Mysore, India
Mysore, India

The University of Mysore is a public state university located in Mysore, Karnataka, India. The university was founded during the reign of Krishnaraja Wodeyar IV, the Maharaja of Mysore. It opened on 27 July 1916, with the first chancellor being the Maharaja of Mysore and the first Vice Chancellor being H. V. Nanjundaiah. The university became the first outside the domain of the Britain administration in India, the sixth university in India as a whole, and the first ever university in Karnataka. It is a state university of the affiliating type, and became autonomous on 3 March 1956, when it gained recognition from the University Grants Commission.The university encompasses 122 affiliated colleges and five constituent colleges . In addition, the university has 37 postgraduate departments, eight specialised research and training centres and two postgraduate centres that together offer about 55 regular academic programmes to 3,500 students. It also runs a number of employment-oriented diploma courses and certificate programmes.The Mysore University Library comprises over 800,000 books, 2,400 journal titles and 100,000 volumes of journals. The main campus features an amphitheater, an auditorium, a swimming pool, and hostel accommodation for men and women. As of July 2013, the University of Mysore was accredited "Grade A" by National Assessment and Accreditation Council , while its academic staff was ranked amongst the top 5 across India. Wikipedia.

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Swamy N.,University of Mysore
Brazilian Journal of Pharmaceutical Sciences | Year: 2014

Two simple, rapid and inexpensive spectrophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in tablets. The methods are based on charge-transfer (CT) complexation reaction involving ALB as n-donor and iodine as σ-acceptor (method A) in dichloromethane or picric acid (PA) as π-acceptor (method B) in chloroform. The absorbance of CT complexes was measured at 380 nm for method A, and 415 nm for method B. The optimization of the experimental conditions is described. Under optimum conditions, Beer’s law obeyed over the concentration ranges 8.0-240 and 2.4-42 mg mL-1for method A and method B, respectively. The apparent molar absorptivity of CT complexes at the respective λmaxare calculated to be 1.17×103and 5.22×103L mol-1cm-1respectively, and the corresponding Sandell sensitivity values are 0.2273 and 0.0509 ng cm-2. The limits of detection (LOD) and quantification (LOQ) are calculated to be (0.69 and 2.08), and (0.10 and 0.30) mg mL-1with method A, and method B, respectively. The intra-day and inter-day accuracy expressed as % RE and precision expressed as % RSD were less than 3%. The methods were applied to the determination of ALB in tablets. © 2014, Faculdade de Ciencias Farmaceuticas (Biblioteca). All right reserved.

Puneeth H.R.,University of Mysore | Chandrashekariah S.A.,University of Mysore
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objective: To investigate the antioxidant properties of curcumin pyrazole derivatives using different in-vitro models and hypoglycemic potential by gluconeogenesis studies. Methods: Antioxidant ability of curcumin pyrazole derivatives was evaluated by using DPPH, nitric oxide, superoxide anion scavenging and lipid peroxidation assays comparing with standard, ascorbic acid (AA). The hypoglycemic effects of the compounds (3a-3e) were assessed by gluconeogenesis inhibition assay using rat liver slices comparing with standard, Insulin. Results: Compounds demonstrated strong scavenging activities against 2, 2-diphenyl, 2-picryl hydrazyl (DPPH), nitric oxide, superoxide anion radicals and also effectively inhibited lipid peroxidation. Compounds 3a, 3b and 3e exhibited significant activity in quenching DPPH, superoxide anion radical, nitric oxide and showed anti-lipid peroxidation. Other compounds 3c and 3d showed moderate activities. The gluconeogenesis inhibitory effects were more pronounced with compounds 3a and 3b compared to compounds 3c, 3d and 3e. Conclusion: Curcumin pyrazole derivatives showed considerable antioxidant activity against free radicals and lipid peroxidation. They exhibited significant IC50values and thus can promote prominent protection against oxidative damage. The compounds 3a and 3b could be promising hypoglycemic agents as they are capable of lowering blood glucose by inhibiting gluconeogenesis and can be selected for further in-vitro and in vivo anti-diabetic investigations. © 2015, International Journal of Pharmacy and Pharmaceutical Science. All rights reserved.

