Nebraska City, NE, United States
Nebraska City, NE, United States

The University of Nebraska Medical Center is a public center of health science research, patient care, and education located in Omaha, Nebraska.Founded as a private medical college in 1880, UNMC became part of the University of Nebraska System in 1902. Rapidly expanding in the early 20th century, the university founded a hospital, dental college, pharmacy college, and a graduate college of medicine. One of Omaha's top employers, UNMC has an endowment valued at $641 million and an economic impact of $3.8 billion.In 2014, UNMC was ranked 6th in the United States by U.S. News & World Report. Wikipedia.


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Nursing-2017 features highly enlightening and interactive sessions to encourage the exchange of ideas across a wide range of disciplines in the field of nursing. They invite the contributions related to nursing research. You can submit your work in these broad themes. For conference themes please see: http://nursing.madridge.com/conference-themes.php The 1st International Conference on Nursing event was a huge success; they also welcomed the exposure to the new research and advancements presented during the 3 day conference. The conference has a gathering of 200 nursing professionals from 18 different countries all over the world. Nursing-2016 Speakers and Delegates: · Nezam Al-Nsair, University of Mount Union, USA · Phyllis Hansell, Seton Hall University, USA · Yvonne Ramlall, Sunnybrook Health Sciences Centre, Canada · Michael Jacqueline Lall, University of Texas at Arlington, USA · Khlood Salman, Duquesne University, USA · Jih-Yuan Chen, Kaohsiung Medical University, Taiwan · Claire Donnellan, Trinity College, Ireland · Francis Florencio, AUT University, Newzealand · Maude Hebert, University of Quebec in Trois-Rivieres, Canada · Julie Slade, Chatham University, USA · Manal Alatrash, Western University of Health Sciences/College of Graduate Nursing, USA · Amera Rashed, Menoufyia University, Egypt · Shauna Davies, University of Regina, Canada · Muder Alkrisat, Chamberlain College of Nursing, USA · Linda J. Ulak, Seton Hall University, USA · Dawn Marie Nair, St. Vincent's College, USA · Kristen Crusoe, Oregon Health & Sciences University, USA · Ma'en ZaidAbu-Qamar, Edith Cowan University, Australia · Pia Yngman-Uhlin, Linköping University, Sweden · Ana Peliteiro Neto, Emirates Home Nursing, Saudi Arabia · Seamus Cowman, Royal College of Surgeons Ireland Bahrain, Bahrain · Audrey Cund, University of the West of Scotland, UK · Louise Johnston, University of the West of Scotland, UK · Sherry Arvidson, University of Regina, Canada · Laureen Turner, University of San Francisco, USA · Hazel Kyle, University of the West of Scotland, UK · Johanna McMullan, Queens University, uk · Nasreena Waheed, Charles Dawin University, Australia · Maryann Godshall, Drexel University, USA · Muyssar Sabri Awadhalla, University of Bahrain, Bahrain · Kristina Schildmeijer, Linnaeus University, Sweden · Susan Carlisle, Queen's University Belfast , UK · Carin Ericsson, Linköping University, Sweden · Ghada ghamdi, University of Dhammam, Saudi Arabia · Janna Skagerström, Linköping University, Sweden · Sylvia Godelia, Sunnybrook Health Sciences Centre, Canada · Ahmed Maghari, Merck KSA · Ahmed Naser, Merck KSA · Ahmed Niaze, Merck KSA · Aida Mohamed, Merck KSA · Areej Khan, Merck KSA · Faten Ahmad, Merck KSA · Faten Ezzeddine, Merck KSA · Fatima Al Maghrabi, Merck KSA · Fayza Hassanin, Merck KSA · Hani Alismaeel, Merck KSA Nursing-2017 Organizing Committee: · Sheila Ryan, University of Nebraska Medical Center, USA · Samy A. Azer, King Saud University, Saudi Arabia · Vivien Dee, Azusa Pacific University, USA · Birsen Yurugen, Okan University of Health Sciences, Turkey · Amal Kadry Nicola Attia, University of Sharjah, Saudi Arabia · Nurhan Bayraktar, Near East University, Turkey · Esther Christian Sellars, The University of Tennessee at Martin, USA · Nezam Al-Nsair, University of Mount Union, USA · Khlood Salman, Duquesne University, USA · Michael Jacqueline Lall, The University of Texas at Arlington,USA · Mohammad Al Qadire, Al Al-Bayt University, Jordan · Aysegel Durmaz, Dumlupinar University, Turkey Nursing-2017 is organizing an outstanding Scientific Exhibition/Program and anticipates the world’s leading specialists