The University of Missouri–Kansas City is a public research university located in Kansas City, Missouri, USA. It is a part of the University of Missouri System. Its main campus is in Kansas City's Rockhill neighborhood east of the Country Club Plaza. The university's enrollment is more than 15,700 in 2014. Wikipedia.
News Article | May 4, 2017
BLUE SPRINGS, MO, May 04, 2017-- James Robert Wyrsch is a celebrated Marquis Who's Who biographee. As in all Marquis Who's Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in a field are all taken into account during the selection process.Marquis Who's Who, the world's premier publisher of biographical profiles, is proud to name Mr. Wyrsch a Lifetime Achiever. An accomplished listee, Mr. Wyrsch celebrates many years' experience in his professional network, and has been noted for achievements, leadership qualities, and the credentials and successes he has accrued in his field.An esteemed and long-standing figure in his industry, Mr. Wyrsch currently serves as the president, partner and shareholder of Wyrsch, Hobbs & Mirakian Professional Corporation.In addition to his status as Lifetime Achiever, Mr. Wyrsch has previously received the Joint Services Commendation Medal, the Service Award from the University of Missouri-Kansas City Law Foundation, the Lawyer of Year Award from Missouri Lawyers Weekly, and the Practitioner of the Year Award from the University of Missouri-Kansas City Law School Alumni Association. Mr. Wyrsch has also received the Liberty & Justice Legacy Award from the Kansas City Metropolitan Bar Association Foundation, the Outstanding Alumnus Award from Springfield Catholic High School, the Dean of Trial Bar Award from the Kansas City Metropolitan Bar Association, and the Charles Shaw Trial Advocacy Award from the Missouri Association of Criminal Lawyers. Additionally, Mr. Wyrsch has been honored as Best of the Bar by the Kansas City Business Journal, the Kansas City Legal Leader of the Year by the Daily Record, and received the Sean O'Brien Freedom Award from the Midwestern Innocence Project. Mr. Wyrsch is a Fellow of the American College of Trial Lawyers, Fellow of the American Bar Association Foundation, Fellow of the International Academy of Trial Lawyers, Advocate of the American Board of Trial Advocates, Fellow of the Litigation Counsel of America and a Senior Counsel of the College of Master Advocates and Barristers. Furthermore, Mr. Wyrsch has been a featured listee in Who's Who in Finance and Industry, Who's Who in America, Who's Who in American Education, Who's Who in American Law, Who's Who in the Midwest, Who's Who in the World and Who's Who of Emerging Leaders in America.About Marquis Who's Who :Since 1899, when A. N. Marquis printed the First Edition of Who's Who in America , Marquis Who's Who has chronicled the lives of the most accomplished individuals and innovators from every significant field of endeavor, including politics, business, medicine, law, education, art, religion and entertainment. Today, Who's Who in America remains an essential biographical source for thousands of researchers, journalists, librarians and executive search firms around the world. Marquis publications may be visited at the official Marquis Who's Who website at www.marquiswhoswho.com
Agency: National Science Foundation | Branch: | Program: STTR | Phase: Phase I | Award Amount: 212.29K | Year: 2016
The broader impact/commercial potential of this project is that due to the increased mobility of human beings and the nature of modern economic and social activities a variety of power challenges need to be addressed for portable electronic and mechanical devices. The needs include quick power delivery, light-weight but high-capacity energy storage, superior low-temperature operation and ability to handle millions of cycles. On average a soldier, a construction worker or an everyday handyman carry between 50 to 100lb of weight while they are working in their duty sites. A significant portion of this load is from the primary and backup batteries used for their tools and equipment, because corded delivery of power is not always possible. Computing, communication, biomedical and avionic industries are also constantly searching for light-weight but highly efficient energy storage gadgets. The ability to integrate graphene and carbon nanostructure based microsupercapacitors in the next generation energy delivery/storage solutions for portable devices and tools will open the doors for new education, research, product development and economic growth. Due to ultra-light-weight, transparency, extremely high thermal stability and tensile strength, and superior electrical conductivity graphene based supercapacitor would also be suitable for flexible, printable, transparent and wearable electronics. This Small Business Technology Transfer (STTR) Phase I project plans to develop a non-Faradic, thin-film and electrochemical microsupercapacitor utilizing graphene and carbon nanotube (CNT) with high gravimetric energy density. The proposed microsupercapacitor would combine high energy storage capacity of batteries with high power delivery capability of regular capacitors. It would be compatible to commercial lithographic techniques and printable circuit technologies. A limiting factor in the miniaturization of the existing carbon-based supercapacitors is a relatively low volumetric energy density (VED) due to the poor packing density of structures like tangled CNTs. The VED of CNT-based supercapacitors is many orders of magnitude lower than the mainstream energy storage devices. The opportunity to miniaturize the supercapacitor exists with novel designs that strive to minimize its intrinsic components like electrodes and separators that do not directly contribute to cell energy storage. The proposed design would primarily use graphene nanoribbon (GNR) as electrode, which will not have the tangling issue of CNT. Due to the 2D flat nature of GNR the scaling and packing density of GNR devices would be extremely high. The long-term goal is to achieve an energy density over 100 Wh/kg using an array of the proposed microsupercapacitors.
