The University of Minnesota, Twin Cities is a public research university located in Minneapolis and St. Paul, Minnesota, United States. The Minneapolis and St. Paul campuses are approximately 5 miles apart, and the Saint Paul campus is actually in neighboring Falcon Heights. It is the oldest and largest campus within the University of Minnesota system and has the sixth-largest main campus student body in the United States, with 51,853 students in 2012–2013. The university is organized into 19 colleges and schools, and it has sister campuses in Crookston, Duluth, Morris, and Rochester.Minnesota's athletic teams are known collectively as the Minnesota Golden Gophers and compete in the NCAA's Division I as members of the Big Ten Conference. Wikipedia.
U.S. Department Of Veterans Affairs and University of Minnesota | Date: 2016-11-22
An ankle-foot prosthesis includes a foot plate, an ankle frame attached to the foot plate, a yoke pivotally connected to the ankle frame and including a member for attaching to a leg, a damper having a first end connected to the yoke and a second end connected to the ankle frame, and a control mechanism for switching the damper between low and high settings.
University of Minnesota and Mayo Foundation For Medical Education And Research | Date: 2016-08-18
This disclosure describes devices, system, and a method for the prediction and prevention of acute decompensated heart failure or other patient conditions involving fluid accumulation in legs or hands. In one example, a wearable device contains a drift-free leg-size sensor and a tissue-elasticity sensor. Both sensors may be relatively inexpensive and developed using innovative new sensing ideas. Preliminary tests with the sensor prototypes show promising results: the leg-size sensor is capable of measuring 1 mm changes in leg diameter and the tissue-elasticity sensor can detect 0.15 MPa differences in elasticity. In another example, a wearable system includes sensors for measuring a variety of physiological parameters, a processing module, and a communication module. A low-profile instrumented sock, e.g., a wearable device, with multiple sensors can provide an indication of heart failure status for a patient.
University of Washington and University of Minnesota | Date: 2016-11-14
Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2 C. has been found effective at inhibiting seizures.
National Health Research Institute and University of Minnesota | Date: 2016-07-12
Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.
University of Minnesota | Date: 2016-09-01
The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same.
University of Minnesota and Intima Bioscience Inc. | Date: 2016-08-29
Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
University of Minnesota | Date: 2016-09-23
This disclosure provides a platform for making live, attenuated viruses. This disclosure also provides methods of using the live, attenuated viruses.
University of Minnesota | Date: 2015-03-10
The present disclosure provides an isolated or purified Porcine Epidemic Diarrhea Virus (PEDV) or Porcine Epidemic Diarrhea Virus (PEDV) S1 protein, and methods of use thereof.
University of Minnesota and Intima Bioscience Inc. | Date: 2016-09-02
Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
University of Minnesota | Date: 2015-04-17
Block copolymers include a poly -methyl--valerolactone (PMVL) block. The PMVL blocks can be formed from biosynthesized -methyl--valero lactone (MVL). The block copolymers can include hard blocks. The block copolymers can be thermoplastic elastomers.
University of Minnesota | Date: 2016-09-16
This disclosure describes biocompatible composites and method for making the biocompatible composites. Generally, the biocompatible composite includes a fibril prepared from a biocompatible polymer and cationic component, and a uniform coating of silica-containing material.
University of Minnesota | Date: 2016-09-19
This disclosure describes, in one aspect, a method that, in general, includes analyzing a tumor tissue sample from a subject for expression of at least two biomarkers, wherein a predetermined ratio of expression of the at least two biomarkers identifies the tumor tissue sample as coming from a subject having a particular subtype of lymphoma; and identifying the subject as having a particular subtype of lymphoma.
University of Minnesota | Date: 2016-10-06
Disclosed herein are synthetic silica-based ocular devices fabricated from a composite material comprising silica and a fibrillar protein, together with methods of making and using the ocular devices.
University of Minnesota | Date: 2015-04-21
Certain embodiments of the invention provide a method of preparing a modified distilled alcoholic spirit, comprising contacting a corresponding starting distilled alcoholic spirit with a base under conditions that cause at least one free carbonyl compound in the starting distilled alcoholic spirit to be reduced, to provide the modified distilled alcoholic spirit that has at an alcohol by volume (ABV) of at least 15%. Certain embodiments also provide a modified distilled alcoholic spirit prepared by the methods described herein.
University of Minnesota | Date: 2016-08-31
APC systems and methods using vehicle mass to assess boardings and alightings of passengers on transit vehicles (e.g., buses). Vehicle mass is determined based on signaled information indicative of a pressure in one or more air bag circuits of an air ride suspension system of the vehicle. In some embodiments, pressure information from three air bag circuits of the vehicle are monitored and reviewed to determine vehicle mass. The passenger count can be estimated based on determined vehicle mass by an Additional Mass Method or an Event-Based Method for example.
University of Minnesota | Date: 2015-11-19
An article may include a substantially perpendicularly magnetized free layer having a first magnetic orientation in the absence of an applied magnetic field. The article may also include a spin Hall channel layer configured to conduct a spin current configured to subject the perpendicularly magnetized free layer to a magnetic switching torque and a substantially in-plane magnetized bias layer configured to bias the substantially perpendicularly magnetized free layer to a second magnetic orientation. The second magnetic orientation is different than the first magnetic orientation and is out of a plane of the substantially perpendicularly magnetized free layer.
University of Minnesota | Date: 2016-12-02
An electrical device includes at least one graphene quantum capacitance varactor. In some examples, the graphene quantum capacitance varactor includes an insulator layer, a graphene layer disposed on the insulator layer, a dielectric layer disposed on the graphene layer, a gate electrode formed on the dielectric layer, and at least one contact electrode disposed on the graphene layer and making electrical contact with the graphene layer. In other examples, the graphene quantum capacitance varactor includes an insulator layer, a gate electrode recessed in the insulator layer, a dielectric layer formed on the gate electrode, a graphene layer formed on the dielectric layer, wherein the graphene layer comprises an exposed surface opposite the dielectric layer, and at least one contact electrode formed on the graphene layer and making electrical contact with the graphene layer.
University of Minnesota | Date: 2015-04-24
Systems and methods for magnetic resonance imaging (MRI) using a frequency swept excitation that utilizes multiple sidebands to achieve significant increases in excitation and acquisition bandwidth are provided. The imaging sequence efficiently uses transmitter power and has increased sensitivity as compared to other techniques used for imaging of fast relaxing spins. Additionally, the imaging sequence can provide information about both fast and slow relaxing spins in a single scan. These features are advantageous for numerous MRI applications, including musculoskeletal imaging, other medical imaging applications, and imaging materials.
Cummins and University of Minnesota | Date: 2015-01-02
Described herein is a continuous process for modifying the properties of polyester and polyester based fibers, such as a poly(butylene terephthalate) (PBT) fiber, comprising subjecting the PBT fiber to alkaline hydrolysis, and optionally further comprising functionalizing the PBT fiber by solution grafting such as fluorination. The alkaline hydrolysis and optionally subsequent functionalization such as fluorination process can be continuous, following the melt blowing/spinning or spun-bonding process. Also described is a nonwoven PBT fiber mat obtained by the surface modification process. Further described is a filtration device comprising the nonwoven PBT fiber mat.
University of Minnesota | Date: 2016-08-22
In some examples, a method including depositing a functional layer over a substrate; depositing a granular layer over the functional layer, the granular layer including a first material defining a plurality of grains separated by a second material defining grain boundaries of the plurality of grains; removing the second material from the granular layer such that the plurality of grains of the granular layer define a hard mask layer on the functional layer; and removing, via reactive ion etching with a carrier gas, portions of the functional layer not masked by the hard mask layer, wherein the carrier gas comprises a gas with an atomic number less than an atomic number of argon.
University of Minnesota | Date: 2015-08-31
A formaldehyde electrochemical sensor employing a formaldehyde sensitive assembly of formaldehyde dehydrogenase attached to graphene in fluid communication with a source of NAD^(+), and a method of measuring formaldehyde utilizing the sensor.
