Jackson, MS, United States
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PubMed | U.S. Food and Drug Administration, The University of Mississippi and National University of Pharmacy
Type: | Journal: Toxicology and applied pharmacology | Year: 2017

German chamomile is one of the most popular herbal ingredients used in cosmetics and personal care products. Allergic skin reactions following topical application of German chamomile have been occasionally reported, although it is not fully understood which of the chemical constituents is responsible for this adverse effect. In the present work, three candidate sensitizers were isolated from German chamomile based on activity-guided fractionation of chamomile extracts tested using the in vitro KeratinoSens assay. The compounds were identified as the polyacetylene tonghaosu (1), and both trans- and cis-glucomethoxycinnamic acids (2 and 3). These three compounds were classified as non- to weakly reactive using in chemico methods; however, aged tonghaosu was found to be more reactive when compared to freshly isolated tonghaosu. The polyacetylene (1) constituent was determined to be chemically unstable, generating a small electrophilic spirolactone, 1,6-dioxaspiro[4.4]non-3-en-2-one (4), upon aging. This small lactone (4) was strongly reactive in both in chemico HTS- and NMR-DCYA methods and further confirmed as a potential skin sensitizer by Local Lymph Node Assay (LLNA).


News Article | December 21, 2016
Site: www.24-7pressrelease.com

OXFORD, MS, December 21, 2016-- Alley Bell, Co-Owner of Align Body.Mind, has been recognized as a Distinguished Professional in her field through Women of Distinction Magazine. Alley Bell was recently featured in a 2016 edition of the Women of Distinction Magazine.Co-Owner and Founder of Align Body.Mind Alley Bell sought to build a business that gives women an opportunity to not only learn how to invest in their physical health, but also their mental, spiritual, and emotion health. She, along with her three business partners, strive to be the best instructors and business owners in the field, passing along their knowledge, expertise, and positive attitudes to as many clients as possible.AlignBody.Mind offers some of the best fitness classes in Oxford, Mississippi, all which are designed to tone the body and strengthen the muscles. All classes are 60 minutes each and include everything from Combat Cardio and Pilates to classes like Define, Clubbin', APEX, Burn, and Mix Up. Each of the owners bring something different to each class, with their own personal twist, making every class constantly engaging and exciting."Health and wellness is something that has been a big part of my life since I was a kid," Bell said. "My mother was a fitness instructor and gym owner, and she was the one who taught me about proper diet and exercise. Working with women to change their physical beings has been a tremendous experience because it affects not only their physical, but also their mental well-being in all aspects of their lives."Becoming a fitness instructor years ago, Bell later went to college to pursuer her BS in Business Marketing at The University of Mississippi. She then became a Certified Group Fitness Instructor, Certified Personal Trainer, Certified Zumba Instructor, and Certified in CPR/AED/First Aid.Recently, Bell and her partners began working on bringing a new concept to the Oxford area, something called Elevate, aerial fitness that incorporates a low-hanging, soft fabric hammock to explore alignment and release chronic tension. Appropriate for all levels of fitness, from beginners to advanced, classes include decompression, supported inversions, core and upper body strengthening, and deep relaxation.Bell Co-Hosts a podcast every other Thursday called 'Living Out Loud with Alley & Amanda'. This podcast encourages women to find freedom in living out their lives to the fullest, while inviting women to be transparent, share their difficulties, joys, sorrows, and excitement. For more information, visit www.livingoutloud.today For more information, visit www.alignbody-mind.com About Women of Distinction Magazine:Women of Distinction Magazine strives to continually bring the very best out in each article published and highlight Women of Distinction. Women of Distinction Magazine's mission is to have a platform where women can grow, inspire, empower, educate and encourage professionals from any industry by sharing stories of courage and success.Contact:Women of Distinction Magazine, Melville, NY631-465-9024 pressreleases@womenofdistinction.net


Silva H.O.,The University of Mississippi | Sotani H.,Japan National Astronomical Observatory | Berti E.,The University of Mississippi | Berti E.,University of Lisbon
Monthly Notices of the Royal Astronomical Society | Year: 2016

The lowest neutron star masses currently measured are in the range 1.0-1.1 M⊙, but these measurement have either large uncertainties or refer to isolated neutron stars. The recent claim of a precisely measured mass M/M⊙ = 1.174 ± 0.004 (Martinez et al. 2015) in a double neutron star system suggests that low-mass neutron stars may be an interesting target for gravitational-wave detectors. Furthermore, Sotani et al. recently found empirical formulas relating the mass and surface redshift of non-rotating neutron stars to the star's central density and to the parameter η ≡ (K0L2)1/3, where K0 is the incompressibility of symmetric nuclear matter and L is the slope of the symmetry energy at saturation density. Motivated by these considerations, we extend the work by Sotani et al. to slowly rotating and tidally deformed neutron stars. We compute the moment of inertia, quadrupole moment, quadrupole ellipticity, tidal and rotational Love number and apsidal constant of slowly rotating neutron stars by integrating the Hartle-Thorne equations at second order in rotation, and we fit all of these quantities as functions of η and of the central density. These fits may be used to constrain η, either via observations of binary pulsars in the electromagnetic spectrum, or via near-future observations of inspiralling compact binaries in the gravitational-wave spectrum. © 2016 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society.


