The University of Minnesota, Twin Cities is a public research university located in Minneapolis and St. Paul, Minnesota, United States. The Minneapolis and St. Paul campuses are approximately 5 miles apart, and the Saint Paul campus is actually in neighboring Falcon Heights. It is the oldest and largest campus within the University of Minnesota system and has the sixth-largest main campus student body in the United States, with 51,853 students in 2012–2013. The university is organized into 19 colleges and schools, and it has sister campuses in Crookston, Duluth, Morris, and Rochester.Minnesota's athletic teams are known collectively as the Minnesota Golden Gophers and compete in the NCAA's Division I as members of the Big Ten Conference. Wikipedia.
U.S. Department Of Veterans Affairs and University of Minnesota | Date: 2016-11-22
An ankle-foot prosthesis includes a foot plate, an ankle frame attached to the foot plate, a yoke pivotally connected to the ankle frame and including a member for attaching to a leg, a damper having a first end connected to the yoke and a second end connected to the ankle frame, and a control mechanism for switching the damper between low and high settings.
University of Minnesota and Mayo Foundation For Medical Education And Research | Date: 2016-08-18
This disclosure describes devices, system, and a method for the prediction and prevention of acute decompensated heart failure or other patient conditions involving fluid accumulation in legs or hands. In one example, a wearable device contains a drift-free leg-size sensor and a tissue-elasticity sensor. Both sensors may be relatively inexpensive and developed using innovative new sensing ideas. Preliminary tests with the sensor prototypes show promising results: the leg-size sensor is capable of measuring 1 mm changes in leg diameter and the tissue-elasticity sensor can detect 0.15 MPa differences in elasticity. In another example, a wearable system includes sensors for measuring a variety of physiological parameters, a processing module, and a communication module. A low-profile instrumented sock, e.g., a wearable device, with multiple sensors can provide an indication of heart failure status for a patient.
University of Washington and University of Minnesota | Date: 2016-11-14
Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2 C. has been found effective at inhibiting seizures.
National Health Research Institute and University of Minnesota | Date: 2016-07-12
Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.
University of Minnesota | Date: 2016-09-01
The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same.
University of Minnesota and Intima Bioscience Inc. | Date: 2016-08-29
Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
University of Minnesota | Date: 2016-09-23
This disclosure provides a platform for making live, attenuated viruses. This disclosure also provides methods of using the live, attenuated viruses.
University of Minnesota | Date: 2017-03-01
The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subjects colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
Voytas D.F.,University of Minnesota
Annual Review of Plant Biology | Year: 2013
Recent advances in genome engineering provide newfound control over a plant's genetic material. It is now possible for most bench scientists to alter DNA in living plant cells in a variety of ways, including introducing specific nucleotide substitutions in a gene that change a protein's amino acid sequence, deleting genes or chromosomal segments, and inserting foreign DNA at precise genomic locations. Such targeted DNA sequence modifications are enabled by sequence-specific nucleases that create double-strand breaks in the genomic loci to be altered. The repair of the breaks, through either homologous recombination or nonhomologous end joining, can be controlled to achieve the desired sequence modification. Genome engineering promises to advance basic plant research by linking DNA sequences to biological function. Further, genome engineering will enable plants' biosynthetic capacity to be harnessed to produce the many agricultural products required by an expanding world population. © Copyright ©2013 by Annual Reviews. All rights reserved.
Dorfman K.D.,University of Minnesota
Reviews of Modern Physics | Year: 2010
Picking up at the conclusion of Viovy's review of the physics of gel electrophoresis [J.-L. Viovy, Rev. Mod. Phys. 72, 813 (2000)], this review synthesizes the experimental data, theoretical models, and simulation results for DNA electrophoresis in microfabricated and nanofabricated devices appearing since the seminal paper by Volkmuth and Austin [Nature (London) 358, 600 (1992)]. Prototype versions of these devices separate DNA by molecular weight at a rate far superior to gel electrophoresis. After providing an overview of the requisite background material in polymer physics, electrophoresis, and microfluidic device fabrication, the focus is on the following three generic problems: (i) collision with an isolated post, (ii) transport in an array of posts, and (iii) entropic trapping and filtration in the slit-well motif. The transport phenomena are examined here in the context of the length and time scales characterizing the DNA, the device, and the applied electric field. ©2010 The American Physical Society.