectors the EU has increased its share of world exports between 1996 and 2006, notably in chemicals, pharmaceuticals, and motor vehicles. SMEs represent 99% of the EU manufacturing sector equating to over 2.5 million companies. As manufacturing is resource intensive both in terms of raw materials and energy consumption, despite rising costs (energy and raw materials) SMEs are under increasing threat to remain competitive against non-EU based companies. The aim of the ICARUS project is to create an absorption power generation technology for low temperature (60-120oC) heat. This will enable us to create a waste-heat power generation system for industrial (chemical, cement etc.) applications that can achieve an efficiency of up to 20% for electricity to be generated from industrial waste heat (<120oC) without affecting industrial processes. By doing this, the absorption power generation system created will offer greatly improved environmental performance due to improved efficiency and reduced CO2 emissions at a cost that is affordable to the end-user. This will lead to significant economic and societal benefits to manufacturers. The SME consortium will target up to 10 % of the EU manufacturing SMEs operating within the Chemicals and Cement Industry within a 5 year period, thus achieving direct estimated annual sales of over 100 million, ~700 new jobs and thus helping manufacturing SMEs to make annual average CO2 emissions savings of up to 4,000 t p.a per company.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FoF-08-2015 | Award Amount: 7.01M | Year: 2015

OPTIMISED aims to develop novel methods and tools for deployment of highly optimised and reactive planning systems that incorporate extensive factory modelling and simulation based on empirical data captured using smart embedded sensors and pro-active human-machine interfaces. The impact of energy management on factory planning and optimisation will be specifically assessed and demonstrated to reduce energy waste and address peak demand so that operations that require or use less energy, can allow this excess energy to be re-routed to local communities. The OPTIMISED environment will use semantically enriched process modelling, big-data generation, capture and perform analytics to effectively support planning specialists, manufacturing engineers, team leaders and shopfloor operatives throughout the systems lifecycle. These next generation manufacturing systems supported by data rich manufacturing execution systems with OPTIMISED technology will support a dramatic improvement in system performance, improved operational efficiency and equipment utilisation, real-time equipment and station performance monitoring, adaptation and resource optimisation. The OPTIMISED vision will be achieved by developing systems which are able to: 1. Monitor system performance through an integrated sensor network, automatically detecting bottlenecks, faults and performance drop-off 2. Continuously evolve to respond to disruptive events, supply chain disruptions and non-quality issues through factory simulation modelling 3. Improve understanding and monitoring of energy demand curve and energy usage per industrial process and globally improve efficiency of production line through reduced energy waste 4. Understand potential benefits, added value and impacts of participating in Demand Side Response (DSR) processes and becoming an active player in the changing energy industry, instead of remaining a conventional passive element that simply acquires a service from energy providers


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2012.6.5-1 | Award Amount: 8.51M | Year: 2012

COBWEB will leverage the UNESCO World Network of Biosphere Reserves (WNBR). Concentrating initially on the Welsh Dyfi Biosphere Reserve, we will develop a citizens observatory framework, and then validate the work within the context of the UK National Spatial Data Infrastructure (SDI) and internationally, within the WNBR; specifically, within Greek and German Reserves. The infrastructure we develop will exploit technological developments in ubiquitous mobile devices, crowd-sourcing of geographic information and the operationalising of standards based SDI such as the UK Location Information Infrastructure. It will enable citizens living within Biosphere Reserves to collect environmental information on a range of parameters including species distribution, flooding and land cover/use. A main driver will be the opportunity to participate in environmental governance. Data quality issues will be addressed by using networks of people as sensors and by analysing observations and measurements in real-time combination with authoritative models and datasets. The citizens observatory framework will integrate with evolving INSPIRE compliant national SDIs and allow the fusion of citizen sourced data with reference data from public authorities in support of policy objectives. To maximise impact, COBWEB will work within the processes of the standards defining organisations. Specifically, we will aim to improve the usability of Sensor Web Enablement standards with mobile devices, develop widespread acceptance of the data quality measures we develop and maximise the commercial appeal of COBWEB outputs. The end result we are aiming for is a toolkit and a set of models that demonstrably works in different European countries and which is accepted as a core information system component of the WNBR. Implementations of COBWEB will act as models for how technology may be used to empower citizens associations in environmental decision making.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.32M | Year: 2012

Landslides and debris flows are serious geo-hazards common to countries with mountainous terrains. The high speed and the enormity of debris mass make debris flows one of the most dangerous natural hazards. Debris flows are often triggered by landslides partially or completely mobilizing into debris flows. Globally, landslides cause billions of dollars in damage and thousands of deaths and injuries each year. The numerous devastating events worldwide have made us aware of the complexity of landslides and debris flows and our insufficient knowledge to make reliable predictions. Traditional tools for prediction and design are based on limit equilibrium analysis for landslides and shallow water model with Finite Difference solver for debris flows. Usually soil and debris are modelled as single phase materials with constant material properties. That the simple models are unable to account for the complex behaviour of landslides and debris flows, which can be best described as multiphase and multiscale, is well known to researchers and stakeholders. Obviously there is an urgent need for better understanding of the triggering mechanisms, for reliable prediction of runout dynamics, deposition pattern and impact forces and for rational design of stabilization and protection structures. The last decade saw rapid developments in advanced constitutive models, experimental techniques in laboratory and in-situ, mechanics of multiphase media, localized deformation analysis, Discrete Element Method (DEM), advanced Finite Element Method (FEM) and Computational Fluid Dynamics (CFD). Training in these subjects has been rather sporadic and scattered in various disciplines. By integrating these advances into a coherent research network we expect to achieve the breakthrough in the research on landslides and debris flows, i.e. a consistent physical model with robust numerical scheme to provide reliable prediction and rational design of protection measures for landslides and debris flows.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SiS.2011.1.1.1-4 | Award Amount: 2.09M | Year: 2012

The aim of the EST-Frame project is to contribute to socially robust and ethically sound research and technology development by providing further methodological development of appropriate tools for social impact assessment and technology evaluation. The project will appraise current assessment methods for evaluating emerging science and technology with the objectives of mapping their strengths and weaknesses and determining their appropriate application domains. It will examine the current policy context for emerging science and technology (EST) policy advice and will identify future trends and needs that should be considered. The project will, in close dialogue with end users, also identify to what extent and in what contexts a framework of a more integrated nature can be applied, and it will examine the appropriate position that such an integrated framework can operate in, within a context characterised by internationalisation, market politics, and new forms of public-private partnerships in technology governance. Finally, this work will result in the design of a flexible, integrated framework that is intended to facilitate holistic societal dialogue and reflection and policy advice on emerging science and technologies. This integrated framework can be applied by policy forming actors (economic councils; ethical councils; technology appraisal institutes, government technology assessment boards, etc.) who are involved in the process of conducting analyses and coordinating policy deliberations on the broad range of science and technological developments. The project will use four examples of emerging science and technologies (1) nanotechnology in food production, (2) synthetic biology, (3) biofuels and (4) security in emerging ICTs to determine how current frameworks are applied to assess social impacts and then evaluate these assessments in light of the integrated framework. An added value of the project is policy relevant advice on the four cases.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.4.1 | Award Amount: 4.24M | Year: 2011

Cultural heritage institutions nowadays face the important challenge of making their collections more engaging to visitors, especially the young digital natives, while exploiting, in new forms of cultural interactive experiences, the recently developed digital libraries. An approach for cultural heritage institutions (e.g. museums) would be to capitalize on the pervasive use of interactive digital content and systems in order to offer experiences that connect to their visitors interests, needs, dreams, familiar faces or places; in other words, to the personal narratives they carry with them and, implicitly or explicitly, build when visiting a cultural site.The principal objective of CHESS is to research, implement and evaluate an innovative conceptual and technological framework that will enable both the experiencing of personalised interactive stories for visitors of cultural sites and their authoring by the cultural content experts. Essentially, CHESS proposes to create narrative-driven cultural adventures through hybrid structures, which adapt continuously to their visitors, extend over space and time, and involve multiple users with different interfaces. To achieve this, CHESS will integrate interdisciplinary research in personalization and adaptivity, digital storytelling, interaction methodologies, and narrative-oriented mobile and mixed reality technologies, with a sound theoretical basis in the museological, cognitive, and learning sciences. This tightly integrated framework will be applied and tested in different types of cultural heritage sites; most notably two world-renowned museums, the New Acropolis Museum, and the Cit de lEspace in France. Access to end-users will be further enhanced through the international User Group, a diverse body of cultural institutions and organisations.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: AAT.2011.4.4-5. | Award Amount: 34.53M | Year: 2011

The All-Electric Aircraft is a major target for the next generation of aircraft to lower consumption of non-propulsive power and thus fuel burn. To eliminate hydraulic circuits, pumps and reservoirs, Electro Mechanical Actuators (EMA) are mandatory but now need to meet cost, reliability and weight requirements from the airframers. ACTUATION 2015 aims to develop and validate a common set of standardised, modular and scalable EMA resources for all actuators (flight control, high lift, main landing gear, door, thrust reverser) and all types of aircraft (business/regional/commercial airplanes and helicopters). Compared to the A320, ACTUATION 2015 will reduce the overall Life Cycle Costs of actuators by 30%, improve reliability by 30% and reduce aircraft weight by 500kg. The project relies on recent advances made in EU and national projects to integrate the required technologies (solid state power distribution, power electronics, operation in harsh conditions, jam tolerant EMA) to overcome the current barriers to EMA and mature EMA technologies to TRL 5. Standardising EMA modules (motors, power drive electronics, mechanics, sensing) will be a key enabler to succeed in achieving cost objectives and developing the supply chain. Standardisation will start during the project with the support of a standardisation body (CEN). The technical approach will be to gather detailed airframes requirements, specify a set of standard modules and develop prototypes for assessment at component and actuator level through rig tests and the virtual validation of modules. In parallel, a unified EMA design process supported by standard methods and tools will also be developed. ACTUATION 2015 will complement existing projects, notably CLEAN SKY SGO with an EMA solution, and pave the way towards the ACARE 2020 All-Electric Aircraft. ACTUATION 2015 is a 4,5 year integrated project comprising 54 partners representing the European stakeholders of the actuation and airframe sectors from 12 countries