Avula B.,The University of Mississippi | Sagi S.,The University of Mississippi | Gafner S.,American Botanical Council | Upton R.,American Herbal Pharmacopoeia | And 3 more authors.
Analytical and bioanalytical chemistry | Year: 2015

Ginkgo biloba is one of the most widely sold herbal supplements and medicines in the world. Its popularity stems from having a positive effect on memory and the circulatory system in clinical studies. As ginkgo popularity increased, non-proprietary extracts were introduced claiming to have a similar phytochemical profile as the clinically tested extracts. The standardized commercial extracts of G. biloba leaf used in ginkgo supplements contain not less than 6% sesquiterpene lactones and 24% flavonol glycosides. While sesquiterpene lactones are unique constituents of ginkgo leaf, the flavonol glycosides are found in many other botanical extracts. Being a high value botanical, low quality ginkgo extracts may be subjected to adulteration with flavonoids to meet the requirement of 24% flavonol glycosides. Chemical analysis by ultra high performance liquid chromatography-mass spectrometry revealed that adulteration of ginkgo leaf extracts in many of these products is common, the naturally flavonol glycoside-rich extract being spiked with pure flavonoids or extracts made from another flavonoid-rich material, such as the fruit/flower of Japanese sophora (Styphnolobium japonicum), which also contains the isoflavone genistein. Recently, genistein has been proposed as an analytical marker for the detection of adulteration of ginkgo extracts with S. japonicum. This study confirms that botanically authenticated G. biloba leaf and extracts made therefrom do not contain genistein, and the presence of which even in trace amounts is suggestive of adulteration. In addition to the mass spectrometric approach, a high performance thin layer chromatography method was developed as a fast and economic method for chemical fingerprint analysis of ginkgo samples.


PubMed | The University of Mississippi, American Botanical Council and U.S. Department of Agriculture
Type: Journal Article | Journal: Planta medica | Year: 2016

A selective UHPLC-DAD-QToF-MS method was developed to screen grapefruit seeds, and the seeds of other Citrus species for limonoid aglycones, acids, glucosides, and flavonoids. These classes of compounds were identified in positive and negative ion modes over a mass-to-charge range from 100-1500. Accurate mass values, elution times, and fragmentation patterns obtained by QToF-mass spectrometry were used to identify or tentatively characterize the compounds detected in the sample of this study. Limonin was the major limonoid in most of the seeds of Citrus species, followed by nomilin. This analytical method was successfully applied for the analysis of commercial extracts and dietary supplements claiming to contain grapefruit seed extract, or extracts made from the seed and other fruit parts such as the peel or pulp. Many commercial products contained large numbers of flavonoids, indicating the use of peel, pulp, or seed coat. This method also permitted detection of synthetic preservatives such as benzethonium chloride, methylparaben, and triclosan in commercial grapefruit seed extract products. Out of the 17 commercial products analyzed, two contained the synthetic antimicrobial agent benzethonium chloride.


Bialonska D.,University of Mississippi | Bialonska D.,Jagiellonian University | Ramnani P.,University of Reading | Kasimsetty S.G.,University of Mississippi | And 4 more authors.
International Journal of Food Microbiology | Year: 2010

We have examined the gut bacterial metabolism of pomegranate by-product (POMx) and major pomegranate polyphenols, punicalagins, using pH-controlled, stirred, batch culture fermentation systems reflective of the distal region of the human large intestine. Incubation of POMx or punicalagins with faecal bacteria resulted in formation of the dibenzopyranone-type urolithins. The time course profile confirmed the tetrahydroxylated urolithin D as the first product of microbial transformation, followed by compounds with decreasing number of phenolic hydroxy groups: the trihydroxy analogue urolithin C and dihydroxylated urolithin A. POMx exposure enhanced the growth of total bacteria, Bifidobacterium spp. and Lactobacillus spp., without influencing the Clostridium coccoides-Eubacterium rectale group and the C. histolyticum group. In addition, POMx increased concentrations of short chain fatty acids (SCFA) viz. acetate, propionate and butyrate in the fermentation medium. Punicalagins did not affect the growth of bacteria or production of SCFA. The results suggest that POMx oligomers, composed of gallic acid, ellagic acid and glucose units, may account for the enhanced growth of probiotic bacteria. © 2010 Elsevier B.V.


