The University of Naples Federico II is a university located in Naples, Italy. It was founded in 1224 and is organized into 13 faculties. It is the world's oldest state university and one of the oldest academic institutions in continuous operation. The university is named after its founder Frederick II. Wikipedia.
University of Arizona and University of Naples Federico II | Date: 2015-06-03
The invention relates to compounds of the formula (VIII) wherein the moieties R_(1), R_(2), R_(3), R_(4), and R_(5 )are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.
University of Naples Federico II | Date: 2017-04-05
A lock (1) is described, comprising: a body (2) suitable to define a housing (3) having a longitudinal development direction (L) along an insertion direction (I) of a key (200), said housing (3) comprising a first portion (4) and a second portion (5) mutually adjacent along the longitudinal development direction (L) of the body (2); a first rotor (37) suitable to be rotationally housed within the first portion (4) of said housing (3) of such body (2) about the longitudinal development direction (L) of the body (2), said first rotor (37) being suitable to define a further housing (38); a second rotor (39) comprising a first portion (55) suitable to be rotationally housed within the second portion (5) of said housing (3) of the body (2) about the longitudinal development direction (L) of such body (2), said second rotor (39) comprising a second portion (56) suitable to be rotationally housed within the further housing (38) defined by the first rotor (37) about the longitudinal development direction (L) of such body (2). The second rotor (39), by the insertion of the key (200), is suitable to translate along the longitudinal development direction (L) of the body (2) with respect to the first rotor (37). The second rotor (39), by a first rotation portion of the key (200), is suitable to rotate about the longitudinal development direction (L) of the body (2) with respect to the first rotor (37), to pass from a disengagement position to an engagement position with said first rotor (37). In the engagement position, said first rotor (37) and said second rotor (39), by a second portion of rotation of the key (200), are suitable to integrally translate along the longitudinal development direction (L) of the body (2) to reach an actuating position of the lock (1).
News Article | May 22, 2017
CrowdReviews Partnered with Madridge Publishers to Announce: International Pharma Conference and Expo Pharma-2017 aims to discover advances, practical experiences and innovative ideas on issues related to pharma industry, pharmacology and pharmaceutical sciences as well as a breadth of other topics Pharma-2017 invites the contributions related to Pharma. Submit your work on these broad themes (or) any other topics related to Pharma. Abstracts of all the pharma related interest areas are accepted, but are not limited to the following conference themes. Pharma-2017 Conference Themes: · Pharma applications in Microbiology and Biotechnology · Pharmaceutical Chemistry · Biopharmaceutics and Pharmaceutics · Pharmacy Practice · Pharmacology · Drug Discovery and Development · Protein-Protein Interactions as Drug Targets · Pharmaceutical Nanotechnology · Drug Regulatory Affairs · Clinical Pharmacy · Pharmaceutical Technology · Pharmaceutics · Pharmacognosy and Phytochemistry For Abstract submission please see: http://pharma.madridge.com/abstract-submission.php Pharma-2017 Organizing Committee: · Bülent Gumusel, Hacettepe University, Turkey · Abubaker Ibrahim Mohamed Saeed Elbur, Taif University, Saudi Arabia. · Francesco Maione, University of Naples Federico II, Italy. · Gavin Andrews, Queens University Belfast, United kingdom. · Gian Carlo Tenore, University of Naples "Federico II," Italy. · Lisa E. Davis, University of Arizona, USA. · Majed Isa, Taif University, Saudi Arabia. · Mirza R. Baig, Dubai Pharmacy College, UAE. · Majed AIRobaian, Taif University, Saudi Arabia. · Prakash Kinthada, Sri Vidyanikethan Engineering College, India. · Tahani Alrabeni, Riyadh Colleges, Saudi Arabia. Pharma-2017 organizing an outstanding Scientific Exhibition/Program and anticipates the world’s leading specialists involved in Pharma Research. Pharma-2017 welcomes Sponsorship and Exhibitions from the Companies and Organizations who wish to showcase their products at this exciting event. Register for the conference and book your slots at: http://pharma.madridge.com/register.php Contact person: Narasimha Chary firstname.lastname@example.org email@example.com Naples, FL, May 22, 2017 --( PR.com )-- International Pharma Conference and Expo is going to be held during November 20-22, 2017 at Dubai, UAE.Pharma-2017 aims to discover advances, practical experiences and innovative ideas on issues related to pharma industry, pharmacology and pharmaceutical sciences as well as a breadth of other topicsPharma-2017 invites the contributions related to Pharma. Submit your work on these broad themes (or) any other topics related to Pharma. Abstracts of all the pharma related interest areas are accepted, but are not limited to the following conference themes.Pharma-2017 Conference Themes:· Pharma applications in Microbiology and Biotechnology· Pharmaceutical Chemistry· Biopharmaceutics and Pharmaceutics· Pharmacy Practice· Pharmacology· Drug Discovery and Development· Protein-Protein Interactions as Drug Targets· Pharmaceutical Nanotechnology· Drug Regulatory Affairs· Clinical Pharmacy· Pharmaceutical Technology· Pharmaceutics· Pharmacognosy and PhytochemistryFor Abstract submission please see:Pharma-2017 Organizing Committee:· Bülent Gumusel, Hacettepe University, Turkey· Abubaker Ibrahim Mohamed Saeed Elbur, Taif University, Saudi Arabia.· Francesco Maione, University of Naples Federico II, Italy.· Gavin Andrews, Queens University Belfast, United kingdom.· Gian Carlo Tenore, University of Naples "Federico II," Italy.· Lisa E. Davis, University of Arizona, USA.· Majed Isa, Taif University, Saudi Arabia.· Mirza R. Baig, Dubai Pharmacy College, UAE.· Majed AIRobaian, Taif University, Saudi Arabia.· Prakash Kinthada, Sri Vidyanikethan Engineering College, India.· Tahani Alrabeni, Riyadh Colleges, Saudi Arabia.Pharma-2017 organizing an outstanding Scientific Exhibition/Program and anticipates the world’s leading specialists involved in Pharma Research. Pharma-2017 welcomes Sponsorship and Exhibitions from the Companies and Organizations who wish to showcase their products at this exciting event.Register for the conference and book your slots at:Contact person:Narasimha Chary
University of Arizona and University of Naples Federico II | Date: 2017-04-12
The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.
