The University of Notre Dame du Lac is a Catholic research university located near South Bend, Indiana, in the United States. In French, Notre Dame du Lac means "Our Lady of the Lake" and refers to the university's patron saint, the Virgin Mary.The school was founded by Father Edward Sorin, CSC, who was also its first president. Today, many Holy Cross priests continue to work for the university, including as its president. It was established as an all-male institution on November 26, 1842, on land donated by the Bishop of Vincennes. The university first enrolled women undergraduates in 1972. As of 2013 about 48 percent of the student body was female. Notre Dame's Catholic character is reflected in its explicit commitment to the Catholic faith, numerous ministries funded by the school, and the architecture around campus.The university today is organized into five colleges and one professional school, and its graduate program has 15 master's and 26 doctoral degree programs. Over 80% of the university's 8,000 undergraduates live on campus in one of 29 single-sex residence halls, each of which fields teams for more than a dozen intramural sports, and the university counts approximately 120,000 alumni.The university is globally recognized for its Notre Dame School of Architecture, a faculty that teaches traditional and classical architecture and urban planning . It also awards the renowned annual Driehaus Architecture Prize.The university's athletic teams are members of the NCAA Division I and are known collectively as the Fighting Irish. The football team, an Independent, has accumulated eleven consensus national championships, seven Heisman Trophy winners, and 62 members in the College Football Hall of Fame. Other ND teams, chiefly in the Atlantic Coast Conference, have accumulated 16 national championships. Wikipedia.
University of Connecticut and University of Notre Dame | Date: 2017-07-19
Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles as well as bioinformatics techniques. The identification of immunologically protective neo-epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a method of using the conformational stability of an epitope in an MHC protein -binding groove to predict immunogenicity of peptides in a putative neo-peptide set from a tumor from a cancer patient. Pharmaceutical compositions and methods of administration are also included.
Neo Industries Llc, Ionic Research Technologies LLC and University of Notre Dame | Date: 2017-02-22
An electrolyte and a method to electroplate a metal on a substrate using the electrolyte are described. The electrolyte includes an imidazolium compound, a metal salt, and water. The imidazolium compound has formula (I) wherein R1, R2, R3, R4, and R5 are each independently selected from an H atom and an organic radical. L- is a compatible anion. The metal salt can include but is not limited to salts of the metals Li, Mg, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Pb, Bi, La, Ce, Al, Ag, Au, Ga, V, In, Nb, Mo, and W.
University of Notre Dame and Indiana Integrated Circuits, LLC | Date: 2017-04-21
First, second, and third integrated devices each include one or more interconnecting structure. Each interconnecting structure includes (i) one or more interconnecting nodules extending from an edge surface of the device, (ii) one or more interconnect voids formed in an edge surface of the device, or (iii) both (i) and (ii). The one or more interconnecting structures on each of the first and second device is mated with the one or more interconnecting structures on the second device. The first integrated device includes a signal output, the third integrated device includes a signal input; and the second integrated device includes a conductor for conducting a signal from the signal output to the signal input.
University of Notre Dame | Date: 2017-02-10
The viscosity of various ionic liquids (IL), the solvent tetraethylene glycol dimethyl ether (G4), and their mixtures, with or without lithium salts, were measured experimentally. Various compositions were studied spectroscopically. Detailed analysis reveals that G4 preferentially solvates cations, leading to a reduction in the interaction energy between cations and anions and a subsequent enhancement in anion mobility. Diffusivity and ionic conductivity of certain compositions were improved at G4 mole fractions below levels required for a solvate ionic liquid. When an IL was combined with low amounts of a 1:1 stoichiometric ratio of G4 and lithium salt, the viscosity of composition remained constant and ion mobility increased.
University of Notre Dame | Date: 2017-05-31
Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that impart s a reduction, in non-specific binding, -an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed ( wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans. Soluble modified TCRs are also provided, Therapeutic preparations comprising modified T-cells, modified TCRs, and modified TCR-therapeutic agent-conjugates, are also provided.