Holman C.M.,University of Missouri - Kansas City
Nature Biotechnology | Year: 2012
The fear that human gene patents pose a threat to whole-genome sequencing is based largely on widely held misconceptions. © 2012 Nature America, Inc. All rights reserved.
Bonewald L.F.,University of Missouri - Kansas City
Journal of Bone and Mineral Research | Year: 2011
The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the "passive placeholder in bone," this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as an endocrine cell. The osteocyte is a source of soluble factors not only to target cells on the bone surface but also to target distant organs, such as kidney, muscle, and other tissues. This cell plays a role in both phosphate metabolism and calcium availability and can remodel its perilacunar matrix. Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment. As we age, these cells die, leaving behind empty lacunae that frequently micropetrose. In aged bone such as osteonecrotic bone, empty lacunae are associated with reduced remodeling. Inflammatory factors such as tumor necrosis factor and glucocorticoids used to treat inflammatory disease induce osteocyte cell death, but by different mechanisms with potentially different outcomes. Therefore, healthy, viable osteocytes are necessary for proper functionality of bone and other organs. © 2011 American Society for Bone and Mineral Research.
Agency: NSF | Branch: Continuing grant | Program: | Phase: ANIMAL DEVELOPMENTAL MECHANSMS | Award Amount: 515.00K | Year: 2015
A fundamental problem in biology is how the proper size of an organism is achieved. The size of tissues and organs is a consequence of both cell size and number and is controlled by both extrinsic signals, such as insulin peptides, and intrinsic cell signals that measure nutritional and environmental inputs. This research program will exploit a genetic model organism to understand how cell division is balanced by cell growth by the action of a gene named Tribbles. Tribbles is found in all animals, and in humans it has been connected to cancer and Type 2 diabetes, but its functions are poorly understood. It has been shown that Tribbles blocks: (1) cell division by binding the protein Cdc25, a key trigger of division, and (2) insulin-stimulated cell growth by binding the protein Akt kinase. This research program will shed light on the functions of Tribbles that regulate animal size during development, and will have implications for scientists studying the role of Tribbles in human disease. The research program will also support ongoing efforts to train students in molecular and cell biological approaches to dissect conserved developmental mechanisms in a model organism.
These studies of the conserved role of Trbl in cell growth and proliferation will offer insight into the genetic basis of animal diversity, the mechanism of evolution, the effect of environmental conditions on a developmental program, and the underlying causes of developmental aberrations and metabolic disease. Body sizes vary impressively between closely related animal species, and species-specific adaptations, such as the mammalian forelimb and specialized head segments among insects, show incredible size scaling. Size is subject to intense evolutionary selection pressure with consequences for mate selection, predation and tolerance to environmental changes, moreover animals adjust size to both nutrient availability and a host of environmental cues including temperature and O2 levels. The mechanisms coordinating this developmental plasticity are incompletely understood, and include integration of cues from hormonal signals, growth factors and insulin-like peptides to ensure that energy expended on growth matches energy intake. The kinase Tribbles (Trbl) binds and blocks a number of key targets that regulate cell growth, division and differentiation, notably cdc25 phosphatase to inhibit cell proliferation and Akt kinase to inhibit insulin-stimulated cell growth and metabolism. The notion that Trbl is an conserved adaptor protein that regulates both cell proliferation (by binding and degrading Cdc25) and cell size (by binding and inhibiting Akt) in response to diet will be tested in three aims: (1) to explore the role of Trbl in cell growth during normal and dietary stress; (2) to perform a structure/function analysis of Trbl, focused on its conserved features; and (3) to conduct a screen for proteins that physically interact with Trbl by (a) yeast two hybrid screens and (b) co-immuno-pulldown using Trbl-specific antisera.
Agency: NSF | Branch: Standard Grant | Program: | Phase: NSF INCLUDES | Award Amount: 240.75K | Year: 2016
This award supports a conference entitled Accelerating Data-Driven Collaboration for Large-Scale Progress which will support the progress of INCLUDES (Inclusion across the Nation of Communities of Learners that have been Underrepresented for Diversity in Engineering and Science) Launch Pilots toward their broadening participation goals. The issues and challenges affecting the persistence of students of color, students from low-income households, females, and students with disabilities in STEM learning surpass the scope of programs designed to promote awareness of STEM career options. The Launch Pilots will need technical assistance to leverage their strategic plans, become poised for the next level of becoming an Alliance, and ultimately show impact that results in large-scale progress.