Tiffin P.,University of Minnesota |
Ross-Ibarra J.,University of California at Davis
Trends in Ecology and Evolution | Year: 2014
Local adaptation shapes species diversity, can be a stepping stone to ecological speciation, and can facilitate species range expansion. Population genetic analyses, which complement organismal approaches in advancing our understanding of local adaptation, have become widespread in recent years. We focus here on using population genetics to address some key questions in local adaptation: what traits are involved? What environmental variables are the most important? Does local adaptation target the same genes in related species? Do loci responsible for local adaptation exhibit trade-offs across environments? After discussing these questions we highlight important limitations to population genetic analyses including challenges with obtaining high-quality data, deciding which loci are targets of selection, and limits to identifying the genetic basis of local adaptation. © 2014 Elsevier Ltd.
Morrell P.L.,University of Minnesota |
Buckler E.S.,Cornell University |
Ross-Ibarra J.,University of California at Davis
Nature Reviews Genetics | Year: 2012
The completion of reference genome sequences for many important crops and the ability to perform high-throughput resequencing are providing opportunities for improving our understanding of the history of plant domestication and to accelerate crop improvement. Crop plant comparative genomics is being transformed by these data and a new generation of experimental and computational approaches. The future of crop improvement will be centred on comparisons of individual plant genomes, and some of the best opportunities may lie in using combinations of new genetic mapping strategies and evolutionary analyses to direct and optimize the discovery and use of genetic variation. Here we review such strategies and insights that are emerging. © 2012 Macmillan Publishers Limited. All rights reserved.
Luxton G.W.G.,University of Minnesota |
Starr D.A.,University of California at Davis
Current Opinion in Cell Biology | Year: 2014
Nuclear-cytoskeletal connections are central to fundamental cellular processes, including nuclear positioning and chromosome movements in meiosis. The cytoskeleton is coupled to the nucleoskeleton through conserved KASH-SUN bridges, or LINC complexes, that span the nuclear envelope. KASH proteins localize to the outer nuclear membrane where they connect the nucleus to the cytoskeleton. New findings have expanded the functional diversity of KASH proteins, showing that they interact with microtubule motors, actin, intermediate filaments, a nonconventional myosin, RanGAP, and each other. The role of KASH proteins in cellular mechanics is discussed. Genetic mutations in KASH proteins are associated with autism, hearing loss, cancer, muscular dystrophy and other diseases. © 2014 Elsevier Ltd.
Agency: GTR | Branch: NERC | Program: | Phase: Research Grant | Award Amount: 583.88K | Year: 2015
Terrestrial biodiversity is declining globally because of human impacts, of which land-use change has so far been the most important. When people change how land is used, many of the species originally present decline or disappear from the area, while others previously absent become established. Although some species are affected immediately, others might only respond later as the consequences of the land-use change ripple through the ecosystem. Such delayed or protracted responses, which we term biotic lag, have largely been ignored in large-scale models so far. Another shortcoming of much previous work is that it has focused on numbers of species, rather than what they do. Because winners from the change are likely to be ecologically different from losers, the land-use change impacts how the assemblage functions, as well as how many species it contains. Understanding how - and how quickly - land-use change affects local assemblages is crucial for supporting better land-use decisions in the decades to come, as people try to strike the balance between short-term needs for products from ecosystems and the longer-term need for sustainability. The most obvious way to assess the global effects of land-use change on local ecological communities would be to have monitored how land use and the community have changed over a large, representative set of sites over many decades. The sites have to be representative to avoid a biased result, and the long time scale is needed because the responses can unfold over many years. Because there is no such set of sites, less direct approaches are needed. We are planning to scour the ecological literature for comparisons of communities before and after land-use change. We can correct for bias because we have estimates of how common different changes in land use have been; and we will model how responses change over time after a land-use change so that we can use longer-term and shorter-term studies alike. There are many hundreds of suitable studies, and we will ask the researchers who produced them to share their data with us; we will then make them available to everyone at the end of the project. We will combine data on species abundances before and after the land-use change with information about their ecological roles, to reveal how - and how quickly - changing land use affects the relative abundances of the various species and the ecological structure and function of the community. Does conversion of natural habitats to agriculture tend to favour smaller species over large ones, for instance, and if so how quickly? Is metabolism faster in more human-dominated land uses? These analyses will require new compilations of trait data for several ecologically important and highly diverse arthropod groups; to produce these, we will make use of the expertise, collections and library of the Natural History Museum. In an earlier NERC-funded project (PREDICTS: www.predicts.org.uk), we have already compiled over 500 data sets - provided by over 300 different researchers - that compared otherwise-matched sites where land use differed. The PREDICTS database has amassed over 2,000,000 records, from over 18,000 sites in 88 countries. The database contains more than 1% as many species as have been formally described. Our analyses of this unprecedentedly large and representative data set indicates that land-use change has had a marked global impact on average local diversity. However, because PREDICTS data sets are spatial rather than temporal comparisons, they are not well-suited to analysing the dynamics of how assemblages respond to land-use change. More fundamentally, PREDICTS assumption that spatial comparisons are an adequate substitute for temporal data now needs testing. This proposal will deliver the necessary tests, as well as producing the most comprehensive picture of how land-use change reshapes ecological assemblages through time.
