The University of Missouri is a public research university located in the state of Missouri. In 1839, the university was founded in Columbia, Missouri as the first public institution of higher education west of the Mississippi River. As the largest university in Missouri, MU enrolls 35,441 students offering over 300 degree programs in 19 academic colleges in the 2014–15 year. The university is the flagship of the University of Missouri System, which maintains campuses in Rolla, Kansas City and St. Louis.MU is one of the nation's top-tier R1 institutions and one of the 34 public universities to be members of the Association of American Universities. There are more than 270,000 MU alumni living worldwide with almost one half continuing to reside in Missouri. The University of Missouri was ranked 99 in the 2015 U.S. News & World Report among the national universities.The campus of the University of Missouri is 1,262 acres just south of Downtown Columbia and is maintained as a botanical garden. The historical campus is centered on Francis Quadrangle, a historic district that is listed on the National Register of Historic Places, and a number of buildings on the National Register of Historic Places. In 1908, the world's first school of journalism was founded by Walter Williams as the Missouri School of Journalism.The University of Missouri Research Reactor Center is the world's most powerful university research reactor. It is one of only six public universities in the United States with a school of medicine, veterinary medicine, engineering, agriculture, and law all on one campus. The university also owns the University of Missouri Health Care system, which operates four hospitals in Mid-Missouri.Missouri's only athletic program that operates a Division I FBS football team is known as the Missouri Tigers and competes as a member of the Southeastern Conference. The school's mascot, Truman the Tiger, is named after Missourian and former U.S. president Harry S. Truman. According to the NCAA, the American tradition of homecoming was established at the University in 1911; the tradition has since been adopted nationwide. Wikipedia.
University of Missouri | Date: 2017-07-12
The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probes 3 terminus, 5 terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patients blood sample.
University of Missouri | Date: 2017-01-18
Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided.
University of Missouri | Date: 2017-08-09
Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, IL6, MMP1, RANTES, MMP9, IL1B, Apolipoprotein A1, Apolipoprotein E, DCN, CILP and COMP. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
University of Missouri and Nanova, Inc. | Date: 2016-10-26
The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides compounds as therapeutic agents in methods for treating pneumonia, methods for reducing bacterial virulence, methods for treating a bacterial wound infection, and methods for treating a urinary tract infection. The present disclosure also provides methods for treating a bacterial infection, wherein the bacterial infection has or is suspected of having an antibiotic-resistant bacteria. The present disclosure also provides surfaces coated with the chemical compounds disclosed herein.
University of Missouri | Date: 2016-10-18
Methods for stimulating exocytosis from a cell are provided where the same electrochemical microelectrode is used to electroporate an adjacent cell and then measure quantal exocytosis from the adjacent cell. Also provided are methods for stimulating and measuring exocytosis from a select cell population arrayed on a chip comprising addressable electrodes. Calcium independent stimulation of exocytosis with inorganic anions such as chloride ions is also provided. These methods can provide for specific stimulation of a desired subset of cells without exposing other nearby cells to the stimulus.
University of Missouri | Date: 2017-02-03
A method for determining the risk of a person falling is provided. The method includes acquiring depth image data that comprises a plurality of frames that depict a person walking through a home, and extracting a foreground object from the depth image data. The method additionally includes generating a three-dimensional data object based on the foreground object, and identifying a walking sequence from the three-dimensional data object. The method further includes generating one or more gait parameters from the identified walking sequence, and comparing the one or more gait parameters against a standard clinical measure of the one or more gait parameters to determine a level of risk at which the person is of falling.
University of Missouri and Musc Foundation For Research Development | Date: 2017-02-03
A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.
University of Missouri | Date: 2017-05-10
A collapsible blood filtering aortic arch bridge (18) including an expandable and collapsible chassis (46) structured to provide the bridge (18) with a dumbbell-like shape when expanded having a tubular waist (50), a first conical end (38), and a second conical end (42) formed such that only a periphery of the first and second ends (38, 42) contact the intima (34) of an aortic arch (26) when the bridge (18) is disposed within the aortic arch (26) of a patient. The bridge (18) additionally includes a blood filtering sleeve (172) disposed over an interior or an exterior of the chassis (46) that is structured and operable to filter blood flowing through the bridge into aortic arch vessels of the patient when the bridge (19) is disposed within the aortic arch (26). The bridge (18) further includes a retrieval mechanism (178) structured and operable to collapse the bridge (18) to a cylindrical form for retrieval of the bridge (18) from the aortic arch (26).
University of Missouri | Date: 2016-11-15
A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO_(4 )to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.
University of Missouri | Date: 2016-08-05
A fluorescence sensing compound for separately detecting and visualizing one or more monoamine neurotransmitters in cells, the fluorescence sensing compound having the following formula: