The University of North Carolina at Chapel Hill is a coeducational public research university located in Chapel Hill, North Carolina, United States. North Carolina has been consistently listed among the highest and best ranked universities in the United States and is one of the original eight Public Ivy schools that provide an Ivy League experience for a public schooling price. After being chartered in 1789, the university first began enrolling students in 1795, which allows it to be one of three schools to claim the title of the oldest public university in the United States.The first public institution of higher education in North Carolina, the school opened its doors to students on February 12, 1795. The university offers degrees in over 70 courses of study through fourteen colleges and the College of Arts and science. All undergraduates receive a liberal arts education and have the option to pursue a major within the professional schools of the university or within the College of Arts and science from the time they obtain junior status. Under the leadership of President Kemp Plummer Battle, in 1877 North Carolina became coeducational and began the process of desegregation in 1951 when African-American graduate students were admitted under Chancellor Robert Burton House. In 1952, North Carolina opened its own hospital, UNC Health Care, for research and treatment, and has since specialized in cancer care. The school's students, alumni, and sports teams are known as "Tar Heels".The campus of North Carolina is located in Chapel Hill, North Carolina, a university town. The campus covers a rather small 729 acres over Chapel Hill's downtown area, encompassing places like the Morehead Planetarium and the many stores and shops located on Franklin Street. Students can participate in over 550 officially recognized student organizations. The student-run newspaper The Daily Tar Heel has won national awards for collegiate media, while the student radio station WXYC provided the world's first internet radio broadcast. North Carolina is one of the charter members of the Atlantic Coast Conference, which was founded on June 14, 1953. Competing athletically as the Tar Heels, North Carolina has achieved great success in sports, most notably in men's basketball, women's soccer, and women's field hockey. Wikipedia.
Entegrion and University of North Carolina at Chapel Hill | Date: 2017-02-22
The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding. (Drawing Figure 1)
GeneCentric Diagnostics and University of North Carolina at Chapel Hill | Date: 2017-04-05
Methods and compositions are provided for the molecular subtyping of lung cancer samples. Specifically, a method of assessing whether a patients lung cancer subtype is adenocarcinoma, squamous cell carcinoma, or a neuroendocrine (encompassing both small cell carcinoma and carcinoid) is provided herein. A method for assessing whether a patients lung cancer subtype is adenocarcinoma, squamous cell carcinoma, small cell carcinoma or carcinoid lung cancer is also provided. The methods provided herein entail probing the levels of the classifier biomarkers of Table 1-Table 6 or a subset thereof at the nucleic acid level, in a lung cancer sample obtained from the patient. Based in part on the levels of the classifier biomarkers, the lung cancer sample is classified as a particular lung cancer subtype.
University of North Carolina at Chapel Hill | Date: 2017-02-15
The present invention includes pyrrolopyrimidine compounds that selectively inhibit Mer tyrosine kinase (MerTK) activity and/or Tyro3 tyrosine kinase activity, and use of these pyrrolopyrimidine compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
University of North Carolina at Chapel Hill | Date: 2017-02-15
The present invention includes pyrimidine compounds that selectively inhibit Mer tyrosine kinase (MerTK) activity and/or Tyro3 tyrosine kinase activity, and use of these pyrimidine compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
University of North Carolina at Chapel Hill | Date: 2017-03-08
A universal strike plate system for use on a strike jamb is provided. The strike plate system may include a face plate. The face plate may include a back surface configured for mounting the strike plate saddle onto the strike jamb; a strike plate seat for mounting a strike plate to the strike plate seat, wherein strike plate seat is recessed relative to a front face of the face plate as a recessed area of a front face surface; and an elongated vertical side forming an open side of the strike plate seat configured to receive a latch or bolt mounted on a door. The strike plate seat defines a primary through hole to receive the latch or the bolt, and the strike plate seat further defines at least two secondary through holes configured to receive fastening members so as to mount said strike plate saddle onto said strike jamb.
University of North Carolina at Chapel Hill | Date: 2017-03-15
Described herein are methods for treating preterm labor, stopping labor prior to Cesarean delivery, preventing preterm labor, or controlling the timing of parturition by administering a chemical compound, such as a muscarinic receptor antagonist preferably a M, receptor antagonist, or a -3 adrenergic agonist. Also described are methods for treating preterm labor, stopping labor preparatory to Cesarean delivers, preventing preterm labor, or controlling the timing of parturition by administering an effective amount of transdermal stimulation, posterior tibial nerve stimulation or another form of non-invasive or invasive neuromodulatton, unstimulated or stimulated acupuncture, magnetic field therapy, or vibratory stimulation. These methods may be practiced individually, in combination with each other, or in combination with known tocolytic methods or medications.
University of North Carolina at Chapel Hill, Roach and Malavarca | Date: 2017-09-13
University of North Carolina at Chapel Hill | Date: 2017-09-27
The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.
Roth B.L.,University of North Carolina at Chapel Hill
Neuron | Year: 2016
To understand brain function, it is essential that we discover how cellular signaling specifies normal and pathological brain function. In this regard, chemogenetic technologies represent valuable platforms for manipulating neuronal and non-neuronal signal transduction in a cell-type-specific fashion in freely moving animals. Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are now commonly used by neuroscientists to identify the circuitry and cellular signals that specify behavior, perceptions, emotions, innate drives, and motor functions in species ranging from flies to nonhuman primates. Here I provide a primer on DREADDs highlighting key technical and conceptual considerations and identify challenges for chemogenetics going forward. Here a primer for the use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) by neuroscientists is provided. The review highlights current DREADDs and their uses as well as areas for technological improvements. © 2016 Elsevier Inc.
Hammond S.M.,University of North Carolina at Chapel Hill
Advanced Drug Delivery Reviews | Year: 2015
The discovery of the first microRNA (miRNA) over 20. years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches. © 2015 Elsevier B.V.