Girish K.S.,University of Mysore | Kemparaju K.,University of Mysore
Current Topics in Medicinal Chemistry | Year: 2011

Snakebite is a medical emergency in many parts of the world, particularly in the temperate regions. According to 2007 World Health Organization (WHO) report, there are about 5 million snakebite incidences resulting in 2.5 million envenoming, and 125,000 deaths occur annually. Most affected are the healthy individuals like children and farming populations with resource poor settings and away from health care centers in low-income countries of Africa, Asia and Latin America. In view of this, the WHO has declared snakebite as an ignored health crisis and a tropical disease. Although the death rate has reduced markedly due to anti-venom regiment, several limitations of it offer scope for better understanding of various ignored issues. Currently, snakebite therapeutics facing plethora of scientific, technological and public health challenges, including secondary/long term complications that have not been given importance so far. Because of dearth of knowledge, venom researchers and medical practitioners from affected countries worldwide should join together to accomplish this scenario. In view of this, the present review provides a broader perspective on the possible production and application of highly effective therapeutic master anti-venom, designing master diagnostic kit and also to deal with the inefficacy of anti-venom therapy against local manifestations and secondary complications of snakebite. The review demands thorough understanding of venom pharmacology, inculcating new strategies to handle and to enhance the efficacy of snakebite management and urge the governing systems of affected countries to take steps to curtail accidental debilitation and death rate of healthy individuals due to snakebite. © 2011 Bentham Science Publishers.

Ajay Kumar K.,University of Mysore | Jayaroopa P.,University of Mysore
International Journal of PharmTech Research | Year: 2013

Pyrazoles are an important class of five membered heterocyclic compounds; are widely found as the core structure in a large variety of compounds that possess important agrochemical and pharmaceutical activities. Pyrazoles have been the recent target of numerous methodologies, mostly due to their prevalence as scaffolds in synthesis of bioactive compounds and reactions in different media. The aim of this review is to provide an up to date developments in the synthetic strategies, biological activities associated with pyrazole derivatives. Different synthetic methodologies and the diverse pharmacological activities of pyrazole moiety was discussed.

Ajay Kumar K.,University of Mysore
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

The unique reactivity of cyclopropanes due to the high level of strain offers considerable utility in organic synthesis. Many imaginative applications of cyclopropanes as useful building blocks have been predicated on regio-and stereo-controlled ring-opening reactions of substituted cyclopropanes. Cyclopropane analogs have known to exhibit diverse pharmacological applications that created enormous interest in Bioorganic, Medicinal and Pharmaceutical chemistry. This review article depicts the up to date information about the conventional to modified methods of synthesis of cyclopropane analogs and their biological activities. The structure activity relationship was also discussed.

University of Mysore, National University of Singapore, Bangalore University and Cambridge Enterprise Ltd | Date: 2016-01-22

The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.

Bai A.J.,University of Mysore | Rai V.R.,University of Mysore
Comprehensive Reviews in Food Science and Food Safety | Year: 2011

Food spoilage and biofilm formation by food-related bacteria are significant problems in the food industry. Even with the application of modern-day food preservative techniques, excessive amounts of food are lost due to microbial spoilage. A number of studies have indicated that quorum sensing plays a major role in food spoilage, biofilm formation, and food-related pathogenesis. Understanding bacterial quorum-sensing signaling systems can help in controlling the growth of undesirable food-related bacteria. This review focusses on the various signaling molecules produced by Gram-negative and Gram-positive bacteria and the mechanism of their quorum-sensing systems, types of signaling molecules that have been detected in different food systems using biosensors, the role of signaling molecules in biofilm formation, and significance of biofilms in the food industry. As quorum-sensing signaling molecules are implicated in food spoilage, based on these molecules potential, quorum-sensing inhibitors/antagonists can be developed to be used as novel food preservatives for maintaining food integrity and enhancing food safety. Practical Application: Bacteria use signaling molecules for inter- and intracellular communication. This phenomenon of bacterial cell-to-cell communication is known as quorum sensing. Quorum-sensing signals are implicated in bacterial pathogenicity and food spoilage. Therefore, blocking the quorum-sensing signaling molecules in food-related bacteria may possibly prevent quorum-sensing-regulated phenotypes responsible for food spoilage. Quorum-sensing inhibitors/antagonists could be used as food preservatives to enhance the shelf life and also increase food safety. © 2011 Institute of Food Technologists ®.