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: ICT-38-2015 | Award Amount: 1.16M | Year: 2016
The aim of the 30-months PICASSO project is (1) to reinforce EU-US collaboration in ICT research and innovation focusing on the pre-competitive research in key enabling technologies related to societal challenges - 5G Networks, Big Data, Internet of Things and Cyber Physical Systems, and (2) to support the EU-US ICT policy dialogue by contributions related to e.g. privacy, security, internet governance, interoperability, ethics. PICASSO is oriented to industrial needs, provides a forum for ICT communities and involves 24 EU and US prominent specialists in the three technology-oriented ICT Expert Groups and an ICT Policy Expert Group, working closely together to identify policy gaps in the technology domains and to take measures to stimulate the policy dialogue in these areas. A synergy between experts in ICT policies and in ICT technologies is a unique feature of PICASSO. An analysis of the industrial drivers, societal needs, and priorities for EU-US ICT collaboration will be done, and policy gaps will be highlighted. An Opportunity Report will point out new avenues for EU-US research, innovation and policy collaboration. An ICT Industry Toolkit app will support companies and academia in exploiting collaboration opportunities. Policy briefs focusing on specific aspects of identified policy gaps will provide visibility for EU policies and propose ways forward. Strategic initiatives will be investigated and discussed, and a White Paper will be prepared. The outreach campaign will include 30\ events, success stories factsheets, info sessions and webinars. PICASSO will directly contribute to the strengthening of the European industrial leadership in ICT. PICASSOs approach will be integrative, inclusive, industry-driven, societally responsible and beneficial for both EU and US. It is supported by NIST, National Institute of Standard and Technology, US, and the European Cluster Alliance.
President And Fellows Of Harvard College and University of Minnesota | Date: 2014-03-03
Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device may include a sample zone on a first porous, hydrophilic layer, a reference zone and a microfluidic channel, wherein the microfluidic channel provides for predominantly diffusive fluid communication between the sample zone and the reference zone; (therefore realizing a similar function of a reference electrode), a fluid-impermeable material that defines each of the sample zone, reference zone and microfluidic channel, a first electrode in fluid communication with the sample zone and a second electrode in fluid communication with the reference zone. Also described are microfluidic, electrochemical devices containing an ion-selective membrane for potentiometric ion sensing.
Fernandes R.M.,University of Minnesota |
Chubukov A.V.,University of Wisconsin - Madison |
Schmalian J.,Karlsruhe Institute of Technology
Nature Physics | Year: 2014
Although the existence of nematic order in iron-based superconductors is now a well-established experimental fact, its origin remains controversial. Nematic order breaks the discrete lattice rotational symmetry by making the x and y directions in the iron plane non-equivalent. This can happen because of a regular structural transition or as the result of an electronically driven instability-in particular, orbital order or spin-driven Ising-nematic order. The latter is a magnetic state that breaks rotational symmetry but preserves time-reversal symmetry. Symmetry dictates that the development of one of these orders immediately induces the other two, making the origin of nematicity a physics realization of the 'chicken and egg problem'. In this Review, we argue that the evidence strongly points to an electronic mechanism of nematicity, placing nematic order in the class of correlation-driven electronic instabilities, like superconductivity and density-wave transitions. We discuss different microscopic models for nematicity and link them to the properties of the magnetic and superconducting states, providing a unified perspective on the phase diagram of the iron pnictides. © 2014 Macmillan Publishers Limited.