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: ENV.2010.4.1.3-1 | Award Amount: 1.21M | Year: 2011

In the next future, the number of GNSS will drastically increase. Not only more signals and frequencies will be available, but also the new generation of navigation satellites (GALILEO), will greatly enhance the performance of GNSS based applications, both scientific and mass-market. Current and next generation GNSS can improve and sustain GEEO applications, as well as be the enablers of novel applications. With the scope to support the GEOSS 10-year implementation plan (2005-2015) the 2010 Environment FP7 work program is launching various topics under sub-activity 6.4.1 Earth and ocean observation systems and monitoring methods for the environment and sustainable development. In line with the objectives of sub-activity 6.4.1, a coordination action promoting discipline connection, identity building and integration while defining future research, technology and policy directions is needed. GNSS for GEEO and GEOSS (Gfg2) responds to these needs addressed by work program topic: ENV.2010.4.1.3-1 Exploring GNSS applications for GEEO and GEOSS. The goals of this three-year long initiative are: 1) to consolidate a community of experts with interest to exploit GNSS for GEEO and GEOSS; 2) to explore novel applications derived from GNSS for GEEO and GEOSS while enhancing research-industry collaboration to implement these applications; 3) to identify the research and technological challenges and define the strategic vision, roadmap and policy for GNSS for GEEO and GEOSS available or under development (EU and non-EU); 4) to assess the value (in this context) of the European GNSS independent constellation (EGNOS-GALILEO); 5) to promote the public understanding of GNSS for GEEO and GEOSS research and use within the GEO community, providing support to GEO tasks. Gfg2 will achieve its objectives especially by using a working methodology based on active community interaction and events (2 summer schools, 4 workshops and a socioeconomic impact workshop).


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.9.5 | Award Amount: 2.07M | Year: 2014

We propose to solve the long-standing problem of coupling quantum states in atoms to solid-state quantum devices. The realization of such a quantum interface represents a major breakthrough for information science, as it enables the development of a powerful hybrid architecture, where long-lived states of atoms store quantum information that can be processed rapidly using superconducting quantum circuits. Within such a hybrid approach, the problem of scalability, fast information processing and long-time storage of quantum information can all be solved on a single integrated platform. The major obstacle, thus far, has been to find a suitable quantum interface between atoms (memory) and the surface of the solid-state device (processor), hampered by too low coupling strengths and/or too fast information loss due to fluctuating atom surface interactions. In this project, we propose to develop and implement a novel approach that solves both of these problems simultaneously. On the one hand, we will make use of the strong microwave transition between highly-excited, atomic Rydberg states to achieve strong coupling to a superconducting stripline cavity. On the other hand, the key point of this proposal is the use the enormous interactions between Rydberg atoms for collective encoding of quantum information in large ensembles that will be immunised against parasitic field fluctuations by the strong interactions. We will tackle this ambitious goal within a consortium that combines strong experimental and theoretical expertise in all the necessary areas and contributes complementary setups for state-of-the-art experiments on cold Rydberg atoms superconducting quantum circuits.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.03M | Year: 2012

The global navigation market (products and services) is expected to grow to more than 160 billion EUR revenue by 2015 with significant growth being driven by mobile terminals. The pillars of the future wireless society will be the trustworthiness of the wireless positioning device (e.g., what user can get in terms of location integrity, availability, privacy) and eco-friendliness of the transmission-reception process (e.g., long battery life, energy saving devices, high levels of integration, low interference to others). These are triggered by the user needs, preferences and targeted applications, and by the type of the environment where navigation takes place. A link is still missing between these user needs/environment awareness (or application layer) and the physical layer where the wireless device is actually designed. It is our belief that the missing link can be created by cognitive approaches, borrowed on one hand from cognitive human behavior, and on the other hand from cognitive computing. Building a cognition stage between the application and physical layers would create a myriad of new possibilities for flexible location-based services and positioning-based applications, and possibly a new paradigm in wireless location research. MULTI-POS will bridge the gap between the lower technology layer and upper application layer involved in wireless mobile location. In addition, MULTI-POS will offer comprehensive training to young fellows in the broad field of wireless location, will create novel technologies and business models for the future location-enabled wireless devices, will promote the exchange of fellows in mixed academic-industrial R&D trajectories and in multiple European cultures, and will initiate an educational and research framework that unifies the currently fragmented research activities on technological and applications aspects of wireless navigation. There is strong involvement of industrial partners in the network to accomplish this.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.72M | Year: 2013

The CI-NERGY Marie Curie Initial Training Network (ITN) aims to train young scientists to develop urban decision making and operational optimisation software tools to minimise non-renewable energy use in cities. The training will be carried out by a close collaboration of six of the best academic research centres and four leading industrial companies from the energy and software technology sector (Siemens, WienEnergie, EDF/EIFER, and IES). The research fellows will apply their results in two case study cities (Geneva and Vienna), which were chosen for their very ambitious sustainability goals. The CI-NERGY network will be a highly multi-disciplinary coordinated PhD programme on urban energy sustainability, covering the key challenges in cities related to a low carbon future. There is a gap in high level integrated training in the urban energy research field, which is due to the wide range of fragmented disciplines from building physics and energy supply technologies with electrical and thermal engineering up to software engineering and information technology. The CI-NERGY network wide training provided by excellent academic and industry partners from all areas of smart cities will close this gap. The impact of the network training activities will be highly noticeable for energy supply utilities, IT companies, policy makers, urban planners, researchers on sustainable urban energy systems and finally the inhabitants of cities themselves. All sectors mentioned will provide excellent career opportunities for the research fellows, who will gain excellent knowledge of the sectorial requirements by a structured secondment plan.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.2.2-3 | Award Amount: 18.59M | Year: 2014

Highly efficient Power Electronics (PE) employed in power generation, transmission, and distribution is the prerequisite for the Europe-wide penetration of renewable energies; improves the energy efficiency; increases the power quality and enables continuous voltage regulation, reactive power compensation and automated distribution. It also facilitates the integration of distributed resources like local energy storages, photovoltaic generators, and plug-in electric vehicles. The development of a new generation of high power semiconductor devices, able to operate above 10kV, is crucial for reducing the cost of PE in the above-mentioned applications. The material properties of SiC, clearly superior to those of Si, will lead to enhanced power devices with much better performance than conventional Si devices. However, todays SiC PE performs rather poorly compared to the predictions and the production costs are by far too high. Pooling world-leading manufacturers and researchers, SPEED aims at a breakthrough in SiC technology along the whole supply chain: Growth of SiC substrates and epitaxial-layers. Fabrication of power devices in the 1.7/>10kV range. Packaging and reliability testing. SiC-based highly efficient power conversion cells. Real-life applications and field-tests in close cooperation with two market-leading manufacturers of high-voltage (HV) devices. Known and new methodologies will be adapted to SiC devices and optimized to make them a practical reality. The main targets are cost-savings and superior power quality using more efficient power converters that exploit the reduced power losses of SiC. To this end, suitable SiC substrates, epitaxial-layers, and HV devices shall be developed and eventually be implemented in two demonstrators: A cost-efficient solid-state transformer to support advanced grid smartness and power quality. A windmill power converter with improved capabilities for generating AC and DC power.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2012.6.2-1 | Award Amount: 11.49M | Year: 2012

Despite improved understanding of the links between ecosystem health, provision of ecosystem services and human well-being, further conceptual and empirical work is needed to make the ideas of ecosystem services (ESS) and natural capital (NC) operational. OpenNESS will therefore develop innovative and practical ways of applying them in land, water and urban management: it will identify how, where and when the concepts can most effectively be applied to solve problems. To do this, it will work with public and private decision makers and stakeholders to better understand the range of policy and management problems faced in different case study contexts (ranging across locales, sectors, scales and time). OpenNESS will consolidate, refine and develop a range of spatially-explicit methods to identify, quantify and value ecosystem services, and will develop hybrid assessment methods. It will also explore the effectiveness of financial and governance mechanisms, such as payments for ecosystem services, habitat banking, biodiversity offsetting and land and ecosystem accounting. These types of interventions have potential for sustaining ESS and NC, and for the design of new economic and social investment opportunities. Finally, OpenNESS will assess how current regulatory frameworks and other institutional factors at EU and national levels enable or constrain consideration of ESS and NC, and identify the implications for issues related to well-being, governance and competitiveness. OpenNESS will analyse the knowledge that is needed to define ESS and NC in the legal, administrative and political contexts that are relevant to the EU. The work will deliver a menu of multi-scale solutions to be used in real life situations by stakeholders, practitioners, and decision makers in public and business organizations, by providing new frameworks, data-sets, methods and tools that are fit-for-purpose and sensitive to the plurality of decision-making contexts.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2013-5 | Award Amount: 8.59M | Year: 2013