The conference will support the Launch Pilots in their broadening participation goals by providing opportunities to (1) develop innovative new ways to gather data and make evidence-based decisions, (2) connect with best practices on the frontiers of data-driven collaboration, and (3) apply new knowledge and innovations to their projects that address societal needs. The overarching design of Data-Driven Collaboration is to facilitate the sharing of ideas, struggles, and promising practices in a collaborative and participatory manner. This will occur by fostering a network improvement community (within and across Launch Pilots), engaging participants in systems thinking and problem-solving through collaborative modeling, and a 2.5-day Public Support and Engagement Lab conference. Launch Pilots who engage support from Data-Driven Collaboration will have a variety of technical assistance services available between November 2016 and April 2017.
Agency: NSF | Branch: Standard Grant | Program: | Phase: COMPUTING RES INFRASTRUCTURE | Award Amount: 772.06K | Year: 2016
The aim of this NSF CRI-II-NEW project is to develop a testbed for computer aided design (CAD) simulations, experimental metrology, and software and hardware calibrations to support cross-layer evaluation of novel nanoscale 3D heterogeneous integration of CMOS and post-CMOS technologies. Proposed tools and equipment acquisitions and sustainment will allow bottom-up evaluations from materials, fundamental physics, and experimental metrology to device and circuits to large-scale systems. The proposed infrastructure is unique and will enable thorough evaluation of new 3D heterogeneous integration concepts with accuracy only parallel to full-scale experimental prototyping. It will directly impact the nano-electromagnetics, nano-device, circuits, 3D IC and manufacturing research directions, and will also have significant impact on the big data analytics, renewable energy, smart-city, RF and electromagnetics research initiatives in Computer Science and Electrical Engineering (CSEE) department at University of Missouri-Kansas City (UMKC). The testbed will not only facilitate transformative research, but will also allow broad ranging educational and outreach activities such as new undergraduate and graduate curriculum development with lab modules, training and mentoring of research students, research dissemination thorough forums and seminars, development of online repositories and online labs, and nanotechnology awareness for K-12 students through summer workshops. The boarder impact of this project is that the proposed infrastructure will provide unique opportunities for research, education and community outreach in the fields of nanomaterials, nanodevice, nanocircuit, biosensing, heterogonous integration, and nanomanufacturing.
The research focus of this collaborative project will be to develop nanoscale heterogeneous 3D integration and testing framework for bio-sensing and computing applications leveraging novel materials, devices, circuits and integration schemes. 3D integration provides opportunities to realize systems with heterogeneous layers, such as bio-analytical device and mixed-signal information processing layers that can be vertically stacked and electrically connected through dense vias. However, such implementation with CMOS is challenging due to CMOS?s scaling limits, noise coupling between dissimilar analog and digital circuit components and limitations of die-die or layer-layer stacking. We propose a new 3-D heterogeneous integration approach that overcomes challenges by utilizing new materials such as Carbon Nanotube, MoS2, and nanoscale geometry to realize highly sensitive bio-sensors for bio-molecule detections, scalable 2-D material based ultra-low power devices that exhibit FET like switching and Negative Differential Resistance (NDR) for seamless integration of signal processing and logic components, and monolithic 3-D integration techniques with dense vias. Initial projections reveal significant benefits for such heterogeneous integration over conventional 2-D CMOS based multi-chip based approaches. If realized, this can be game-changing for mixed-signal ASICs, and as well for bio-medical applications such as point-of-care and lab-on-a-chips.
Agency: NSF | Branch: Standard Grant | Program: | Phase: ELECTRONIC/PHOTONIC MATERIALS | Award Amount: 308.17K | Year: 2016
Nontechnical description: This project is focused on the effect of hydrogenation on the microwave absorption properties of titanium dioxide nanoparticles. These nanoparticles have the potential to advance the field of microwave absorption, leading to a number of practical applications in areas such as telecommunication, spacecraft communication, wireless communication, radar detection, satellite navigation, etc. The research team aims to understand the underlying mechanisms of how hydrogenation affects the microwave absorption of inorganic nanoparticles with various phase compositions and surface morphologies. The principal investigator provides training opportunities for graduate and undergraduate students and popularizes his research efforts and results via various outreach activities, reaching to the local community and underrepresented groups. He develops online courses focused on electronic and photonic properties of these materials, which are available to the public.