University of Minnesota and Purdue Research Foundation | Date: 2016-07-11
The invention provides cellular assays for detecting the activity of one or more kinase from multiple conditions simultaneously, by encoding biochemically identical substrates with isotope labels that enable them to be distinguished in pooled samples by mass spectrometry.
University of Minnesota and Purdue Research Foundation | Date: 2016-06-28
The invention provides a method for detecting the activities of two or more kinases. The method enables multiplexed detection with high signal to noise in a high-throughput-compatible format and a platform that could be applied to other lanthanide metal and fluorophore combinations to achieve even greater multiplexing without the need for phosphospecific antibodies.
University of Minnesota and University of Pennsylvania | Date: 2015-12-10
The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases.
Cicchetti D.,University of Minnesota |
Cicchetti D.,University of Rochester
Journal of Child Psychology and Psychiatry and Allied Disciplines | Year: 2013
Background: Through a process of probabilistic epigenesis, child maltreatment progressively contributes to compromised adaptation on a variety of developmental domains central to successful adjustment. These developmental failures pose significant risk for the emergence of psychopathology across the life course. In addition to the psychological consequences of maltreatment, a growing body of research has documented the deleterious effects of abuse and neglect on biological processes. Nonetheless, not all maltreated children develop maladaptively. Indeed, some percentage of maltreated children develops in a resilient fashion despite the significant adversity and stress they experience. Methods: The literature on the determinants of resilience in maltreated children is selectively reviewed and criteria for the inclusion of the studies are delineated. Results: The majority of the research on the contributors to resilient functioning has focused on a single level of analysis and on psychosocial processes. Multilevel investigations have begun to appear, resulting in several studies on the processes to resilient functioning that integrate biological/genetic and psychological domains. Conclusions: Much additional research on the determinants of resilient functioning must be completed before we possess adequate knowledge based on a multiple levels of analysis approach that is commensurate with the complexity inherent in this dynamic developmental process. Suggestions for future research on the development of resilient functioning in maltreated children are proffered and intervention implications are discussed. © 2012 The Author. Journal of Child Psychology and Psychiatry © 2012 Association for Child and Adolescent Mental Health.
Arizona State University, University of Minnesota and Crestovo LLC | Date: 2016-05-23
The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patients gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.
Life Services, Llc and University of Minnesota | Date: 2014-08-26
Apparatus and method that includes providing a variable-parameter electrical component in a high-field environment and based on an electrical signal, automatically moving a movable portion of the electrical component in relation to another portion of the electrical component to vary at least one of its parameters. In some embodiments, the moving uses a mechanical movement device (e.g., a linear positioner, rotary motor, or pump). In some embodiments of the method, the electrical component has a variable inductance, capacitance, and/or resistance. Some embodiments include using a computer that controls the moving of the movable portion of the electrical component in order to vary an electrical parameter of the electrical component. Some embodiments include using a feedback signal to provide feedback control in order to adjust and/or maintain the electrical parameter. Some embodiments include a non-magnetic positioner connected to an electrical component configured to have its RLC parameters varied by the positioner.
Apple Inc and University of Minnesota | Date: 2016-08-12
A method includes: receiving sensor measurements from a pre-processing module, in which the sensor measurements include image data and inertial data for a device; transferring, using a processor, information derived from the sensor measurements, from a first set of variables associated with a first window of time to a second set of variables associated with a second window of time, in which the first and second windows consecutively overlap in time; and outputting, to a post-processing module, a state of the device based on the transferred information.
Life Services, Llc and University of Minnesota | Date: 2014-10-07
A progressive series of five new coils is described. The first coil solves problems of transmit-field inefficiency and inhomogeneity for heart and body imaging, with a close-fitting, 16-channel TEM conformal array design with efficient shield-capacitance decoupling. The second coil progresses directly from the first with automatic tuning and matching, an innovation of huge importance for multi-channel transmit coils. The third coil combines the second, auto-tuned multi-channel transmitter with a 32-channel receiver for best transmit-efficiency, control, receive-sensitivity and parallel-imaging performance. The final two coils extend the innovative technology of the first three coils to multi-nuclear (^(31)P^(1)H) designs to make practical human-cardiac imaging and spectroscopy possible for the first time at 7 T.