In the past, customers invested in high cost, long service-life products. Today, they demand complex product-services capable of adapting to new customer goals and rapidly changing markets. The Use-it-wisely project will enable European manufacturers to operate successfully within this new paradigm. The project will investigate a new business model that implements continuous product-service adaptation through a sequence of small innovative steps. It will demonstrate that product-service agility and extended service life realized in this way is more viable than large and infrequent upgrades in terms of cost, duration and environmental impact. Use-it-wisely will develop and demonstrate the adaptation platform consisting of the following three elements: (1) multi-disciplinary actors-product-service system model; (2) adaptation mechanism based on the knowledge and skills of all actors involved with the system; (3) interactive collaborative distributed environment, where the actors work out the adaptation steps. The scientific breakthrough will be achieved by creating and validating a holistic systems engineering structure that combines human-machine systems, product lifecycle management, business and organizational dynamics and lifecycle assessment. The industry-led consortium is founded on complementary clusters in six key industry sectors: energy, machinery, space, office workplace, vehicles, and ship building. Use-it-wisely will enable new business for the manufacturers and their suppliers, subcontractors and open new opportunities for the customers. It will increase their competitive advantage by means of product-service agility, lower costs, shorter lead times, and reduced environmental impact. Finally, it will help to transform peoples knowledge and skills into product-service value thus strengthening Europes global competitiveness and securing domestic employment. With Use-it-wisely, the more the product-service is used, the better it gets.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2 | Award Amount: 2.86M | Year: 2011

5,720 people die yearly in the European Union as a consequence of work-related accidents, according to EUROSTAT figures (2005). Beside human losses, these incidents cost SMEs time and the availability of specific human expertise which directly translates into money and competitiveness. Moreover, to reduce time to market, shorter decision times and high speed productivity are demanded, and this might potentially lead to more risks for safety and health. On the other hand, and although occupational safety and health (OSH) regulations are obligatory and enforced by legal authorities, SMEs have limited resources in time, money and personnel, so it tends to be not regarded as a priority. Therefore, it seems necessary to stimulate awareness and to provide European SMEs with modern and user-friendly tools to support their understanding and compliance of OSH regulations. The IMOSHION project will establish novel methods to enhance SMEs productivity at both organisational and technological levels through better integration of OSH into their daily workflow. The project is targeting all manufacturing sectors (e.g. construction, machine building, metal working, aerospace, food industry) for which OSH concerns are the most challenging. Initial work will be carried out to elicit the technological requirements of SMEs by providing the RTD performers with a further definition of the tools to be developed. The RTD performers in collaboration with the SME associations will develop the set of OSH-related tools of the IMOSHION project. This will include (a) an OSH knowledge and learning management system, (b) a workplace simulation for experimenting and training on OSH issues, (c) an immersive training and learning tool for OSH procedures, and (d) a planning tool for OSH prevention at workstation and workplace levels. The SME associations will support validation, training as well as dissemination activities to transfer the project results to their SME members and beyond.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: REGIONS-2011-1 | Award Amount: 3.21M | Year: 2011

This proposal is presented by a consortium of regional research clusters whose core members are already pursuing research and technology development (RTD) in programmes that map on to their local or regional transport policy priorities. Common themes of expertise within the consortium apply to the fields of Traffic, Health and Environment (THE); the objective of the project is to apply this research base to achieve Intelligent Solutions for Sustaining Urban Economies. (ISSUE). This proposal truly addresses THE ISSUE. Several research areas are identified that deal directly with headline themes of this FP7 Call, namely: -transport impacts on urban mobility, -transport greening; -health, safety and security of citizens, -associated economic impacts. Diverse technologies and research applications will be brought to bear on the above issues, including: Computer intelligence solutions and real-time satellite navigation data integrated into existing operational urban traffic management systems. Space and in-situ measurements to help mitigate risk to citizens health from traffic-induced air pollution. Technology demonstration and pre-operational real time trials of a hydrogen fuel cell powered car operating in a city environment (2012). THE ISSUE programme will create a vibrant partnership of regional research clusters to bring together and coordinate already-existing and projected RTD programmes relevant to Traffic, Health and Environment both within the clusters and more widely in the broader European research community. In parallel, consultations will be held with participating regional and local authorities to identify economic priorities of those regions, specific to the themes of Traffic, Health and Environment. Tensioning RTD actions against regional economic objectives will be the next step. This approach paves the way to shape the application of research outputs towards delivery of regional strategies by developing a framework for coordinating research actions and exploitation. The coordination process requires proactive knowledge exchange between core partners through a focussed dissemination programme and a structured approach for mentoring and knowledge transfer to regions with less well developed research structures. The core partners are East Midlands, UK, Mazovi Region, Poland, MOLISE REGION, Italy, Midi Pyrenees and Aquitaine regions, France. In each case we can identify active regional research clusters with programmes and expertise in relevant thematic areas. Each core partner can satisfy the triple helix requirement. A wider network of new regional clusters will also be built up. Their regional representatives and research teams will be encouraged to participate in THE ISSUEs series of workshop and dissemination events and to become active partners in downstream RTD actions that THE ISSUE will be seeking to develop. Promotion of the new cluster programme will be facilitated, in part, through nationally-based knowledge transfer and innovation networks as well as the transnational NEREUS regional network. The expected outcome will be a Europe-wide research forward look and implementation plan for the exploitation and further development of relevant economy-driving, environmentally-sensitive traffic and transport initiatives for more sustainable transport economies in the cities, towns and regions of Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2010.2.3-1 | Award Amount: 8.02M | Year: 2011

The importance of developing novel approaches for bone repair is underscored by the heavy burden on health care costs and patient suffering caused by traumatic, osteoporotic and osteolytic metastatic bone lesions. To address these health challenges, we will develop optimally performing bioinspired biomaterials mimicking the natural physiological processes underlying bone repair. Our overall approach is to produce smart bioactive 3D scaffolds to fit within bone lesions, which we will then inject with functional, genetically-engineered self-solidifying elastin-like polymers with absolute-controlled molecular architecture and sequences containing specific domains for cell attachment, growth factors and calcium phosphate nanoparticles. The resulting bioactive, biodegradable scaffolds, biogels and regenerated bone will be analysed for biomaterial effects on bone growth, healing, foreign body reactions using cutting-edge in vitro assays, BioMEMS technology, in vivo animal models, non-invasive imaging and gene expression profiling for discovery of biomarkers associated with bone repair. Biomaterials will also be tested with biodynamic assays to assess strength, durability, toxicology, sterilisation reaction, eco-toxicology and risk assessment. Our multidisciplinary consortium with its extensive, state-of-the-art expertise consisting of private and public partners, cellular and molecular biologists, immunologists, physicists, bioengineers, and orthopaedic surgeons will tackle serious bone lesions with a comprehensive work plan to develop a prototype, evaluate it in vivo and in vitro, upscale its production and prepare the final material for clinical phase trials and commercialisation of the dual component product. Our ultimate aims are to ensure strong, healthy bone regeneration, reduce pain and suffering and to become a competitor in the biomaterials market of Europe.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: ICT-21-2014 | Award Amount: 3.36M | Year: 2015

3D-Tune-In brings together relevant stakeholders: the SME digital games industry (Reactify, Vianet, XTeam and Nerlaska); academic institutes (De Montfort University, University of Nottingham, University of Malaga); a large European hearing aid manufacturer (GN); and hearing communities (Associations - Extra Care, Hearing Link, Action Deafness, Accesibilidad y Personas Sordas and Ente Nazionale Sordi); to produce digital games applied to hearing aids, addressing social inclusion, generating new markets and creating job opportunities. With Europes ageing population the demand for assistive hearing devices is likely to rapidly increase. While the technology has dramatically advanced in the last 25 years since the commercialization of the first digital hearing aid, the new functions are often unexploited or inaccessible, particularly for children and older adults. Producers of hearing aid devices find that individuals prefer to use simpler less flexible devices even though functionality offered by miniaturised digital devices can considerably improve hearing in different acoustic environments (e.g. classroom, office, restaurant, street) leading to greater confidence, improved social interaction and more significantly inclusion back into society. 3D-Tune-In aims to exploit existing, overlooked or neglected hearing aid functionalities to greatly improve peoples quality of life and their interactions with other people and their surrounding environment. This will be achieved through creating the novel 3D-Tune-In toolkit based on participatory design methods and advances in 3D visual, audio and haptic technologies; to enable SMEs in digital games to generate a set of non-leisure game applications employing gamification techniques for supporting hearing impairment. The technology transfer between these scientific, technological and industrial communities will enable the game industry to expand into assistive technologies and support active ageing and healthy living.


Grant
Agency: Cordis | Branch: H2020 | Program: CS2-RIA | Phase: JTI-CS2-2014-CFP01-SYS-02-07 | Award Amount: 496.69K | Year: 2016

The goal of this project is the development of Modelica libraries (Dymola compatible) to simulate Electrical Environmental Control System (E-ECS) architectures including thermal management perimeter. The efforts will be focused on developing an optimized model to simulate vapour cycle systems (VCS) and liquid loop systems at both steady state and transient operational conditions. In addition, an appropriate strategy will be adopted to couple the thermal and the electrical environments to achieve an integrated simulation of the complete architecture. E-ECS architectures include different cooling systems and electrical components which will be modelled within this project. The system/components to be modelled are: Vapour cycle systems (VCS), including compressors, reservoirs, valves, heat exchangers, etc. Liquid loop systems, including pipes, pumps, cold plates, heat exchangers, liquid and diphasic coolants, etc. Air cycle systems, including compressors, turbines, air-to-air heat exchangers, fans, sprayers, etc. Jet pumps Electrical components, such as power electronics and electrical motors Wing ice protection systems A multi-level approach will be considered given the object-oriented nature of Modelica. In general, components will be modelled based on their appropriate governing equations (e.g. conservation law of energy, mass and momentum), needed empirical information (e.g. heat transfer correlations), and needed relevant parameters (e.g. compressor efficiencies). However, the modelling will be carried out considering different levels of detail. For instance, heat exchangers will be modelled from simple lumped approaches (e.g. -NTU based) to more detailed distributed approaches (e.g. finite volume method).


