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Winston-Salem, NC, United States

The University of North Carolina School of the Arts is a public coeducational arts conservatory in Winston-Salem, North Carolina that grants high school, undergraduate and graduate degrees. It is one of the seventeen constituent campuses of the University of North Carolina. Founded in 1963 as the North Carolina School of the Arts by then-Governor Terry Sanford, it was the first public arts conservatory in the United States. The school owns and operates the Stevens Center in Downtown Winston-Salem and is accredited by the Southern Association of Colleges and Schools. Wikipedia.

Hoenig M.P.,Beth Israel Deaconess Medical Center | Hoenig M.P.,Harvard University | Shapiro E.,American Society of Nephrology | Hladik G.A.,University of North Carolina School of the Arts | Hladik G.A.,University of North Carolina at Chapel Hill
Clinical Journal of the American Society of Nephrology | Year: 2013

Nephrology ranks next to last in career choices among US medical school graduates. The American Society of Nephrology established a Workforce Committee to help address this issue. Surveys of US medical students indicate that experiences during kidney pathophysiology courses in the preclerkship yearsmay impact their decision to consider a career in nephrology. InOctober of 2011, preclinical kidney physiology and pathophysiology course directors at US medical schools were surveyed about teaching methods, curricular content, resources, and institutional support for teaching to identify what worked well and what impairs their teaching efforts. A Listserv of these educators, the American Society of Nephrology Renal Educators Listserv, was used to electronically administer the survey. Course leaders from 62 of 114 (54.4%) surveyed medical schools responded. Most of these educators are nephrologists, but physiologists and other clinicians also lead courses; 60% of course directors noted that lectures are videotaped, resulting in decreased attendance. A range of resources is used: 68% use audience response systems, 16% use the simulation center, and none of the educators indicated use of social media (such as Twitter or Facebook); 50%of respondents receive no remuneration, and 68%receive no full-time equivalent for their efforts. Audience response systems, virtual microscopy, and flash animations were identified as valuable teaching tools. Course directors, during subsequent dialogue on the American Society of Nephrology Renal Educators Listserv, have cited incorporation of case scenarios and integration of clinical exposure during preclinical years asmethods that inspired interest. Hopefully, adoption of such approaches will ultimately serve to stimulate interest in nephrology. © 2013 by the American Society of Nephrology. Source

Jonas D.E.,University of North Carolina School of the Arts
North Carolina medical journal | Year: 2013

Pharmacogenomics offers the hope of greater individualization of treatment. Therapies that exemplify the promise of pharmacogenomics include anticoagulation with warfarin and the use of antiplatelet medications (eg, clopidogrel) for secondary prevention after acute coronary syndrome. Good evidence of clinical utility must be obtained before pharmacogenomic testing is widely implemented. Source

Meltzer E.O.,Allergy and Asthma Medical Group and Research Center | Kuna P.,Medical University of Lodz | Nolte H.,Sharp Corporation | Nayak A.S.,Wheeze and Itch Associates LLC | LaForce C.,University of North Carolina School of the Arts
European Respiratory Journal | Year: 2012

This study evaluated the effect of mometasone furoate (MF)/formoterol (F) versus its monocomponents, each administered via metered-dose inhaler, on asthma deteriorations and lung function. This 26-week, multicentre, double-blind, placebo-controlled study included subjects aged ≥ 12 yrs with not well-controlled asthma on low-dose inhaled corticosteroids. After a 2-3-week open-label runin (MF 100 μg b.i.d.), 746 subjects were randomised to receive placebo, F 10 μg, MF 100 μg or MF/F 100/10 μg b.i.d. Co-primary end-points were time to first asthma deterioration (MF/F versus F to assess effect of MF) and change in forced expiratory volume in 1 s (FEV1) area under the curve of serial spirometry measurements over the 12-h period following the morning dose (AUC0-12h) (baseline to week 12; MF/F versus MF to assess effect of F). The therapeutic effect of MF in the combination was demonstrated by a reduction in asthma deterioration incidence with MF/F versus F and a delayed time to first asthma deterioration (p<0.001). Asthma deterioration incidence was also reduced with MF/F versus MF (p50.006). The therapeutic effect of F in the combination was demonstrated by MF/F versus MF in FEV1 AUC0-12h change (4.00 versus 2.53 L·h, respectively; p50.001). MF/F treatment also resulted in a marked improvement in health-related quality of life. MF/F 100/10 μg b.i.d. treatment showed greater clinical efficacy than its individual components or placebo; both components contributed to the efficacy of MF/F. Copyright©ERS 2012. Source

Lazaro-Munoz G.,University of North Carolina School of the Arts
Journal of Law, Medicine and Ethics | Year: 2014

This paper examines how the application of legal fiduciary principles (e.g., physicians' duty of loyalty and care, duty to inform, and duty act within the scope of authority), can serve as a framework to promote management of clinical genomic "incidental" or secondary target findings that is patient-centered and consistent with recognized patient autonomy rights. The application of fiduciary principles to the clinical genomic testing context gives rise to at least four physician fiduciary duties in conflict with recent recommendations by the American College of Medical Genetics and Genomics (ACMG). These recommendations have generated much debate among lawyers, clinicians, and bioethicists hence I believe this publication will be of value and interest to your readership. © 2014 American Society of Law, Medicine & Ethics, Inc. Source

Olbert C.M.,Fordham University | Gala G.J.,University of North Carolina School of the Arts | Tupler L.A.,Duke University
Journal of Abnormal Psychology | Year: 2014

Heterogeneity within psychiatric disorders is both theoretically and practically problematic: For many disorders, it is possible for 2 individuals to share very few or even no symptoms in common yet share the same diagnosis. Polythetic diagnostic criteria have long been recognized to contribute to this heterogeneity, yet no unified theoretical understanding of the coherence of symptom criteria sets currently exists. A general framework for analyzing the logical and mathematical structure, coherence, and diversity of Diagnostic and Statistical Manual diagnostic categories (DSM-5 and DSM-IV-TR) is proposed, drawing from combinatorial mathematics, set theory, and information theory. Theoretical application of this framework to 18 diagnostic categories indicates that in most categories, 2 individuals with the same diagnosis may share no symptoms in common, and that any 2 theoretically possible symptom combinations will share on average less than half their symptoms. Application of this framework to 2 large empirical datasets indicates that patients who meet symptom criteria for major depressive disorder and posttraumatic stress disorder tend to share approximately three-fifths of symptoms in common. For both disorders in each of the datasets, pairs of individuals who shared no common symptoms were observed. Any 2 individuals with either diagnosis were unlikely to exhibit identical symptomatology. The theoretical and empirical results stemming from this approach have substantive implications for etiological research into, and measurement of, psychiatric disorders. © 2014 American Psychological Association. Source

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