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2011.1.3-2 | Award Amount: 3.71M | Year: 2012
Manufacturated nanomaterials and nanocomposites are being considered for various uses in the construction industry and related infrastructure industries, not only for enhancing material properties and functions but also in the context of energy conservation. Despite the current relatively high cost of nano-enabled products, their use in construction materials is likely to increase because of highly valuable properties imparted at relatively low additive ratios, rapid development of new applications and decreasing cost of base MNMs as they are produced in larger quantities. Thus the use of nano-products in the construction industry is a reality and can be expected to grow in the near future. Consequently, there is a general uncertainty with respect to health and safety risks and how to properly manage them to protect workers and be in compliance with OHS legislation. SCAFFOLD is an industrial oriented idea specifically addressed to provide practical, robust, easy-to-use and cost effective solutions for the European construction industry, regarding current uncertainties about occupational exposure to MNMs. This will be achieved by introducing a new paradigm to improve workers protection against NMs in construction, based on a novel holistic Risk Management approach (RMM). The aim of the SCAFFOLD project is to develop, test, validate and disseminate a new holistic, consistent and cost effective Risk Management Model (RMM) to manage occupational exposure to MNMs in the construction sector. This will be done by integration of a set of innovative strategies, methods and tools developed by the project into consistent state-of-the-art safety management systems (OHSAS 18001 \ ISO31000).
Kozak K.H.,University of Minnesota |
Wiens J.J.,State University of New York at Stony Brook
Ecology Letters | Year: 2010
A major goal of ecology is to explain differences in species richness between regions and among clades. The diversification rate of clades is a key parameter for understanding both patterns. Here, we combine phylogenetic and climatic data for 250 species of plethodontid salamanders and show for the first time that rapid species diversification is associated with accelerated climatic-niche evolution among species. Both rates are particularly rapid in tropical regions, and where few clades geographically overlap. These results offer a surprising ecological explanation for why diversification rates are often higher in the tropics: rapid shifts between climatic regimes, rather than specific environmental conditions (e.g. high productivity, energy) drive higher diversity. They also suggest that climatic-niche evolution may be particularly rapid in regions where climate is particularly stable. Finally, these results indicate that evolutionary conservatism in climatic niches may be influenced by interactions between species and clades, rather than physiological tolerances alone. © 2010 Blackwell Publishing Ltd/CNRS.
Agency: National Science Foundation | Branch: | Program: STTR | Phase: Phase I | Award Amount: 225.00K | Year: 2015
This Small Business Technology Transfer (STTR) Phase I project will develop a neurocognitive training device for the education market which targets executive function (EF) and attention deficit hyperactivity disorder (ADHD) and their impact on learning disabilities, reading comprehension and academic success. As many as one out of every five people in the United States has a learning disability (LD) and the cost of educating a student with a LD is 1.6 times the expenditure for a general education student. Thirty-five percent of students with learning disabilities drop out of high school, which is twice the rate of students without LD. This STTR project will benefit children with learning disabilities through development of a device to train cognitive ability. In a broader sense, the technology could also be used to aid adults that have a learning disability. The commercial outcome of the proposed STTR project leads to a marketable product used initially in the context of school or during other real-world activities to improve outcomes for children with a LD resulting in lower overall education costs and higher productivity as an adult. The goal of this research is to develop an untethered neurofeedback system enabling students to apply neurocognitive training within multiple environments including during school and while at home studying. A key innovation of the proposed work is decoupling of the neurofeedback system from conventional computerized interfaces which enables neurocognitive training during real-world activities. It is hypothesized that this approach will lead to improved transference of the training to new scenarios rather than only working for a specific training task. To accomplish this, an alternative wearable based solution will be developed that signals real-time cognitive status to the user through visual feedback enabling them to train their cognitive ability. This phase I project will develop a prototype system capable of real-time electroencephalography (EEG) measurement and classification which provides feedback to the user through wearable eyeglasses. The feasibility will be demonstrated during a neurofeedback training pilot study.
University of Minnesota and Battelle | Date: 2015-06-29
A method may include annealing a material including iron and nitrogen in the presence of an applied magnetic field to form at least one Fe_(16)N_(2 )phase domain. The applied magnetic field may have a strength of at least about 0.2 Tesla (T).