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.96M | Year: 2015

NMR and MRI play unique roles in contemporary Science, from Physics, Chemistry and Biology, to clinical research and diagnosis. Despite its irreplaceable role, further progress in NMR and MRI is hampered by sensitivities that are much lower than those of alternatives such as mass-spec, or PET. The prospects of solving this problem by bigger machines are uncertain and of poor return, given the high maturity already achieved by NMR/MRI. This ETN challenges this status from an untapped perspective, combining NMR/MRI with nuclear hyperpolarization eliciting signals that surpass those currently available by up to 50,000x. Focus is placed on two particular approaches, dynamic nuclear polarization and para-hydrogen-driven polarization, exhibiting the highest potential for biophysical, metabolomic, pre-clinical and clinical research. To maximize these supersignals we assembled leading experts in the physics and engineering of magnetic resonance, in the synthetic chemistry essential for the success of these methods, in the uses of NMR to structural/cell biology, and in preclinical and clinical MRI applications. Guiding this assembling is the conception that only by teaming together key areas of expertise, can hyperpolarisations promises be realized. In addition to fostering synergies among experts from academia and industry, EUROPOL will provide frontier training for ESRs in all the topics underlying the advancement of MR. This will include advanced physics, new instruments and forms of exploiting NMR/MRIs hyperpolarisation, biophysical NMR, screening of healthy and diseased metabolomes, expanded portfolios of substrates to be targeted by in vivo MR, ancillary in cell and system biology explorations clarifying the nature of the metabolic phenomena, and in vivo hyperpolarisation strategies in MRI. This ETN is unparalleled in scope, breadth and potential for synergies.


Grant
Agency: Cordis | Branch: H2020 | Program: ERC-POC | Phase: ERC-PoC-2015 | Award Amount: 150.00K | Year: 2016

Surface defect detection and characterization is a safety-critical non-destructive testing (NDT) process for many regulated industries, including railway networks, oil and gas, energy generation, aerospace, automotive, and civil infrastructure. The cost of repairing and replacing defective or old components can be extremely high, both in terms of the costs of the components and the related economical costs of a system shut-down. There are several NDT approaches in common use, but these have a number of operational drawbacks that impact adversely on in-situ examination cycle times, and can lead to the requirement for destructive testing. Through NonContactUltrasonic (Starting Grant, 202735) we have shown the promise of surface-wave ultrasonics for characterizing surface-breaking defects in metals. We have shown that the geometry of the defects has a significant effect on the scattered waves, and developed theory and industrially viable techniques for characterising individual defects. All measurements have used non-contact ultrasonic techniques, giving the potential for a fast and simple measurement system, removing the need for visual testing or removal of parts from service, and which could operate in hazardous environments. The concept has been tested successfully in the lab and a Proof of Concept unit is now needed to combine the processes for analysing various crack formations into a single device. This project will develop a demonstrator unit using electromagnetic acoustic transducers and laser ultrasound testing and adopting industrially viable detection methods in place of the lab-based system used previously. This will lead to a simple, on-line measuring system for industry, with the potential for productivity improvements of up to 50% over competing radiographic methods, and with substantially lower capital costs, with the potential to measure even in the presence of thin coatings without requiring their removal prior to testing.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.45M | Year: 2015

The continuous trend towards miniaturization and multi-functionality embedded in products and processes calls for an ever increasing innovation, research and development within the European manufacturing sector. A necessary condition for the European productive sector to be at the global forefront of technology, ensuring job creation and sustainable growth, is to have access to innovative, entrepreneurial, highly skilled research engineers in the fields of micro manufacturing and micro product/process development. The MICROMAN ITN will provide world excellent research training to 13 ESR in the field of micro manufacturing proposing: (1) innovative technological solutions for high quality and high throughput micro production (micro manufacturing process fingerprint, zero-defect net-shape micro manufacturing) for the micro manufacturing industry; (2) cutting edge inter-disciplinary training in different domains (-polymer moulding, -metal forming, -extrusion, -tooling technologies, -product metrology, -manufacturing process metrology); (3) validation of different micro manufacturing processes by integration into process chains for the production of micro component for the bio-medical, health-care, machine tool, pharmaceutical, quality control sectors. The training strategy is based on the 50-30-20 principle, in which each single ESR will develop a core technical competence, a complementary technical competence, and a general technical competence in all domains addressed by the project with a research effort proportional to the 50%-30%-20% of the total effort. An all-round, comprehensive yet specialized, training in micro manufacturing will be ensured. Specific training on project engineering research management and entrepreneurship completes the training and provides the ESR the required skills to effectively contribute to the competitiveness of the European micro manufacturing industry, and in turn to job creation and well-being of the European society.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 438.49K | Year: 2015

The isolation of single-atomic layer graphene has led to a surge of interest in other layered crystals with strong in-plane bonds and weak, van der Waals-like, interlayer coupling. A variety of two-dimensional (2D) crystals have been investigated, including large band gap insulators and semiconductors with smaller band gaps such as transition metal dichalcogenides. Interest in these systems is motivated partly by the need to combine them with graphene to create field effect transistors with high on-off switching ratios. More importantly, heterostructures made by stacking different 2D crystals on top of each other provide a platform for creating new artificial crystals with potential for discoveries and applications. The possibility of making van der Waals heterostructures has been demonstrated experimentally only for a few 2D crystals. However, some of the currently available 2D layers are unstable under ambient conditions, and those that are stable offer only limited functionalities, i.e. low carrier mobility, weak optical emission/absorption, band gaps that cannot be tuned, etc. In a recent series of pilot experiments, we have demonstrated that nanoflakes of the III-VI layer compound, InSe, with thickness between 5 and 20 nanometers, have a thickness-tuneable direct energy gap and a sufficiently high chemical stability to allow us to combine them with graphene and related layer compounds to make heterostructures with novel electrical and optical properties. The main goal of this project is to develop graphene-hybrid heterostructures based on this novel class of two-dimensional (2D) III-VI van der Waals crystals. This group of semiconductors will enrich the current library of 2D crystals by overcoming limitations of currently available 2D layers and by offering a versatile range of electronic and optical properties. From the growth and fabrication of new systems to the demonstration of prototype devices, including vertical tunnel transistors and optical-enhanced-microcavity LEDs, our project will provide a platform for scientific investigations and will contribute to the technology push required to create new routes to device miniaturization, fast-electronics, sensing and photonics. There is great potential for further growth of all these sectors as the fabrication of 2D systems improves and as new properties are discovered and implemented in functional devices.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.91M | Year: 2015

Bacterial endospores are the most resistant life-forms on earth and the most important single feature of the genus Clostridium. Thus, whilst the pathogenesis of its notorious pathogens (C. botulinum, C. perfringens and C. difficile) is ascribed to the devastating toxins produced (neurotoxins, endotoxins and cytotoxins), it is their capacity to produce spores that lies at the heart of the diseases they cause. This is because spores play the pivotal role in the spread of infection (eg, C. difficile) and in foodstuff contamination and food poisoning (eg, C. botulinum and C. perfringens). The processes of spore formation (sporulation) and germination (return of the dormant spore to toxin-producing, vegetative cells), therefore, represent key intervention points. On the other hand, the majority of clostridia are entirely benign and can sustainably produce all manner of useful chemicals and fuels. Crucially, the regulation of chemical production is intimately linked to that of sporulation. Spores of benign species may also be used as a delivery system for treating cancer. Yet, despite the spores importance, little is known of the developmental processes of sporulation and germination. This is because research and training efforts on Clostridium spores are fragmented and there is no coherence between researchers working on pathogenic and industrially important species. CLOSPORE will address this deficiency by pooling the resources of Europes leading universities, research organisations and companies, to create an intersectorial Research and Training Programme that is multi-facetted, interdisciplinary and focused on clostridial spores. Accordingly, CLOSPORE will produce the innovative, applied research leaders of the future, able to tackle the big societal challenges facing Europe and the world.


Grant
Agency: Cordis | Branch: H2020 | Program: ERC-ADG | Phase: ERC-ADG-2015 | Award Amount: 3.39M | Year: 2016

To reduce the burden of mental disorders it is a formidable aim to identify widely applicable disease markers based on neural processes, which predict psychopathology and allow for targeted interventions. We will generate a neurobehavioural framework for stratification of psychopathology by characterising links between network properties of brain function and structure and reinforcementrelated behaviours, which are fundamental components of some of the most prevalent mental disorders, major depression, alcohol use disorder and ADHD. We will assess if network configurations define subtypes within and if they correspond to comorbidity across these diagnoses. We will identify discriminative data modalities and characterize predictors of future psychopathology. To identify specific neurobehavioural clusters we will carry out precision phenotyping of 900 patients with major depression, ADHD and alcohol use disorders and 300 controls, which we will investigate with innovative deep machine learning methods derived from artifical intelligence research. Development of these methods will optimize exploitation of a wide range of assessment modalities, including functional and structural neuroimaging, cognitive, emotional as well as environmental measures. The neurobehavioural clusters resulting from this analysis will be validated in a longitudinal population-based imaging genomics cohort, the IMAGEN sample of over 2000 participants spanning the period from adolescence to adulthood and integrated with information generated from genomic and imaging-genomic meta-analyses of >300.000 individuals. By targeting specific neural processes the resulting stratification markers will serve as paradigmatic examples for a diagnostic classification, which is based upon quantifiable neurobiological measures, thus enabling targetted early intervention, identification of novel pharmaceutical targets and the establishment of neurobehaviourally informed endpoints for clinical trials.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.89M | Year: 2015

