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Montreal, Canada

The Université de Montréal is a public research university in Montreal, Quebec, Canada. The francophone institution comprises thirteen faculties, more than sixty departments and two affiliated schools: the École Polytechnique and HEC Montréal . It offers more than 650 undergraduate programmes and graduate programmes, including 71 doctoral programmes. The Times Higher Education World University Rankings of 2012-2013 ranks the Université de Montréal at 84th place globally.The university has Quebec's largest sponsored research income and the third largest in Canada, allocating close to $524.1 million to research conducted in more than 150 research centres as of 2011. It is also part of the U15 universities. More than 55,000 students are enrolled in undergraduate and graduate programs, making it the second-largest university in Canada in terms of student enrolment. Wikipedia.

Charbonneau P.,University of Montreal
Annual Review of Astronomy and Astrophysics

The Sun's magnetic field is the engine and energy source driving all phenomena collectively defining solar activity, which in turn structures the whole heliosphere and significantly impacts Earth's atmosphere down at least to the stratosphere. The solar magnetic field is believed to originate through the action of a hydromagnetic dynamo process operating in the Sun's interior, where the strongly turbulent environment of the convection zone leads to flow-field interactions taking place on an extremely wide range of spatial and temporal scales. Following a necessarily brief observational overview of the solar magnetic field and its cycle, this review on solar dynamo theory is structured around three areas in which significant advances have been made in recent years: (a) global magnetohydrodynamical simulations of convection and magnetic cycles, (b) the turbulent electromotive force and the dynamo saturation problem, and (c) flux transport dynamos, and their application to model cycle fluctuations and grand minima and to carry out cycle prediction. Copyright © 2014 by Annual Reviews. Source

Audet M.,University of Montreal

G-protein-coupled receptors serve as key signal transduction conduits, linking extracellular inputs with diverse cellular responses. These receptors eluded structural characterization for decades following their identification. A landmark structure of rhodopsin provided a basis for structure-function studies and homology modeling, but advances in receptor biology suffered from a lack of receptor-specific structural insights. The recent explosion in GPCR structures confirms some features predicted by rhodopsin-based models, and more importantly, it reveals unexpected ligand-binding modes and critical aspects of the receptor activation process. The new structures also promise to foster studies testing emerging models for GPCR function such as receptor dimerization and ligand-biased signaling. Copyright © 2012 Elsevier Inc. All rights reserved. Source

Histone methylation is a dynamic and reversible process proposed to directly impact on stem cell fate. The Jumonji (JmjC) domain-containing family of demethylases comprises 27 members that target mono-, di-, and trimethylated lysine residues of histone (or nonhistone) proteins. To evaluate their role in regulation of hematopoietic stem cell (HSC) behavior, we performed an in vivo RNAi-based functional screen and demonstrated that Jarid1b and Jhdm1f play opposing roles in regulation of HSC activity. Decrease in Jarid1b levels correlated with an in vitro expansion of HSCs with preserved long-term in vivo lymphomyeloid differentiation potential. Through RNA sequencing analysis, Jarid1b knockdown was associated with increased expression levels of several HSC regulators (Hoxa7, Hoxa9, Hoxa10, Hes1, Gata2) and reduced levels of differentiation-associated genes. shRNA against Jhdmlf, in contrast, impaired hematopoietic reconstitution of bone marrow cells. Together, our studies identified Jarid1b as a negative regulator of HSC activity and Jhdmlf as a positive regulator of HSC activity. Source

University of Montréal | Date: 2013-08-30

A compound of Formula I or Formula II:

RSEM Ltd Partnership and University of Montréal | Date: 2014-04-04

Novel methods for modulating acute myeloid leukemia stem/progenitor cell expansion and/or differentiation are disclosed. These methods are based on the use of aryl hydrocarbon receptor (AhR) modulators and/or compounds of formula I or II Screening assays to identify compounds that may be useful for inhibiting and/or eliminating AML initiating cells using AhR modulators and/or the compounds of formula I or II are also disclosed. The use of pharmaceutically acceptable agonists of the AhR for preventing or inhibiting minimal residual disease (MRD) in an AML patient is also disclosed.

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