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Matera A.G.,University of North Carolina | Wang Z.,University of North Carolina at Chapel Hill
Nature Reviews Molecular Cell Biology | Year: 2014

One of the most amazing findings in molecular biology was the discovery that eukaryotic genes are discontinuous, with coding DNA being interrupted by stretches of non-coding sequence. The subsequent realization that the intervening regions are removed from pre-mRNA transcripts via the activity of a common set of small nuclear RNAs (snRNAs), which assemble together with associated proteins into a complex known as the spliceosome, was equally surprising. How do cells coordinate the assembly of this molecular machine? And how does the spliceosome accurately recognize exons and introns to carry out the splicing reaction? Insights into these questions have been gained by studying the life cycle of spliceosomal snRNAs from their transcription, nuclear export and re-import to their dynamic assembly into the spliceosome. This assembly process can also affect the regulation of alternative splicing and has implications for human disease. © 2014 Macmillan Publishers Limited.

News Article | February 28, 2017
Site:, a leading career and education website focused on graduate programs in accounting and finance, has released its ranking of the Top Online Master’s in Accounting Programs. To be considered for the list, schools with an online master’s in accounting program were checked for not-for-profit status and accreditation from one of the six regional accreditation agencies in the US recognized by the US Department of Education. The online degrees from the schools on the list are also the same degrees granted to traditional, on-campus students. The rankings were based on factors measuring academic quality, student experience, and graduate success. The ranking uses a unique methodology that considers such factors as the average tuition cost per online credit hour; program accreditation by the AACSB, ACBSP, or IACBE; the average mid-career pay of alumni; and school rankings according to US News & World Report in the regional, national, and online categories. Rob Voce, founder of, said about the list: “Enrollment in online degree programs is increasing and schools are responding by offering more distance education programs at the graduate level - which can be particularly convenient for those who are already working full-time. Our ranking is designed to help these prospective students learn about and compare first-rate online master’s in accounting programs that offer long-term value.” Overall, 37 schools with online master’s in accounting programs satisfied the inclusion requirements and ranked on this list. Auburn University, in Auburn, Alabama, captured the top spot on the list, followed by the University of North Carolina at Chapel Hill in the second spot. As well as providing schools’ results on ranking factors, the Top Online Master’s in Accounting Programs list includes detailed information on schools’ admissions statistics and requirements as well as tuition comparisons. For the top-ranking schools the list also provides: The top schools on this year’s list are: 1. Auburn University Raymond J. Harbert College of Business (Auburn, AL) 2. University of North Carolina Kenan-Flagler Business School (Chapel Hill, NC) 3. University of Connecticut School of Business (Storrs, CT) 4. University of Massachusetts Amherst Isenberg School of Management (Amherst, MA) 5. Pennsylvania State University World Campus (State College, PA) 6. University of Southern California Marshall School of Business (Los Angeles, CA) 7. Emporia State University School of Business (Emporia, KS) 8. Rutgers, The State University of New Jersey Business School (New Brunswick, NJ) 9. Colorado State University College of Business (Fort Collins, CO) 10. University of Alabama at Birmingham Collat School of Business (Birmingham, AL) 11. University of Texas at Dallas Naveen Jindal School of Business (Richardson, TX) 12. St. John’s University Peter J. Tobin College of Business (Jamaica, NY) 13. Georgia Southern University College of Business Administration (Statesboro, GA) 14. Northeastern University D’Amore-McKim School of Business (Boston, MA) 15. DePaul University Kellstadt Graduate School of Business (Chicago, IL) 16. Golden Gate University Edward S. Ageno School of Business (San Francisco, CA) 17. Southern New Hampshire University College of Online and Continuing Education (Hooksett, NH) 18. California State University, Sacramento College of Business Administration (Sacramento, CA) 19. University of Scranton Kania School of Management (Scranton, PA) 20. Syracuse University Martin J. Whitman School of Management (Syracuse, NY) 21. University of Hartford Barney School of Business (West Hartford, CT) 22. University of Miami School of Business Administration (Coral Gables, FL) 23. George Mason University School of Business (Fairfax, VA) 24. University of South Dakota Beacom School of Business (Vermillion, SD) 25. Florida Atlantic University College of Business (Boca Raton, FL) 26. Stetson University M.E. Rinker Sr. Institute of Tax and Accountancy (DeLand, FL) 27. Rider University College of Business Administration (Lawrenceville, NJ) 28. New England College School of Graduate and Professional Studies (Henniker, NH) 29. Western Governors University (Salt Lake City, UT) 30. Indiana Wesleyan University DeVoe School of Business (Marion, IN) 31. Plymouth State University College of Business Administration (Plymouth, NH) 32. Bellevue University College of Business (Bellevue, NE) 33. Loyola University Chicago Quinlan School of Business (Chicago, IL) 34. Franklin University Ross College of Business (Columbus, OH) 35. Nova Southeastern University Huizenga College of Business (Fort Lauderdale, FL) 36. Saint Mary’s University Graduate School of Business and Technology (Winona, MN) 37. Baypath University School of Science & Management (Longmeadow, MA) *See the full rankings and program details here: About is a free online resource focused on providing accurate and up-to-date information on degrees, programs, and schools for prospective master’s in accounting students. The site also provides additional resources such as career outlooks, graduate student guides, scholarships, and more.’s goal is to be best in class.

Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 428.16K | Year: 2011

DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is the most common life shortening inherited disorder amongst Caucasians, and Pseudomonas aeruginosa pulmonary infections are the leading cause of mortality in CF patients. Treatment of patients infected with P. aeruginosa is complicated by the cell-to-cell signaling systems of this organism, which regulate biofilm formation, virulence genes, and antibiotic resistance genes such as efflux pumps. These mechanisms augment bacterial resistance to both antibiotics and host defense, causing a vicious cycle in which the body's immune system continuously mounts an unproductive assault on bacterial infection, resulting in chronic inflammation, tissue damage, and eventually respiratory failure. The co-foundersof Agile Sciences, Inc. have discovered simple derivatives of sponge-derived marine natural products with unprecedented activity toward inhibiting and dispersing bacterial biofilms. These Agilyte compounds work synergistically with antibiotics to reducebacterial growth and lower the MICs of antibiotics toward antibiotic-resistant bacteria. In preliminary work, Agilyte molecules have shown efficacy toward: 1) inhibiting and dispersing biofilms of P. aeruginosa at low-micromolar concentrations and 2) working synergistically with tobramycin to stop growth of P. aeruginosa in broth culture. The goal of this proposal is to assess the efficacy of Agile Sciences' lead Agilyte compounds in an in vivo mouse model of chronic P. aeruginosa infection developed by Dr. Richard Boucher at UNC Chapel Hill. To this end, the Specific Aims of this Phase I STTR Project are: 1. To perform advanced in vitro studies of 5 Agilyte compounds to inform lead compound selection for in vivo studies. 2. To evaluate efficacy of two leadcompounds selected in Specific Aim #1 in the Boucher mouse model of chronic P. aeruginosa pulmonary infection. Dr. Laura Guogas, a microbiologist with expertise in cystic fibrosis pulmonary disease, will lead the in-house efforts t Agile Sciences as wellas coordinate a team of expert collaborators. Testing of Agilyte molecules in vivo will be conducted in the laboratory of the co-PI, Dr. Richard Boucher, the Kenan Professor of Medicine and Cystic Fibrosis and Pulmonary Research and Treatment Center Director at UNC. Guidance on preclinical development of the Agilyte molecules will be provided by Dr. Ward Peterson, former Vice President of Research and Preclinical Development at Inspire Pharmaceuticals, a biotechnology company formerly focused on CF therapeutics. Agile co-founder Dr. Christian Melander will provide expertise on the biological properties of the Agilyte molecules. This multidisciplinary team will work cooperatively to assess the potential of Agile's novel technology to decrease P. aeruginosa proliferation under in vivo conditions relevant to the CF lung. If successfully developed, our proposed therapeutic has the potential to modulate the significant mortality and morbidity associated with CF disease through the eradication of chronic bacterialinfection. PUBLIC HEALTH RELEVANCE: Developing therapeutics to treat cystic fibrosis (CF) is especially challenging due to the formation of communities of bacteria called biofilms in the lungs of cystic fibrosis patients. Agile Sciences is developing molecules that both inhibit and disperse bacterial biofilms and thus have the potential to significantly enhance the effectiveness of antibiotic therapy for CF. An improved treatment for CF has the potential to both extend the life expectancy and improve the quality of life for the hundreds of thousands of individuals worldwide who are living with CF.

Majchrzak A.,University of Southern California | Malhotra A.,University of North Carolina
Journal of Strategic Information Systems | Year: 2013

Recent years have seen an increasing emphasis on open innovation by firms to keep pace with the growing intricacy of products and services and the ever changing needs of the markets. Much has been written about open innovation and its manifestation in the form of crowdsourcing. Unfortunately, most management research has taken the information system (IS) as a given. In this essay we contend that IS is not just an enabler but rather can be a shaper that optimizes open innovation in general and crowdsourcing in particular. This essay is intended to frame crowdsourcing for innovation in a manner that makes more apparent the issues that require research from an IS perspective. In doing so, we delineate the contributions that the IS field can make to the field of crowdsourcing. © 2013 Elsevier B.V. All rights reserved.

