The Nice Sophia Antipolis University is a university located in Nice, France and neighboring areas. It was founded in 1965 and is organized in eight faculties, two autonomous institutes and an engineering school. It also hosts the very first WWW Interactive Multipurpose Server . Wikipedia.
Gallet A.,University of Nice Sophia Antipolis
Trends in Cell Biology | Year: 2011
A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule required for numerous processes during animal development. Emphasizing the importance of this molecule for both growth control and patterning, Hedgehog signaling activity is often deregulated during cancer formation and progression. The secretion and spread of Hedgehog are not passive processes, but require accessory molecules involved in Hedgehog processing, release, spread and reception. In this review, I focus on the factors that are required to control the spread and activity of Hedgehog, highlighting recent data that have shed light on these processes. © 2010 Elsevier Ltd. Source
University of Nice Sophia Antipolis | Date: 2014-03-14
The invention relates to an AMPK activator (such as for instance metformin) for use in preventing metastasis in a patient suffering from a cancer, wherein said patient has a non-mutated p53 gene or lacks a mutant form of the p53 protein. The invention also relates to an AMPK activator for use in improving the survival time of a patient suffering from a cancer, wherein said patient has a non-mutated p53 gene or lacks a mutant form of the p53 protein.
University of Nice Sophia Antipolis | Date: 2013-02-28
The invention relates to an in vitro analysis method for predicting resistance to azacitidine treatment in a patient, using the BCL2L10 protein contained in a sample of biological fluid taken from said patient, and also biological molecules which specifically bind the BCL2L10 protein. It is characterized in that a sample of biological fluid is recovered from a patient; the percentage of total cells in said biological fluid expressing the BCL2L10 protein is calculated; this calculated percentage is compared with a reference threshold value, this threshold value being between 20% and 60%; and resistance to azacitidine treatment is diagnosed in a patient who has a percentage of cells expressing the BCL2L10 protein in said biological fluid which is greater than said reference value.
Institute Curie, French National Center for Scientific Research, University Pierre, Marie Curie and University of Nice Sophia Antipolis | Date: 2013-11-29
The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques
University of Nice Sophia Antipolis and French National Center for Scientific Research | Date: 2013-10-23
A method and system for storing a multi-dimensional digital data object is provided. A multi-scale transform function is applied to the multi-dimensional object to generate a plurality of high and low frequency data sub-bands. High frequency data sub-bands are rotated in one or several of the multi-dimensions. The rotated and the non-rotated data sub-bands are assembled into a data bit stream. The multi-dimensional digital data object is then saved as a data bit stream. The method and system allows applying a reverse method to the data bit stream to reconstruct the multi-dimensional digital data object.