Mysore, India
Mysore, India

The University of Mysore is a public state university located in Mysore, Karnataka, India. The university was founded during the reign of Krishnaraja Wodeyar IV, the Maharaja of Mysore. It opened on 27 July 1916, with the first chancellor being the Maharaja of Mysore and the first Vice Chancellor being H. V. Nanjundaiah. The university became the first outside the domain of the Britain administration in India, the sixth university in India as a whole, and the first ever university in Karnataka. It is a state university of the affiliating type, and became autonomous on 3 March 1956, when it gained recognition from the University Grants Commission.The university encompasses 122 affiliated colleges and five constituent colleges . In addition, the university has 37 postgraduate departments, eight specialised research and training centres and two postgraduate centres that together offer about 55 regular academic programmes to 3,500 students. It also runs a number of employment-oriented diploma courses and certificate programmes.The Mysore University Library comprises over 800,000 books, 2,400 journal titles and 100,000 volumes of journals. The main campus features an amphitheater, an auditorium, a swimming pool, and hostel accommodation for men and women. As of July 2013, the University of Mysore was accredited "Grade A" by National Assessment and Accreditation Council , while its academic staff was ranked amongst the top 5 across India. Wikipedia.

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Swamy N.,University of Mysore
Brazilian Journal of Pharmaceutical Sciences | Year: 2014

Two simple, rapid and inexpensive spectrophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in tablets. The methods are based on charge-transfer (CT) complexation reaction involving ALB as n-donor and iodine as σ-acceptor (method A) in dichloromethane or picric acid (PA) as π-acceptor (method B) in chloroform. The absorbance of CT complexes was measured at 380 nm for method A, and 415 nm for method B. The optimization of the experimental conditions is described. Under optimum conditions, Beer’s law obeyed over the concentration ranges 8.0-240 and 2.4-42 mg mL-1for method A and method B, respectively. The apparent molar absorptivity of CT complexes at the respective λmaxare calculated to be 1.17×103and 5.22×103L mol-1cm-1respectively, and the corresponding Sandell sensitivity values are 0.2273 and 0.0509 ng cm-2. The limits of detection (LOD) and quantification (LOQ) are calculated to be (0.69 and 2.08), and (0.10 and 0.30) mg mL-1with method A, and method B, respectively. The intra-day and inter-day accuracy expressed as % RE and precision expressed as % RSD were less than 3%. The methods were applied to the determination of ALB in tablets. © 2014, Faculdade de Ciencias Farmaceuticas (Biblioteca). All right reserved.

University of Mysore, National University of Singapore, Bangalore University and Cambridge Enterprise Ltd | Date: 2016-01-22

The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.

Harinarayana N.S.,University of Mysore | Raju N.V.,Government First Grade College
Electronic Library | Year: 2010

Purpose - The purpose of this paper is to explore recent trends in the application of Web 2.0 and Library 2.0 features as exemplified through university library web sites around the world. Design/methodology/approach - The top 100 universities from the ranked list of 200 provided on the Times Higher Education web site were considered for collection of data and from this list a selection was made of 57 of these universities. This selection was based on whether the site was in English and whether it had at least one Web 2.0 feature. For each of these universities their web sites were visited and data on their Web 2.0 features (such as Blogs, RSS, Instant Messaging, Wikis and the like) were collected and analyzed. Findings - Results reveal that 37 university libraries use RSS feeds for dissemination of library news, events and announcements and 15 university libraries provide blog space for users. Whereas wiki is the least applied Web 2.0 technology, with only one university using it, Instant Messaging is another most widely applied feature with 37 libraries already providing reference service through it. Podcast (used in three libraries) and Vidcast (used in six libraries) are yet to become popular facilities to be offered in university library web sites. Research limitations/implications - The study is based on the university ranking for 2007, as the World Top 200 Universities 2008 was not published until October 2008 when this article was being finalized. However, this does not affect the outcome of the Web 2.0 features being utilized by the universities. Originality/value - Most of the earlier studies on the subject deal with Web 2.0 tools and how they could be used in the library context. The present paper, however, provides concrete evidence of the application of Web 2.0 in university libraries. As such it should prove of interest to all types of libraries, even though its context is university libraries. © Emerald Group Publishing Limited 0264-0473.