News Article | April 24, 2017
Springer is partnering with Federica Weblearning, which is an academic platform devoted to innovation, experimentation and the dissemination of multimedia distance learning. The collaboration allows authors and lecturers several options of preparing both a textbook and a MOOC (Massive Open Online Course) on a particular topic. This initiative allows Springer to further strengthen its expertise in textbook publishing, and offer its authors and customers an enhanced pedagogical experience. The MOOCs and books project invites authors worldwide to plan from the outset a textbook together with an accompanying MOOC. Also, lecturers who are currently running a MOOC on the Federica Weblearning platform have the opportunity to publish a complementary textbook with Springer. Authors and lecturers from institutes all over the world can participate in this initiative. Federica Weblearning was developed by the University of Naples Federico II in Italy, and it hosts courses on a wide spectrum of fields covered by the university, including mathematics and statistics, computer science, engineering and physical sciences, biomedical and life sciences, business and economics, and humanities and social sciences. Courses promote international authorship, topical coverage, and dissemination to a global readership of scholars, students, researchers, professionals and policy makers. Mauro Calise, director of Federica Weblearning, said: "Federica Weblearning and Springer have joined forces in this new venture to showcase the best international research around the globe. The MOOC and book format offers a unique opportunity to create a MOOC based on a textbook, or a book based on an online course, and combine the quality of a scientific essay with the communicative power of an online educational product. We intend to publish high quality research results and, to start with, we have selected a number of top researchers, who are winners of European Research Council grants." Francesca Bonadei, executive editor and project manager for MOOCs initiatives at Springer, said: "The wide range of subjects offered on the Federica Weblearning platform perfectly matches Springer's broad portfolio. One of our first collaborations will be a new MOOC based on a textbook on robotics by one of our bestselling authors, Bruno Siciliano, and we look forward to working with lecturers of MOOCs on Federica Weblearning to help them plan their accompanying textbook. This editorial cooperation expands on the existing Springer policy which provides coupons to registered MOOC students, allowing them to purchase specific books at a discounted rate." Springer is a leading global scientific, technical and medical portfolio, providing researchers in academia, scientific institutions and corporate R&D departments with quality content through innovative information, products and services. Springer has one of the strongest STM and HSS eBook collections and archives, as well as a comprehensive range of hybrid and open access journals. Springer is part of Springer Nature, a global publisher that serves and supports the research community. Springer Nature aims to advance discovery by publishing robust and insightful science, supporting the development of new areas of research and making ideas and knowledge accessible around the world. As part of Springer Nature, Springer sits alongside other trusted brands like Nature Research, BioMed Central and Palgrave Macmillan. Visit http://www. and follow @SpringerNature Federica Weblearning is the first Italian university centre fully devoted to innovation and experimentation of multimedia distance education. With 300 blended courses and 75 MOOCs Federica is the largest worldwide provider of open access multimedia courseware in Italian.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.61M | Year: 2017
Though Big Data has become common in many domains nowadays, the challenges to develop efficient and automated mining of the ever increasing data sets by new generations of data scientists are eminent. These challenges span wide swathes of society, business and research. Astronomers with their high-tech observatories are historically at the forefront of this field, but obviously, the impact in e.g. commercial applications, security, environmental monitoring and experimental research is immense. We aim to contribute to this general discussion by training a number of young scientists in the fields of computer science and astronomy, focussing on techniques of automated learning from large quantities of data to answer fundamental questions on the evolution of properties of galaxies. While these techniques will lead to major advances in our understanding of the formation and evolution of galaxies, we will also promote, in collaboration with industry, much more general applications in society, e.g. in medical imaging or remote sensing. We have put together a team of astronomers and computer scientists, from academic and private sector partners, to develop techniques to detect and classify ultra-faint galaxies and galaxy remnants in a deep survey of the Fornax cluster, and use the results to study how galaxies evolve in the dense environment of galaxy clusters. With a team of young researchers we will develop novel computer science algorithms addressing fundamental topics in galaxy formation, such as the huge dark matter fractions inferred by theory, and the lack of detected angular momentum in galaxies. The collaboration is unique - it will develop a platform for deep symbiosis of two radically different strands of approaches: purely data-driven machine learning and specialist approaches based on techniques developed in astronomy. Young scientists trained with such skills are highly demanded both in research and business.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-33-2016 | Award Amount: 2.86M | Year: 2017