Belugali Nataraj N.,University of Mysore | Salimath B.P.,University of Mysore
Cellular Signalling | Year: 2013

We have identified and characterized a novel proangiogenic glycoprotein (NAP) with molecular weight of 67. kDa from synovial fluid of rheumatoid arthritis patients. Proteomic analysis of the protein revealed 29% sequence coverage with maximum identity for human retinoblastoma binding protein 2. N-terminal amino acid sequence showed no identity to recently discovered protein sequences. NAP was also identified in both normal and tumor cell lines by Western blotting. NAP is a permeability factor as verified by miles permeability assay. The proangiogenic potential of NAP was identified using shell less CAM, rat cornea and tumor on CAM assays. NAP induces expression of VEGF and Flt-1 gene as verified by promoter reporter gene analysis. Further NAP induces proliferation of endothelial cells and formation of tube like structures. NAP is also involved in migration and invasion of tumor cells. Clinical data revealed the presence of NAP in breast cancer biopsies. We have developed monoclonal antibody (mAb), and specific ELISA, which confirmed the presence of NAP in the cytosol of tumor cells. The mAb effect was evaluated with established angiogenic assays. Further, we investigated the detailed mechanism by which NAP induces angiogenesis. NAP is phosphorylated by VEGF induced activation of MAPK and JNK pathways through VEGFR2 phosphorylation. NAP involves JNK pathway predominantly with further activation of NFκB in downstream processing of VEGF activation. Together these findings establish that NAP displays angiogenic properties and promotes efficient neovascularization both in vitro and in vivo models. These observations suggest that anti-NAP-mAb can be targeted for antiangiogenic therapy of cancer. © 2012 Elsevier Inc.

Quorum sensing mechanism allows the microorganisms to resist the antibiotic treatment by forming biofilms. Quorum quenching is one of the mechanisms to control the development of drug resistance in microbes. Endophyte bacteria are beneficial to plant growth as they support the immune system against the pathogen attack. The endophytic bacteria present in Pterocarpus santalinus were screened for the presence of N-acyl homoserine lactones (AHLs) degrading bacteria using biosensor strains and further confirmed by quantifying the violacein production. Cell-free lysate of endophytic bacteria, Bacillus firmus PT18 and Enterobacter asburiae PT39 exhibited potent AHL degrading ability by inhibiting about 80% violacein production in biosensor strain. Furthermore, when the cell-free lysate was applied to Pseudomonas aeruginosa PAO1 and PAO1-JP2 biofilm it resulted in significant (p<. 0.01) inhibition of biofilm formation. The biofilm inhibition was confirmed by visualization of biofilm slides under fluorescence microscopy, which showed decrease in total biomass formation in treated slides. Isolation and amplification of the gene (aiiA) indicated that the presence of AHL lactonase in cell-free lysate and sequence alignment indicated that AiiA contains a "HXHXDH" zinc-binding motif that is being conserved in several groups of metallohydrolases. Therefore, the study shows the potential of AHLs degradation by AHL lactonase present in cell-free lysate of isolated endophytic bacteria and inhibition of quorum sensing regulated biofilm formation in P. aeruginosa PAO1. © 2013 Elsevier GmbH.

Prakash J.,University of Mysore
Journal of the Science of Food and Agriculture | Year: 2014

Safe and adequate food is a human right, safety being a prime quality attribute without which food is unfit for consumption. Food safety regulations are framed to exercise control over all types of food produced, processed and sold so that the customer is assured that the food consumed will not cause any harm. From the Indian perspective, global harmonisation of food regulations is needed to improve food and nutrition security, the food trade and delivery of safe ready-to-eat (RTE) foods at all places and at all times. The Millennium Development Goals (MDGs) put forward to transform developing societies incorporate many food safety issues. The success of the MDGs, including that of poverty reduction, will in part depend on an effective reduction of food-borne diseases, particularly among the vulnerable group, which includes women and children. Food- and water-borne illnesses can be a serious health hazard, being responsible for high incidences of morbidity and mortality across all age groups of people. Global harmonisation of food regulations would assist in facilitating food trade within and outside India through better compliance, ensuring the safety of RTE catered foods, as well as addressing issues related to the environment. At the same time, regulations need to be optimum, as overregulation may have undue negative effects on the food trade. © 2013 Society of Chemical Industry.

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