Time filter

Source Type

Moron, Argentina

The Universidad de Morón is a private university located in Morón, Buenos Aires, Argentina, founded in 1960. Ten faculties offer courses on Agronomy and Agro-alimentary science; Architecture, Design, Art and Urbanism; Law, Political and Social science; Exact, Chemical, and Material science; Philosophy, Education science, and Humanities; Information, Communication science, and Special Techniques; Engineering; Medicine; Applied Tourism science and Population. Wikipedia.

Arias H.R.,Midwestern University | Feuerbach D.,Novartis | Bhumireddy P.,Western University of Health Sciences | Ortells M.O.,University of Moron
International Journal of Biochemistry and Cell Biology | Year: 2010

Functional and structural approaches were used to examine the inhibitory mechanisms and binding site location for fluoxetine and paroxetine, two serotonin selective reuptake inhibitors, on nicotinic acetylcholine receptors (AChRs) in different conformational states. The results establish that: (a) fluoxetine and paroxetine inhibit hα1β1γδ AChR-induced Ca2+ influx with higher potencies than dizocilpine. The potency of fluoxetine is increased ∼10-fold after longer pre-incubation periods, which is in agreement with the enhancement of [3H]cytisine binding to resting but activatable Torpedo AChRs elicited by these antidepressants, (b) fluoxetine and paroxetine inhibit the binding of the phencyclidine analog piperidyl-3,4-3H(N)]-(N-(1-(2 thienyl)cyclohexyl)-3,4-piperidine to the desensitized Torpedo AChR with higher affinities compared to the resting AChR, and (c) fluoxetine inhibits [3H]dizocilpine binding to the desensitized AChR, suggesting a mutually exclusive interaction. This is supported by our molecular docking results where neutral dizocilpine and fluoxetine and the conformer of protonated fluoxetine with the highest LUDI score interact with the domain between the valine (position 13′) and leucine (position 9′) rings. Molecular mechanics calculations also evidence electrostatic interactions of protonated fluoxetine at positions 20′, 21′, and 24′. Protonated dizocilpine bridges these two binding domains by interacting with the valine and outer (position 20′) rings. The high proportion of protonated fluoxetine and dizocilpine calculated at physiological pH suggests that the protonated drugs can be attracted to the channel mouth before binding deeper within the AChR ion channel between the leucine and valine rings, a domain shared with phencyclidine, finally blocking ion flux and inducing AChR desensitization. © 2010 Elsevier Ltd. All rights reserved.

Duro E.A.,University of Moron | Moussou I.,Hospital Zonal General de Agudos Magdalena V. de Martinez
Iranian Journal of Pediatrics | Year: 2011

Background: Chorioangiomas are the most common benign tumors of the placenta originating from primitive angioblastic tissues. It comprises near 1 percent of placental tumors. Clinical manifestations in the newborn are rare and usually associated with tumors greater than 5 cm in diameter and consist of polyhydramnios, fetal anemia, massive edema with pleural effusion, ascites and intrauterine growth retardation. We present a case with large chorioangioma as the cause of non-immunologic hydrops fetalis with a successful outcome. Case Presentation: The patient was a female newborn with history of polyhydramnios, symptoms of congestive heart failure and associated anemia, thrombocytopenia and coagulopathy. The pathophysiology and management of the complications of hydrops fetalis with chorioangioma are discussed Conclusion: Chorioangioma of the placenta has potentially serious perinatal risks and so the pregnancy needs to have regular surveillance. The chance of developing complications is directly related with the tumor size. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.

Landini F.,University of Moron
Chilean Journal of Agricultural and Animal Sciences | Year: 2015

Rural extension is a valuable strategy to promote rural development and innovation in the context of family agriculture. Taking into account the complexity of rural extension and the multiplicity of problems faced by practitioners in their practice, a research was conducted aimed at describing and understanding the problems faced by them in Northeastern Argentina. A total of 40 semi-structured interviews were conducted to extensionists who work in the public extension system in the provinces of Chaco, Corrientes, Formosa and Misiones, Argentina. The pressure of agribusiness, top-down policies and planning, limited education of extensionists, implementation of inadequate productive practices and farmers' lack of adoption of technologies were identified as the most important problems.

Martinez Y.,University of Moron | Cachero C.,University of Alicante | Melia S.,University of Alicante
Information and Software Technology | Year: 2013

Context: Today's project managers have a myriad of methods to choose from for the development of software applications. However, they lack empirical data about the character of these methods in terms of usefulness, ease of use or compatibility, all of these being relevant variables to assess the developer's intention to use them. Objective: To compare three methods, each following a different paradigm (Model-Driven, Model-Based and Code-Centric) with respect to their adoption potential by junior software developers engaged in the development of the business layer of a Web 2.0 application. Method: We have conducted a quasi-experiment with 26 graduate students of the University of Alicante. The application developed was a Social Network, which was organized around a fixed set of modules. Three of them, similar in complexity, were used for the experiment. Subjects were asked to use a different method for each module, and then to answer a questionnaire that gathered their perceptions during such use. Results: The results show that the Model-Driven method is regarded as the most useful, although it is also considered the least compatible with previous developers' experiences. They also show that junior software developers feel comfortable with the use of models, and that they are likely to use them if the models are accompanied by a Model-Driven development environment. Conclusions: Despite their relatively low level of compatibility, Model-Driven development methods seem to show a great potential for adoption. That said, however, further experimentation is needed to make it possible to generalize the results to a different population, different methods, other languages and tools, different domains or different application sizes. © 2012 Elsevier B.V. All rights reserved.

Korstanje M.E.,University of Moron
Anatolia | Year: 2011

In spite of all technological advances in favor of humankind to promote travel, people are experiencing an increasing fear of travelling or flying. Most likely, the events of September 11, 2001, not only increased the risk perception but also brought to attention the importance of security in tourism. Whatever the case may be, the present article is aimed at critically discussing the contributions and limitations of psychoanalysis as well as system psychology, risk travel perception and secure base theory. Paradoxically, in a context wherein more people make use of mass means of transport, a considerable number of travelers feel a major discomfort because of security issues. Of course, progress and development in the last few years have converged on the idea that even if the fear of travelling could be studied regardless of time and country, evidence suggests that, in western Societies, these kinds of psychological attitudes have spread pandemically. Under these circumstances, it is important to discuss the contributions and problems that current theories demonstrates in applied research. © 2011 Taylor & Francis.

Discover hidden collaborations