Avula B.,The University of Mississippi | Wang Y.-H.,The University of Mississippi | Rumalla C.S.,The University of Mississippi | Ali Z.,The University of Mississippi | And 4 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011

Analytical methods including HPLC, UPLC and HPTLC are presented for the determination of major alkaloid and triterpene saponins from the roots of Caulophyllum thalictroides (L.) Michx. (blue cohosh) and dietary supplements claiming to contain blue cohosh. A separation by LC was achieved using a reversed phase column, PDA with ELS detection, and ammonium acetate/acetonitrile gradient as the mobile phase. Owing to their low UV absorption, the triterpene saponins were detected by evaporative light scattering. The eight triterpene saponins (cauloside H, leonticin D, cauloside G, cauloside D, cauloside B, cauloside C, cauloside A and saponin PE) and the alkaloid magnoflorine could be separated within 35. min using HPLC method and within 8.0. min using UPLC method with detection limits of 10μg/mL for saponins and 1μg/mL for magnoflorine. The detection wavelength was 320. nm for magnoflorine and ELS detection was used for the eight saponins. The methods were also successfully applied to analyze different dietary supplements. For the products claiming to contain blue cohosh, there was a significant variability in the amounts of triterpene saponins detected. Calculations based on the analysis results for dietary supplements showed that maximum daily intake of alkaloid and saponins vary with the form (solids/liquids) and recommended doses according to the products label. Intakes varied from 0.57 to 15.8. mg/day for magnoflorine and from 5.97 to 302.4. mg/day for total saponins. LC-mass spectrometry coupled with electrospray ionization (ESI) method is described for the identification and confirmation of nine compounds in plant samples and dietary products. A HPTLC method was also developed for the fast chemical fingerprint analysis of C. thalictroides samples. © 2011 Elsevier B.V.


Avula B.,The University of Mississippi | Wang Y.-H.,The University of Mississippi | Ali Z.,The University of Mississippi | Smillie T.J.,The University of Mississippi | And 2 more authors.
Biomedical Chromatography | Year: 2014

Ultra high-performance liquid chromatography (UHPLC) with evaporative light scattering detection was used for the quantification of steroidal saponins and diosgenin from the rhizomes or tubers of various Dioscorea species and dietary supplements that were purported to contain Dioscorea. The analysis was performed on an Acquity UPLC™ system with an UPLC™ BEH Shield RP18 column using a gradient elution with water and acetonitrile. Owing to their low UV absorption, the steroidal saponins were observed by evaporative light scattering detection. The 12 compounds could be separated within 15min using the developed UHPLC method with detection limits of 5-12μg/mL with 2μL injection volume. The analytical method was validated for linearity, repeatability, accuracy, limits of detection and limits of quantification. The relative standard deviations for intra- and inter-day experiments were <3.1%, and the recovery efficiency was 97-101%. The total content of standard compounds was found to be in the ranges 0.01-14.5% and 0.9-28.6mg daily intake for dry plant materials and solid commercial preparations, respectively. UHPLC-mass spectrometry with a quadrupole mass analyzer and ESI source was used only for confirmation of the identity of the various saponins. The developed method is simple, rapid and especially suitable for quality control analysis of commercial products. © 2013 John Wiley & Sons, Ltd.


PubMed | The University of Mississippi and University of Mississippi
Type: | Journal: International journal of pharmaceutics | Year: 2016

The main objective of this work was to explore the potential of coupling fused deposition modeling in three-dimensional (3D) printing with hot-melt extrusion (HME) technology to facilitate additive manufacturing, in order to fabricate tablets with enhanced extended release properties. Acetaminophen was used as the model drug and different grades and ratios of polymers were used to formulate tablets. Three-point bending and hardness tests were performed to determine the mechanical properties of the filaments and tablets. 3D-printed tablets, directly compressed mill-extruded tablets, and tablets prepared from a physical mixture were evaluated for drug release rates using a USP-II dissolution apparatus. The surface and cross-sectional morphology of the 3D-printed tablets were assessed by scanning electron microscopy. Differential scanning calorimetry and thermogravimetric analysis were used to characterize the crystal states and thermal properties of materials, respectively. The 3D-printed tablets had smooth surfaces and tight structures; therefore, they showed better extended drug release rates than the directly compressed tablets did. Further, this study clearly demonstrated the feasibility of coupling HME with 3D printing technology, which allows for the formulation of drug delivery systems using different grades and ratios of pharmaceutical polymers. In addition, formulations can be made based on the personal needs of patients.


OXFORD, Miss. & SAN DIEGO--(BUSINESS WIRE)--#AR--The University of Mississippi takes its Rebel Rewards app to new levels of fan engagement with fun-filled augmented reality game, powered by Spark Compass.

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