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in todays drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of todays employers in drug development industries.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.99M | Year: 2017

Sustainable Multi-functional Automated Resilient Transport Infrastructures ETN, will bring together a stimulating platform where the stakeholders of the transport infrastructure sector will work alongside world-wide experts in smartening of systems (developers of high-tech sensors, advanced monitoring equipment, automated structures, etc.,) with direct support from the roads, railways and airports managers. This environment will enable talented graduates to conceive the transport infrastructure network of the future and will provide them with world-wide extended training in each of the four pillars supporting the SMARTI vision: designed to last by maximising recycling and minimizing impact (Sustainable), conceived not for transport purposes only and towards optimisation of land use (Multi-functional), equipped for communicating with managers and users, to allow a more intuitive use and a simplified management (Automated), built to be adaptable to natural and anthropogenic hazards (Resilient). The consortium will combine and share expertise to offer advanced scientific training structured into network-wide thematic taught modules combined with original research supported by secondments that will expose fellows to both academia and industry and will also allow them with the possibility to be award with Doctoratus Europeus. The training programme will be enriched by specific modules to support job creation by enabling the fellows with business, entrepreneurship, communication, project management and other transferrable skills. A tailored Dissemination strategy will evaluate the variety of channels and means appropriate to allow the fellows to be prepared and successful in reaching both scientific and larger public audiences. As a result, SMARTI ETN will create a new generation of highly-skilled and appealing professionals that will be in great demand in this rapidly expanding field and will benefit Europe and developing countries


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 3.42M | Year: 2015

Wireless Chip-to-Chip (C2C) communication and wireless links between printed circuit boards operating as Multiple Input Multiple Output devices need to become dominant features of future generations of integrated circuits and chip architectures. They will be able to overcome the information bottleneck due to wired connections and will lead the semiconductor industry into a new More-Than-Moore era. Designing the architecture of these wireless C2C networks is, however, impossible today based on standard engineering design tools. Efficient modelling strategies for describing noisy electromagnetic fields in complex environments are necessary for developing these new chip architectures and wireless interconnectors. Device modelling and chip optimization procedures need to be based on the underlying physics for determining the electromagnetic fields, the noise models and complex interference pattern. In addition, they need to take into account input signals of modern communication systems being modulated, coded, noisy and eventually disturbed by other signals and thus extremely complex. Recent advances both in electrical engineering and mathematical physics make it possible to deliver the breakthroughs necessary to enable this future emerging wireless C2C technology by creating a revolutionary electromagnetic field simulation toolbox. Increasingly sophisticated physical models of wireless interconnects and associated signal processing strategies and new insight into wave modelling in complex environments based on dynamical systems theory and random matrix theory make it possible to envisage wireless communication on a chip level. This opens up completely new pathways for chip design, for carrier frequency ranges as well as for energy efficiency and miniaturisation, which will shape the electronic consumer market in the 21st century.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 2.96M | Year: 2016

2D-INK is targeted at developing inks of novel 2D semiconducting materials for low-cost large-area fabrication processes on insulating substrates through a new methodology, which will exceed the properties of state-of-the-art graphene- and graphene oxide based inks. Achieving this would represent an important step forward in the processing of 2D semiconducting materials and will provide the key parameters for fabricating the next generation of ultrathin electronic appliances. The inherent high-risk of 2D-INK is countered by a strongly interdisciplinary research team composed of 9 partners (8 academics \ 1 SME) with demonstrated experience in their corresponding fields and with different yet highly complementary backgrounds. Therefore only together and in synergy they will be able to address the challenges of the multiple research and innovation aspects of 2D-INK that cover the entire value chain from materials design and synthesis, characterisation, formulation and processing to device implementation. In addition 2D-INK has the potential to revolutionise research on 2D semiconducting materials way beyond the current interests on synthesis (high impact), since the efficient dispersion and formulation of 2D semiconducting materials into inks enables the applications of 2D semiconducting materials over different scientific and technological disciplines, such as electronics, sensing, photonics, energy storage and conversion, spintronics, etc. Overall, 2D-INK addresses perfectly the challenge of this call as it is an archetype of an early stage, high risk visionary science and technology collaborative research project that explores radically new manufacturing and processing technologies for novel 2D semiconducting materials.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 3.35M | Year: 2014

Our 21st century lives will be increasingly connected to our digital identities, representations of ourselves that are defined from trails of personal data and that connect us to commercial and public services, employers, schools, families and friends. The future health of our Digital Economy rests on training a new generation of leaders who can harness the emerging technologies of digital identity for both economic and societal value, but in a fair and transparent manner that accommodates growing public concern over the use of personal data. We will therefore train a community of 80 PhD students with the interdisciplinary skills needed to address the profound challenges of digital identity in the 21st century. Our training programme will equip students with a unique blend of interdisciplinary skills and knowledge across three thematic aspects of digital identity - enabling technologies, global impacts and people and society - while also providing them with the wider research and professional skills to deliver a research project across the intersection of at least two of these. Our students will be situated within Horizon, a leading centre for Digital Economy research and a vibrant environment that draws together a national research Hub, CDT and a network of over 100 industry, academic and international partners. Horizon currently provides access to a large network of over 75 potential supervisors, ranging from from leading Professors to talented early career researchers. Each student will work with an industry, public, third sector or international partner to ensure that their research is grounded in real user needs, to maximise its impact, and also to enhance their employability. These external partners will be involved in co-sponsorship, supervision, providing resources and hosting internships. Our external partners have already committed to co-sponsor 30 students so far, and we expect this number to grow. Our centre also has a strong international perspective, working with international partners to explore the global marketplace for digital identity services as well as the cross-cultural issues that this raises. This will build on our success in exporting the CDT model to China where we have recently established a £17M International Doctoral Innovation Centre to train 50 international students in digital economy research with funding from Chinese partners. We run an integrated four-year training programme that features a bespoke core covering key topics in digital identity, optional advanced specialist modules, practice-led team and individual projects, training in research methods and professional skills, public and external engagement, and cohort building activities including an annual writing retreat and summer school. The first year features a nine month structured process of PhD co-creation in which students, supervisors and external partners iteratively refine an initial PhD topic into a focused research proposal. Building on our experience of running the current Horizon CDT over the past five years, our management structure responds to external, university and student input and manages students through seven key stages of an extended PhD process: recruitment, induction, taught programme, PhD co-creation, PhD research, thesis, and alumni. Students will be recruited onto and managed through three distinct pathways - industry, international and institutional - that reflect the funding, supervision and visiting constraints of working with varied external partners.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2013-8 | Award Amount: 7.37M | Year: 2013

The vision of SelSus is to create a new paradigm for highly effective, self-healing production resources and systems to maximise their performance over longer life times through highly targeted and timely repair, renovation and up-grading. These next generation machines, fixtures and tools will embed extended sensory capabilities and smart materials combined with advanced ICT for self-diagnosis enabling them to become self-aware and supporting self-healing production systems. Distributed diagnostic and predictive repair and renovation models will be embedded into smart devices to early prognosis failure modes and component degradations. Self-aware devices will built on synergetic relationship with their human operators and maintenance personnel through continuous pro-active communication to achieve real self-healing systems. This will drastically improve the resilience and long term sustainability of highly complex manufacturing facilities to foreseen and unforeseen disturbances and deteriorations thereby minimising energy and resource consumption and waste. The SelSus vision will be achieved by the development of a new synergetic diagnostic and prognosis environment which is fully aware of the condition and history of all the machine components within a system or factory and is in constant knowledge enriched dialogue with their human personnel. The SelSus project will adopt a systematic approach, supported by a well-defined work plan. The work plan comprises nine carefully defined work packages. In order to guarantee fully committed teams towards comprising goals, the number of individual work packages is kept clearly constrained. The strong industrial pull for the project will be translated into a clear set of industrial requirements aimed at well-defined demonstration scenarios from the automotive and white goods industry.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.3-2 | Award Amount: 7.47M | Year: 2013

IMMODGEL aims to identify adverse immune reactions to dental and larynx titanium implants and to develop a novel therapeutic strategy to significantly decrease the implant and medical device failure caused by these reactions via design of an innovative immunomodulatory system. The system will be designed to be fixed to an implant via an adhesive polyelectrolyte multilayer and control the immune response by autologous, phenotype modulated macrophages encapsulated in a hydrogel. The auxiliary nature of the design allows it to be adjusted to any implant, medical device or transplant. IMMODGEL will apply complex systems immunology, epidemiology, and functional approaches to identify key adverse immune reactions caused by implants and detrimental macrophage phenotypes around titanium implants. This will be used to establish the optimal biomaterial composition and cytokine delivery system for the immunomodulatory hydrogel design to revert macrophage-induced inflammatory reactions (M1) to the optimal tolerogenic and healing reactions (M2). Long-term fixation of the desired M2 phenotype will significantly decrease the level and duration of implant-induced inflammation, and optimise healing phase. The interaction of implants and medical devices with the immune system will be modelled to develop a Foreign Body Response on-a-chip to predict patients specific responses to implant materials and modify the immunomodulatory hydrogel accordingly, as a step towards personalized implants with minimal adverse reactions. The gels will be incorporated to engineered tissues for validation. Validation of the approach will be performed in vivo in animal models. Significantly suppressed inflammatory responses and optimal tissue remodelling and healing around titanium implants is expected. The key innovation will be the development of IMMODGEL as an auxiliary system to improve the outcomes of implantation and reduce the cost of implant complication and related medical costs in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2008-3.4-1 | Award Amount: 7.17M | Year: 2010