Bai A.J.,University of Mysore | Rai V.R.,University of Mysore
Comprehensive Reviews in Food Science and Food Safety | Year: 2011

Food spoilage and biofilm formation by food-related bacteria are significant problems in the food industry. Even with the application of modern-day food preservative techniques, excessive amounts of food are lost due to microbial spoilage. A number of studies have indicated that quorum sensing plays a major role in food spoilage, biofilm formation, and food-related pathogenesis. Understanding bacterial quorum-sensing signaling systems can help in controlling the growth of undesirable food-related bacteria. This review focusses on the various signaling molecules produced by Gram-negative and Gram-positive bacteria and the mechanism of their quorum-sensing systems, types of signaling molecules that have been detected in different food systems using biosensors, the role of signaling molecules in biofilm formation, and significance of biofilms in the food industry. As quorum-sensing signaling molecules are implicated in food spoilage, based on these molecules potential, quorum-sensing inhibitors/antagonists can be developed to be used as novel food preservatives for maintaining food integrity and enhancing food safety. Practical Application: Bacteria use signaling molecules for inter- and intracellular communication. This phenomenon of bacterial cell-to-cell communication is known as quorum sensing. Quorum-sensing signals are implicated in bacterial pathogenicity and food spoilage. Therefore, blocking the quorum-sensing signaling molecules in food-related bacteria may possibly prevent quorum-sensing-regulated phenotypes responsible for food spoilage. Quorum-sensing inhibitors/antagonists could be used as food preservatives to enhance the shelf life and also increase food safety. © 2011 Institute of Food Technologists ®.

Belugali Nataraj N.,University of Mysore | Salimath B.P.,University of Mysore
Cellular Signalling | Year: 2013

We have identified and characterized a novel proangiogenic glycoprotein (NAP) with molecular weight of 67. kDa from synovial fluid of rheumatoid arthritis patients. Proteomic analysis of the protein revealed 29% sequence coverage with maximum identity for human retinoblastoma binding protein 2. N-terminal amino acid sequence showed no identity to recently discovered protein sequences. NAP was also identified in both normal and tumor cell lines by Western blotting. NAP is a permeability factor as verified by miles permeability assay. The proangiogenic potential of NAP was identified using shell less CAM, rat cornea and tumor on CAM assays. NAP induces expression of VEGF and Flt-1 gene as verified by promoter reporter gene analysis. Further NAP induces proliferation of endothelial cells and formation of tube like structures. NAP is also involved in migration and invasion of tumor cells. Clinical data revealed the presence of NAP in breast cancer biopsies. We have developed monoclonal antibody (mAb), and specific ELISA, which confirmed the presence of NAP in the cytosol of tumor cells. The mAb effect was evaluated with established angiogenic assays. Further, we investigated the detailed mechanism by which NAP induces angiogenesis. NAP is phosphorylated by VEGF induced activation of MAPK and JNK pathways through VEGFR2 phosphorylation. NAP involves JNK pathway predominantly with further activation of NFκB in downstream processing of VEGF activation. Together these findings establish that NAP displays angiogenic properties and promotes efficient neovascularization both in vitro and in vivo models. These observations suggest that anti-NAP-mAb can be targeted for antiangiogenic therapy of cancer. © 2012 Elsevier Inc.

Rajesh P.S.,University of Mysore | Rai V.R.,University of Mysore
Biochemical and Biophysical Research Communications | Year: 2014

The aiiA homologous gene known to encode AHL- lactonase enzyme which hydrolyze the N-acylhomoserine lactone (AHL) quorum sensing signaling molecules produced by Gram negative bacteria. In this study, the degradation of AHL molecules was determined by cell-free lysate of endophytic Enterobacter species. The percentage of quorum quenching was confirmed and quantified by HPLC method (p< 0.0001). Amplification and sequence BLAST analysis showed the presence of aiiA homologous gene in endophytic Enterobacter asburiae VT65, Enterobacter aerogenes VT66 and Enterobacter ludwigii VT70 strains. Sequence alignment analysis revealed the presence of two zinc binding sites, "HXHXDH" motif as well as tyrosine residue at the position 194. Based on known template available at Swiss-Model, putative tertiary structure of AHL-lactonase was constructed. The result showed that novel endophytic strains of Enterobacter genera encode the novel aiiA homologous gene and its structural importance for future study. © 2013 Elsevier Inc.