University of Notre Dame | Date: 2017-03-29
Disclosed are methods, compositions, and devices for an integrated, heterogeneous ion-exchange membrane-based plastic microfluidic biochip platform that can be used to detect multiple diagnostic markers present in real samples. Its various components can be easily integrated in a modular fashion for different applications. Automated control allows sequential and dynamic activation of different components on the chip. The integrated platform consists of three units and is designed to execute the following functions: (i) separation of the target biomolecules from the real sample, (ii) localizing and concentrating the targeted molecules at a specific location in the microfluidic chip, and (iii) detection of the targeted molecules using hybridization/docking events against a complementary ssDNA oligoprobe sequence or a specific antibody.
University of Notre Dame | Date: 2017-02-17
Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography. In some embodiments, the small molecule may be an indole, and in particular embodiments, the small molecule may be indole-3-butyric acid.
Indiana Integrated Circuits, LLC and University of Notre Dame | Date: 2017-03-02
First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is positioned contiguous to the first edge surface of the first integrated device. The interconnect structures disposed on the first integrated device are in physical contact with the interconnect structures disposed on the edge surface of the second integrated device so as to provide alignment for conveying at least one signal between the optical components on the first and second integrated devices.
Kamat P.V.,University of Notre Dame
Accounts of Chemical Research | Year: 2012
The demand for clean energy will require the design of nanostructure-based light-harvesting assemblies for the conversion of solar energy into chemical energy (solar fuels) and electrical energy (solar cells). Semiconductor nanocrystals serve as the building blocks for designing next generation solar cells, and metal chalcogenides (e.g., CdS, CdSe, PbS, and PbSe) are particularly useful for harnessing size-dependent optical and electronic properties in these nanostructures.This Account focuses on photoinduced electron transfer processes in quantum dot sensitized solar cells (QDSCs) and discusses strategies to overcome the limitations of various interfacial electron transfer processes. The heterojunction of two semiconductor nanocrystals with matched band energies (e.g., TiO 2 and CdSe) facilitates charge separation. The rate at which these separated charge carriers are driven toward opposing electrodes is a major factor that dictates the overall photocurrent generation efficiency. The hole transfer at the semiconductor remains a major bottleneck in QDSCs. For example, the rate constant for hole transfer is 2-3 orders of magnitude lower than the electron injection from excited CdSe into oxide (e.g., TiO 2) semiconductor. Disparity between the electron and hole scavenging rate leads to further accumulation of holes within the CdSe QD and increases the rate of electron-hole recombination. To overcome the losses due to charge recombination processes at the interface, researchers need to accelerate electron and hole transport.The power conversion efficiency for liquid junction and solid state quantum dot solar cells, which is in the range of 5-6%, represents a significant advance toward effective utilization of nanomaterials for solar cells. The design of new semiconductor architectures could address many of the issues related to modulation of various charge transfer steps. With the resolution of those problems, the efficiencies of QDSCs could approach those of dye sensitized solar cells (DSSC) and organic photovoltaics. © 2012 American Chemical Society.
Hartland G.V.,University of Notre Dame
Chemical Reviews | Year: 2011
The fundamental optical properties of metal nanoparticles, the dynamics that occur following absorption of photons, are studied. The spectra of metal nanoparticles are dominated by the localized surface plasmon resonance (LSPR) and the position of the LSPR depends on the size and shape of the particles, their composition, and the properties of the environment. Link and co-workers examined nanorods with aspect ratios between 2 and 3, and widths between 30 and 120 nm and observed a significant broadening and red-shifting of the dipolar longitudinal LSPR with increasing width. Transient absorption data for different sized Ag particles taken over a slightly longer time range show that decay in the signal arises from energy loss from the electron distribution because of electron-phonon coupling. The vibrational periods measured in the transient absorption experiments are found to depend on the intensity of the pump laser.