involved in Nursing Research. They welcome Sponsorship and Exhibitions from the Companies and Organizations who wish to showcase their products at this exciting event. Register for the conference and book your slots at: http://nursing.madridge.com/register.php Contact person: Bhagya Rekha nursing@madridge.com nursing@madridge.net Naples, FL, May 13, 2017 --( PR.com )-- 2nd International Nursing Conference is going to be held during November 1-3, 2017 at Barcelona, Spain.Nursing-2017 features highly enlightening and interactive sessions to encourage the exchange of ideas across a wide range of disciplines in the field of nursing.They invite the contributions related to nursing research. You can submit your work in these broad themes. For conference themes please see:The 1st International Conference on Nursing event was a huge success; they also welcomed the exposure to the new research and advancements presented during the 3 day conference. The conference has a gathering of 200 nursing professionals from 18 different countries all over the world.Nursing-2016 Speakers and Delegates:· Nezam Al-Nsair, University of Mount Union, USA· Phyllis Hansell, Seton Hall University, USA· Yvonne Ramlall, Sunnybrook Health Sciences Centre, Canada· Michael Jacqueline Lall, University of Texas at Arlington, USA· Khlood Salman, Duquesne University, USA· Jih-Yuan Chen, Kaohsiung Medical University, Taiwan· Claire Donnellan, Trinity College, Ireland· Francis Florencio, AUT University, Newzealand· Maude Hebert, University of Quebec in Trois-Rivieres, Canada· Julie Slade, Chatham University, USA· Manal Alatrash, Western University of Health Sciences/College of Graduate Nursing, USA· Amera Rashed, Menoufyia University, Egypt· Shauna Davies, University of Regina, Canada· Muder Alkrisat, Chamberlain College of Nursing, USA· Linda J. Ulak, Seton Hall University, USA· Dawn Marie Nair, St. Vincent's College, USA· Kristen Crusoe, Oregon Health & Sciences University, USA· Ma'en ZaidAbu-Qamar, Edith Cowan University, Australia· Pia Yngman-Uhlin, Linköping University, Sweden· Ana Peliteiro Neto, Emirates Home Nursing, Saudi Arabia· Seamus Cowman, Royal College of Surgeons Ireland Bahrain, Bahrain· Audrey Cund, University of the West of Scotland, UK· Louise Johnston, University of the West of Scotland, UK· Sherry Arvidson, University of Regina, Canada· Laureen Turner, University of San Francisco, USA· Hazel Kyle, University of the West of Scotland, UK· Johanna McMullan, Queens University, uk· Nasreena Waheed, Charles Dawin University, Australia· Maryann Godshall, Drexel University, USA· Muyssar Sabri Awadhalla, University of Bahrain, Bahrain· Kristina Schildmeijer, Linnaeus University, Sweden· Susan Carlisle, Queen's University Belfast , UK· Carin Ericsson, Linköping University, Sweden· Ghada ghamdi, University of Dhammam, Saudi Arabia· Janna Skagerström, Linköping University, Sweden· Sylvia Godelia, Sunnybrook Health Sciences Centre, Canada· Ahmed Maghari, Merck KSA· Ahmed Naser, Merck KSA· Ahmed Niaze, Merck KSA· Aida Mohamed, Merck KSA· Areej Khan, Merck KSA· Faten Ahmad, Merck KSA· Faten Ezzeddine, Merck KSA· Fatima Al Maghrabi, Merck KSA· Fayza Hassanin, Merck KSA· Hani Alismaeel, Merck KSANursing-2017 Organizing Committee:· Sheila Ryan, University of Nebraska Medical Center, USA· Samy A. Azer, King Saud University, Saudi Arabia· Vivien Dee, Azusa Pacific University, USA· Birsen Yurugen, Okan University of Health Sciences, Turkey· Amal Kadry Nicola Attia, University of Sharjah, Saudi Arabia· Nurhan Bayraktar, Near East University, Turkey· Esther Christian Sellars, The University of Tennessee at Martin, USA· Nezam Al-Nsair, University of Mount Union, USA· Khlood Salman, Duquesne University, USA· Michael Jacqueline Lall, The University of Texas at Arlington,USA· Mohammad Al Qadire, Al Al-Bayt University, Jordan· Aysegel Durmaz, Dumlupinar University, TurkeyNursing-2017 is organizing an outstanding Scientific Exhibition/Program and anticipates the world’s leading specialists involved in Nursing Research. They welcome Sponsorship and Exhibitions from the Companies and Organizations who wish to showcase their products at this exciting event.Register for the conference and book your slots at:Contact person:Bhagya Rekha Click here to view the company profile of topseos.com Click here to view the list of recent Press Releases from topseos.com