Agency: Department of Defense | Branch: Navy | Program: STTR | Phase: Phase I | Award Amount: 150.00K | Year: 2012

Chalcogenide glass fibers are extensively used for delivery of mid-infrared (2 to 5 micron) laser wavelengths. They are needed for development of next-generation directed infrared countermeasure (DIRCM) systems. These new systems will have a reduction of both weight and size allowing their installation in vehicle and aircraft with stringent weight and size requirements. These fibers have industrial uses, such as remote sensing, environmental monitoring, and spectroscopy. Chalcogenide fibers, however, lose about 50% transmission beyond ~ 10 meters and suffer from low mechanical strength passing the 15 kpsi tensile proof test. The main contributors to the loss level and mechanical strength are the various impurities in the glass, and contaminant exposure and imperfections introduced during the fiber draw. Therefore, to obtain good fiber transmission over 10 meters and improved mechanical properties, a novel manufacturing process will be developed. The proposed work will demonstrate the feasibility and plan of developing an innovative manufacturing process for producing improved chalcogenide glass fibers. This new process will bring modification to both glass and fiber production processes. The new manufacturing technology will enable production of optical fibers with losses below 0.15 dB/m and tensile proof strength at 20 kpsi or greater.

News Article | February 28, 2017

Tanning devices cost the US $343.1 million a year in medical costs because of the skin cancers their use is associated with, according to a new study published in the Journal of Cancer Policy. In a new study, Dr. Hugh Waters and his colleagues from the University of North Carolina established how prevalent indoor tanning-related skin cancers are in the US, and calculated the costs of these diseases. They estimate that in 2015 there were 263,600 cases of skin cancer that could be attributed to indoor tanning. These cases cost US $343.1 million in medical costs in 2015, and cause a total economic loss of $127 billion over the lifetime of the people affected. The authors conclude that effective policies and strategies are needed to reduce the use of tanning devices, in order to mitigate their significant health and financial impacts. There is strong evidence that tanning devices cause skin cancer. They emit UV radiation; UV-A damages cells and DNA, causing skin cancer, and UV-B causes burning and contributes to skin cancer. In addition, there are several other diseases linked to indoor tanning, including dermatitis, keratitis and porokeratosis. Despite this, the proportion of people in the US who use indoor tanning devices has risen over the last 20 years; an estimated 30 million people now use the devices at least once a year, in the approximately 25,000 tanning salons across the country. "Skin cancer is the most common cancer in the US and its incidence is increasing, due in part to the increase in the use of tanning devices," said Dr. Waters. "We know these devices have significant health and financial impacts, and with this study we wanted to establish these impacts clearly to support efforts to reduce their use, especially among younger people." The researchers focused on three types of skin cancer: cutaneous melanoma, basal cell carcinoma and squamous cell carcinoma. They identified the total number of cases in the US in 2015 and worked out how many of these cases were likely due to the use of tanning devices, by using data on prevalence of use of tanning devices and previously published estimates of relative risk - the likelihood of having the disease for people who use tanning devices compared to people who don't. There were 9,000 cases of melanoma, 86,600 cases of squamous cell carcinoma and 168,000 cases of basal cell carcinoma that could be attributed to the use of tanning devices. They then estimated the healthcare cost of these cases, based on the average annual cost of treating patients with each of the diseases. This resulted in an estimated cost of US $343.1 million a year in medical costs. By working out the years of potential life lost due to the diseases, and the average lost earnings per person, they also determined the cost of working time missed due to the conditions. These productivity losses amounted to US $127 billion over the lifetime of the people who had the conditions attributable do tanning devices in 2015. "Our calculations are all conservative, so this is the lower end of the estimate - the impact could be even higher than this," said Dr. Waters. "Tanning devices cause hundreds of thousands of people to suffer a number of different diseases, costing billions of dollars and, most importantly, people's lives. We hope that our results will help in the efforts toward reducing the use of tanning devices." The article is "The Health and Economic Implications of the Use of Tanning Devices," by Hugh R. Waters (doi:10.1016/j.jcpo.2016.12.003). It appears in the Journal of Cancer Policy, volume 12 (2017), published by Elsevier. Copies of this paper are available to credentialed journalists upon request; please contact Elsevier's Newsroom at or +31 20 485 2492. The Journal of Cancer Policy is an international journal which publishes research and reviews on global cancer policy. The journal encompasses all aspects of cancer policy and public health, including: health economics related to cancer; drug development, including cost and regulatory issues; drug and lifestyle mediated prevention of cancer; the management of cancer in low, middle and high income countries; inequalities in cancer care; priorities for cancer policy development; cancer systems and organization of care, research and education; social determinants of cancer; political economy of cancer; and the role of patient advocacy groups in cancer policy. Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions -- among them ScienceDirect, Scopus, Research Intelligence and ClinicalKey -- and publishes over 2,500 journals, including The Lancet and Cell, and more than 35,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group, a world-leading provider of information and analytics for professional and business customers across industries. http://www.

