University of Naples Federico II

www.unina.it/
Naples, Italy

The University of Naples Federico II is a university located in Naples, Italy. It was founded in 1224 and is organized into 13 faculties. It is the world's oldest state university and one of the oldest academic institutions in continuous operation. The university is named after its founder Frederick II. Wikipedia.

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Patent
University of Arizona and University of Naples Federico II | Date: 2017-04-12

The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.


Patent
University of Naples Federico II and Bellani | Date: 2017-02-15

Suspension (1) for a wheeled vehicle provided with at least one wheel (50) and a frame (51), comprising at least one elastic element (5) functionally combinable between said at least one wheel (50) and said frame (51 ), characterized by comprising at least one hydro-pneumatic spring (7) functionally combined in series with said at least one elastic element (5) so that the equivalent spring modulus (Keq) of said at least one elastic element (5) and said at least one hydro-pneumatic spring (7) is variable as a function of the distance between said frame and said wheel, said at least one hydro- pneumatic spring being shaped and sized to behave also as an energy dissipator in series to said at least one elastic element.


Patent
University of Arizona and University of Naples Federico II | Date: 2015-06-03

The invention relates to compounds of the formula (VIII) wherein the moieties R_(1), R_(2), R_(3), R_(4), and R_(5 )are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.


Patent
University of Naples Federico II | Date: 2017-04-05

A lock (1) is described, comprising: a body (2) suitable to define a housing (3) having a longitudinal development direction (L) along an insertion direction (I) of a key (200), said housing (3) comprising a first portion (4) and a second portion (5) mutually adjacent along the longitudinal development direction (L) of the body (2); a first rotor (37) suitable to be rotationally housed within the first portion (4) of said housing (3) of such body (2) about the longitudinal development direction (L) of the body (2), said first rotor (37) being suitable to define a further housing (38); a second rotor (39) comprising a first portion (55) suitable to be rotationally housed within the second portion (5) of said housing (3) of the body (2) about the longitudinal development direction (L) of such body (2), said second rotor (39) comprising a second portion (56) suitable to be rotationally housed within the further housing (38) defined by the first rotor (37) about the longitudinal development direction (L) of such body (2). The second rotor (39), by the insertion of the key (200), is suitable to translate along the longitudinal development direction (L) of the body (2) with respect to the first rotor (37). The second rotor (39), by a first rotation portion of the key (200), is suitable to rotate about the longitudinal development direction (L) of the body (2) with respect to the first rotor (37), to pass from a disengagement position to an engagement position with said first rotor (37). In the engagement position, said first rotor (37) and said second rotor (39), by a second portion of rotation of the key (200), are suitable to integrally translate along the longitudinal development direction (L) of the body (2) to reach an actuating position of the lock (1).


Patent
Medical Components Inc. and University of Naples Federico II | Date: 2017-09-27

A device (210) for the expression of liquids, such as for the maintenance treatment of vascular catheters. A syringe (216) has a support structure (215) and includes at least two separate compartments (211,212) in which liquids for treating the lumen (283) of a catheter (280) with which the device is associated. The syringe further includes a closure plug (213) to be associated with the lumen being treated, which is coupled, by virtue of a releasable securement arrangement, to support structure (215). At least one plunger (216) is also included for infusing, in preset order, the different treatment liquids into the lumen to be treated, and the syringe further includes a duct which is in fluid communication with the two compartments and is arranged through a through hole through the closure plug (213) in order to allow access of the treatment liquid to the interior of the lumen (283) upon activation of the plunger.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.61M | Year: 2017

Though Big Data has become common in many domains nowadays, the challenges to develop efficient and automated mining of the ever increasing data sets by new generations of data scientists are eminent. These challenges span wide swathes of society, business and research. Astronomers with their high-tech observatories are historically at the forefront of this field, but obviously, the impact in e.g. commercial applications, security, environmental monitoring and experimental research is immense. We aim to contribute to this general discussion by training a number of young scientists in the fields of computer science and astronomy, focussing on techniques of automated learning from large quantities of data to answer fundamental questions on the evolution of properties of galaxies. While these techniques will lead to major advances in our understanding of the formation and evolution of galaxies, we will also promote, in collaboration with industry, much more general applications in society, e.g. in medical imaging or remote sensing. We have put together a team of astronomers and computer scientists, from academic and private sector partners, to develop techniques to detect and classify ultra-faint galaxies and galaxy remnants in a deep survey of the Fornax cluster, and use the results to study how galaxies evolve in the dense environment of galaxy clusters. With a team of young researchers we will develop novel computer science algorithms addressing fundamental topics in galaxy formation, such as the huge dark matter fractions inferred by theory, and the lack of detected angular momentum in galaxies. The collaboration is unique - it will develop a platform for deep symbiosis of two radically different strands of approaches: purely data-driven machine learning and specialist approaches based on techniques developed in astronomy. Young scientists trained with such skills are highly demanded both in research and business.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-33-2016 | Award Amount: 2.86M | Year: 2017

