University of Nice Sophia Antipolis
Nice, France

The Nice Sophia Antipolis University is a university located in Nice, France and neighboring areas. It was founded in 1965 and is organized in eight faculties, two autonomous institutes and an engineering school. It also hosts the very first WWW Interactive Multipurpose Server . Wikipedia.

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Chanel Parfums Beaute, French National Center for Scientific Research and University of Nice Sophia Antipolis | Date: 2016-11-25

An alcoholic extract of aerial parts of Solidago virgaurea subsp. alpestris, the method of production thereof, a cosmetic or dermatological composition containing it, as well as cosmetic and dermatological uses thereof, notably in the treatment of signs of skin ageing.

Naturex, Societe Francaise Dingenierie Appliquee Aux Cosmetiques, French National Center for Scientific Research, Agence Conseil Pour La Phytotherapie Et Laromatherapie and University of Nice Sophia Antipolis | Date: 2015-03-20

The invention relates to an extract of Santolina chamaecyparissus, to a process for preparing said extract, to a composition comprising it, and to its use a preservative, particularly as antioxidant, bactericidal and/or fungicidal.

French National Center for Scientific Research and University of Nice Sophia Antipolis | Date: 2017-01-18

The method for detecting a moving object comprises: generating a plurality of fields of view (Zkp) by means of a first telescope array (Tij), the set of fields (FOVij) of each telescope (Tij) having a spatial distribution inscribed in a conical crown (CC) of a defined spatial plane (PO) called the optical plane, said optical plane being nonparallel to at least one of the optical axes (AO(Tij)) of a telescope (Tij) and said conical crown (CC) having a diameter defining a large detection field; detecting at least one trace of a moving object (M1) in the field (FOVij) of at least one telescope (Tij) using an electronic detector (Tij), the integration time of the electronic detector being defined so that the trace extends over a plurality of pixels for a given maximum orbital speed (VM) of the moving object and a minimum altitude of its orbit; and deducing a trajectory (TJSAT) of the moving object (M1).

French National Center for Scientific Research and University of Nice Sophia Antipolis | Date: 2015-05-19

Antenna system comprising at least two radiating elements, a first line for neutralising electromagnetic coupling between the at least two radiating elements, at least one radiofrequency power supply line for each radiating element and at least one short-circuiting line to a ground plane of the antenna system per radiating element, characterised in that the antenna system further comprises: at least one second line for neutralising electromagnetic coupling between said at least two radiating elements; elements for activating at least some of the neutralisation lines; and in that the activation elements are configured to selectively activate or deactivate at least some of the neutralisation lines, in such a way that depending on the activation/deactivation thereof the neutralisation lines provide a maximum neutralisation of the electromagnetic coupling of the radiating elements for a plurality of different frequencies.

Nilius B.,Catholic University of Leuven | Honore E.,University of Nice Sophia Antipolis
Trends in Neurosciences | Year: 2012

Opening of stretch-activated ion channels (SACs) is the earliest event occurring in mechanosensory transduction. The molecular identity of mammalian SACs has long remained a mystery. Only very recently, Piezo1 and Piezo2 have been shown to be essential components of distinct SACs and moreover, purified Piezo1 forms cationic channels when reconstituted into artificial bilayers. In line with these findings, dPiezo was demonstrated to act in the Drosophila mechanical nociception pathway. Finally, the 3D structure of the two-pore domain potassium channel (K2P), TRAAK [weakly inward rectifying K+ channel (TWIK)-related arachidonic acid stimulated K+ channel], has recently been solved, providing valuable information about pharmacology, selectivity and gating mechanisms of stretch-activated K+ channels (SAKs). These recent findings allow a better understanding of the molecular basis of molecular and cellular mechanotransduction. © 2012 Elsevier Ltd.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-22-2015 | Award Amount: 6.87M | Year: 2016

Mental, cognitive, vision and hearing health problems in elderly people are amongst the top 10 public health challenges in Europe. They frequently occur co-concurrently and have an additive negative effect on quality of life and mental well-being. To address this negative impact, and promote mental well-being, particularly from a gender and minority community perspective, SENSE-Cogs aim is to: (1) understand the inter-relationship of sensory impairments and cognitive and mental health functioning; (2) identify novel means of screening/detection for diagnostic and therapeutic purposes; and (3) translate this knowledge into clinical applications for the mental well-being of EU citizens. Methods: SENSE-Cog will use a mixed methods approach with a trans-EU, UK-led, multidisciplinary collaboration of 7 EU countries with academics, SMEs, city government and patient-public voice members. We will deliver linked Work Packages (WPs) reflecting 7 themes: (1) exploration: an epidemiological analysis of 5 large EU longitudinal databases to detect risk profiles for good and poor mental health outcomes; (2) assessment: the adaptation/validation of assessment tools for cognition and sensory impairment for vulnerable populations, including the development of a composite e-screen for sensory, cognitive and mental functioning; (3) intervention: a clinical trial of a newly developed sensory support intervention; (4) participation: an EU patient and public voice and innovative public engagement network to inform the WPs and communicate findings; (5) valuation: health economic and cost effectiveness analyses; & (6) management, governance/ethics. Impact: SENSE-Cog will promote earlier detection of sensory, cognitive and mental impairments to enable swift interventions, prevent deterioration and limit negative impacts.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: DRS-01-2015 | Award Amount: 14.54M | Year: 2016