In COPERNICO a novel approach is adopted which will look at ALL factors of the production system in a holistic manner (machines, humans, environment) and model the interactions. Particular attention will be paid to factory ramp-up, which is critical for new products and can be a major stumbling block achieving fast time-to-market. We believe that it is only possible to design a virtual manufacturing process by developing a detailed understanding of the system at all levels. COPERNICO is directed at generic issues spanning the interests of all our industrial partners and indeed common to all factories. The problems include optimizing capacity, removing bottlenecks and scheduling (coordinating with both the upstream and downstream supply chain and minimizing work in progress). The emphasis of COPERNICO is on virtual simulation to eliminate problems before they happen. The preplanning stage is an ideal time in the life-cycle of the plant to include human and environmental concerns, safety factors and work-place satisfaction metrics. The objectives are to: 1. Identify and merge the range of mathematical, physical, data driven and knowledge based models with soft data such as worker and environmental considerations to create a tool to predict the behaviour of production processes and overall factory environments. 2. Use the models to develop optimum processing routes 3. Develop novel experimental methodologies to validate the models in a virtual test bed facility 4. Condense the validation and certification time to reduce cost and time 5. Build from machine tools to cells and factories 6. Build on the close working relationship with our industrial collaborators and transfer knowledge 7. Create a modular factory layout system with a diagnostic and solutions toolkit 8. Demonstrate this system in a virtual facility, validate it across a real test-bed facility and implement it in at least 1 SME factory and 1 OEM production process


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 2.27M | Year: 2014

This proposal seeks funding to acquire a stepper and associated wafer coater, tools to enable photolithographic patterning of semiconductor wafers for device and circuit fabrication. The stepper will be located at Southampton University in the recent £120m cleanroom complex. It will relieve the bottleneck within the cleanroom, an electron beam lithography tool, which is a slower alternative patterning tool. This will increase capacity within the cleanroom complex and facilitate and underpin a wealth of world class research. Not only will research at Southampton be enhanced, but Southampton (SOU), Glasgow (GLA), and Surrey (SUR) universities will pool resources to establish a Silicon Photonics Fabrication Capability within the UK, to facilitate an increasing demand for the fabrication of Silicon Photonics devices from the UKs premier researchers. This will encourage wider usage of world class equipment within the UK, in line with EPSRC policy. We seek funding for both the equipment and 3.5 RAs across the 3 institutions, over a 4 year period, to establish and deliver the Capability. Access to a very significant inventory of additional equipment at these 3 universities will be facilitated. The Capability is extremely timely, as silicon foundry services around the world are moving towards a model in which standard platforms and devices will be offered, making it more difficult for researchers to carry out innovative work at the device level, or in non-standard platforms. The proposal is supported by 36 members of academic staff at Southampton, with a total current research portfolio of projects valued in excess of £88m. Furthermore we have 10 project partners who will take part in the use and assessment of the silicon photonics capability by designing and subsequently testing fabricated devices. Their total in-kind contribution is valued at £793,300. These partners have expressed an interest in using the capability after the project has been completed. In addition have contacted a few example potential users from within the industrial sector (SMEs), and from around the world who have also provided letters of support indicating that they would use the capability after the project is complete. Taking this net proposed usage, it is clear that the equipment will be sustained beyond the period of the funded project. The Southampton users alone need only generate a tiny fraction (0.2%) of their research portfolio to cover running costs and depreciation. Consumables will increase with usage, but clearly, the silicon photonics capability will generate paying users, to further sustain the capability beyond the project, which will, in turn, allow UK researchers to compete effectively on the world stage in the buoyant field of silicon photonics. Beyond the 4 year project, the Silicon Photonics Capability will be operated by the commercial arms of the 3 partner universities, all of whom have provided letters of support confirming their ongoing participation.


RHINOS aims at increasing the use of EGNSS to support the safety-critical train localization function for train control in emerging regional and global markets. RHINOS adds value to EGNSS by leveraging the results from prior or existing projects, and develops a Railway High Integrity Navigation Overlay System to be used by the rail community. RHINOS pillar is the GNSS infrastructure realized for the aviation application with additional layers that meet the rail requirements in the difficult railway environments. RHINOS will feature an international cooperation with the Stanford University that has been involved in the aviation application since the birth of the GPS, gaining an undeniable knowledge of the GNSS performance and high-integrity applications. The ambition is a positive step beyond the proliferation of GNSS platforms, mainly tailored for regional applications, to favor a global solution to release the potential benefits of the EGNSS in the fast growing train signaling world market. The RHINOS work programme includes the investigation of candidate concepts for the provision of the high integrity needed to protect the detected position of the train, as required by the train control system application. The EGNSS (GALILEO and EGNOS) plus GPS and WAAS constitute the reference infrastructure that is available world-wide. Moreover, local augmentation elements, ARAIM techniques and other sensors on the train are the add-on specific assets for mitigating the hazards due to the environmental effects which dominate the rail application. A further objective of RHINOS is to contribute to the definition of a standard for the Railway High Integrity Navigation Overlay System leveraging on the EU-US Cooperation Agreement on ARAIM. The RHINOS dissemination plan includes three specific Workshops with the rail and satellite stakeholders, at Stanford University for the US community, in Roma for the Western European community and in Prague for the Eastern European community.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: SC5-10b-2014 | Award Amount: 2.81M | Year: 2015

The aim of INSPIRATION is to adopt a funder and end-user demand-driven approach to establish and promote the adoption of the knowledge creation, transfer and implementation agenda for land use, land-use changes and soil management in the light of current and future societal challenges. Main objectives are: Formulate, consult on and revise an end-user oriented strategic research agenda (SRA), Scope out models of implementing the SRA, Prepare a network of public and private funding institutions willing to commonly fund the execution of the SRA. INSPIRATIONs mission is to improve the supply and effectiveness of science/knowledge take-up by those who really need it. The proposed methodology is based on a multi-stakeholder, multi-national and interdisciplinary approach that covers the variety of stakeholders (public bodies, business, science, citizens and society) and the variety of relevant. The vehicle to engage with all relevant stakeholders across the Member States is a National Focal Point (NFP) in 16 countries. The NFPs will organize workshops with national stakeholders of funders, end users and researchers across the various soil and land management disciplines. The results will be taken up, structured along four integrative themes and merging into thematic knowledge needs to satisfy the as yet unmet societal challenges and to ensure that knowledge contributes primarily to enable meeting these challenges. Based on these results a cross country and cross discipline dialogue will subsequently be organized among the relevant user communities, funding bodies and scientific communities in Europe in order to reach a trans-national, prioritized SRA as well as a model for execution of this SRA. Thus to achieve an SRA of which national funders believe that for any Euro they spend, they will get a multitude of Euros worth of knowledge in return. Knowledge welcomed to face their national, societal challenges.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-15-2015 | Award Amount: 12.49M | Year: 2016

To meet the ambitious EC target of an 80% reduction in greenhouse gas emissions by 2050, CO2 Capture and Storage (CCS) needs to move rapidly towards full scale implementation with geological storage solutions both on and offshore. Onshore storage offers increased flexibility and reduced infrastructure and monitoring costs. Enabling onshore storage will support management of decarbonisation strategies at territory level while enhancing security of energy supply and local economic activities, and securing jobs across Europe. However, successful onshore storage also requires some unique technical and societal challenges to be overcome. ENOS will provide crucial advances to help foster onshore CO2 storage across Europe through: 1) Developing, testing and demonstrating in the field, under real-life conditions, key technologies specifically adapted to onshore storage. 2) Contributing to the creation of a favourable environment for onshore storage across Europe. The ENOS site portfolio will provide a great opportunity for demonstration of technologies for safe and environmentally sound storage at relevant scale. Best practices will be developed using experience gained from the field experiments with the participation of local stakeholders and the lay public. This will produce improved integrated research outcomes and increase stakeholder understanding and confidence in CO2 storage. In this improved framework, ENOS will catalyse new onshore pilot and demonstration projects in new locations and geological settings across Europe, taking into account the site-specific and local socio-economic context. By developing technologies from TRL4/5 to TRL6 across the storage lifecycle, feeding the resultant knowledge and experience into training and education and cooperating at the pan-European and global level, ENOS will have a decisive impact on innovation and build the confidence needed for enabling onshore CO2 storage in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.2.1-01 | Award Amount: 2.55M | Year: 2013

The iMars project will focus on developing tools and value-added datasets to massively increase the exploitation of space-based data from NASA and ESA mission imaging and 3D data beyond the PI teams. iMars proposes to add value by creating more complete and fused 3D models of the surface from combined stereo and laser altimetry and use these 3D models to create a set of co-registered imaging data through time, permitting a much more comprehensive interpretation of the Martian surface to be made. Emphasis will be placed on co-registration of multiple datasets from different space agencies and orbiting platforms around Mars and their synergistic use to discover what surface changes have occurred since NASAs Viking Orbiter spacecraft in the mid-1970s. iMars brings together the best expertise in Europe for the processing of Martian orbital data within a single environment for handling, visualising and interpreting these data. The ESA Mars Express High Resolution Camera (HRSC) will provide the base data, where possible. The iMars base data can then be used by the ESA ExoMars Trace Gas Orbiter 2016 and subsequent ESA missions to provide the necessary inputs for selection of a future landing site for the ESA ExoMars 2018 rover and for any Mars Sample Return missions in the 2020s. It will greatly extend the use of archived data by providing mapped and co-registered images. The resultant time-stamped imagery will be interfaced to automated data mining analysis software based on techniques developed for Earth surveillance. We will also build on the huge momentum, developed in the Zoouniverse system by building a MarsZoo project for mass public participation in the feature mapping of Mars. Co-operation with US colleagues will be through the Technical Advisory board at annual project meetings and with European scientists through the workshops as well as the exploitation of the 3D datasets in visualisation engines such as Google Mars. The iMars datasets and tools will allow the creation of new communities of geoscientists. iMars will also allow much greater public participation in data analysis so stimulating a much greater interest in space-based data.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.1.6 | Award Amount: 4.95M | Year: 2013