Gurudatt D.M.,University of Mysore | Mohana K.N.,University of Mysore
Industrial and Engineering Chemistry Research | Year: 2014

The influence of three newly synthesized oxadiazole derivatives on the corrosion inhibition of mild steel in 0.5 M HCl solution was studied using mass loss and electrochemical techniques. The corrosion rate decreased with increasing concentration of inhibitors and increased with increase in temperature of the medium. Adsorption of the all the three inhibitors obeyed the Langmuir isotherm model. Polarization curves indicated that the inhibitors are of mixed type. Electrochemical impedance spectroscopy measurements explained the mechanism of action of inhibitors. Various activation and adsorption thermodynamic parameters were calculated. The surface adsorbed film was characterized by scanning electron microscopy (SEM) and energy dispersive analysis of X-ray (EDAX). The electronic properties of the inhibitors were obtained from AM1 semiempirical quantum chemical approach. Excellent correlation was found between theoretical and experimental results. © 2014 American Chemical Society.

Positron lifetime spectroscopy is used to develop a new approach to characterize the individual interfaces in ternary polymer blends and hence determine composition dependent miscibility level. This approach has its genesis in KSR and KRZ models for the evaluation of hydrodynamic interaction parameters (α ij). The method successfully applied for binary blends (single interface) earlier is theoretically modified for ternary blends and experimentally verified by measuring free volume content in blends and their constituents. We have tested the efficacy of this method in two ternary blends namely SAN/PVC/PMMA and SAN/EVA/PVC at different compositions. The effective hydrodynamic parameter α eff evaluated using individual α values turns out to be handy in predicting the overall miscibility level of a ternary blend. Results show that SAN/PVC/PMMA exhibits maximum α eff of -9.67 at composition 75/5/20 and SAN/EVA/PVC shows -3.18 at 50/35/15 indicating that miscibility level is high at these compositions for these two blends. DSC and SEM studies have also been used to supplement positron results. © 2011 Elsevier Ltd. All rights reserved.

Quorum sensing mechanism allows the microorganisms to resist the antibiotic treatment by forming biofilms. Quorum quenching is one of the mechanisms to control the development of drug resistance in microbes. Endophyte bacteria are beneficial to plant growth as they support the immune system against the pathogen attack. The endophytic bacteria present in Pterocarpus santalinus were screened for the presence of N-acyl homoserine lactones (AHLs) degrading bacteria using biosensor strains and further confirmed by quantifying the violacein production. Cell-free lysate of endophytic bacteria, Bacillus firmus PT18 and Enterobacter asburiae PT39 exhibited potent AHL degrading ability by inhibiting about 80% violacein production in biosensor strain. Furthermore, when the cell-free lysate was applied to Pseudomonas aeruginosa PAO1 and PAO1-JP2 biofilm it resulted in significant (p<. 0.01) inhibition of biofilm formation. The biofilm inhibition was confirmed by visualization of biofilm slides under fluorescence microscopy, which showed decrease in total biomass formation in treated slides. Isolation and amplification of the gene (aiiA) indicated that the presence of AHL lactonase in cell-free lysate and sequence alignment indicated that AiiA contains a "HXHXDH" zinc-binding motif that is being conserved in several groups of metallohydrolases. Therefore, the study shows the potential of AHLs degradation by AHL lactonase present in cell-free lysate of isolated endophytic bacteria and inhibition of quorum sensing regulated biofilm formation in P. aeruginosa PAO1. © 2013 Elsevier GmbH.

Prakash J.,University of Mysore
Journal of the Science of Food and Agriculture | Year: 2014

Safe and adequate food is a human right, safety being a prime quality attribute without which food is unfit for consumption. Food safety regulations are framed to exercise control over all types of food produced, processed and sold so that the customer is assured that the food consumed will not cause any harm. From the Indian perspective, global harmonisation of food regulations is needed to improve food and nutrition security, the food trade and delivery of safe ready-to-eat (RTE) foods at all places and at all times. The Millennium Development Goals (MDGs) put forward to transform developing societies incorporate many food safety issues. The success of the MDGs, including that of poverty reduction, will in part depend on an effective reduction of food-borne diseases, particularly among the vulnerable group, which includes women and children. Food- and water-borne illnesses can be a serious health hazard, being responsible for high incidences of morbidity and mortality across all age groups of people. Global harmonisation of food regulations would assist in facilitating food trade within and outside India through better compliance, ensuring the safety of RTE catered foods, as well as addressing issues related to the environment. At the same time, regulations need to be optimum, as overregulation may have undue negative effects on the food trade. © 2013 Society of Chemical Industry.

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