Vose J.M.,University of Nebraska Medical Center
American Journal of Hematology | Year: 2013

Disease Overview: Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood, and bone marrow with a short remission duration to standard therapies and a median overall survival of 4-5 years. Diagnosis: Diagnosis is based on lymph node, bone marrow, or tissue morphology of centrocytic lymphocytes, small cell type, or blastoid variant cells. A chromosomal translocation t(11:14) is the molecular hallmark of MCL, resulting in the overexpression of cyclin D1. Cyclin D1 is detected by immunohistochemistry in 98% of cases. The absence of SOX-11 or a low Ki-67 may correlate with a more indolent form of MCL. The differential diagnosis of MCL includes small lymphocytic lymphoma, marginal zone lymphoma, and follicular lymphoma. Risk Stratification: The Mantle Cell Lymphoma International Prognostic Index (MIPI) is the prognostic model most often used and incorporates ECOG performance status, age, leukocyte count, and lactic dehydrogenase. A modification of the MIPI also adds the Ki-67 proliferative index if available. The median overall survival (OS) for the low risk group was not reached (5-year OS of 60%). The median OS for the intermediate risk group was 51 months and 29 months for the high risk group. Risk-Adapted Therapy: For selected indolent, low MIPI MCL patients, initial observation may be appropriate therapy. For younger patients with intermediate or high risk MIPI MCL, aggressive therapy with a cytarabine containing regimen±autologous stem cell transplantation should be considered. For older MCL patients with intermediate or high risk MIPI, combination chemotherapy with R-CHOP, R-Bendamustine, or a clinical trial should be considered. At the time of relapse, agents directed at activated pathways in MCL cells such as bortezomib (NFkB inhibitor) or lenalidamide (anti-angiogenesis) are approved agents. Clinical trials with Ibruitinib (Bruton's Tyrosine Kinase inhibitor) or Idelalisib (PI3K inhibitor) have demonstrated excellent clinical activity in MCL patients. Autologous or allogeneic stem cell transplantation can also be considered in young patients. © 2013 Wiley Periodicals, Inc.


Talmadge J.E.,University of Nebraska Medical Center | Gabrilovich D.I.,Wistar Institute
Nature Reviews Cancer | Year: 2013

Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T cell suppression. Initially, these myeloid cells were identified as granulocytes or monocytes; however, recent studies have revealed that this hyperplasia is associated with populations of multipotent progenitor cells that have been identified as myeloid-derived suppressor cells (MDSCs). The study of MDSCs has provided a wealth of information regarding tumour pathobiology, has extended our understanding of neoplastic progression and has modified our approaches to immune adjuvant therapy. In this Timeline article, we discuss the history of MDSCs, their influence on tumour progression and metastasis, and the crosstalk between tumour cells, MDSCs and the host macroenvironment. © 2013 Macmillan Publishers Limited. All rights reserved.