The explosion of information available online and the ubiquity of connected media devices are rendering existing content recommendation and content delivery system inadequate. The recent data deluge has made finding relevant content a daunting task. Users are presented with seemingly infinite choices for consumption and because recommendation systems are typically service or application specific and based on little or narrow data, which results in too coarse-grained recommendations. Furthermore, existing content delivery systems focus their media adaptation to match device and network characteristics, instead of users context and profile that could help increase the relevance of content search and the viewing conditions.\n\nWe introduce User Centric Networking (UCN), a new communication paradigm that leverages user information at large to store, discover and deliver content in the most optimal conditions at any time, for a given user in a specific context. UCN relies on a distributed Personal Information Hub (PIH) that contains information such as the user context, her mood, historical data about her taste, expectation, social acquaintances, and her network/device resources. UCN will use these data to decide at any point in time where to search content and where to deliver it from, and how to configure the delivery for a user in her context. In addition, UCN creates opportunities for a new range of personalized services, based on geo-location or fusion of very different sensor data for example.\n\nUCN will deliver prototypes for a new generation of Internet-based applications and services in the digital media sector and beyond. These prototypes will deployed in Technicolors Home Networking product line, designed with real data and tested in real conditions at Portugal Telecom and a NICTA who both use Technicolors most recent gateway technology.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: ENERGY.2012.8.8.1 | Award Amount: 2.63M | Year: 2013

The InSMART concept brings together cities, scientific and industrial organizations in order to establish and implement a comprehensive methodology for enhancing sustainable planning addressing the current and future city energy needs through an integrative and multidisciplinary planning approach. This approach will identify the optimum mix of short, medium and long term measures for a sustainable energy future, addressing the efficiency of energy flows across various city sectors with regards to economic, environmental and social criteria and paving the way towards actual implementation of priority actions. Extensive technical expertise and specialized tools and models will be used to create a platform for implementation of the project idea. Each citys energy system will be analysed, covering all relevant sectors and a comprehensive GIS energy database will be developed. Apart from being a valuable planning tool the GIS database will inform and be linked to the TIMES planning model. This model will be used to analyse the cost-optimal mix of measures required to meet sustainable energy targets taking into account exogenous parameters (e.g. environmental targets, city expansion). These measures will be further assessed with respect to non-technical criteria using a multi-criteria decision making method (PROMIHEE) that will address economic, environmental as well as social issues. A detailed economic analysis of the mid-term measures identified through this two stage optimisation procedure will be undertaken, identifying all relevant investment indicators. Finally, a detailed, realistic and applicable mid-term implementation plan will be developed to describe the necessary steps, required resources and monitoring procedures for each city. The approach will be used on the four city partners, all actively involved in developing a more sustainable energy system. Further on, the proposed approach will be replicable in other cities with sustainability target.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.9.3 | Award Amount: 2.04M | Year: 2014

Biological evolution has produced an extraordinary diversity of organisms, even the simplest of which is highly adapted, with multiple complex structures. Evolutionary computation has found that many innovative solutions to optimisation and design problems can be achieved by artificial evolution via random variation and selection.Despite the centrality of evolution to biology and the usefulness of evolutionary algorithms in optimisation, the dynamics of evolution are not well understood. Consequently, population genetics theory can only make quantitative predictions about short-term, simple biological evolution, and the design and parameter tuning of evolutionary algorithms is mostly done ad-hoc in a laborious and cost-intensive process.Both fields have studied the speed of adaptation independently, and with orthogonal approaches. Our project brings together an interdisciplinary consortium of ambitious researchers from the theory of evolutionary computation and theoretical population genetics to synergise these complementary approaches and to create the foundation of a unified quantitative theory describing the speed of adaptation in both biological and artificial evolution.The transformative impact of this unified theory will lie in enabling long-term predictions about the efficiency of evolution in settings that are highly relevant for both fields and related sciences. Our approach will reveal how this efficiency is fundamentally determined by evolutionary and environmental parameters. Tuning these parameters will allow researchers from biology and computation to increase the efficiency of evolutionary processes, revolutionising applications ranging from evolutionary algorithms to experimental evolution and synthetic biology.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.1.4-1;HEALTH.2012.2.3.2-1 | Award Amount: 7.81M | Year: 2013

Worldwide, 200 million people are infected with the hepatitis C virus (HCV). An estimated 15 million individuals are living with HCV infection within the EU. The economic, health and societal costs of chronic HCV infection are significant. HCV is the principal cause of death from liver disease and the leading indication for liver transplantation. The only treatment for end-stage liver disease is a liver transplant, yet the transplanted liver becomes rapidly re-infected and is frequently destroyed within 5 years after transplantation. In this cohort of patients current antiviral treatments are too toxic - there is an urgent need to develop safe and effective treatments for use in this setting. Human monoclonal antibodies (MAbs) that target virus entry, are as yet an underutilised and potentially highly effective and safe weapon in the armoury against HCV infection. The consortium has identified MAb leads which, in pre-clinical analyses, potently block HCV infection. HCV exhibits a high degree of genetic and antigenic variability, which enables the virus to escape protective immune responses. Crucially, the lead antibodies identified by the consortium are capable of preventing infection by a wide range of genetically distinct isolates because they target highly conserved epitopes on the virus or host receptor molecules. This limits the chances of virus resistance. Also, each lead antibody targets a unique component of the viral entry pathway, thereby paving the way for powerful combinatorial approaches which maximises clinical potency. HepaMAb harnesses leading expertise in MAb technology, preclinical efficacy and safety testing, biomanufacture and clinical trial to progress at least one anti-viral and one anti-receptor human MAb to phase I/IIa proof of concept clinical trial in the liver transplant setting for the prevention of graft reinfection. We will establish a much-needed therapeutic MAb pipeline for use in this solid organ transplant setting.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-1.3-2014 | Award Amount: 4.64M | Year: 2015

PASSME aims to deliver industry-driven, passenger-centric novel solutions (up to TRL6) for passengers, airports and airlines to address the anticipated increase in demand for commercial flights in Europe by 2050. The goal is to reduce travel time by at least 60 minutes by integrating information between all stakeholders and transforming airport and aircraft operations and interiors to make the passenger journey time efficient, seamless, robust and accessible. This requires significant breakthrough solutions, such as: a real-time passenger-centric system for managing passenger flows that use input from the airport and passenger to provide predictive analytics on passenger flows 20-30 minutes ahead of time; a passenger independent system for managing luggage flows that reduce the time in arrival/departure airports by at least 30 minutes and increases the control passengers have over their luggage; radically redesigned passenger-centric airport and airplane processes and facilities that enable highly personalised and less stressful experience through key touch points (check-in and boarding); and a personalised device and smartphone application that measures physiological/psychological state and links with airport/airline services to provide relevant and timely information to support the passenger in decision-making. The research institutes (TUD, UNott, ICCS, TUHH, NLR, DLR) with interior design partners (Alma, Optimares) and communication experts (CARR) will work closely with Amsterdam and Hamburg airport clusters and KLM airlines to drive the user-centred design and evaluation methodology; to ensure the success of the solutions and that benefits will be shared with passengers, airlines and airports to have the necessary impact on the air transport system. Linking with the Airport Council International Europe (a selection of the 450 airports) and airport service SMEs will guarantee the results will have the maximum dissemination and exploitation across EU industries.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP-SICA | Phase: SSH.2013.2.1-3 | Award Amount: 3.09M | Year: 2014

The GLOBAL VALUE project develops an innovative framework for assessing impacts of Multinational Corporations (MNCs) on issues related to the Millennium Declaration, sustainable development, human rights, transparency, and anti-corruption. To ensure utility, we will monitor the policy debate on global and sustainable development and deliver a regularly updated catalogue of goals and indicators. We will shed light on institutional arrangements; analyse systems of governance for responsible business practices; explore responsible competitiveness; assess the complementarity of public and private sector activities; and derive recommendations for decision makers in business, policy and CSOs. For addressing MNCs, the project will deliver a modular, user-friendly and customizable toolkit, including a web-based assessment platform, a tool navigator, a user guide, and training materials. It will take into account the most relevant pathways of impact (through business operations, community investments, regional, supply chain and product related impacts) and link up with powerful management approaches (such as supply chain management, life cycle assessment and base of the pyramid innovation). The toolkit will be tested in close collaboration with leading MNCs: BATA (garment, Bangladesh), OLAM (food, Tanzania) and MONDI (paper & packaging, Russia a.o.). Research organizations, CSOs, and sector experts from these countries are members of the consortium and ensure the involvement of stakeholders and local actors. Reflexive learning workshops contribute to a continuous improvement of the toolkit. The project is carried out by leading researchers from Europe and ICPC countries, and involves relevant UN bodies in an advisory capacity. Special emphasis is put on research capacity building in and networking with ICPC countries and CSOs. By establishing an expert crowd we take business, society, and policy perspectives into account - more than 200 experts are currently part of the crowd.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2012.2.1-01 | Award Amount: 2.50M | Year: 2013