Technical description: This project tackles newly observed phenomena by the PIs group of significantly increased microwave absorption in hydrogenated titanium dioxide nanoparticles that cannot be explained with traditional mechanisms. The project goal is to reveal the underlying mechanisms and to elucidate the effects of hydrogenation by comprehensive approach, studying structural, chemical, optical, electronic, dielectric and microwave absorption properties by employing various characterization methods such as X-ray diffraction, high-resolution transmission electron microscopy, Raman spectroscopy, ultraviolet-visible absorption spectroscopy, Fourier transform infrared spectroscopy, (valence band) X-ray photoelectron spectroscopy, and a transmission line technique with a network analyzer. The project integrates the research activities with educational opportunities for graduate, undergraduate and high-school students.
Agency: NSF | Branch: Standard Grant | Program: | Phase: SOFTWARE & HARDWARE FOUNDATION | Award Amount: 461.11K | Year: 2016
Over the last sixty years silicon based integrated circuit technologies have been successfully meeting the demands of higher performance and lower energy consumption through the miniaturization of the transistor and circuit dimensions. As the conventional devices and materials are now approaching their fundamental physical limits, new devices and circuits and materials need to be investigated for the next generation logic, memory, sensor and energy harvesting applications. Within this framework, the proposed research on a new nanoscale ultra-low-power electronic device makes use of convergence of technologies in advanced computing, electronic engineering, mathematics, physics, chemistry and information-theory. This EPSCoR initiative would directly or indirectly impact a large number of students of the PIs institution, and an even larger number of local high school and pre-collegiate students through the Kansas City STEM Alliance, for which the PI plans to develop a summer bridge program to promote nanotechnology education.
From a technical standpoint the project plans to develop a new field effect transistor (FET) technology to achieve an effective negative capacitance (NC) inside the transistor structure by utilizing ferroelectric materials. It has recently been reported that ferroelectric materials can provide a negative capacitance that can be the solutions to many of the challenges of nanoelectronics. While many contemporary researchers are investigating ways to exploit this NC effect to break the performance and energy efficiency barriers of the existing silicon based transistors, the proposed effort combines the concept of the emerging negative capacitance based field effect transistor (NCFET) and the conventional silicon-on-insulator (SOI) technologies.
Agency: NSF | Branch: Standard Grant | Program: | Phase: MATHEMATICAL BIOLOGY | Award Amount: 156.05K | Year: 2016
This project develops and uses mathematical models and computational methods to study human immunodeficiency virus (HIV) infection dynamics under conditioning of drugs of abuse. Drug-addicted HIV patients often suffer from enhanced HIV-associated pathogenic consequences, such as reduced host defenses against infection and development of HIV-associated neurocognitive disorders (HAND). Despite being a critical problem for both science and society, the HIV infection dynamics in the context of drug abuse currently remains one of the least understood areas of HIV biology. In the absence of such knowledge, the ability to devise effective strategies to properly manage the virus infection under drug-abuse conditioning remains one of the biggest challenging efforts. In this project, mathematical and computational models are developed to study HIV dynamics in the circulation and in the brain under drug-abuse conditioning, such as the presence of morphine within the host. Further complex models are developed to study the effects of pharmacodynamic properties of morphine on HIV infection in the circulation and in the brain. The developed models are also used for formulating optimal control problems in order to identify ideal antiretroviral treatment as pre-exposure prophylaxis for HIV-infected drug abusers. In addition to improving our current knowledge of HIV dynamics, pathogenesis and development of HAND under conditioning of drugs of abuse, this research endures a significant positive and practical impact on developing therapies and vaccines to control the burden of HIV among drug abusers.
This project produces autonomous models of the HIV dynamics under conditioning of drugs of abuse in the circulation and in the brain, as well as nonautonomous models incorporating the effects of pharmacodynamic properties of drugs of abuse on HIV infection dynamics. The models are parameterized using experimental data from simian immunodeficiency virus (SIV) infections of morphine-addicted macaques (animal model of HIV). The developed models are extensively analyzed using the tools of mathematical modeling, dynamical systems theory, bifurcation theory, asymptotic analysis, theory of periodic systems, stability and persistence theory, as well as statistical and numerical methods. Mathematical challenges anticipated in this research offer opportunities to develop new mathematical theories that advance the field of applied differential equations and optimal control theory. Results, including optimal antiretroviral therapy treatment protocols, help healthcare professionals to mitigate burdens from HIV infection and HAND in drug abusers, thereby, providing the quality of life to drug-addicted HIV infected patients and their families. In addition, this project provides extensive interdisciplinary collaborative research training opportunities for undergraduate and graduate students from mathematics and biology departments, as well as the School of Pharmacy at University of Missouri-Kansas City (UMKC). The research opportunities will be especially extended to a variety of undergraduate research programs that place priority on involving underrepresented students, particularly, undergraduate rural students from Missouri and Kansas. The research will be incorporated into an interdisciplinary mathematical biology course, cross-listed between graduate and undergraduate levels.