Despite process heat is recognized as the application with highest potential among solar heating and cooling applications, Solar Heat for Industrial Processes (SHIP) still presents a modest share of about 0.3% of total installed solar thermal capacity. As of todays technology development stage economic competitiveness restricted to low temperature applications; technology implementation requiring interference with existing heat production systems, heat distribution networks or even heat consuming processes - Solar thermal potential is mainly identified for new industrial capacity in outside Americas and Europe. In this context, INSHIP aims at the definition of a ECRIA engaging major European research institutes with recognized activities on SHIP, into an integrated structure that could successfully achieve the coordination objectives of: more effective and intense cooperation between EU research institutions; alignment of different SHIP related national research and funding programs, avoiding overlaps and duplications and identifying gaps; acceleration of knowledge transfer to the European industry, to be the reference organization to promote and coordinate the international cooperation in SHIP research from and to Europe, while developing coordinated R&D TRLs 2-5 activities with the ambition of progressing SHIP beyond the state-of-the-art through: an easier integration of low and medium temperature technologies suiting the operation, durability and reliability requirements of industrial end users; expanding the range of SHIP applications to the EI sector through the development of suitable process embedded solar concentrating technologies, overcoming the present barrier of applications only in the low and medium temperature ranges; increasing the synergies within industrial parks, through centralized heat distribution networks and exploiting the potential synergies of these networks with district heating and with the electricity grid.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: DRS-03-2015 | Award Amount: 21.10M | Year: 2016
Effective EU support to a large external crisis requires new approaches. In response to this challenge and to identified user and market needs from previous projects, Reaching Out proposes an innovative multi-disciplinary approach that will optimize the efforts, address a wide spectrum of users and maximize market innovation success. This approach results in five main objectives: to 1. Develop a Collaborative Framework, with distributed platforms of functional services, 2. Implement a flexible and open collaborative innovation process involving users and SMEs, suppliers, operators and research organisations, 3. Develop, upgrade and integrate 78 new connectable and interoperable tools, 4. Conduct 5 large scale demonstrations on the field: o health disaster in Africa (Epidemics in Guinea, with strong social and cultural issues), o natural disaster in a politically complex region and a desert environment (Earthquake in the Jordan Valley, led jointly by Jordan, Israel and Palestine), o three global change disasters in Asia targeted at large evacuation and humanitarian support in Bangladesh (long lasting floods, huge storms and associated epidemics,), EU citizen support and repatriation in Shanghai (floods & storm surge), radiological and industrial disasters impacting EU assets in Taiwan (flash floods, landslides, storm surge and chemical and radiological disasters), supported and co-funded by local authorities, 5. Provide recommendations and evaluations for future legal and policy innovations. The project will be conducted under the supervision of senior end-users. It will be performed with flexible and proven procedures by a balanced consortium of users, industry, innovative SMEs, RTO and academia in the EU and the demonstration regions. The main expected impact is to improve external disaster and crisis management efficiency and cost-benefit and increase the EU visibility whilst enhancing EU industry competitiveness and enlarging the market.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.93M | Year: 2017
Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens. The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads. The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification. Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.
Andolfo I.,University of Naples Federico II
Blood | Year: 2013
Autosomal dominant dehydrated hereditary stomatocytosis (DHSt) usually presents as a compensated hemolytic anemia with macrocytosis and abnormally shaped red blood cells (RBCs). DHSt is part of a pleiotropic syndrome that may also exhibit pseudohyperkalemia and perinatal edema. We identified PIEZO1 as the disease gene for pleiotropic DHSt in a large kindred by exome sequencing analysis within the previously mapped 16q23-q24 interval. In 26 affected individuals among 7 multigenerational DHSt families with the pleiotropic syndrome, 11 heterozygous PIEZO1 missense mutations cosegregated with disease. PIEZO1 is expressed in the plasma membranes of RBCs and its messenger RNA, and protein levels increase during in vitro erythroid differentiation of CD34(+) cells. PIEZO1 is also expressed in liver and bone marrow during human and mouse development. We suggest for the first time a correlation between a PIEZO1 mutation and perinatal edema. DHSt patient red cells with the R2456H mutation exhibit increased ion-channel activity. Functional studies of PIEZO1 mutant R2488Q expressed in Xenopus oocytes demonstrated changes in ion-channel activity consistent with the altered cation content of DHSt patient red cells. Our findings provide direct evidence that R2456H and R2488Q mutations in PIEZO1 alter mechanosensitive channel regulation, leading to increased cation transport in erythroid cells.