Agency: Department of Defense | Branch: Air Force | Program: STTR | Phase: Phase I | Award Amount: 99.61K | Year: 2012

As recent technology trends usher us into the many-core era, novel techniques are needed for high-performance applications to exploit massive local concurrency. To position software applications to run faster on machines with more cores requires substantial restructuring of software applications, middleware, and the operating system. Contemporary operating systems are not designed to run on hundreds or thousands of cores. New operating system mechanisms must be developed to handle scheduling, resource sharing, and communication in a many-core system. The solution must help the application developer create concurrent software and must be easy to use. Real-Time Innovations (RTI) and the University of North Carolina (UNC) Real-Time Systems Group are teaming together to create mechanisms for scheduling and communication for many-core systems that is scalable, high-performance, and adaptable. Our solution has three key innovations: a component architecture, a smart scheduler, and a high-throughput communication infrastructure. The component architecture will help developers to partition applications into concurrent components. The smart scheduler will assign components to clusters of cores to efficiently use the underlying processing capacity. Finally, the high-throughput communication infrastructure will optimize data transfer between components. Our solution will be implemented in Data Distribution Service (DDS) middleware to simplify application development.

Pavelsky T.M.,University of North Carolina
Hydrological Processes | Year: 2014

Remote estimation of river discharge from river width variations is an intriguing method for gauging rivers without conventional measurements. Entirely cloud-free imagery of an entire river reach is often rare, but partial coverage is more frequent. Discharge is estimated from spatially discontinuous imagery via construction of multiple width-discharge rating curves within a 62-km reach of the Tanana River, Alaska. The resulting discharge error is as low as 6.7% root mean squared error. Imagery covering <20% of the study reach can be used. © 2014 John Wiley & Sons, Ltd.

Fisher J.A.,University of North Carolina
Sociology of Health and Illness | Year: 2015

The first stage of testing new pharmaceuticals in humans is referred to as a phase I clinical trial. The purpose of these studies is to test the safety of the drugs and to establish appropriate doses that can later be given to patients. Most of these studies are conducted under controlled, in-patient conditions using healthy volunteers who are paid for their participation. To explore healthy volunteers' experiences in clinical trials, an ethnographic study was conducted at six in-patient phase I clinics in the USA. In addition to the observation of clinic activities (from informed consent procedures to dosing to blood draws), 268 semi-structured interviews were conducted, 33 with clinic staff and 235 with healthy volunteers. Drawing on this dataset, this article explores healthy volunteers' exchange of contemporary legends about phase I clinical trials. In addition to potentially scaring the listener and communicating distrust in the medical community, these incredible stories help participants cope with perceived stigma and establish a gradient of risk of trial participation, creating potential boundaries to their participation in medical research. The article argues that contemporary legends play a productive role in society, shaping how people view themselves and others and influencing their decisions about risky activities. © 2015 Foundation for the Sociology of Health & Illness/John Wiley & Sons Ltd.

Agency: Department of Defense | Branch: Army | Program: STTR | Phase: Phase II | Award Amount: 500.00K | Year: 2015

Clinical monitoring of mental health status has not evolved much from the routine meeting between patient and clinician, which suffers from a lack of quantification, irregular and anecdotal reporting, and does not necessarily include input from family. This is unfortunate given current technology, in which people routinely volunteer to track their own health related behavior, such as exercise and sleep, via smartphone. This same technology could be used by clinicians to improve the timeliness, accuracy, and quality of care, in part by leveraging input from family, as well as patients. To address this opportunity, we propose SupportTeam, a mobile application that collects, analyzes, and monitors the input about the status and behavior of patients suffering from PTSD/TBI. SupportTeam is novel because it includes input from family, as well as patients, and uses statistical techniques to help personalize, analyze, and focus treatment. Data and results will be securely transmitted and stored, for processing and subsequent clinical review. In addition to building SupportTeam, we will conduct an experimental trial to measure its impact on providers, patients, and families in the context of cognitive behavioral therapy for veterans with PTSD.

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