The international community of planetary science and exploration has launched, landed and operated dozens of human and robotic missions to the planets and the Moon. They have collected various surface imagery that has only been partially utilized for further scientific application purposes. Few attempts have been made so far to bring these data into a unified spatial context, or to exploit spatial relationships implicit in these images, including orbiter data. PRoViDE will assemble a major portion of the imaging data gathered so far from vehicles and probes on planetary surfaces into a unique database, bringing them into a spatial context and providing access to a complete set of 3D vision products. Processing is complemented by a multi-resolution visualization engine that combines various levels of detail for a seamless and immersive real-time access to dynamically rendered 3D scene representations. PRoViDE aims to (1) complete relevant 3D vision processing of planetary surface missions, such as Surveyor, Viking, Pathfinder, MER, MSL, Phoenix, Huygens, and Lunar ground-level panoramas & stereoscopic & multiscopic images from Apollo and Russian Lunokhod and selected Luna missions (2) provide highest resolution & accuracy remote sensing (orbital) vision data processing results for these sites to embed the robotic imagery and its products into spatial planetary context, (3) collect 3D Vision processing and remote sensing products within a single coherent spatial data base, (4) realize seamless fusion between orbital and ground vision data, (5) demonstrate the potential of planetary surface vision data by maximising image quality visualisation in 3D publishing platform , (6) collect and formulate use cases for novel scientific application scenarios exploiting the newly introduced spatial relationships and presentation, (7) demonstrate the concepts for MSL, (9) realize on-line dissemination of key data & its presentation by means of a web-based GIS and rendering tool


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SiS.2013.2.2.3-1 | Award Amount: 2.48M | Year: 2014

The project aims to research the use of technology in formative assessment classroom practices in ways that allow teachers to respond to the emerging needs of low achieving learners in mathematics and science so that they are better motivated in their learning of these important subjects. This international project will adapt and develop existing research-informed pedagogical interventions (developed by the partners), suited to implementation at scale, for working with low attaining pupils and transforming teaching. The project will seek to: report the differences in the way that systemic structures influence the trajectories of lower achieving students within the participating countries; identify their typical pathways through the school system and reveal the educational opportunities that are open to these students. It will report on the varying assessment tools that are used to identify lower achieving students and may determine these pathways, with attention paid to the different interpretations of low achievement in each country. This project aims to: foster high quality interactions in international classrooms that are instrumental in raising achievement for low achievers; expand our knowledge of technologically enhanced teaching and assessment methods addressing low achievement in mathematics and science Major objectives for the project are to: offer approaches for the use of new technologies to support the formative assessment of lower achieving students. develop sustainable teaching practices that improve attainment in M&S for the targeted students. produce a toolkit for teachers to support the development of practice and a professional development resource to support it disseminate the outcomes


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.92M | Year: 2011

TRANSMIT will provide a coordinated programme of academic and industrial training in an area of immediate interest to the European society. It focuses on atmospheric phenomena that can significantly impair a wide range of systems and applications that are at the core of several activities embedded in our daily life. TRANSMIT deals with the harmful effects of the ionosphere on these systems, which will become increasingly significant as we approach the next solar maximum, predicted for 2013. It will gather major European stakeholders in a large multi-site ITN to develop real time integrated state of the art tools to mitigate ionospheric threats to Global Navigation Satellite Systems (GNSS) and several related applications, such as civil aviation, marine navigation and land transportation. TRANSMIT will expand the European knowledge base and ensure its sustainability by preparing young researchers in a multidisciplinary, intersectorial, industry-led training programme. Its driving forces are the EC prediction of an annual global market for GNSS of 300bn by 2020 and the fact that Europes own GNSS, Galileo, will be fully operational by 2013, just when the impact of the ionosphere will be greatest. GNSS satellite signals and any others operating below 10 GHz, including communications (satellite and HF), remote sensing and Earth observation systems, are extremely vulnerable to ionospheric phenomena. This formidable fast growing community lacks robust counter-measures to deal with these threats. Advancement in this area has been limited by: A shortage of human resources in relevant Engineering disciplines; The lack of a multidisciplinary framework where the various specialist research groups can devise solutions of practical value to end users. TRANSMIT will overcome this by providing a concerted training programme including taught courses, research projects and secondments that will arm the researchers of tomorrow with the necessary skills and knowledge.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 101.31K | Year: 2015

The Internet of Things has great potential to revolutionise the way in which we deploy networked devices, and to provide networking capability to every-day objects, making them smart objects. Security should be at the core of these newly developed smart objects, but innovation is outstripping the development of security in this context. There is much emphasis on the positive side of this technology without considering the negative implications. It is not too challenging to think of many ways how the Internet of Things can be abused letting outsiders in through a digital ruse. This would include intruders gaining access to a lighting system, to remotely switch off the lights in a property, to assist in home burglary. Its also not too far of stretch to imagine an intruder turning on a cooker remotely, with the potential to cause a form of digital arson which we have never before experienced. Yes, it is amazing to be able to text your cooker so that dinner is ready when you get home. However, do we really want these features if it leaves us vulnerable to digital attack on our properties? Vast improvements need to be made in the state of the art of cyber defences in order to prepare and protect ourselves for the imminent innovations in digital technology. Novel and effective solutions in computer based security are imperative to research as current techniques may not prove effective in this new context. In order to create the next generation of cyber defence tools we must look to new sources of inspiration. One of these can be in the form of studying how this problem is solved in natural systems, in particular the defence and response mechanisms of the human immune system. Artificial immune systems (AIS) are one potential solution which may have significant impact on future cyber defence. They are designed to solve computational problems through studying natural mechanisms in immunology. Current research in AIS for computer security focuses purely on detection of anomalies, leaving the user to respond to the detected threat. Few of these systems actually produce any form of response as a result of detecting a potential intrusion. This is problematic in the Internet of Things as the responsibility would lie with the homeowner who is not a cyber security expert, leaving homes potentially vulnerable to digital intrusions. The novelty of this proposed research is to create a prototype responsive artificial immune system - RAIS, which can both detect intruders and produce appropriate responses in order to mitigate the problem of automatically responding intrusion detection systems. Persistent engagement with a cyber defence stakeholder will ensure that the prototype system is useful in cyber defence applications. Our approach to this is to perform a deep interdisciplinary study of the translation of detection to response within the human immune system by modelling immune responses. A mechanism in immunology termed the immunological synapse will be studied form the basis of a model used to create a novel blueprint for the responsive artificial immune system. This will occur through constructing agent-based models of the natural system from which these necessary properties can be abstracted by looking at how two cell types, Dendritic Cells and T-helper cells interact to produce immune responses to pathogens. We will model this interaction using knowledge already amassed by the host group, and aim to extend the research through performing further experiments to refine these models. The discipline hop is to be hosted within an immunology lab, whose research aims to understand immune mechanisms of response in order to create immunotherapies for treating cancers, by turning the immune system against detected tumour cells. Understanding of natural immune responses is key for both the future developments of artificial immune systems and also in how to use the immune system therapeutically in the fight against cancer.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2011-IRSES | Award Amount: 220.50K | Year: 2012

Proposal Full title: Biomimetic Approaches of Natural Functional Surfaces with hierarchical micro & nano structure and the extreme Wettability (Acronym: BioApproNFS Wett) Abstract: In the natural world, plants and animals have evolved over time to best adapt to the environment. They interact very effectively with the surrounding environment by exchanging energies and mass flow across their cuticles making use of specific micro structures and functions to achieve the perfect energy balance. The proposed international research staff exchange programme of BioApproNFS Wett brings together five leading universities from four different countries to collaborate in the research area of biomimetic approaches of natural functional surfaces and the extreme wettability. The aim of the proposed programme is to facilitate research staff exchange between the leading institutions in biomimetics so that complementary and synergistic skills can be acquired as per the needs and skills offered by the respective partners. These can then be exploited in the future through initiatives as part of the international joint laboratory that will be established through this project. The programme will have major benefits for early staged researchers from high education institutes and also the industrial companies from both Europe and China. Through research collaboration and staff exchanges, the state-of-the-art technologies of studying biomimetics (or bionics), such as micro scaled fabrication, functional nanoparticle coating, hierarchical micro & nano structure, and surface wettability will be studied and/or applied. Major programmes of the research staff exchanges include research visits, training for early staged researchers, and organising regular open research seminars, workshops and conferences. The dissemination and exploitation will be based on joint research publications and open seminars where the industrial community will be actively encouraged to attend.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2016 | Award Amount: 794.45K | Year: 2017

Modern aeronautical structures are increasingly made of composite materials due to their well-known benefits. Composite materials have however a wide range of possible failure modes, implying lengthy and expensive structural inspection processes for modern aircrafts. Ultrasonic guided wave technologies are nowadays confined in baseline subtraction approaches, where structural damage can be detected but not identified. This is due to lack of efficient techniques for predicting wave interaction with damage in composite structures. A genuine need is therefore identified for a programme that will: i)Develop, deliver and implement novel SHM technological tools within the European aerospace industry, ii)Nurture and train the next European generation of SHM research professionals. SAFE-FLY has an intensely intersectoral character engaging a European leading aerospace industry (ANOVA) and an academic research team at the forefront of aerospace innovation (UNOTT). It also has an intensely multi-disciplinary character, coupling expertise from mechanical, civil and electronic engineering, as well as from the area of applied mathematics. On the research side, SAFE-FLY will focus on developing multiscale models for obtaining a comprehensive description of damage in a composite structural segment. Understanding the interaction of ultrasonic GW with such nonlinear damaged segments is another scientific challenge that the Network will tackle. SAFE-FLY aims at developing reliable tools for predicting the reflection, conversion and transmission of each GW type, when impacting on the damaged section. On the training side, SAFE-FLY will provide a fully supportive environment for 3 ESRs. A training programme aiming at developing both the research as well as the transferable skills of the Fellows has been designed. All Fellows will have the opportunity to work in a multi-disciplinary environment, spending at least 50% of their time at the premises of the industrial beneficiary.

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