The ultimate purpose of ANYWHERE is to empower exposed responder institutions and citizens to enhance their anticipation and pro-active capacity of response to face extreme and high-impact weather and climate events. This will be achieved through the operational implementation of cutting-edge innovative technology as the best way to enhance citizens protection and saving lives. ANYWHERE proposes to implement a Pan-European multi-hazard platform providing a better identification of the expected weather-induced impacts and their location in time and space before they occur. This platform will support a faster analysis and anticipation of risks prior the event occurrence, an improved coordination of emergency reactions in the field and help to raise the self-preparedness of the population at risk. This significant step-ahead in the improvement of the pro-active capacity to provide adequate emergency responses is achievable capitalizing on the advanced forecasting methodologies and impact models made available by previous RTD projects, maximizing the uptake of their innovative potential not fully exploited up to now. The consortium is build upon a strong group of Coordinators of previous key EC projects in the related fields, together with 12 operational authorities and first responders institutions and 6 leading enterprises of the sector. The platform will be adapted to provide early warning products and locally customizable decision support services proactively targeted to the needs and requirements of the regional and local authorities, as well as public and private operators of critical infrastructures and networks. It will be implemented and demonstrated in 4 selected pilot sites to validate the prototype that will be transferred to the real operation. The market uptake will be ensured by the cooperation with a SME and Industry Collaborative Network, covering a wide range of sectors and stakeholders in Europe, and ultimately worldwide.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: DRS-03-2015 | Award Amount: 21.10M | Year: 2016

Effective EU support to a large external crisis requires new approaches. In response to this challenge and to identified user and market needs from previous projects, Reaching Out proposes an innovative multi-disciplinary approach that will optimize the efforts, address a wide spectrum of users and maximize market innovation success. This approach results in five main objectives: to 1. Develop a Collaborative Framework, with distributed platforms of functional services, 2. Implement a flexible and open collaborative innovation process involving users and SMEs, suppliers, operators and research organisations, 3. Develop, upgrade and integrate 78 new connectable and interoperable tools, 4. Conduct 5 large scale demonstrations on the field: o health disaster in Africa (Epidemics in Guinea, with strong social and cultural issues), o natural disaster in a politically complex region and a desert environment (Earthquake in the Jordan Valley, led jointly by Jordan, Israel and Palestine), o three global change disasters in Asia targeted at large evacuation and humanitarian support in Bangladesh (long lasting floods, huge storms and associated epidemics,), EU citizen support and repatriation in Shanghai (floods & storm surge), radiological and industrial disasters impacting EU assets in Taiwan (flash floods, landslides, storm surge and chemical and radiological disasters), supported and co-funded by local authorities, 5. Provide recommendations and evaluations for future legal and policy innovations. The project will be conducted under the supervision of senior end-users. It will be performed with flexible and proven procedures by a balanced consortium of users, industry, innovative SMEs, RTO and academia in the EU and the demonstration regions. The main expected impact is to improve external disaster and crisis management efficiency and cost-benefit and increase the EU visibility whilst enhancing EU industry competitiveness and enlarging the market.

Antonny B.,University of Nice Sophia Antipolis
Annual Review of Biochemistry | Year: 2011

Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs or domains that recognize the curvature, concave or convex, deep or shallow, of lipid membranes. These sensors contrast with classical lipid-binding domains by their extended structure and, sometimes, counterintuitive chemistry. Among the sensors are long amphipathic helices, such as the ALPS motif and the N-terminal region of αα- synuclein, whose apparent "design defects"translate into a remarkable ability to specifically adsorb to the surface of small vesicles. Fundamental differences in the lipid composition of membranes of the early and late secretory pathways probably explain why some sensors use mostly electrostatics whereas others take advantage of the hydrophobic effect. Membrane curvature sensors help to organize very diverse reactions, such as lipid transfer between membranes, the tethering of vesicles at the Golgi apparatus, and the assembly-disassembly cycle of protein coats. © 2011 by Annual Reviews. All rights reserved.

Gallet A.,University of Nice Sophia Antipolis
Trends in Cell Biology | Year: 2011

A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule required for numerous processes during animal development. Emphasizing the importance of this molecule for both growth control and patterning, Hedgehog signaling activity is often deregulated during cancer formation and progression. The secretion and spread of Hedgehog are not passive processes, but require accessory molecules involved in Hedgehog processing, release, spread and reception. In this review, I focus on the factors that are required to control the spread and activity of Hedgehog, highlighting recent data that have shed light on these processes. © 2010 Elsevier Ltd.

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