University of Miyazaki | Date: 2017-02-08
There is provided a novel adrenomedullin derivative capable of sustainably acting for a longer period than natural adrenomedullin. The invention relates to a compound represented by formula (I): A-L_(n)-B (I), wherein A is a modifying group selected from the group consisting of a palmitoyl group and a polyethylene glycol group, L is a divalent linking group, n is an integer of 0 or 1, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is bound to the modifying group A or the linking group L via the N-terminal amino group of the peptide moiety B, or a salt thereof, or a hydrate thereof.
University of Miyazaki and Fuso Pharmaceutical Industries Ltd. | Date: 2017-03-22
The present invention provides a heparin which does not substantially contain a nitrous acid degradation-resistant impurity, wherein, with respect to the peak total area value detected by refractive index (RI) which appears at the elution point of the heparin obtained when a reference heparin is analyzed by high performance liquid chromatography (HPLC), the peak total area value which appears at the elution point of the heparin which has been degraded with the above nitrous acid and analyzed by HPLC under the same conditions, is 5% or less,wherein the analysis is conducted by high performance liquid chromatography (HPLC) under the conditions disclosed in the Molecular Weight section in the Parnaparin sodium Standard Test Method described in The Japanese Pharmacopoeia, fifteenth edition.
University of Miyazaki | Date: 2017-03-03
An object of the present invention is to provide methods for preventing or treating a steroid-resistant or steroid-dependent inflammatory bowel disease. The object can be achieved by a method for preventing or treating a steroid-resistant or steroid-dependent inflammatory bowel disease in a patient in need of the prevention or treatment of the inflammatory bowel disease, comprises administering an effective amount of adrenomedullin, a modified product thereof having an activity of suppressing steroid-resistant or steroid-dependent inflammation, or a salt thereof having an activity of suppressing steroid-resistant or steroid-dependent inflammation, to the patient.
Kyushu University, University of Miyazaki, Konan Gakuen and Nippon Suisan Kaisha Ltd. | Date: 2016-01-13
Disclosed is a transformation method whereby an ability to produce a useful substance of a stramenopile can be improved. The method for transforming a stramenopile comprises transferring a foreign gene into the stramenopile which is a microorganism belonging to the class Labyrinthula, more specifically, to a genus Labyrinthula, Altornia, Aplanochytrium, Schizochytrium, Aurantiochytrium, Thraustochytrium, Ulkenia, etc. Said foreign gene, which is a gene relating to tolerance against an antibiotic, a colorimetric protein and/or a fatty acid desaturase (5 desaturase gene, 12 desaturase gene and/or 3 desaturase gene), is transferred by using the electroporation or gene-gun technique.
Kyushu University, University of Miyazaki, Konan Gakuen and Nippon Suisan Kaisha Ltd. | Date: 2015-05-13
To provide a transformation method for producing a stramenopile organism having an improved unsaturated fatty acid production capability by disrupting a gene of the stramenopile organism or inhibiting the expression of the gene in a genetically engineering manner. [Solution] A method for transforming a stramenopile organism, which comprises disrupting a gene of the stramenopile organism or inhibiting the expression of the gene in a genetically engineering manner, and which is characterized in that the stramenopile organism is selected from Thraustochytrium aureum, Parietichytrium sarkarianum, Thraustochytrium roseum and Parietichytrium sp. and the gene to be disrupted or of which the expression is to be inhibited is a gene associated with the biosynthesis of a fatty acid.
Xu Y.,University of Miyazaki
Chemical Society Reviews | Year: 2011
Telomeres are present at the ends of all eukaryotic chromosomes. Human telomeres play an important role in critical processes underlying genome stability, cancer, and aging, and their importance was recognized via the award of the 2009 Nobel Prize in Physiology or Medicine. Chemistry has made vast and almost unparalleled contributions to telomere biology. This critical review highlights the contributions of chemistry in human telomeres and summarizes the significant development of human telomere biology. First, I provide an overview of the advances in understanding of the structures and functions of human telomeres. Second, I focus on the current efforts on developing various chemical approaches to targeting human telomeres and telomerase for the treatment of cancer. Third, studies on a newly discovered telomeric repeat-containing RNA are discussed in detail. Last, future challenges in the field are outlined, including perspectives of both chemistry and biology (412 references). © 2011 The Royal Society of Chemistry.
Japan National Institute of Advanced Industrial Science, Technology and University of Miyazaki | Date: 2015-09-23
An object of the present invention is to provide a -1,3-glucan derivative which is a polymer having -1,3-glucan as a main chain, and has thermoplasticity and excellent moldability, and a preparation method thereof. That is, the present invention provides a -1,3-glucan derivative having a structure represented by General Formula (1) as a main chain.^(1)s independently represents a hydrogen atom or -COR^(2), n represents an integer of 1 or greater, and R^(2) represents an aliphatic hydrocarbon group or an aromatic hydrocarbon group. In Formula (1), a plurality of the R^(1)s may be the same as or different from each other, and at least a part of a plurality of the R^(1)s is -COR^(2).)
University of Miyazaki | Date: 2015-09-16
An object of the present invention is to discover a novel component of the renin-angiotensin system (RAS) and to provide the same as a novel biomarker of a cardiovascular disease or a renal disease. This invention provides a novel peptide associated with the renin-angiotensin system comprising the amino acid sequence as shown in SEQ ID NO: 1 or an amino acid sequence derived therefrom by deletion, substitution, or addition of one to several amino acids other than the asparagine residue at position 14 and an N-linked glycan added thereto at the asparagine residue at position 14. With the use of such peptide as a biomarker, a renal disease or a cardiovascular disease can be diagnosed at an early stage in a simple manner without imposing burdens on a subject.
University of Miyazaki | Date: 2015-08-11
The present invention provides a peptide having antagonist activity against SP, pain control activity, anti-inflammation activity, and anti-pruritic activity. The present invention further provides a method for searching for a therapeutic agent for pain, a therapeutic agent for inflammation, and a therapeutic agent for pruritus using G protein coupled receptor (GPR) 83, which is an HK-1 specific receptor.
University of Miyazaki, Fujita Health University Hospital and Perseus Inc. | Date: 2016-07-13
It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.