Fey P.D.,University of Nebraska Medical Center
Current Opinion in Microbiology | Year: 2010

It is well accepted that bacterial pathogens growing in a biofilm are recalcitrant to the action of most antibiotics and are resistant to the innate immune system. New treatment modalities are greatly warranted to effectively eradicate these infections. However, bacteria growing in a biofilm are metabolically unique in comparison to the bacteria growing in a planktonic state. Unfortunately, most antibiotics have been developed to inhibit the growth of bacteria in a planktonic mode of growth. This review focuses on the metabolism and physiology of biofilm growth with special emphasis on staphylococci. Future treatment options should include targeting unique metabolic niches found within bacterial biofilms in addition to the enzymes or compounds that inhibit biofilm accumulation molecules and/or interact with quorum sensing and intercellular bacterial communication. © 2010.


Talmadge J.E.,University of Nebraska Medical Center
Seminars in Cancer Biology | Year: 2011

The infiltration of tumors and their metastases by hematopoietic cells can contribute both positively and negatively to tumor growth, invasion, and patient outcomes. These differing outcomes are associated with both tumor heterogeneity and the diversity of leukocytes infiltrating neoplastic lesions. Tumors infiltration by histiocytes (macrophages and dendritic cells (DCs)) is associated with poor clinical outcomes, although infiltration by a subset of DCs is related to improved outcomes. T-cell infiltration of tumors and metastases are surrogates for positive outcomes, although subset analysis suggests that not all infiltrating T-cells have this potential. Overall, tumor infiltration by CD8+ T-cells is associated with a positive outcome, while the frequency of infiltrating CD4+ cells may be a negative predictor. In addition to tumor infiltration by macrophages and T-cells, recent studies have shown that myeloid-derived suppressor cells (MDSCs), also infiltrate tumors, inhibiting T-cell and DC number and function and facilitate tumor growth, angiogenesis, and metastasis. In summary, hematopoietic cell infiltration of tumors can regulate tumor progression and provide a useful diagnostic surrogate. Further, strategies focused on the manipulation of cellular infiltration via cellular, gene and molecular immunotherapies have the potential to provide a novel target for adjuvant therapy. © 2010 Elsevier Ltd.


Shukla V.,University of Nebraska Medical Center
Blood | Year: 2013

Interferon regulatory factor 4 (IRF4) is a critical transcriptional regulator of B-cell development and function. A recent genome-wide single-nucleotide polymorphism (SNP) association study identified IRF4 as a major susceptibility gene in chronic lymphocytic leukemia (CLL). Although the SNPs located in the IRF4 gene were linked to a downregulation of IRF4 in CLL patients, whether a low level of IRF4 is critical for CLL development remains unclear. In rodents, CLL cells are derived from B1 cells whose population is dramatically expanded in immunoglobulin heavy chain Vh11 knock-in mice. We bred a Vh11 knock-in allele into IRF4-deficient mice (IRF4(-/-)Vh11). Here, we report that IRF4(-/-)Vh11 mice develop spontaneous early-onset CLL with 100% penetrance. Further analysis shows that IRF4(-/-)Vh11 CLL cells proliferate predominantly in spleen and express high levels of Mcl-1. IRF4(-/-)Vh11 CLL cells are resistant to apoptosis but reconstitution of IRF4 expression in the IRF4(-/-)Vh11 CLL cells inhibits their survival. Thus, our study demonstrates for the first time a causal relationship between low levels of IRF4 and the development of CLL. Moreover, our findings establish IRF4(-/-)Vh11 mice as a novel mouse model of CLL that not only is valuable for dissecting molecular pathogenesis of CLL but could also be used for therapeutic purposes.


