The University of Minnesota, Twin Cities is a public research university located in Minneapolis and St. Paul, Minnesota, United States. The Minneapolis and St. Paul campuses are approximately 5 miles apart, and the Saint Paul campus is actually in neighboring Falcon Heights. It is the oldest and largest campus within the University of Minnesota system and has the sixth-largest main campus student body in the United States, with 51,853 students in 2012–2013. The university is organized into 19 colleges and schools, and it has sister campuses in Crookston, Duluth, Morris, and Rochester.Minnesota's athletic teams are known collectively as the Minnesota Golden Gophers and compete in the NCAA's Division I as members of the Big Ten Conference. Wikipedia.
University of Minnesota | Date: 2017-03-01
The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subjects colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
University of Minnesota | Date: 2017-02-22
Block copolymers include a poly -methyl--valerolactone (PMVL) block. The PMVL blocks can be formed from biosynthesized -methyl--valero lactone (MVL). The block copolymers can include hard blocks. The block copolymers can be thermoplastic elastomers.
University of Minnesota | Date: 2017-02-06
Disclosed herein are isolated polypeptides, antibody preparations, treatment methods, diagnostic methods, and screening methods related to tauopathy. Generally, the isolated polypeptide includes a core pentapeptide, with the proviso that the isolated polypeptide is not a native full-length tau protein. Generally, the antibody preparations include antibody that specifically binds to SEQ ID NO:12. Generally, the treatment methods include administering to a subject a composition that includes the isolated polypeptide. Generally, the diagnostic methods includes contacting a sample from a subject with an antibody preparation that includes antibody that specifically binds to SEQ ID NO:12, and then detecting a ligand in the sample that specifically binds the antibody preparation. Generally, the screening method includes incubating a mixture of caspase-2, a labeled caspase-2 cleavage substrate, and a test compound under conditions effective to permit the caspase-2 to cleave the caspase-2 cleavage substrate, then determining whether the test compound inhibits cleavage of the substrate by caspase-2.
The United States Of America and University of Minnesota | Date: 2017-05-24
Disclosed herein are aerosol particle growth systems including polymer electrolyte membranes and related methods of increasing the size of aerosol particles. In some embodiments, an outer housing contains a reservoir of a working fluid, and a PEM conduit extends through the outer housing, the reservoir, and the working fluid so that the working fluid is in contact with an outer surface of the PEM conduit. The conduit can be generally helical or coiled, for example. In some embodiments, the working fluid is molecularly transported across the PEM and disperses into an aerosol flowing through the PEM conduit. As the aerosol flows through the PEM conduit, the aerosol particles act as nucleation sites for the gaseous working fluid, which condenses on the particles, causing the particles to grow in size and making them easier to detect, collect, measure, count, study, or otherwise investigate.
University of Minnesota, Adama Materials, Qian, Moriarty and Macosko | Date: 2017-04-05
The invention concerns nanofiller composition comprising (i) a nanoparticle; (ii) a plurality of coupling groups bonded to the nanoparticle; (iii) one or more (a) oligomers or (b) organic isocyanate residues bonded to the one or more coupling groups; and, optionally, (iv) one or more dispersing moieties that facilitate dispersion of the nanoparticle bonded to one or more of the coupling groups or organic isocyanate residues; as well as laminates comprising such nanoparticles in at least one layer.
University of Minnesota | Date: 2017-05-24
Embodiments relate to devices, systems and methods for monitoring neuromuscular blockage. In an embodiment, a neuromuscular blockage monitoring system comprises a patch device comprising a unitary patch body, at least two electrodes and at least one sensor, the at least one sensor arranged between the at least two electrodes on the unitary patch body; and a stimulator device operatively coupled to the patch device and configured to provide at least one electrical signal to the at least two electrodes to stimulate a muscle motor point and to receive a signal from the at least one sensor related to a result of the stimulation of the muscle motor point.
Ecolab and University of Minnesota | Date: 2017-04-26
The present disclosure provides for a composition and method for attracting bed bugs to a trap or to a location where an insecticide or pesticide is present, or to a trap or a location where a bed bug infestation can be detected. The present disclosure provides for a composition for attracting bed bugs that includes one or more of methyl diethanolamine (MDEA), monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA), and dimethyl trisulfide (DMTS); a carrier; and optionally one or more amides selected from oleamide, octanamide, nonanamide, and laurylamide; urea, biuret, or triuret; and one or more aliphatic fatty acids. The present disclosure further provides for a method for treating an article by applying the composition to the article, where the article comprises a device for trapping or detecting bed bugs or a device for treating a bed bug infestation.
University of Minnesota | Date: 2017-02-01
This disclosure describes, generally, a modified form of CD 16, genetically-modified cells that express the modified CD 16, and methods that involve the genetically-modified cells. The modified form of CD 16 can exhibit increased anti-tumor and/or anti- viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
3M and University of Minnesota | Date: 2017-01-04
A composition and wound dressing for treating a skin wound is disclosed. The composition and dressing comprise a pharmaceutically acceptable carrier; an effective amount of an active ingredient of inorganic solids comprising a potassium salt, a zinc salt, a calcium salt, and a rubidium salt; and an antimicrobial biguanide compound comprising an amount effective to reduce the number of viable microorganisms at a wound site. Methods of use include contacting a wound site with the composition and/or dressing.
Haase A.T.,University of Minnesota
Nature | Year: 2010
Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue. © 2010 Macmillan Publishers Limited. All rights reserved.