Despite process heat is recognized as the application with highest potential among solar heating and cooling applications, Solar Heat for Industrial Processes (SHIP) still presents a modest share of about 0.3% of total installed solar thermal capacity. As of todays technology development stage economic competitiveness restricted to low temperature applications; technology implementation requiring interference with existing heat production systems, heat distribution networks or even heat consuming processes - Solar thermal potential is mainly identified for new industrial capacity in outside Americas and Europe. In this context, INSHIP aims at the definition of a ECRIA engaging major European research institutes with recognized activities on SHIP, into an integrated structure that could successfully achieve the coordination objectives of: more effective and intense cooperation between EU research institutions; alignment of different SHIP related national research and funding programs, avoiding overlaps and duplications and identifying gaps; acceleration of knowledge transfer to the European industry, to be the reference organization to promote and coordinate the international cooperation in SHIP research from and to Europe, while developing coordinated R&D TRLs 2-5 activities with the ambition of progressing SHIP beyond the state-of-the-art through: an easier integration of low and medium temperature technologies suiting the operation, durability and reliability requirements of industrial end users; expanding the range of SHIP applications to the EI sector through the development of suitable process embedded solar concentrating technologies, overcoming the present barrier of applications only in the low and medium temperature ranges; increasing the synergies within industrial parks, through centralized heat distribution networks and exploiting the potential synergies of these networks with district heating and with the electricity grid.


Giuditta A.,University of Naples Federico II
Frontiers in Systems Neuroscience | Year: 2014

According to the sequential hypothesis (SH) memories acquired during wakefulness are processed during sleep in two serial steps respectively occurring during slow wave sleep (SWS) and rapid eye movement (REM) sleep. During SWS memories to be retained are distinguished from irrelevant or competing traces that undergo downgrading or elimination. Processed memories are stored again during REM sleep which integrates them with preexisting memories. The hypothesis received support from a wealth of EEG, behavioral, and biochemical analyses of trained rats. Further evidence was provided by independent studies of human subjects. SH basic premises, data, and interpretations have been compared with corresponding viewpoints of the synaptic homeostatic hypothesis (SHY). Their similarities and differences are presented and discussed within the framework of sleep processing operations. SHY’s emphasis on synaptic renormalization during SWS is acknowledged to underline a key sleep effect, but this cannot marginalize sleep’s main role in selecting memories to be retained from downgrading traces, and in their integration with preexisting memories. In addition, SHY’s synaptic renormalization raises an unsolved dilemma that clashes with the accepted memory storage mechanism exclusively based on modifications of synaptic strength. This difficulty may be bypassed by the assumption that SWS-processed memories are stored again by REM sleep in brain subnuclear quantum particles. Storing of memories in quantum particles may also occur in other vigilance states. Hints are provided on ways to subject the quantum hypothesis to experimental tests. © 2014 Giuditta.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.93M | Year: 2017

Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens. The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads. The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification. Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.


Andolfo I.,University of Naples Federico II
Blood | Year: 2013

Autosomal dominant dehydrated hereditary stomatocytosis (DHSt) usually presents as a compensated hemolytic anemia with macrocytosis and abnormally shaped red blood cells (RBCs). DHSt is part of a pleiotropic syndrome that may also exhibit pseudohyperkalemia and perinatal edema. We identified PIEZO1 as the disease gene for pleiotropic DHSt in a large kindred by exome sequencing analysis within the previously mapped 16q23-q24 interval. In 26 affected individuals among 7 multigenerational DHSt families with the pleiotropic syndrome, 11 heterozygous PIEZO1 missense mutations cosegregated with disease. PIEZO1 is expressed in the plasma membranes of RBCs and its messenger RNA, and protein levels increase during in vitro erythroid differentiation of CD34(+) cells. PIEZO1 is also expressed in liver and bone marrow during human and mouse development. We suggest for the first time a correlation between a PIEZO1 mutation and perinatal edema. DHSt patient red cells with the R2456H mutation exhibit increased ion-channel activity. Functional studies of PIEZO1 mutant R2488Q expressed in Xenopus oocytes demonstrated changes in ion-channel activity consistent with the altered cation content of DHSt patient red cells. Our findings provide direct evidence that R2456H and R2488Q mutations in PIEZO1 alter mechanosensitive channel regulation, leading to increased cation transport in erythroid cells.

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