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Murcia, Spain

The University of Murcia is the main university in Murcia, Spain. With 38,000 students, it is the largest university in the Región de Murcia. The University of Murcia is the third oldest university in Spain, after the University of Salamanca and the University of Valladolid , and the thirteenth in the world. The University of Murcia was established in 1272 by the King Alfonso X of Castile under the Crown of Castile.The majority of the University's facilities and buildings are spread over two campuses: the older is La Merced, situated in the town centre, and the larger is Espinardo, just 5 km to the north of Murcia. A third campus for Medical and Health Studies is currently being built next to the suburban area known as Ciudad Sanitaria Virgen de la Arrixaca, 5 km south of the city. A new campus had been made in San Javier too, that hosts the Sports Science faculty. Wikipedia.


Lozano P.,University of Murcia
Green Chemistry | Year: 2010

Biphasic systems based on neoteric solvents, e.g. ionic liquids (ILs), supercritical carbon dioxide (scCO2), fluorous solvents (FSs) and liquid polymers (LPs), represent interesting alternatives to organic solvents for designing continuous clean biotransformations methods in non-aqueous environments that directly provide pure products. The classical advantages of scCO2- its ability to extract, dissolve and transport chemicals - are complemented by the high catalytic efficiency of enzymes in liquid neoteric solvents (e.g. ILs, LPs or FSs). Enzyme behaviour in scCO2 and ILs, as well as the phase behaviour of ILs/scCO2, are key parameters for carrying out integral green bioprocesses in continuous operation. Experimental approaches, reactor designs and results are discussed in this Critical review. © 2010 The Royal Society of Chemistry. Source


The new variable power accommodative intraocular lens is comprised by a central body or optical zone that has at least four refracting interfaces that separate different materials. These are connected by means of a substrate that holds them in an equatorial manner, and which includes the bases of the fasteners of the lens embedded in its core. The lens changes its power in response to variations in the equatorial diameter of the materials that comprise the optical zone. Thanks to its design, the lens can achieve variations in the optical powers greater than one dioptre per micrometre of equatorial compression. This is achieved through the real change of the curvature radii of the refracting interfaces that comprise the optical zone, as well as the central thicknesses along the length of the optical axis of the different materials that limit said refracting interfaces. Preferably the intraocular lens works in combination with a capsular ring, to which the haptics are fixed and whose external diameter determines the power of the lens. The change of power mechanism in the lens initiates with the contraction of the ciliary muscle of the patient in response to the accommodative force.


Patent
University of Murcia | Date: 2012-04-11

The present invention relates to a method for measuring ocular scattering, comprising the steps of: sequentially projecting images from an extensive light source, corresponding to different visual angles, onto the retina; recording the output light in a camera or detector once it has passed through the eye twice; calculating the intensity at the center of each recorded image; calculating the PSF for each angle from the previous intensities; and calculating the average of the value of the PSF between the angles. The invention also relates to a system for carrying out said method. The invention can be used to measure the intensity of the scattered light in an objective manner.


An ophthalmic instrument for measurement of ocular refraction and visual simulation and a method of measurement obtaining the ocular refraction in a binocular manner, which incorporates a digitally controlled phase modulator for generating best ophthalmic correction in each subject. The instrument enables measuring refraction, not only associated with blurring and astigmatism, but also optical aberration of any order. The phoropter can simulate vision by any phase profile, including those of a diffractive or discontinuous type. The instrument also incorporates a subsystem for presentation of stimuli that produces stereoscopic vision of the same, enabling the subject to enjoy a three dimensional perception during the process, and two output pupils. The instrument, by its electro-optical features, enables simulation of vision as it would be modified after submitting an eye to different surgical techniques, such as refractive surgery or interocular lens implantation.


The invention provides a method of treatment of melanoma comprising administering a tyrosinase expression enhancer, such as MTX, and a tyrosinase-activated prodrug, such as TMECG or TMCG, to an individual in need thereof. Also provided is a method of treating melanoma comprising administering a tyrosinase-activated prodrug and a compound for differentiating a stem-like tumor cell into a matured cell that is a tyrosinase producer to an individual in need thereof. Further provided is a method of treatment of melanoma comprising administering a tyrosinase expression enhancer and a tyrosinase-activated prodrug to an individual in need thereof, wherein the individual has a melanoma in which one or more of BRAF, NRAS, p53, GNAQ, EGFR, PDGFR, RAC or c-kit carries a mutation.

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