Verma V.,University of Nebraska Medical Center
Nature Reviews Clinical Oncology | Year: 2015

Owing to the institution of annual low-dose CT for lung cancer screening in the USA, the presumed increase in detection of early stage lung cancers elicits many questions about so-called 'grey areas' of the management of this disease that have been inadequately addressed to date. Herein, important and potentially difficult ambiguous cases that oncologists might come across are discussed. © 2015 Macmillan Publishers Limited.


Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimmunoblastic T-cell lymphomas, 11 peripheral T-cell lymphomas not otherwise specified (PTCLNOS), and normal T cells, and demonstrated that ALCLs express many of the miRNAs that are highly expressed in normal T cells with the prominent exception of miR-146a. Unsupervised hierarchical clustering demonstrated distinct clustering of ALCL, PTCL-NOS, and the AITL subtype of PTCL. Cases of ALK(+) ALCL and ALK(-) ALCL were interspersed in unsupervised analysis, suggesting a close relationship at the molecular level. We identified an miRNA signature of 7 miRNAs (5 upregulated: miR-512-3p, miR-886-5p, miR-886-3p, miR-708, miR-135b; 2 downregulated: miR-146a, miR-155) significantly associated with ALK(+) ALCL cases. In addition, we derived an 11-miRNA signature (4 upregulated: miR-210, miR-197, miR-191, miR-512-3p; 7 downregulated: miR-451, miR-146a, miR-22, miR-455-3p, miR-455-5p, miR-143, miR-494) that differentiates ALK(-) ALCL from other PTCLs. Our in vitro studies identified a set of 32 miRNAs associated with ALK expression. Of these, the miR-17∼92 cluster and its paralogues were also highly expressed in ALK(+) ALCL and may represent important downstream effectors of the ALK oncogenic pathway.


Lockridge O.,University of Nebraska Medical Center
Pharmacology and Therapeutics | Year: 2015

Phase I clinical trials have shown that pure human butyrylcholinesterase (BChE) is safe when administered to humans. A potential therapeutic use of BChE is for prevention of nerve agent toxicity. A recombinant mutant of BChE that rapidly inactivates cocaine is being developed as a treatment to help recovering cocaine addicts avoid relapse into drug taking. These clinical applications rely on knowledge of the structure, stability, and properties of BChE, information that is reviewed here. Gene therapy with a vector that sustains expression for a year from a single injection is a promising method for delivering therapeutic quantities of BChE. © 2014 Elsevier Inc.. All rights reserved.


Geng L.,University of Nebraska Medical Center
Oncogene | Year: 2014

Metastasis causes most deaths from colon cancer yet mechanistic understanding and therapeutic options remain limited. Here we show that expression of microRNA (miR)-192 is inversely correlated with metastatic potential of colon cancer cells. Ectopic expression of miR-192 sensitizes colon cancer cells to growth factor deprivation stress-induced apoptosis, whereas inhibition of miR-192 confers resistance. Overexpression of miR-192 inhibits metastatic colonization to the liver in an orthotopic mouse model of colon cancer. Alterations associated with the metastatic phenotype in the primary tumors include increased apoptosis, decreased proliferation and angiogenesis. Further studies indicate that miR-192 downregulates expression of Bcl-2, Zeb2 and VEGFA in vitro and in vivo, which is responsible for enhanced apoptosis, increased expression of E-cadherin and decreased angiogenesis in vivo, respectively. Finally, studies performed on human colonic adenocarcinoma show that expression of miR-192 is significantly reduced in neoplastic cells as compared with normal colonic epithelium. Importantly, there is a significant decrease in miR-192 expression in stage IV tumors when compared with stage I or II lesions. These findings indicate that miR-192 has an important role in colon cancer development and progression. Our studies underscore the clinical relevance and prognostic significance of miR-192 expression in colon cancer. Therefore, a major implication of our studies is that restoration of miR-192 expression or antagonism of its target genes (Bcl-2, Zeb2 or VEGFA) may have considerable therapeutic potential for anti-metastatic therapy in patients with colon cancer.

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